Identification of Crucial Genes Associated With MYCN‐Driven Neuroblastoma Based on Single‐Cell Analysis and Machine Learning by Jiasi Zhang, Yichen Lei, Yaqin Wang, Wen Yu, Xiaoyan Zhao, Yongbing Zhu, Dedong Zhang, Siying Liu, Aiguo Liu

“…Finally, we visualized the expression levels and global function of these genes in single‐cell datasets and validated their expression in patient samples through RT‐qPCR. …”
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Morphological responses of a temperate intertidal foraminifer, Haynesina sp., to coastal acidification by Christopher Powers, Christopher Powers, Alberto Paz, Amaelia Zyck, Kaylee Harri, Madison Geraci, Madison Geraci, Joan M. Bernhard, Ying Zhang

“…Therefore, with the acceleration of coastal acidification due to anthropogenic production of CO2, benthic foraminifera and other calcifying organisms among coastal ecosystems could reach a tipping point that leads to thinning and dissolution of their calcareous tests, which in turn, will impair their ecological function as a carbon sink.…”
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Harnessing TAGAP to improve immunotherapy for lung squamous carcinoma treatment by targeting c-Rel in CD4+ T cells by Peian Cai, Haibo Sun, Tongmeng Jiang, Huawei Li, Dejing Huang, Xiaopei Hao, Wei Wang, Wenqun Xing, Guanghui Liang

“…Abstract Revealing the immunosenescence, particularly in CD4+ T cell function in lung squamous carcinoma (LUSC) assists in devising individual treatment strategies. …”
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Effects of subanesthetic dose of ketamine on motor and cognitive outcomes of harmaline-induced essential tremor model: a focus on Lingo-1 and inflammatory pathways by Mehran Ilaghi, Zeynab Pirmoradi, Zahra Esmaili, Shamim Hosseinalipour, Leili Rouhi, Adel Soltanizadeh, Mohsen Nakhaie, Kiana Sharififar, Moazamehosadat Razavinasab, Mohammad Shabani

“…Conclusion Our findings suggest that ketamine has limited efficacy in the harmaline ET model, showing some improvements in motor function and anxiety-like behavior but failing to address core tremor symptoms or modulate inflammatory and Lingo-1 pathways. …”
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Mechanisms of anesthetic-induced immune dysregulation by Tatiane Renata Fagundes, Carolina Coradi, Marina Rayciki Sotomayor, Aline Graciele Henriques Campos, Luísa Cristina Fortuna da Silva, Hellena Alves Ferneda, Wilson da Silva Pereira Junior, Gabriela Bonetti Bellandi, Maria Eduarda Pardal Simonato, Valentina Vieira Steffanello, Larissa de Oliveira Manes, Rafael Gomes Paz, Edina Cassiane Padilha, Felipe da Silva Bender, Ricardo Nogueira Vincensi, Maria Paula de Andrade Berny, Mateus Lucas Falco, Odirlei João Titon, Carolina Panis

“…However, its impact on the immune system has become a growing area of research, as anesthetic agents can modulate immune function in complex ways. Emerging evidence suggests that anesthetics may induce immune dysregulation, affecting both innate and adaptive immunity, with potential consequences for patient outcomes, particularly in the context of infection, inflammation and cancer. …”
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Ultrasound‐Responsive HBD Peptide Hydrogel with Antibiofilm Capability for Fast Diabetic Wound Healing by Lanlan Zong, Runxin Teng, Huiqi Zhang, Wenshang Liu, Yu Feng, Zhengmao Lu, Yuxiao Zhou, Zhen Fan, Meng Li, Xiaohui Pu

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Effective Dose of Oliceridine Fumarate Co-Administered with Remimazolam in Suppressing Gastroscope Insertion Responses for Adults by Yang W, Zhou R, Zhou X, Chen X, Zhou D, Zhang X

“…Weilin Yang,1,* Rui Zhou,2,* Xinyu Zhou,1 Xuemeng Chen,1 Dan Zhou,1 Xianjie Zhang1 1Department of Anesthesiology, Deyang People’s Hospital, Deyang, 618000, People’s Republic of China; 2Shanghai Key Laboratory of Anesthesiology and Brain Functional Modulation, Translational Research Institute of Brain and Brain‑Like Intelligence, Clinical Research Center for Anesthesiology and Perioperative Medicine, Department of Anesthesiology and Perioperative Medicine, Shanghai Fourth People’s Hospital, School of Medicine, Tongji University, Shanghai, 200434, People’s Republic of China*These authors contributed equally to this workCorrespondence: Dan Zhou, Department of Anesthesiology, Deyang People’s Hospital, NO. 173, Section 1 of North Taishan Road, Jingyang District, Deyang, Sichuan Province, 618000, People’s Republic of China, Email zd13069617@163.com Xianjie Zhang, Department of Anesthesiology, Deyang People’s Hospital, NO. 173, Section 1 of North Taishan Road, Jingyang District, Deyang, Sichuan Province, 618000, People’s Republic of China, Email zhangxianjie791002@163.comObjective: To determine the 50% effective dose (ED50) and 95% effective dose (ED95) of oliceridine in suppressing gastroscope insertion responses during painless gastroscopy when combined with 0.3 mg/kg remimazolam.Methods: This prospective study enrolled 52 patients scheduled for elective painless gastroscopy. …”
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Prevalence and genetic characteristics of Campylobacter jejuni from laying-hens in Hubei Province, China by Shichang Kuang, Zhaoyang Wang, Xiuzhong Hu, Zeyuan Dong, Chun Wang, Yuncai Xiao, Zili Li, Deshi Shi, Shaowen Li, Zutao Zhou

“…A comprehensive analysis of virulence genes isolated from C. jejuni strains revealed a total of 117 virulence genes, categorized according to their functional roles. These categories encompass adhesion (cadF, jlpA, porA, pebA), invasion (ciaB), motility (flaA, flgB, flhB), toxin production (cdtA, cdtB, cdtC), and immune modulation (htrB, wlaN). …”
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Integrating machine learning and multi-omics analysis to unveil key programmed cell death patterns and immunotherapy targets in kidney renal clear cell carcinoma by Fanyan Ou, Yi Pan, Qiuli Chen, Lixiong Zeng, Kanglai Wei, Delin Liu, Qian Guo, Liquan Zhou, Jie Yang

“…Integrating multi-omics analysis, including immune cell infiltration, phenotyping, functional analysis, immune checkpoint exploration, and gene set enrichment analysis (GSEA), we explored the relationship between key cell death patterns and patients’ responses to immunotherapy. …”
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The Effects of Specific Gut Microbiota on Hyperuricemia — A Mendelian Randomization Analysis and Clinical Validation by Αikepa D, He Y, Chen W, Liang M, Du Y, Chen X, Du M, Zhu Y, Wang J, Sun Y

“…The intestines play a significant role in UA excretion, and emerging evidence suggests that gut microbiota modulate UA excretion and degradation. However, the specific functional microbial biomarkers and their roles in HUA remain underexplored.Methods: Based on this, we hypothesize that the Mendelian randomization (MR) analysis method can be used to identify and define microbial biomarkers associated with HUA. …”
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Qimai Feiluoping Decoction Inhibits EndMT to Alleviate Pulmonary Fibrosis by Reducing PI3K/AKT/mTOR Pathway-Mediated the Restoration of Autophagy by Ma J, Ding L, Zang X, Yang Y, Zhang W, Li X, Zhao D, Zhang Z, Wang Z, Zhao L, Tong X

“…Supporting evidence from zebrafish models demonstrated that QM not only counteracts EndMT but also improves a range of vascular functional disorders and remodeling issues following EndMT.Conclusion: Our research validates the active compounds, core targets, and signaling pathways through which QM counters PF, providing valuable insights for its therapeutic application in PF management.Keywords: Qimai Feiluoping decoction, pulmonary fibrosis, network pharmacology, molecular docking, endothelial mesenchymal transition, autophagy…”
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Intervening Non-Small-Cell Lung Cancer Progression by Cell Membrane Coated Platycodin D via Regulating Hsa-miR-1246/FUT9/GSK3β Pathway by Zheng S, Xie Z, Zhou Z, Wang S, Xin Y, Lin J, Cheng K, Lu T, Qi R, Guo Y

“…Furthermore, a homologous cell membrane-based PD delivery system was established to improve the biosafety and efficacy of PD in vivo.Results: Hsa-miR-1246 was upregulated by PD treatment, and functional experiments demonstrated that the miR-1246-mimic enhanced PD’s suppressive effects on NSCLC cell proliferation, colony formation, migration, and invasion, while the miR-1246-inhibitor abrogated these effects. …”
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Prognostic significance and immune infiltration analysis of HMGA2 in endometrial cancer by Peng Jiang, Jiaxin Yu, Yunfeng Zheng, Chenfan Tian, Yuan Tu, Chunxia Gong, Hangkun Yu, Yi Luo, Zhuoying Hu

“…Functional enrichment analysis (GSEA and KEGG) identified HMGA2-associated pathways. …”
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Cornus officinalis Protects Against Steroid-Induced Osteonecrosis of the Femoral Head Through Inhibiting Inflammatory Responses and Apoptosis via Network Pharmacology and Experimen... by Wang Y, Fan Y, Li M, Song Z, Wang P, Xie F, Miao Y, Wang Y, Zhang P, Zhan Q

“…The protein–protein interaction (PPI) network, Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) functional enrichment analyses were performed to predict the core targets and pathways of SZY in the treatment of SONFH. …”
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Tripartite Motif-Containing 1 Influences the Prognosis of Cervical Cancer by Ge Zhang, Huan Chen, Yin Tao

“…Survival outcomes were assessed using Kaplan-Meier method, revealing significant correlations between TRIM11 expression levels and both progression-free survival (PFS) and overall survival (OS) rates in TCGA CC cases. Functional pathway associations were elucidated through gene set enrichment analysis (GSEA), identifying TRIM11-related oncogenic mechanisms. …”
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THE CONTENT OF INTERLEUKINS IN ORAL FLUID OF PATIENTS WITH NON-REMOVABLE METAL CERAMIC PROSTHESES by Yu. M. Hotsko, L. Ye. Lapovets

“…Currently, the most common are the metal-ceramic structures, which have the high mechanical properties and are aesthetic and functional, because they restore chewing efficiency by 85-100% and provide a high level of adaptation to them. …”
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Integrated single-cell analysis reveals distinct epigenetic-regulated cancer cell states and a heterogeneity-guided core signature in tamoxifen-resistant breast cancer by Kun Fang, Aigbe G. Ohihoin, Tianxiang Liu, Lavanya Choppavarapu, Bakhtiyor Nosirov, Qianben Wang, Xue-Zhong Yu, Sailaja Kamaraju, Gustavo Leone, Victor X. Jin

“…A variety of cell types among breast tumor tissues were identified, PT- and RT-specific cancer cell states (CSs) were defined, and a heterogeneity-guided core signature (HCS) was derived through such integrated analysis. Functional experiments were performed to validate the oncogenic role of BMP7, a key gene within the core signature. …”
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Efficacy of an Intelligent and Integrated Older Adult Care Model on Quality of Life Among Home-Dwelling Older Adults: Randomized Controlled Trial by Rongrong Guo, Jiwen Zhang, Fangyu Yang, Ying Wu

“…The primary end point was the percent change in QOL from baseline to the 3-month follow-up, assessed using the World Health Organization Quality of Life Instrument - Older Adults Module. Secondary end points included functional status at the 3-month follow-up and percent changes in health self-management ability, social support, and confidence in avoiding falling from baseline to the 3-month follow-up. …”
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Longitudinal evaluation of common and unique brain-networks in variants of primary progressive aphasia by Rajan Kashyap, Rose Dawn Bharath, Changsong Zhou, Kyrana Tsapkini, John E. Desmond, SH Annabel Chen, Kaviraja Udupa, PT Sivakumar, Sagarika Bhattacharjee

“…Result We found the existence of a left lateralised functional network identical in both PPA groups. This CN, comprising regions associated with language and cognition, remained stable over time (12 months period) and was associated with the severity of dementia. …”
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Effects of innovative modular prone positioning tools in patients with acute respiratory distress syndrome due to COVID-19 during awake prone position: a prospective randomized con... by Dunbing Huang, Huan Tian, Wei Song, Jiaqi Wang, Zizhe Yao, Lize Xiong, Cai Jiang, Anren Zhang, Xiaohua Ke

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