Targeting p53-p21 signaling to enhance mesenchymal stem cell regenerative potential by Ahsas Goyal, Muhammad Afzal, Nawaid Hussain Khan, Kavita Goyal, Suresh Kumar Srinivasamurthy, Gaurav Gupta, K. Benod Kumar, Haider Ali, Mohit Rana, Ling Shing Wong, Vinoth Kumarasamy, Vetriselvan Subramaniyan

“…Genetic tools like CRISPR-Cas9 and RNA interference also precisely modulate TP53 and CDKN1A expression to optimize MSC functionality. …”
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Control of anterior GRadient 2 (AGR2) dimerization links endoplasmic reticulum proteostasis to inflammation by Marion Maurel, Joanna Obacz, Tony Avril, Yong‐Ping Ding, Olga Papadodima, Xavier Treton, Fanny Daniel, Eleftherios Pilalis, Johanna Hörberg, Wenyang Hou, Marie‐Claude Beauchamp, Julien Tourneur‐Marsille, Dominique Cazals‐Hatem, Lucia Sommerova, Afshin Samali, Jan Tavernier, Roman Hrstka, Aurélien Dupont, Delphine Fessart, Frédéric Delom, Martin E Fernandez‐Zapico, Gregor Jansen, Leif A Eriksson, David Y Thomas, Loydie Jerome‐Majewska, Ted Hupp, Aristotelis Chatziioannou, Eric Chevet, Eric Ogier‐Denis

“…Here, using a protein–protein interaction screen to identify cellular regulators of AGR2 dimerization, we unveiled specific enhancers, including TMED2, and inhibitors of AGR2 dimerization, that control AGR2 functions. We demonstrate that modulation of AGR2 dimer formation, whether enhancing or inhibiting the process, yields pro‐inflammatory phenotypes, through either autophagy‐dependent processes or secretion of AGR2, respectively. …”
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Whole Transcriptome-Based ceRNA Regulatory Network Analysis of Radiation-Induced Esophageal Epithelial Cell Injury by Lin H, Feng Y, Liu H, Zhang J, Zhang X, Ying X, Shi Y, Tan H, Tu W

“…Gene set enrichment analysis showed that radiation disrupted channel activity, cell replication, repair, and immune response. Functional enrichment analysis revealed modulation of metabolic pathways, particularly involving UGT1A family members.Discussion: This study established a ceRNA network related to radiation-induced esophageal epithelial cell injury, advancing our understanding of its pathophysiology. …”
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Multi-Target Synergy Against Acute Lung Injury: Systems Pharmacology Decoding Dahuang-Huangqin Herb Pair’s Therapeutic Mechanism by Zhang J, Zhu X, Chen X, Liu H, Yan Z, Chen Z, Li Q, Yu W

“…PPI network analysis revealed five key regulatory targets: GAPDH, IL1B, IL10, MMP9, and TP53. Functional enrichment analyses demonstrated DH-HQ’s modulation of critical pathways including HIF-1 signaling and cytokine-cytokine receptor interaction. …”
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Network pharmacology integrated with molecular docking and experimental validation elucidates the therapeutic potential of Forsythiae Fructus extract against hepatitis B virus-rela... by Fuqing Chen, Yifan Cai, Changzhou Chen, Jianyin Zhou

“…In vitro experiments demonstrated that FF extract significantly inhibited the viability and proliferation of HepG2.2.15 cells, induced apoptosis, and exerted its effects via modulation of the IL-17/MAPK signaling pathway. Notably, adenovirus-mediated overexpression experiments showed that ESR1 enhanced FF’s anti-HCC effects, whereas JUN and MMP9 partially counteracted them, confirming their roles as functional targets. …”
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Experimental evidence-based construction of electroacupuncture for ischemic stroke: a meta-analysis and systematic review by Yaoguang Guo, Sihan Hu, Sihan Hu, Shiman Luo, Lang Tu, Yao Tang, Fang Zeng, Fang Zeng, Fang Zeng

“…The heterogeneity of the included studies points to complex underlying mechanisms, potentially involving modulation of apoptotic pathways and cerebral blood flow.ConclusionThis meta-analysis substantiates the neuroprotective potential of EA in ischemic stroke models, primarily through apoptosis modulation and possibly through improved cerebral perfusion. …”
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Illustrate the metabolic regulatory effects of Ganoderma Lucidum polysaccharides on cognitive dysfunction in formaldehyde-exposed mouse brain by mass spectrometry imaging by Wen Wang, Yuanyuan Sun, Renting Cao, Wenhui Luo, Shujuan Beng, Jing Zhang, Xiaoqun Wang, Can Peng

“…While some studies suggest Ganoderma lucidum polysaccharides (GLP) can improve cognitive function, such as Alzheimer's disease. However, the effects of GLP on FA-exposed cognitive dysfunction and the regulation of GLP on brain metabolic disturbances caused by FA remain unclear. …”
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Nafamostat Mesylate Regulates Glycosylation to Alleviate Aristolochic Acid Induced Kidney Injury by Pei Xie, Huijun Liu, Xingli Huo, Junlong Chen, Yu Li, Yu Huang, Zongning Yin

“…Glycosylation, a post-translational modification of proteins, is essential for maintaining protein stability and function, and its dysregulation leads to protein misfolding and amyloid aggregation. …”
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Advanced Water Production via Point of Use Super‐Ultralow‐Pressure Reverse Osmosis and Cellulose‐Polyamide Thin‐Film Nanocomposite Membranes by Juan Luis Fajardo‐Diaz, Armando David Martinez‐Iniesta, Ayaka Yamanaka, Syogo Tejima, Kazou Izu, Shigero Saito, Jun Maeda, My Ali El Khakani, Winadda Wongwiriyapan, Feng Wang, Takuya Hayashi, Kenji Takeuchi, Rodolfo Cruz‐Silva, Morinobu Endo

“…The CM‐CNF with an increased number of oxygen‐containing functional groups that positively impacts water flux, salt rejection stability, antifouling characteristics, and resistance to chlorine degradation compared to commercial RO‐PA membranes. …”
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Cascade reaction–driven biomimetic scintillant/metal–organic frameworks for X-ray triggered combinational therapy against glioma by Lansheng Wang, Duo Xu, Xudong Hu, Rui Quan, Dong Lu, Zhen Li, Changshui Yu, Xingjun Li, Shuo Ma, Xiaoming Li, Zhengkui Zhang, Rutong Yu

“…This nanoparticle system has potential as a dual-functional agent for GBM treatment.…”
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Phase-pure ferroelectric quantum wells with tunable photoluminescence for multi-state optoelectronic applications by Rui Sun, Yuping Jia, Bo Lai, Zhiming Shi, Mingrui Liu, Weili Yu, Ke Jiang, Shanli Zhang, Shunpeng Lv, Yang Chen, Xiaojuan Sun, Dabing Li

“…Abstract Quasi-two-dimensional (quasi-2D) metal halide perovskite (MHP) ferroelectrics, characterized by spontaneous polarization and semiconducting properties, hold promise for functional photoferroelectrics in applications such as optical storage and in-memory computing. …”
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Tetraspanin7 in adipose tissue remodeling and its impact on metabolic health by Shino Nemoto, Kazuyo Uchida, Tetsuya Kubota, Manabu Nakayama, Yong-Woon Han, Shigeo Koyasu, Hiroshi Ohno

“…Morphological, molecular, and omics analyses, including proteomics and transcriptomics, were performed to investigate TSPAN7 function. Physiological effects were assessed by measuring blood markers associated with lipid regulation under metabolic challenges, such as high-fat feeding and aging. …”
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Multi‐Omics Analysis of Gut Microbiome and Host Metabolism in Different Populations of Chinese Alligators (alligator sinensis) During Various Reintroduction Phases by Chong Wang, Changcheng Li, Fuyong You, Yongkang Zhou, Genjun Tu, Ruoya Liu, Pingsi Yi, Xiaobing Wu, Haitao Nie

“…In terms of species function, reintroduction significantly upregulated the expression of host immune‐related genes and significantly decreased the expression of gut bacterial pathogenic genes and antibiotic resistance genes. …”
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Effects of Vitamin D, Melatonin, and Omega-3 Fatty Acids on Periodontal Health: A Narrative Review by Dora Dragičević Tomičić, Nikolina Lešić, Ivana Škrlec, Larissa Steigmann, Kristina Tseneva, Martina Čalušić Šarac, Tin Crnić, Igor Tomičić, Željka Perić Kačarević, Marija Čandrlić

“…Vitamin D is essential for calcium homeostasis, bone remodeling, and immune function. It modulates both innate and adaptive immune responses, enhancing antimicrobial peptide production and reducing inflammatory cytokine expression. …”
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Dysregulated C1q and CD47 in the aging monkey brain: association with myelin damage, microglia reactivity, and cognitive decline by Sarah A. DeVries, Christina Dimovasili, Maria Medalla, Maria Medalla, Tara L. Moore, Tara L. Moore, Douglas L. Rosene, Douglas L. Rosene

“…Normal aging, though lacking widespread neurodegeneration, is nevertheless characterized by cognitive impairment in learning, memory, and executive function. The aged brain is spared from neuron loss, but white matter is lost and damage to myelin sheaths accumulates. …”
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Influence of the Degree of Unsaturation in Fish Oil Supplements on Oxidative Stress and Protein Carbonylation in the Cerebral Cortex and Cerebellum of Healthy Rats by Francisco Moreno, Lucía Méndez, Ingrid Fernández, Bernat Miralles-Pérez, Montserrat Giralt, Marta Romeu, Sara Ramos-Romero, Josep Lluís Torres, Isabel Medina

“…ω-3 polyunsaturated fatty acids (PUFAs) are crucial for brain structure and function, especially docosahexaenoic acid (DHA). However, an excess of DHA may increase lipid peroxidation due to its high degree of unsaturation, particularly in tissues highly susceptible to oxidative stress, such as the brain. …”
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Lacticaseibacillus paracasei sh2020 induced antitumor immunity and synergized with anti-programmed cell death 1 to reduce tumor burden in mice by Shi-Long Zhang, Bing Han, Yu-Qin Mao, Zheng-Yan Zhang, Zhan-Ming Li, Chao-Yue Kong, You Wu, Guo-Qiang Chen, Li-Shun Wang

“…In vitro and in vivo studies revealed that L. paracasei sh2020 stimulation triggered the upregulated expression of CXCL10 in the tumors and subsequently enhanced CD8+ T cell recruitment. Meanwhile, the modulation of gut microbiota caused by L. paracasei sh2020 enhanced its antitumor effect and gut barrier function. …”
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Exercise Promotes Hippocampal Neurogenesis in T2DM Mice via Irisin/TLR4/MyD88/NF-κB-Mediated Neuroinflammation Pathway by Haocheng Xu, Xin Tian, Yuanxin Wang, Junjie Lin, Baishu Zhu, Chen Zhao, Bin Wang, Xin Zhang, Yu Sun, Nan Li, Xun Sun, Fanxi Zeng, Mingzhi Li, Xiquan Ya, Renqing Zhao

“…Ten-week exercise significantly decreased T2DM-induced inflammation levels and markedly promoted hippocampal neurogenesis and memory function. However, these positive effects were reversed by 10 weeks of treatment with cyclo RGDyk, an inhibitor of irisin receptor signaling. …”
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Resveratrol Ameliorates Chronic Stress in Kennel Dogs and Mice by Regulating Gut Microbiome and Metabolome Related to Tryptophan Metabolism by Zhaowei Bian, Ziyang Li, Hao Chang, Jun Luo, Shiyan Jian, Jie Zhang, Peixin Lin, Baichuan Deng, Jinping Deng, Lingna Zhang

“…In conclusion, Res could ameliorate canine stress by increasing 5-HT, BDNF, and the antioxidant capacity and improving the immune function and stress response, which was attributed to the role of Res in the restructuring of gut microbiota and the modulation of tryptophan metabolism.…”
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High-fat stimulation induces atrial structural remodeling via the TPM1/P53/SHISA5 Axis by Yansong Cui, Shuting Bai, Zhenlin Liu, Haifeng Ding, Kuan Li, Zhan Li, Yinglong Hou

“…Hyperlipidemia, a potential contributor to AF, affects cardiac function through multiple pathways. This study aimed to investigate the underlying mechanisms by which high lipid levels promote AF progression. …”
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