Multiomics approach reveals the comprehensive interactions between nutrition and children’s gut microbiota, and microbial and host metabolomes by Mingyu Zhu, Qi Wang, Yan Yang, Xiaobing Liu, Jiawen Zhang, Guanghao Li, Wenqing Liu, Xuesong Xiang, Juanjuan Chen

“…Abstract The gut microbiome can modulate nutrient metabolism to produce many metabolites interacting with the host. …”
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Unveiling the chemical composition, antioxidant and antibacterial properties, and mechanistic insights of Convolvulus arvensis extract through molecular docking simulations by Fatemeh Mosallaie, Motahare Pirnia, Zahra Dehghan, Fereshteh Falah, Reihaneh Sabbaghzadeh, Behrooz Alizadeh Behbahani, Fahimeh Lavi Arab, Farideh Tabatabaei Yazdi, Alireza Vasiee

“…High Performance Liquid Chromatography (HPLC) and Fourier transform infrared (FTIR) spectroscopy were utilized to identify the chemical composition and functional groups present in the extract. The findings revealed that ultrasound-assisted extraction exhibited significantly higher extraction efficiency (p < 0.05). …”
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Type III interferon primes pDCs for TLR7 activation and antagonizes immune suppression mediated by TGF-β and PGE2 by Candice Sakref, Alexis Saby, Céline Rodriguez, Maude Ardin, Lyvia Moudombi, Anne-Claire Doffin, Elisa Gobbini, Aurélien Voissiere, Laurie Besson, Léo Laoubi, Jan Böttcher, Stéphane Depil, Margaux Hubert, Nathalie Bendriss-Vermare, Christophe Caux, Jenny Valladeau-Guilemond

“…Abstract Conventional dendritic cell and plasmacytoid dendritic cell (pDC) subsets have specialized functions that can be modulated by the tumor microenvironment, and produce different interferons that are central to antitumor immune responses. …”
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Profiling bitter taste receptors (TAS2R) along the gastrointestinal tract and their influence on enterohormone secretion. Gender- and age-related effects in the colon by Florijan Jalševac, Maria Descamps-Solà, Carme Grau-Bové, Helena Segú, Teresa Auguet, Francesc Xavier Avilés-Jurado, Francesc Xavier Avilés-Jurado, Francesc Balaguer, Rosa Jorba, Raúl Beltrán-Debón, Raúl Beltrán-Debón, Maria Teresa Blay, Maria Teresa Blay, Ximena Terra Barbadora, Ximena Terra Barbadora, Montserrat Pinent, Montserrat Pinent, Anna Ardévol, Anna Ardévol

“…Stimulating TAS2R14 in Hutu-80 cells induced GLP-1 secretion, while stimulating TAS2R5 modulated GLP-1 and PYY secretion. Given the modifications TAS2R agonists may undergo along the GIT, as well as the distinctive expression patterns and possible functional roles of TAS2R receptors along the intestinal tract, our findings suggest the viability of a targeted strategy aimed at enhancing specific functions to improve health outcomes. …”
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Protective effects of Nippostrongylus brasiliensis-derived uridine via the apical sodium-dependent bile acid transporter in a mouse model of TNBS-induced inflammatory bowel disease by Caiyi Yuan, Qiang Wang, Yuying Chen, Yuying Chen, Xin Ding, Qiang Zhang, Jiakai Yao, Bei Zhang, Yang Dai, Yang Dai, Hongxia Bai

“…Moreover, we conducted an RNA sequencing (RNA-Seq) analysis to elucidate the relevant possible functional mechanisms responsible for the protective and anti-inflammation effects of ES or uridine administration.ResultsCurrent results have demonstrated that uridine can exhibit a protective effect on TNBS-induced IBD in mice. …”
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Effect of broccoli extract supplement on carcass traits and lipid metabolism in Holstein steers by Shuangshuang Chen, Xinyu Zhang, Tao Zhu, Die Tang, Mingxing Wen, Chuang Tang, Ling Hou, Zhiyao Zeng, Shanfeng Tong, Xuelong Li, Lu Lu, Keren Long, Quanhui Peng, Anan Jiang, Jideng Ma

“…These findings highlight its potential as a functional feed additive for improving beef cattle production.…”
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Two-dimensional nanomaterials for bone disease therapy: multifunctional platforms for regeneration, anti-infection and tumor ablation by Xuejie Cai, Zehui Lv, Zhao Wang, Yingjie Wang, Jiawei Xu, Xingdong Yang, Han Wang, Yixin Bian, Yang Zhu, Bin Feng, Xisheng Weng

“…Graphical Abstract Molecular structures, physicochemical properties, biological function and orthopedic applications offered by 2D nanomaterials.…”
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Taste perception and muscular response: EMG based experimental evaluation by Bhavya Rohatgi, Ramya Ramadoss, K. Nitya, Sandhya Sundar, Suganya Panneer Selvam, K. Hema Shree

“…Future research with a larger sample size and advanced statistical methods may further elucidate the role of taste in modulating masticatory muscle function.…”
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Multi-Scale Kolmogorov-Arnold Network (KAN)-Based Linear Attention Network: Multi-Scale Feature Fusion with KAN and Deformable Convolution for Urban Scene Image Semantic Segmentati... by Yuanhang Li, Shuo Liu, Jie Wu, Weichao Sun, Qingke Wen, Yibiao Wu, Xiujuan Qin, Yanyou Qiao

“…The local attention channel adopts MKLA block by bringing the merits of KAN convolution in Mamba like the linear attention block to improve the ability of handling linear and nonlinear feature and complex function approximation with a few extra computations. …”
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Fermented Erigeron breviscapus flavonoids: anti-pseudorabies virus efficacy and mechanisms in vitro and in vivo by Ying Zhang, Ting Li, Chunkun Yang, Qiong Pan, Changxu Pan, Xue Zhang, Ying Zhang, Xianghua Shu, Zheng Wang, Zhenghong He, Zichen Qu, Chunlian Song

“…IntroductionErigeron breviscapus exhibits anti-inflammatory properties, protects neuronal cells and enhances immune function. Modern traditional Chinese medicine fermentation techniques can increase the bioactive compound content in Erigeron breviscapus. …”
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Loss of CTRP10 results in female obesity with preserved metabolic health by Fangluo Chen, Dylan C Sarver, Muzna Saqib, Leandro M Velez, Susan Aja, Marcus M Seldin, G William Wong

“…Here, we report that CTRP10/C1QL2-deficient mice represent a unique female model of MHO. CTRP10 modulates weight gain in a striking and sexually dimorphic manner. …”
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Identification of a Novel Regulatory Gene, <i>trmE,</i> that Orchestrates <i>Salmonella</i> Flagellar Synthesis and Virulence by Haoyu Geng, Linyan Luo, Jian Zhang, Jingying Gao, Shizhong Geng, Paul Barrow

“…In this study, we identified the <i>trmE</i> gene as a novel modulator of flagellar synthesis in <i>Salmonella</i> Enteritidis. …”
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CCR2 Regulates Referred Somatic Hyperalgesia by Mediating T-Type Ca²⁺ Channel Currents of Small-Diameter DRG Neurons in Gastric Ulcer Mice by Ziyan Yuan, Huanhuan Liu, Zhijun Diao, Wei Yuan, Yuwei Wu, Simeng Xue, Xinyan Gao, Haifa Qiao

“…<b>Conclusions</b>: Therefore, these findings indicate that CCR2 may function as a critical regulator in the generation of neurogenic inflammation and mechanical allodynia by modulating the gating properties of the T-type Ca²⁺ channels.…”
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Faecal microbiota transplantation as a novel approach for autism-associated anxiety: A critical therapeutic appraisal by Tanushree D. Malode, Pranali Chandurkar, Brijesh G. Taksande, Amol A. Tatode, Mohammad Qutub, Tanvi Premchandani, Milind J. Umekar, Jayshree B. Taksande

“…Mechanistically, FMT is thought to reduce neuroinflammation, restore neurotransmitter balance, and normalize stress responses by enhancing gut microbial diversity and metabolic function. However, significant challenges remain, including concerns about safety, standardization, donor selection, and regulatory approval. …”
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Integrative in silico and Petra/Osiris/Molinspiration (POM) analysis of baicalein: identification of therapeutically relevant pharmacophores against keloid pathology by Abhay Mishra, Anothai Tangsumranjit, Manisha Nigam, Harish Chandra, Faisal A. Almalki, Taibi Hadda, Neti Waranuch

“…Such ligands are crucial for forming bimetallic complexes that can function as efficient biocatalysts against various biological targets. …”
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C-X-C motif chemokine ligand 1 derived from oral squamous cell carcinoma promotes cancer-associated fibroblast differentiation and tumor growth by Soon Chul Heo, In-hye Nam, Bo Ram Keum, Yeo Gyun Yun, Jae-Yeol Lee, Hyung Joon Kim

“…CXCL1 synergistically enhanced TGF-β1-induced differentiation of GFs into α-smooth muscle actin (αSMA)- and vimentin-expressing CAFs by approximately 1.5-fold, confirming its co-stimulatory function. Conversely, silencing its receptor CXCR2 reduced CAF marker expression by over 50%, indicating a strong inhibitory effect on CAF differentiation. …”
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Inhibition of TMUB1 blocks apoptosis and NF‐κB pathway‐mediated inflammation in recurrent spontaneous abortion by Xiuping Zhang, Yuanjing Hu, Zhiping Zhang, Xueluo Zhang, Lixia Liang, Xiangrong Cui, Yuanxia Wu, Fen Hu, Xueqing Wu

“…Aberrant expression of transmembrane and ubiquitin‐like domain containing 1 (TMUB1) is closely related to a series of diseases, including RSA. However, the function and underlying mechanism of TMUB1 in the occurrence of RSA has not been described. …”
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Phase-dependent closed-loop deep brain stimulation of the fornix provides bidirectional manipulation of hippocampal theta oscillations by Isaac Grennan, Brook Perry, Anna Verghese, Melissa Jones, Oliver Härmson, Colin G. McNamara, Andrew Sharott

“…Conclusions: Our findings demonstrate that closed-loop fx-DBS is a viable method of modulating the amplitude of hippocampal theta oscillations that could be applied in human devices to provide a constructive intervention with the potential to boost memory circuit function in AD.…”
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Cvill6 and Cvill7: Potent and Selective Peptide Blockers of Kv1.2 Ion Channel Isolated from Mexican Scorpion <i>Centruroides villegasi</i> by Kashmala Shakeel, Muhammad Umair Naseem, Timoteo Olamendi-Portugal, Fernando Z. Zamudio, Lourival Domingos Possani, Gyorgy Panyi

“…Scorpion venoms are a rich source of peptides that modulate the activity of ion channels and can serve as a new drug for channelopathies. …”
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Inhibition of Phosphoglycerate Kinase 1 Enhances Radiosensitivity of Esophageal Squamous Cell Carcinoma to X-rays and Carbon Ion Irradiation by Junru Chen, Hongtao Luo, Xun Wu, Meng Dong, Dandan Wang, Yuhong Ou, Yuhang Wang, Shilong Sun, Zhiqiang Liu, Zhen Yang, Quanlin Guan, Qiuning Zhang

“…To elucidate PGK1’s function, small interfering RNAs and plasmids were used to silence and overexpress PGK1 in two human ESCC cell lines. …”
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