A molecular conveyor belt-associated protein controls the rotational direction of the bacterial type 9 secretion system by Abhishek Trivedi, Jacob A. Miratsky, Emma C. Henderson, Abhishek Singharoy, Abhishek Shrivastava

“…ABSTRACT Many bacteria utilize the type 9 secretion system (T9SS) for gliding motility, surface colonization, and pathogenesis. This dual-function motor supports both gliding motility and protein secretion, where rotation of the T9SS plays a central role. …”
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Activated TBK1 promotes ACSL1-mediated microglia lipid droplet accumulation and neuroinflammation in Parkinson’s disease by Chunlei Han, Huizhi Wang, Moxuan Zhang, Liuliu Wu, Anni Wang, Pengda Yang, Yuan Gao, Chaonan Zhang, Jianing Gao, Tao Xue, Tingting Du, Yucheng Ji, Lin Shi, Chunkui Zhang, Renpeng Li, Yilei Xiao, Jianguo Zhang, Fangang Meng

“…The results of multiple loss- and gain-of-function experiments indicate that ACSL1 localized to the endoplasmic reticulum (ER) promotes lipid droplet accumulation to exacerbate microglial activation and dopaminergic neurons death. …”
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Suppression of Leukotriene B4 Generation by Ex-vivo Neutrophils Isolated from Asthma Patients on Dietary Supplementation with Gammalinolenic Acid-containing Borage Oil: Possible Im... by Vincent A. Ziboh, Stanley Naguwa, Kao Vang, Julie Wineinger, Brian M. Morrissey, J. A. McIntyre, Mitchell Watnik, M. Eric Gershwin

“…Patients were monitored by daily asthma scores, pulmonary function, and exhaled NO. Ingestion of daily GLA (i) increased DGLA (GLA metabolite) in PMN-phospholipids; (ii) increased generation of PMN-15-HETrE (5-LOX metabolite of DGLA). …”
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Physiological Oxygen Levels in the Microenvironment Program Ex Vivo-Generated Conventional Dendritic Cells Toward a Tolerogenic Phenotype by Antonia Peter, Morgane Vermeulen, Mats Van Delen, Amber Dams, Stefanie Peeters, Hans De Reu, Waleed F. A. Marei, Zwi N. Berneman, Nathalie Cools

“…Dendritic cells (DCs) are critical regulators of immune homeostasis, balancing tolerance and immunity through antigen presentation and T cell modulation. While the influence of hypoxia (<2% O₂) on DC function in pathological settings is well-documented, the impact of physiological O₂ levels remains underexplored. …”
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Biarylacetamides: a novel class of late-stage autophagy inhibitors by Mélissa Lallier, Rani Robeyns, Freke Mertens, Angela Sisto, Guido R.Y. De Meyer, Koen Augustyns, Maya Berg, Winnok H. De Vos, Vincent Timmerman, George M.C. Janssen, Peter van Veelen, Alexander L.N. van Nuijs, Nikolai Engedal, Wim Martinet, Pieter Van der Veken

“…Further mechanistic studies indicated that 5d and 5j triggered an ER stress response and may impair lysosomal function, as suggested by the accumulation of pro-cathepsin D. …”
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Pulse Profiles of Accreting Neutron Stars from GRMHD Simulations by Pushpita Das, Tuomo Salmi, Jordy Davelaar, Oliver Porth, Anna Watts

“…The emission from these hotspots is modulated by stellar rotation, giving rise to pulsations. …”
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Formicarium-Inspired Hierarchical Conductive Architecture for CoSe₂@MoSe₂ Catalysts Towards Advanced Anion Exchange Membrane Electrolyzers by Zhongmin Wan, Zhongkai Huang, Changjie Ou, Lihua Wang, Xiangzhong Kong, Zizhang Zhan, Tian Tian, Haolin Tang, Shu Xie, Yongguang Luo

“…The exploration of high-performance, low-cost, and dual-function electrodes is crucial for anion exchange membrane water electrolysis (AEMWE) to meet the relentless demand for green H₂ production. …”
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Putative type III effector SkP48 of Bradyrhizobium sp. DOA9 encoding a SUMO protease blocks nodulation in Vigna radiata by Pongdet Piromyou, Pongpan Songwattana, Jenjira Wongdee, Teerana Greetatorn, Pakpoom Boonchuen, Tarnee Phimphong, Hien P. Nguyen, Monchai Manassila, Waraporn Tanthanuch, Bussayarat Maikhunthod, Kamonluck Teamtisong, Panlada Tittabutr, Nantakorn Boonkerd, Eric Giraud, Neung Teaumroong

“…In addition, nodulation may be modulated by the function of defensins involved in jasmonic acid signalling in V. radiata SUT1.…”
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Multifunctional hydrogel targeting senescence to accelerate diabetic wound healing through promoting angiogenesis by Hao Yang, Yongfei Chen, Yanchao Rong, Yuxi Zhou, Shuting Li, Xiaohui Li, Honglin Wu, Dongming Lv, Xiaoling Cao, Peng Wang, Jiayuan Zhu, Bing Tang, Zhicheng Hu

“…In vitro studies demonstrated that the hydrogel significantly reduced oxidative stress, suppressed senescence markers and senescence-associated secretory phenotypes, and restored endothelial cell function under high-glucose conditions by inhibiting NF-κB pathway activation. …”
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Transcription factor 3 is dysregulated in megakaryocytes in myelofibrosis by Ryan J Collinson, Lynne Wilson, Darren Boey, Zi Yun Ng, Bob Mirzai, Hun S Chuah, Rebecca Howman, Carolyn S Grove, Jacques A J Malherbe, Michael F Leahy, Matthew D Linden, Kathryn A Fuller, Wendy N Erber, Belinda B Guo

“…Genomic analysis of isolated megakaryocytes showed three mutations, all predicted to result in a loss of function, in patients with MF; none were seen in megakaryocytes isolated from ET or PV marrow samples. …”
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Risk Factors and Autoimmunity in Diet - A Narrative Review of Literature by Maciej Tenderenda, Zuzanna Mularczyk, Bartosz Buczkowski, Krzysztof Nowakowski, Aleksandra Śmigiel, Aleksandra Broniak

“… Introduction   The role of dietary factors in modulating immune function and influencing the risk and progression of autoimmune diseases has recently gained increasing attention. …”
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Combination Treatment of Timosaponin BII and Pirfenidone Attenuated Pulmonary Fibrosis Through Anti-Inflammatory and Anti-Fibrotic Process in Rodent Pulmonary Fibrosis Model and Ce... by Xuebin Shen, Yueyue Zheng, Hui Yang, Li Liu, Lizhen Yu, Yuanxiang Zhang, Xiaojun Song, Yuqing He, Runze Jin, Jianhao Jiao, Zhihui Gu, Kefeng Zhai, Sihui Nian, Limin Liu

“…Pirfenidone (PFD) can slow down the decline of lung function, but defects in efficacy and accompanying side effects limit its application; hence, implementing methods including combination therapy might be a viable option. …”
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The role of ferroptosis-related non-coding RNA in liver fibrosis by Guozhu Zhang, Kejia Wu, Kejia Wu, Xiaobo Jiang, Yuan Gao, Dong Ding, Hao Wang, Chongyuan Yu, Xiaozhong Wang, Naixin Jia, Li Zhu

“…This pathological progression is characterized by the excessive accumulation of the extracellular matrix (ECM), which leads to significant structural disruption and ultimately impairs liver function. To date, no specific antifibrotic drugs have been developed, and advanced liver fibrosis remains largely incurable. …”
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Anti‐androgen enzalutamide enhances prostate cancer neuroendocrine (NE) differentiation via altering the infiltrated mast cells → androgen receptor (AR) → miRNA32 signals by Qiang Dang, Lei Li, Hongjun Xie, Dalin He, Jiaqi Chen, Wenbing Song, Luke S. Chang, Hong-Chiang Chang, Shuyuan Yeh, Chawnshang Chang

“…Mechanism dissection found infiltrated mast cells could function through positive feedback to enhance PCa to recruit more mast cells via modulation of the androgen receptor (AR) → cytokines IL8 signals, and interruption by AR‐siRNA or neutralizing anti‐IL8 antibody could partially reverse the recruitment of mast cells. …”
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Wet pulverization combined with temperature cycling strategy for extraction of Stropharia rugosoannulata protein with attenuating hepatic steatosis on obese mice by Peng Liu, Chen Gao, Wen Li, Wanchao Chen, Zhong Zhang, Di Wu, Tingzhao Li, Shuai Sun, Yan Yang

“…Moreover, SRA repaired the cross-talk between gut microbiota and liver via modulating intestinal microecology, and restoring the integrity and function of the intestinal barrier in obese mice. …”
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Randomised controlled clinical trial of a structured cognitive rehabilitation in patients with attention deficit following mild traumatic brain injury: study protocol by Roshan das Nair, Nor Asiah Muhamad, Avril Drummond, Mazlina Mazlan, Norhamizan Hamzah, Vairavan Narayanan, Norlisah Ramli, Nor Atikah Mustapha, Nor Adibah Mohammad Tahir, Li Kuo Tan, Mahmoud Danaee, Sing Yau Goh

“…Objectives To measure the clinical, structural and functional changes of an individualised structured cognitive rehabilitation in mild traumatic brain injury (mTBI) population.Setting A single centre study, Malaysia.Participants Adults aged between 18 and 60 years with mTBI as a result of road traffic accident, with no previous history of head trauma, minimum of 9 years education and abnormal cognition at 3 months will be included. …”
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TSPAN4+ fibroblasts coordinate metastatic niche assembly through migrasome-driven metabolic reprogramming and stromal-immune crosstalk in pancreatic adenocarcinoma by Qingwen Hu, Qingwen Hu, Jiali Chen, Yang Liu, Yang Liu, Haiqing Chen, Haotian Lai, Lai Jiang, Xuancheng Zhou, Shengke Zhang, Jinbang Huang, Hao Chi, Bo Li, Xiaolin Zhong

“…Additionally, gene enrichment, deconvolution, and prognostic analyses were performed, alongside experimental validation through siRNA transfection, qRT-PCR, and various functional assays to investigate the role of TSPAN4 in metastasis.ResultsOur results underscore the critical role of TSPAN4+ fibroblasts in pancreatic cancer. …”
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In-silico proteomic analysis of the role of IL-4 and IL-10 in IVD degeneration: Protein-protein interaction networks for candidate prioritisation by Paola Bermudez-Lekerika, Francesco Gualdi, Christine L. Le Maitre, Janet Piñero, Baldomero Oliva, Benjamin Gantenbein

“…Protein-protein interaction (PPI) networks provide a static map of functional protein interactions, which when combined with algorithms, can prioritize key protein candidates which experimental studies cannot capture. …”
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Transcriptomic analysis of melatonin-mediated drought stress response genes in alfalfa during germination period by Xiaoxia Zhang, Wenxuan Zhu, Zirui Liu, Xiangling Ren, Yingao Li, Guomin Li, Jingzhuo Wang, Xiaoyan Zhu, Yinghua Shi, Chengzhang Wang, Defeng Li, Hao Sun

“…Conclusions Through the application of GO functional annotation and KEGG pathway enrichment analysis, we discovered that DEGs were predominantly enriched in pathways related to flavonoid and isoflavone biosynthesis, plant hormone biosynthesis and signal transduction, glutathione metabolism, and MAPK signaling, and the ABC transporter signaling. …”
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Role of TRIM24 in the regulation of proteasome-autophagy crosstalk in bortezomib-resistant mantle cell lymphoma by Corentin Bouvier, Maria Gonzalez-Santamarta, Núria Profitós-Pelejà, Marc Armengol, Grégoire Quinet, Quentin Alasseur, Laurie Ceccato, Wendy Xolalpa, Raimundo Freire, Julie Guillermet-Guibert, Karine Reybier, Anne-Marie Caminade, Hans C. Beck, Ana Sofia Carvalho, Rune Matthiesen, Jean Christophe Rain, James D. Sutherland, Rosa Barrio, Gaël Roué, Manuel S. Rodriguez

“…Interestingly, the combined apoptogenic activity of dTRIM24 and BTZ was preserved in a second BTZ-resistant clone (JBR) that lacks functional p53, indicating that this tumor suppressor is not required for the observed effect. …”
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