Expression of SIRPα-Fc by oncolytic virus enhances antitumor efficacy through tumor microenvironment reprogramming by Qingzhe Yang, Yongheng Shu, Yanwei Chen, Zhongbing Qi, Shichuan Hu, Yao Zhang, Yu Qin, Xianglin Xu, Jianchuan Hu, Anliang Huang, Ping Cheng

“…Additionally, while both oAdVs increased T cell infiltration in the tumor microenvironment, oAd-SA specifically enhanced T cell immune function. The study also revealed that oAdVs modulate TAMs differently across tumor types, with oAd-SA therapy particularly increasing TAM phagocytosis and promoting an anti-tumor response.…”
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An orally-administered nanotherapeutics with gold nanospheres supplying for rheumatoid arthritis therapy by re-shaping gut microbial tryptophan metabolism by Chuan Yang, Langlang Xie, Zihan Deng, Hongbo Ai, Tingwen Xiang, Xiaojing Yan, Zhiguo Ling, Shiyu Xiao, Yong Tang, Gang Huang, Fei Luo, Yueqi Chen

“…Specifically, GNS notably enriched the probiotic genus Ligilactobacillus while restoring intestinal barrier function by upregulating tight junction proteins Claudin-1 and ZO-1. …”
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Microneedle‐Delivered PDA@Exo for Multifaceted Osteoarthritis Treatment via PI3K‐Akt‐mTOR Pathway by Zihua Li, Hengli Lu, Limin Fan, Xiaoyi Ma, Zhengwei Duan, Yiwei Zhang, Yuesong Fu, Sen Wang, Yonghao Guan, Dong Yang, Qingjing Chen, Tianyang Xu, Yunfeng Yang

“…RNA sequencing of treated chondrocytes demonstrates restored cellular function and activated antioxidant responses, with modulated inflammatory pathways. …”
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An incremental learning framework for pipeline weld crack damage identification and leakage rate prediction by Jing Huang, Zhifen Zhang, Yanlong Yu, Yongjie Li, Shuai Zhang, Rui Qin, Ji Xing, Wei Cheng, Guangrui Wen, Xuefeng Chen

“…Secondly, the depth first search algorithm is combined with the radial basis function neural network to perform online increment labelling of the leakage state. …”
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New insight into the significance of KLF4 PARylation in genome stability, carcinogenesis, and therapy by Zhuan Zhou, Furong Huang, Indira Shrivastava, Rui Zhu, Aiping Luo, Michael Hottiger, Ivet Bahar, Zhihua Liu, Massimo Cristofanilli, Yong Wan

“…Depletion of KLF4 by RNA interference or interference with PARP1 function by KLF4YYR/AAA (a PARylation‐deficient mutant) significantly sensitizes breast cancer cells to PARP inhibitors. …”
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Lung-specific CRBN knockout attenuates influenza a virus-induced acute lung injury in mice: a potential therapeutic approach by Lifang Zhang, Qingchao Zhang, Jiahui Chang, Yunyi Zhou, Wei Wang, Xiliang Wang, Chengyu Jiang, Yanli Zhang

“…Cereblon (CRBN) is a protein known for its role in the ubiquitin-proteasome system and as a target of the drug thalidomide. However, the function of CRBN in influenza virus infection remains poorly understood. …”
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Chronic, Low-Dose Methamphetamine Reveals Sexual Dimorphism of Memory Performance, Histopathology, and Gene Expression Affected by HIV-1 Tat Protein in a Transgenic Model of NeuroH... by Indira S. Harahap-Carrillo, Dominic Fok, Frances Wong, Gabriel Malik, Ricky Maung, Xinru Qiu, Daniel Ojeda-Juárez, Victoria E. Thaney, Ana B. Sanchez, Adam Godzik, Amanda J. Roberts, Marcus Kaul

“…In summary, chronic low-dose METH exerts long-term effects on behavioral function, neuropathology, and mRNA expression, and modulates the effects of Tat, suggesting sex-dependent and -independent mechanisms may converge in HIV brain injury and NCI.…”
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Effects of fermented bamboo fiber on intestinal health and fecal pollutants in weaned piglets by Yubiao Jia, Yubiao Jia, Qiuming Huang, Qiuming Huang, Rui Song, Rui Song, Yanling Tang, Yanling Tang, Mengxin Feng, Mengxin Feng, Jianjun Lu, Jianjun Lu

“…Among the treatment groups, supplementation with 1.5% FBF produced the most significant improvements in piglets’ growth performance and intestinal barrier function, as well as the strongest microbial interactions and the greatest reduction in fecal pollutants.DiscussionThese results suggest that FBF supplementation can alleviate weaning stress and mitigate the environmental impact of pig feces, with 1.5% identified as the optimal supplementation level.…”
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A Phase‐Separated SR Protein Reprograms Host Pre‐mRNA Splicing to Enhance Disease Susceptibility by Dong Yan, Jie Huang, Fengqi Tian, Haidong Shu, Han Chen, Qian Peng, Hongwei Wu, Jianlong Zhao, Anireddy S. N. Reddy, Gang Li, Yuanchao Wang, Suomeng Dong

“…Importantly, the phase separation property is required for the function of SR30 in disease susceptibility and the regulation of genes AS. …”
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Effects of Graphene Quantum Dots on Renal Fibrosis Through Alleviating Oxidative Stress and Restoring Mitochondrial Membrane Potential by Kyu Hong Kim, Jong Bo Park, Jung Nam An, Gaeun Bae, Kyu Hyeon Kim, Seong Joon Park, Youngjin Jung, Yong Chul Kim, Jung Pyo Lee, Jae Wook Lee, Dong Ki Kim, Yon Su Kim, Byung Hee Hong, Seung Hee Yang

“…Despite various strategies targeting mitochondria to improve kidney function, effective treatments remain lacking. This study investigates the potential of graphene quantum dots (GQDs) in mitigating renal fibrosis and elucidates their underlying mechanisms. …”
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Plant-nanoparticles enhance anti-PD-L1 efficacy by shaping human commensal microbiota metabolites by Yun Teng, Chao Luo, Xiaolan Qiu, Jingyao Mu, Mukesh K. Sriwastva, Qingbo Xu, Minmin Liu, Xin Hu, Fangyi Xu, Lifeng Zhang, Juw Won Park, Jae Yeon Hwang, Maiying Kong, Zhanxu Liu, Xiang Zhang, Raobo Xu, Jun Yan, Michael L. Merchant, Craig J. McClain, Huang-Ge Zhang

“…Abstract Diet has emerged as a key impact factor for gut microbiota function. However, the complexity of dietary components makes it difficult to predict specific outcomes. …”
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Docosahexaenoic Acid Inhibits Osteoclastogenesis via FFAR4-Mediated Regulation of Inflammatory Cytokines by Jinghan Ma, Hideki Kitaura, Fumitoshi Ohori, Aseel Marahleh, Ziqiu Fan, Angyi Lin, Kohei Narita, Kou Murakami, Hiroyasu Kanetaka

“…Osteoclastogenesis—the activation and differentiation of osteoclasts—is one of the pivotal processes of bone remodeling and is regulated by RANKL/RANK signaling, the decoy function of osteoprotegerin (OPG), and a cascade of pro- and anti-inflammatory cytokines. …”
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A Transcriptional Sequencing Analysis of Islet Stellate Cell and Pancreatic Stellate Cell by Xiaohang Wang, Wei Li, Juan Chen, Sheng Zhao, Shanhu Qiu, Han Yin, Vladmir Carvalho, Yunting Zhou, Ruifeng Shi, Jiannan Hu, Shenyi Li, Munire Nijiati, Zilin Sun

“…To further identify the differences between PSC and ISC and for better understanding of the physiological function of ISC, we employed genome-wide transcriptional analysis on the PSCs and ISCs of Wistar rats. …”
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A Dynamic Monitoring Framework for Spring Low-Temperature Disasters Affecting Winter Wheat: Exploring Environmental Coercion and Mitigation Mechanisms by Meixuan Li, Zhiguo Huo, Qianchuan Mi, Lei Zhang, Jianying Yang, Fengyin Zhang, Rui Kong, Yi Wang, Yuxin Huo

“…This study establishes a low-temperature disaster (LTD) monitoring system based on machine learning algorithms, which primarily consists of a module for identifying types of disasters and a module for simulating the evolution of LTDs. …”
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How can Blood Flow Restriction Exercise be Utilised for the Management of Persistent Pain Following Complex Injuries in Military Personnel? A Narrative Review by Luke Gray, Peter Ladlow, Russell J Coppack, Robyn P Cassidy, Lynn Kelly, Sarah Lewis, Nick Caplan, Robert Barker-Davies, Alexander N Bennett, Luke Hughes

“…., complex regional pain syndrome, non-freezing cold injury), leading to extensive disability and reduced physical function. Conventional resistance training is commonly contraindicated in load compromised and/or persistent pain populations, compromising rehabilitation progression and potentially leading to extensive pharmacological intervention, invasive procedures, and reduced occupational status. …”
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Inhibiting MARCH5/Mfn2 signaling as an alternative strategy to protect cardiomyocytes from hypoxia-induced mitochondrial dysfunction by Faten Habrat Zoabi, Mulate Zerihun, Roy Lizarovich, Chiara Dalla Torre, Liron Davis, Offir Ertracht, Michal Barsheshet, Shaul Atar, Deborah E. Shalev, Marta De Zotti, Hanoch Senderowitz, Nir Qvit

“…Treatment with CVP-220 enhanced cell viability by 30 % compared to untreated controls and reduced reactive oxygen species (ROS) production by 45 %, suggesting improved mitochondrial function. Notably, CVP-220 selectively modulated MARCH5-mediated ubiquitination of Mfn2 without affecting other MARCH5 interactions, thereby preserving mitochondrial fusion and preventing fragmentation under stress conditions. …”
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Emerging roles of mitochondrial sirtuin SIRT5 in succinylation modification and cancer development by Zhangmin Ke, Zhangmin Ke, Kaikai Shen, Li Wang, Hao Xu, Xia Pan, Zhenjue Qian, Yuting Wen, Tangfeng Lv, Xiuwei Zhang, Yong Song

“…SIRT5 exhibits dual functionalities: it can promote tumor proliferation, metastasis, drug resistance, and metabolic reprogramming, thereby acting as an oncogene; conversely, it can also inhibit tumor cell growth and induce apoptosis, functioning as a tumor suppressor gene. …”
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The neuropeptide sulfakinin is a peripheral regulator of insect behavioral switch between mating and foraging by Hong-Fei Li, Bao Dong, Yuan-Yuan Peng, Hao-Yue Luo, Xiao-Lan Ou, Zheng-Lin Ren, Yoonseong Park, Jin-Jun Wang, Hong-Bo Jiang

“…Further analysis of the mutant flies revealed that sets of odorant receptor (OR) genes were differentially expressed. Functional characterization of the differentially expressed ORs suggested that sulfakinin directly suppresses the expression of ORs that respond to opposite-sex hormones while enhancing the expression of ORs that detect food volatiles. …”
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Counterion-Mediated Assembly of Fluorocarbon–Hydrocarbon Surfactant Mixtures at the Air–Liquid Interface: A Molecular Dynamics Study by Xiaolong Quan, Tong Tong, Tao Li, Dawei Han, Baolong Cui, Jing Xiong, Zekai Cui, Hao Guo, Jinqing Jiao, Yuechang Wei

“…This behavior correlates with hydrogen-bond population reduction, attributed to SDS groups functioning as multidentate ligands—their tetrahedral oxygen arrangement facilitates cooperative hydrogen-bond networks, while counterion-specific charge screening competitively modulates bond formation. …”
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Critical biomarkers for responsive deep brain stimulation and responsive focal cortex stimulation in epilepsy field by Zhikai Yu, Binghao Yang, Penghu Wei, Hang Xu, Yongzhi Shan, Xiaotong Fan, Huaqiang Zhang, Changming Wang, Jingjing Wang, Shan Yu, Guoguang Zhao

“…The resultant model possesses the capability to function as a feedback trigger program for electrical stimulation systems of the feedback variety, specifically within the domain of neural modulation in epilepsy.…”
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