A Kv2 inhibitor combination reveals native neuronal conductances consistent with Kv2/KvS heteromers by Robert G Stewart, Matthew James Marquis, Sooyeon Jo, Brandon J Harris, Aman S Aberra, Verity Cook, Zachary Whiddon, Vladimir Yarov-Yarovoy, Michael Ferns, Jon T Sack

“…KvS proteins are voltage-gated potassium channel subunits that form functional channels when assembled into heteromers with Kv2.1 (KCNB1) or Kv2.2 (KCNB2). …”
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Dual-use on-chip polarizer based on straight silicon nitride platform by Chenxi Zhao, Xinzhi Zheng, Shilong Zhao, Jinman Lv, Mingyang Yu, Bingxi Xiang, Fei Lu, Cangtao Zhou, Yujie Ma, Shuangchen Ruan

“…That is, this straight Si3N4 ridge waveguide structure can function as an on-chip polarizer as well as an optical waveguide.…”
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Molecular simulations reveal intricate coupling between agonist-bound β-adrenergic receptors and G protein by Yanxiao Han, John R.D. Dawson, Kevin R. DeMarco, Kyle C. Rouen, Khoa Ngo, Slava Bekker, Vladimir Yarov-Yarovoy, Colleen E. Clancy, Yang K. Xiang, Surl-Hee Ahn, Igor Vorobyov

“…Summary: G protein-coupled receptors (GPCRs) and G proteins transmit signals from hormones and neurotransmitters across cell membranes, initiating downstream signaling and modulating cellular behavior. Using advanced computer modeling and simulation, we identified atomistic-level structural, dynamic, and energetic mechanisms of norepinephrine (NE) and stimulatory G protein (Gs) interactions with β-adrenergic receptors (βARs), crucial GPCRs for heart function regulation and major drug targets. …”
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Structural analysis and prebiotic properties of the polysaccharides produced by Lactiplantibacillus plantarum YT013 by Min Chen, Hua Zhang, Rui Yang, Xinhang Wang, Liqian Du, Yuqi Yue, Xin Ma, Fanting Zhao, Yingjie Liu, Zhongkun Zhou, Yunhao Ma, Baizhuo Zhang, Yuanchun Zhao, Yan Jin, Hongmei Zhu, Peng Chen

“…These microbial and metabolic shifts suggest that YT013-EPS-1 influences gut microbiota and promotes microbial metabolites associated with intestinal barrier function and host metabolic regulation. Notably, YT013-EPS-1 exerted more pronounced modulatory effects on gut microbiota composition and SCFA profiles than YT013-EPS-2. …”
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Macroalgae Compound Characterizations and Their Effect on the Ruminal Microbiome in Supplemented Lambs by Adriana Guadalupe De la Cruz Gómez, Huitzimengari Campos-García, German D. Mendoza, Juan Carlos García-López, Gregorio Álvarez-Fuentes, Pedro A. Hernández-García, José Alejandro Roque Jiménez, Oswaldo Cifuentes-Lopez, Alejandro E Relling, Héctor A. Lee-Rangel

“…The impact of macroalgae species on rumen function remains largely unexplored. This present study aimed to identify the biocompounds of the three types of marine macroalgae described: <i>Macrocystis pyrifera</i> (Brown), <i>Ulva</i> spp. …”
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The Impact of a Plant-Based Diet on Inflammatory Symptoms In Rheumatoid Arthritis: A Review by Justyna Moszkowicz, Tomasz Ufniarski, Aleksandra Piech, Martyna Grodzińska, Maria Kleczkowska, Karol Poplicha, Piotr Sobkiewicz, Karolina Pasierb, Patrycja Kardasz, Bartłomiej Siuzdak, Marta Jutrzenka

“…A systematic analysis of clinical trials and observational studies reveals that vegan, vegetarian, and plant-forward dietary patterns contribute to significant reductions in disease activity scores (DAS28), inflammatory markers such as C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR), and subjective pain and physical function assessments with vegan, vegetarian, and plant-forward dietary patterns. …”
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Thyrotropin levels in first-episode bipolar disorder and their association with clinical phenotypes: systematic review and meta-analysis by Elisa Gatta, Elisa Gatta, Virginia Maltese, Francesco Dondi, Pietro Bellini, Massimiliano Ugoccioni, Irene Silvestrini, Anna Ceraso, Anna Ceraso, Antonio Vita, Antonio Vita, Mario Rotondi, Mario Rotondi, Francesco Bertagna, Francesco Bertagna, Carlo Cappelli, Carlo Cappelli

“…IntroductionThyroid hormones play a crucial role in brain function, yet the relationship between TSH and bipolar disorder remains unclear. …”
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Reduction of elevated Gli3 does not alter the progression of autosomal recessive polycystic kidney disease by Lauren G. Russell, Maria Kolatsi‐Joannou, Laura Wilson, Jennifer C. Chandler, Nuria Perretta Tejedor, Georgie Stagg, Karen L. Price, Christopher J. Rowan, Tessa Crompton, Norman D. Rosenblum, Paul J. D. Winyard, David A. Long

“…Abstract Polycystic kidney diseases (PKD) are genetic disorders which disrupt kidney architecture and function. Autosomal recessive PKD (ARPKD) is a rare form of PKD, caused by mutations in PKHD1, and clinically more severe than the more common autosomal dominant PKD (ADPKD). …”
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An integrated structural and biophysical approach to study carbon metabolism in Mycobacterium tuberculosis by Evelyn Y.-W. Huang, Francis Kuang, Haozhe Wu, Chai Xin Yu, Xiaoxu Chen, Glenda Vasku, Le Thao Anh Nguyen, Katherine J. Jeppe, Anna K. Coussens, Brooke X.C. Kwai, Ivanhoe K.H. Leung

“…To fully understand their roles and modulation, it is crucial to investigate the relationship between their structure, catalytic mechanism, and function. …”
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Shenyuan granules improve cellular senescence through Klotho-mediated p16/p21 signaling pathway in diabetic kidney disease by Xinyuan Guo, Siyang Zhang, Qingqing Sun, Huimeng Li, Lan Wang, Lan Wang, Lan Wang, Lan Wang

“…Quantification of senescent cells was performed using SA-β-Gal staining, while mRNA and protein expressions were analyzed using immunofluorescence, real-time PCR, and Western blotting.ResultsSYG treatment significantly improved renal function in db/db mice and alleviated histopathological lesions. …”
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The Exocyst Subunits EqSec5 and EqSec6 Promote Powdery Mildew Fungus Growth and Pathogenicity by Jinyao Yin, Xuehuan Zhu, Yalong Chen, Yanyang Lv, Jiaxin Shan, Yuhan Liu, Wenbo Liu, Weiguo Miao, Xiao Li

“…The exocyst complex in eukaryotic cells modulates secretory vesicle transportation to promote exocytosis. …”
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Glucagon-like peptide-1 receptor agonists in neurodegenerative diseases: Promises and challenges by Zhi Dong Zhou, Lingxiao Yi, Karolina Popławska-Domaszewicz, Kallol Ray Chaudhuri, Joseph Jankovic, Eng King Tan

“…Experimental studies have shown that GRA have protective effects to modulate neuroinflammation, oxidative stress, mitochondrial and autophagic functions, and protein misfolding. …”
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Enhancing underwater acoustic communication networks with RIS: Precise performance analysis over κ − μ shadowed fading distribution by Moloy Kumar Ghosh, Mostafa Zaman Chowdhury

“…To evaluate these impacts, the novel closed-form expressions of three essential performance metrics: outage probability (OP), average bit error rate (ABER), and average channel capacity (ACC) are derived in terms of Meijer-G function. To offer deeper insights, the asymptotic behaviors of these performance metrics are also demonstrated. …”
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Neisseria meningitidis regulates P-glycoprotein transporter activity in brain endothelial cells via sphingosine 1–phosphate receptor 1 by Fatemeh Nosratabadi, Leo M. Endres, Fabian Schumacher, Heike Claus, Burkhard Kleuser, Brandon J. Kim, Alexandra Schubert-Unkmeir

“…Conclusions These findings demonstrate that N. meningitidis infection impairs P-gp function through S1PR1-dependent pathways, suggesting that targeting this signaling cascade may offer a novel therapeutic strategy to preserve BBB integrity during bacterial infections.…”
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Ethyltoluenes Regulate Inflammatory and Cell Fibrosis Signaling in the Liver Cell Model by Suryakant Niture, Sashi Gadi, Hieu Hoang, Leslimar Rios-Colon, Wanda Bodnar, Keith E. Levine, Deepak Kumar

“…Acute exposure to induvial ETs and in combination or chronic 2-ET exposure alone modulates cell fibrosis markers such as <i>AST, FGF-23, Cyt-7 p21, TGFβ, TIMP2,</i> and <i>MMP2</i> in liver cell models, suggesting that ETs target liver cells and may dysregulate liver function.…”
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Yangke powder alleviates OVA-induced allergic asthma by inhibiting the PI3K/AKT/NF-κB signaling pathway by Xueyan Li, Lu Ding, Zirui Li, Zhenghua Cao, Min Li, Kai Yin, Siyu Song, Liyuan Cao, Qinjing Xia, Zihan Wang, Daqing Zhao, Xiaolin Tong, Xiangyan Li, Zeyu Wang

“…The asthma model was evaluated using ovalbumin (OVA) and pulmonary function tests, while pathological examination was conducted using hematoxylin and eosin (HE), periodic acid-Schiff (PAS), and Masson trichrome stains. …”
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Application of a Dual-Stream Network Collaboratively Based on Wavelet and Spatial-Channel Convolution in the Inpainting of Blank Strips in Marine Electrical Imaging Logging Images:... by Guilan Lin, Sinan Fang, Manxin Li, Hongtao Wu, Chenxi Xue, Zeyu Zhang

“…Furthermore, a multi-objective loss function is introduced to constrain the semantic coherence and visual authenticity of image reconstruction. …”
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ZeXieYin formula alleviates atherosclerosis by regulating SBAs levels through the FXR/FGF15 pathway and restoring intestinal barrier integrity by Shihan Zhou, Shangbo Hua, Xinyi Chen, Meiling Ni, Jing Liu, Yanqing Wang, Wanning Wu, Anni Ding, Zizhen Qin, Xinyu Yang, Xiaowei Chen, Boran Zhu, Haoxin Wu

“…Purpose of the research This study aims to investigate the pivotal role of enterohepatic bile acid circulation in enhancing intestinal barrier function and mitigating AS by ZXYF. Materials and methods The AS model was established by subjecting male ApoE−/− mice to a high-fat diet (HFD). …”
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Application of Polyglycolic Acid/Poly (Lactic&amp;#x2010;co&amp;#x2010;glycolic Acid) in Thread Embedding Acupuncture for Obesity: New Strategies and Challenges by Wang J, Cao K, Chen Z, Lyu T, Xia Q, Zhu X, Liu L, Li B

“…Additionally, TEA regulates gut microbiota composition and impacts neuroendocrine pathways, enhancing hypothalamic function and appetite control via leptin receptor activation and energy homeostasis modulation. …”
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HMGB1 Mediates Microglia-Astrocyte/Neuron Crosstalk and Pyroptosis by the TLR4/NF-κB Pathway in Multiple Sclerosis by Yang Feng, Liang Wang, Zhuofeng Mao, Weiping Wang

“…Results: Mice treated with MOG35-55 (experimental autoimmune encephalomyelitis, EAE) exhibited reduced body weights and significant nerve function impairment (p < 0.001), accompanied by increased activation of microglia within the CNS (p < 0.05). …”
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