Crosstalk between lactate and tumor-associated immune cells: clinical relevance and insight by Kemin Sun, Kemin Sun, Ye Shen, Xiang Xiao, Xiang Xiao, Hao Xu, Hao Xu, Quanli Zhang, Quanli Zhang, Quanli Zhang, Ming Li, Ming Li

“…Current studies highlight its dual function, where it not only fuels tumor development but also modulates immune responses. …”
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Piezo1/ITGB1 Synergizes With Ca2+/YAP Signaling to Propel Bladder Carcinoma Progression via a Stiffness‐Dependent Positive Feedback Loop by Minghai Ma, Jianpeng Li, Xing Li, Minxuan Jing, Lu Wang, Yunzhong Jiang, Zezhong Yang, Jiale He, Min Wang, Hang Liu, Yutong Chen, Kaibo Mi, Lei Wang, Jinhai Fan, Hongxia Du

“…This study systematically investigates the functional synergy of Piezo1/ITGB1 in orchestrating ECM biomechanical remodeling to fuel BLCA progression. …”
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Proteomic profiling improves prognostic risk stratification of the Sarculator nomogram in soft tissue sarcomas of the extremities and trunk wall by Madhumeeta Chadha, Sara Iadecola, Andrew Jenks, Valeriya Pankova, Yuen Bun Tam, Jessica Burns, Amani Arthur, Christopher P. Wilding, Liang Chen, Priya Chudasama, Dario Callegaro, Dirk C. Strauss, Khin Thway, Alessandro Gronchi, Robin L. Jones, Rosalba Miceli, Sandro Pasquali, Paul H. Huang

“…Results DNA replication and cell cycle proteins were upregulated in high‐risk versus very low‐risk patients. Evaluation of the functional effects of CRISPR‐Cas9 gene knockdown of proteins enriched in high‐risk patients using the cancer cell line encyclopaedia database identified candidate drug targets. …”
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HDL from 36-h fasted participants potently promotes efflux of cholesteryl ester from activated microglia by Joanne K. Agus, Oscar M. Muñoz Herrera, Oscar M. Muñoz Herrera, Christopher H. Rhodes, Jack Jingyuan Zheng, Chenghao Zhu, Maurice Wong, Xinyu Tang, Izumi Maezawa, Lee-Way Jin, Carlito B. Lebrilla, Danielle J. Harvey, Angela M. Zivkovic

“…These findings collectively suggest that prolonged fasting induces structural, compositional, and functional alterations in HDL particles, and influences their capacity to attenuate the effects of excess cholesterol and AβO in microglia.…”
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IFITM3 enhances immunosensitivity via MHC-I regulation and is associated with the efficacy of anti-PD-1/-L1 therapy in SCLC by Yanan Cui, Tianyu Qiu, Jiale Wang, Xinyu Liu, Libo Luo, Jizhong Yin, Xinxin Zhi, Wanying Wang, Gaohua Feng, Chunyan Wu, Zhikai Zhao, Hua Zhang, Fei Li, Fengying Wu, Shengxiang Ren

“…In vitro and in vivo functional studies were conducted to evaluate the role and mechanisms of IFITM3 in modulating tumor sensitivity to PD-1 inhibitors. …”
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Effects of dietary crude protein on antioxidant activity, immunocompetence and the structural properties of the rumen in tibetan sheep (Ovis aries), as determined by transcriptomic... by Zhenling Wu, Fengshuo Zhang, Quyangangmao Su, Qiurong Ji, Kaina Zhu, Tingli He, Xuan Chen, Yu Zhang, Jiacheng Gan, Wei Gao, Xianhua Zhang, Geerli Saren, Shengzhen Hou, Linsheng Gui

“…In conclusion, an 11.58% crude protein diet enhanced papillary development and antioxidant activity in Tibetan sheep, likely by modulating the expression of functional genes.…”
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NK cell immunopotentiators-loaded nanoliposomes enhance ADCC effect for targeted therapy against HER2-positive breast cancer by Ruoxin Du, Changqing Cao, Dong Fan, Guodong Li, Shuangpeng Pu, Xinyao Xu, Mengmeng Liu, Gege Shi, Yuxin Wu, Qiang Hao, Yuan Gao, Juliang Zhang, Huadong Zhao, Cun Zhang

“…To counteract this impediment, we meticulously selected two potent immune-modulating peptides TKD and IP-10p, which are known to recruit and enhance the activity of NK cells. …”
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High-loading inducing Fe-dimer on carbon nitride promotes the generation of ·O2− by Xinran Zheng, Yuchao Wang, Jianping Guan, Xu Liu, Yu Bai, Yingbi Chen, Peiyao Yang, Jing Zhang, Houzheng Ou, Meng Wang, Yu Xiong, Haozhi Wang, Yongpeng Lei

“…The research on metal dimer clusters is of great importance, owing to the potential in modulating the adsorption behavior towards reaction intermediates. …”
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N6-methyladenosine binding protein YTHDF2 inhibits gastric cancer cell growth and predicts better prognosis in patients with gastric cancer by Jun Zheng, Yinhua Liang, Xin Xu, Jianpeng Zhou, Shuang Jiang, Jiwei Yu

“…The expression of YTHDF2 was associated with cancer-related functions and pathways in gastric cancer. We found that YTHDF2 has lower expression in gastric cancer cells and inhibits the growth of GC cells. …”
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Exosomes released by environmental pollutant-stimulated Keratinocytes/PBMCs can trigger psoriatic inflammation in recipient cells via the AhR signaling pathway by Hye Ran Kim, So Yeon Lee, Ga Eun You, Chun Wook Park, Hye One Kim, Bo Young Chung

“…This study addresses this gap by examining the influence of BaP and TCDD on exosome function, specifically focusing on immune-related pathway alterations in normal recipient keratinocytes and peripheral blood mononuclear cells (PBMCs).Methods: HaCaT cells were treated with exosomes from BaP- or TCDD-treated keratinocytes. …”
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Developing and validating utility parameters to establish patient-reported outcome-based perioperative symptom management in patients with lung cancer: a multicentre, prospective,... by Rui Zhang, Wei Dai, Qiang Li, Shaohua Xie, Qiuling Shi, Yuanqiang Zhang, Wenhong Feng, Xiaoqing Liao, Yunfei Mu, Xing Wei, Chuanmei Wu, Heling Zhou, Xuemei Cheng, Yanhua Jiang, Jintao He, Xiaojun Yang

“…The MDASI-LC interference-measured functional status will be used as the anchor for the alert thresholds.Ethics and dissemination Ethics Committee of Sichuan Cancer Hospital approved this study on 16 October 2017 (No. …”
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Hypoxia alters the response of ovarian cancer cells to the mitomycin C drug by Aleksandra Gawrylak, Aleksandra Gawrylak, Klaudia Brodaczewska, Roksana Iwanicka-Nowicka, Roksana Iwanicka-Nowicka, Marta Koblowska, Marta Koblowska, Agnieszka Synowiec, Lubomir Bodnar, Lubomir Bodnar, Cezary Szczylik, Bogdan Lesyng, Rafał Stec, Claudine Kieda, Claudine Kieda

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The influence of genetics on the endocannabinoid system gene expression and relevance for targeting reproductive conditions by Keisuke Tanaka, Akwasi A. Amoako, Sally Mortlock, Peter A. W. Rogers, Sarah J. Holdsworth-Carson, Jacqueline F. Donoghue, Wan Tinn Teh, Grant W. Montgomery, Brett McKinnon

“…The important cellular functions of endocannabinoids have made them and the proteins that modulate their expression targets of potential interest for treatment in many different diseases including gynaecological conditions. …”
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CXCL4 deficiency limits M4 macrophage infiltration and attenuates hyperoxia-induced lung injury by Bingrui Yu, Siyuan Jia, Yu Chen, Rong Guan, Shuyu Chen, Wanwen Tang, Tianping Bao, Zhaofang Tian

“…Conclusion CXCL4 contributes to hyperoxia-induced lung injury and fibrosis through modulation of cytokine release, alveolar cell proliferation, lipid metabolism, and the regulation of macrophage phenotype and function.…”
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Induced mitochondrial deficit by NDUFS3 transient silencing reduces RAB7 expression and causes lysosomal dysfunction in pancreatic cancer cells by Giulia Girolimetti, Sinforosa Gagliardi, Paola Cordella, Grazia Bramato, Riccardo Di Corato, Roberta Romano, Flora Guerra, Cecilia Bucci

“…Seahorse assays, Western blot analysis, mitochondrial staining, and Transmission Electron Microscopy (TEM) were used to assess silencing effects on mitochondrial structure and functioning. Western blotting was used to investigate expression of late endocytic pathway proteins and of the invasion marker vimentin. …”
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C5aR2 Deficiency Lessens C5aR1 Distribution and Expression in Neutrophils and Macrophages by Ting Zhang, Ning Ma, Jiaxing Wang, Xiaoyun Min, Linlin Wei, Ke Li

“…Our article found C5aR2 deficiency lessened C5aR1 distribution and expression in neutrophils and macrophages with different functions, indicating C5aR2 might function differently in different cells.…”
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RNAseq and targeted metabolomics implicate RIC8 in regulation of energy homeostasis, amino acid compartmentation, and asexual development in Neurospora crassa by Monique Quinn, Alexander J. Carrillo, Lida Halilovic, Katherine A. Borkovich

“…These results have broad relevance to human physiology and disease, as arginine modulates immune, vascular, hormonal, and other functions in humans.…”
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INTERGENERATIONAL DIALOGUE IN THE NOVEL “BONJOUR TRISTESSE” BY FRANҪOISE SAGAN by Olga A. Bigun, Nataliia Ya. Yatskiv

“…First of all, in the variation “patronage as a maternal function”, the Mother archetype is characteristic of Anne. …”
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Effects of Methyl Farnesoate on the Growth and Antioxidant Capacity of <i>Neocaridina denticulata</i> by Ying Chen, Xiaojuan Sun, Jiahao Du, Jingjie Hu, Zhenmin Bao, Zhe Qu

“…Methyl farnesoate (MF) functions similarly to juvenile hormone (JH) in crustaceans, playing a broad regulatory role in their growth and development. …”
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Exploration of Key Brain Regions Involved in Acupuncture and Moxibustion Analgesia: An Imaging-Based Study by He L, Zhou R, Hou S, Huang D, Zhao X, Wang M, Huang M, Yin T, Yin H, Yu S

“…Different stimulation modes and disease types produced distinct patterns of brain region activation.Conclusion: Acupuncture and moxibustion modulate key brain regions involved in pain perception, emotional regulation, and cognitive functions. …”
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