Functional resting state connectivity is differentially associated with IL-6 and TNF-α in depression and in healthy controls by Christian N. Schmitz, Gebhard Sammer, Elena Neumann, Carlo Blecker, Gerhard Gründer, Hana Adolphi, Eva Kathrin Lamadé, Bruno Pedraz-Petrozzi

“…We therefore tested the hypothesis that the peripheral inflammation markers IL-6 and TNF-α correlate with neural resting state network functional connectivity in depression using functional magnetic resonance imaging (fMRI) and compared it with healthy controls. …”
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Differential regulation during development, aging, and disease implies heart cell specific functions of the Mediator Complex by Dominic W. Kolonay, Chad E. Grueter, Kedryn K. Baskin

“…The Mediator Complex is a general regulator of transcription in all eukaryotic cells; however, unknown subunit- and tissue-specific functions complicate our understanding of Mediator's influence on the cell. …”
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Exosomes derived from platelet-rich plasma alleviate synovial inflammation by enhancing synovial lymphatic function by Bo Liao, Yu Tian, Mengtong Guan, Wang Han, Weiwei Yi, Kaiting Li, Xiaoliang Yang, Yajuan Niu, Bin Zhang, Peiyu Teng, Dingqun Bai, Liang Kuang, Ying Zhu, Xiaoyu Han

“…Platelet-rich plasma-derived Exosomes (PRP-Exos), known for their low immunogenicity, have demonstrated efficacy in modulating chondrocyte function. However, the specific effects and mechanisms of PRP-Exos in synovial inflammation remain unclear. …”
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Characterization of a Novel Tc-Carbonyl Complex as a Functional Probe of P-Glycoprotein Transport Activity by Mary Dyszlewski, Helen M. Blake, Julie L. Dahlheimer, Christina M. Pica, David Piwnica-Worms

“…Furthermore, the protective function of Pgp-mediated efflux of xenobiotics in various organs has a profound effect on the bioavailability of drugs in general. …”
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Cloning and functional analysis of transcription factor AaCMB1 on carotenoid accumulation in spathe of Anthurium andraeanum by Hong Luo, Chunfang Hu, Lulu Bai, Guangdong Wang

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Impact of transcranial alternating current stimulation on psychological stress: A functional near-infrared spectroscopy study. by M N Afzal Khan, Yara Badr, Sandra Mary Prasad, Usman Tariq, Fadwa Almughairbi, Fabio Babiloni, Fares Al-Shargie, Hasan Al-Nashash

“…This pilot study investigates the impact of transcranial alternating current stimulation (tACS) on psychological stress using functional near-infrared spectroscopy (fNIRS). Forty volunteers were randomly assigned to two groups: the tACS and the control. …”
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Epidemiological pathology of dementia: attributable-risks at death in the Medical Research Council Cognitive Function and Ageing Study. by Fiona E Matthews, Carol Brayne, James Lowe, Ian McKeith, Stephen B Wharton, Paul Ince

“…<h4>Background</h4>Dementia drug development aims to modulate pathological processes that cause clinical syndromes. …”
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Chronic Household Air Pollution Exposure Is Associated with Impaired Alveolar Macrophage Function in Malawian Non-Smokers. by Jamie Rylance, Chikondi Chimpini, Sean Semple, David G Russell, Malcolm J Jackson, Robert S Heyderman, Stephen B Gordon

“…We hypothesised that chronic smoke exposure is detrimental to alveolar macrophage function, causing failure of innate immunity. We report the relationship between macrophage function and prior smoke exposure in healthy Malawians.…”
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Accelerated vascular aging in CuZnSOD-deficient mice: impact on EPC function and reparative neovascularization. by Jessika Groleau, Sylvie Dussault, Julie Turgeon, Paola Haddad, Alain Rivard

“…The effect of moderate aging alone on specific functional activities of EPCs (migration, integration into tubules) was modest. …”
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Plasticity of BRCA2 function in homologous recombination: genetic interactions of the PALB2 and DNA binding domains. by Nicolas Siaud, Maria A Barbera, Akinori Egashira, Isabel Lam, Nicole Christ, Katharina Schlacher, Bing Xia, Maria Jasin

“…Our results reveal functional redundancy within the BRCA2 protein and emphasize the plasticity of this large protein built for optimal HR function in mammalian cells. …”
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Altered neural oscillation patterns and functional connectivity in postherpetic neuralgia: evidence from resting-state EEG by Fei Gao, Mengru Wang, Huibin Jia, Georgi V. Georgiev, Yi Feng, Wenxia Li

“…Correlation analyses indicated that delta and theta frequency band power were positively associated with the Beck Depression Inventory scores, whereas delta frequency band power was negatively correlated with the State Anxiety Inventory scores. Additionally, functional connectivity analysis demonstrated reduced gamma-band connectivity in patients with PHN, particularly in regions of the sensorimotor and pain modulation networks. …”
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Archaeal LOV domains from Lake Diamante: first functional characterization of a halo-adapted photoreceptor by Lorena Valle, Lorena Valle, Yonathan J. Coronel, Yonathan J. Coronel, Guillermina E. Bravo, Joaquín A. Díaz, Virginia Helena Albarracín, Virginia Helena Albarracín, María E. Farías, Inés Abatedaga

“…Mutational studies of key residues (Y30F and Y48F) highlighted their roles in modulating flavin photophysic and revealed a stabilizing function for Y48 at low salt concentrations. …”
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Focused ultrasound suppresses pentylenetetrazol-induced epileptiform activity in rats and alters connectivity measured by functional MRI by Po-Chun Chu, Wei-Hong Ruan, Chen-Syuan Huang, Yi-Jing Juan, Jyh-Horng Chen, Hsiang-Yu Yu, Robert S. Fisher, Hao-Li Liu

“…However, its underlying mechanisms remain unclear, particularly regarding functional connectivity alterations in seizure-related brain networks. …”
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The Effect of the AQP1 Gene Knockout on the Diversity, Composition and Function of Gut Microbiota in Mice with Heart Failure by Haotian Li, Yubo Li, Jianqin Yang, Yanjun Liu

“…Introduction: This study aims to elucidate the impact of AQP1 on cardiac function and the intestinal microbiota in mice with chronic heart failure and to further investigate the broad effects of AQP1 on the gut microbiota composition in these mice. …”
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Functional screening reveals genetic dependencies and diverging cell cycle control in atypical teratoid rhabdoid tumors by Daniel J. Merk, Foteini Tsiami, Sophie Hirsch, Bianca Walter, Lara A. Haeusser, Jens D. Maile, Aaron Stahl, Mohamed A. Jarboui, Anna Lechado-Terradas, Franziska Klose, Sepideh Babaei, Jakob Admard, Nicolas Casadei, Cristiana Roggia, Michael Spohn, Jens Schittenhelm, Stephan Singer, Ulrich Schüller, Federica Piccioni, Nicole S. Persky, Manfred Claassen, Marcos Tatagiba, Philipp J. Kahle, David E. Root, Markus Templin, Ghazaleh Tabatabai

“…Results We here use a functional genomics approach to identify genetic dependencies in ATRT, validate selected hits using a functionally instructed small molecule drug library, and observe preferential activity in ATRT cells without subgroup-specific selectivity. …”
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Mechanisms of formation of nanostructured electrolytic coatings Fe-Ni, Co-Mn, Ni-Cr with functional properties by I. G. Zhikhareva, V. V. Schmidt, D. V. Denisenko, V. P. Shchipanov, A. D. Fedorov, A. I. Neustroev

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Advances in gut microbiota functions in inflammatory bowel disease: Dysbiosis, management, cytotoxicity assessment, and therapeutic perspectives by Ivan Kushkevych, Michaela Dvořáková, Dani Dordevic, Bożena Futoma-Kołoch, Márió Gajdács, Lamiaa A. Al-Madboly, Mohamed Abd El-Salam

“…By bridging methodological advancements with functional implications, this review aims to enhance our understanding of gut microbiota-host interactions, which are crucial for maintaining health and preventing disease through immune modulation, where microbiota help regulate immune responses and prevent excessive inflammation; nutrient metabolism, including the breakdown of dietary fibers into short-chain fatty acids that support gut health; and colonization resistance, where beneficial microbes outcompete harmful pathogens to maintain microbial balance.…”
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A pan-cancer study of ADAM9’s immunological function and prognostic value particularly in liver cancer by Mandana AmeliMojarad, Melika AmeliMojarad, Jiang Wang, Vahid Tavakolpour, Parvin Shariati

“…Abstract A pan-cancer analysis summarizing the overall changes in mRNA and protein stability of ADM9, as well as its oncogenic function on immune cell line modulation and checkpoints within the tumor microenvironment (TME), is lacking, despite the fact that ADM9 up-regulation is correlated with the progression of many cancers. …”
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The circadian regulation of sleep: impact of a functional ADA-polymorphism and its association to working memory improvements. by Carolin F Reichert, Micheline Maire, Virginie Gabel, Marcel Hofstetter, Antoine U Viola, Vitaliy Kolodyazhniy, Werner Strobel, Thomas Goetz, Valérie Bachmann, Hans-Peter Landolt, Christian Cajochen, Christina Schmidt

“…Twenty-four participants were genotyped regarding a functional polymorphism in adenosine deaminase (rs73598374, 12 G/A-, 12 G/G-allele carriers), previously associated with differences in sleep-wake regulation. …”
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Structural and functional roles of conserved residues of human papillomavirus (HPV) E2 protein and biological consequences by Sean Fletcher, Esther E. Biswas-Fiss, Subhasis B. Biswas

“…The HPV E2 protein is a central regulator of viral replication and oncogene expression, making it a critical determinant of HPV-associated malignancies. While its core functions are conserved, variations within the E2 protein are thought to contribute to the differential oncogenic potential among HPV types, though the structural basis for this remains incompletely understood. …”
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