The Impact of Alcohol on the Gut Microbiota: A literature review by Jakub Sikora, Karolina Knychalska, Mikołaj Łabuda, Klaudia Królikowska, Aleksandra Słojewska, Agata Kotkowiak, Teresa Sowińska, Oliwia Mentel, Adrianna Bogucka, Agnieszka Szema

“…Alcohol consumption, particularly in excessive amounts, disrupts the composition and function of the intestinal microbiota, leading to dysbiosis. …”
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Endothelial Cell Inflammation and Barriers Are Regulated by the Rab26-Mediated Balance between β2-AR and TLR4 in Pulmonary Microvessel Endothelial Cells by Huaping Chen, Ming Yuan, Chunji Huang, Zhi Xu, Mingchun Li, Chun Zhang, Zhan Gao, Mingzhou Zhang, Jiancheng Xu, Hang Qian, Jiegen You, Binfeng He, Guansong Wang, Mingdong Hu

“…Rab26 GTPase modulates the trafficking of cell surface receptors, such as G protein-coupled receptors including α2-adrenergic receptors in some cell types. …”
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Empagliflozin Attenuates High-Glucose-Induced Astrocyte Activation and Inflammation via NF-κB Pathway by Dong Hee Kim, Min Jin Lee, Dasol Kang, Ji Young Lee, Sujin Park, Ah Reum Khang, Ji Hyun Bae, Joo Yeon Kim, Su Hyun Kim, Yang Ho Kang, Dongwon Yi

“…Although SGLT2 is expressed in brain regions that influence glucose balance and cognitive function, its roles in the central nervous system are unclear. …”
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Visomitin Attenuates Pathological Bone Loss by Reprogramming Osteoclast Metabolism via the STAT3/LDHB Axis by Putao Yuan, Zhenhua Feng, Haotian Yang, Hong Xue, Hongwei Xie, Zihan Dai, Haoming Wang, Ying Liu, Bin Pan, Hongpu Song, Huali Ye, Ziang Xie, Peihua Shi, Xuewu Sun

“…In the present study, we have discovered Visomitin, a novel antioxidant that specifically targets mitochondria, which efficiently decreases intracellular reactive oxygen species (ROS) levels, inhibits osteoclastogenesis, and impairs the function of bone resorption. Mechanistically, Visomitin directly targets signal transducer and activator of transcription 3 (STAT3), leading to the inhibition of its transcriptional activity and modulation of lactate dehydrogenase B (LDHB) expression levels, consequently triggering metabolic reprogramming and exerting antagonistic effects on osteoclasts. …”
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Definition of clinical immunology around the globe by José C. Crispín, José C. Crispín, José C. Crispín, Tineke Cantaert, Tineke Cantaert, Alberto Pinzon-Charry, Alberto Pinzon-Charry, Alberto Pinzon-Charry, Domenico Mavilio, Domenico Mavilio, Domenico Mavilio, Ahmed Seri, Ahmed Seri, Pierre Miossec, Pierre Miossec

“…Immune cells and immune mediators are now known to participate in the pathogenesis of a wide variety of diseases and therapies based on the modulation of immune function are increasingly used. …”
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Immunotherapy with IL12 and PD1/CTLA4 inhibition is effective in advanced ovarian cancer and associates with reversal of myeloid cell-induced immunosuppression by Paul G. Pavicic, Patricia A. Rayman, Shadi Swaidani, Amit Rupani, Vladimir Makarov, Charles S. Tannenbaum, Robert P. Edwards, Anda M. Vlad, C. Marcela Diaz-Montero, Haider Mahdi

“…We also identified marked differences in treated mice that were in remission compared to those whose tumors progressed, further confirming a pivotal role for the modulation of myeloid cell function to allow for response to immunotherapy. …”
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Gene Expression, Oxidative Stress, and Senescence of Primary Coronary Endothelial Cells Exposed to Postprandial Serum of Healthy Adult and Elderly Volunteers after Oven-Cooked Meat... by Costarelli Laura, Giacconi Robertina, Francesco Piacenza, Andrea Basso, Deborah Pacetti, Michele Balzano, Riccardo Gagliardi, Natale Giuseppe Frega, Eugenio Mocchegiani, Mauro Provinciali, Marco Malavolta

“…However, it is still unknown if the postprandial serum derived after a normal meat meal is able to affect endothelial function, and if the type of meat and the age of the donors are critical factors. …”
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Sleep quality and reproductive health in physically active women - the literature review by Katarzyna Milewska-Plis, Igor Kłak, Jan Szerocki, Wiktoria Nowakowska, Katarzyna Bartnik, Katarzyna Chwaleba, Ksenia Mazur, Monika Karalus, Weronika Curyło, Alina Grudina

“…Moreover, the review highlights how moderate physical activity generally promotes better sleep quality, while excessive or poorly planned exercise can disrupt sleep patterns, elevate cortisol levels, and impair reproductive function. The prevalence of sleep disorders—such as insomnia, restless legs syndrome, and circadian rhythm misalignment—among female athletes is examined, with emphasis on their underdiagnosis and potential consequences for performance and health. …”
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RBBP6‐Mediated ERRα Degradation Contributes to Mitochondrial Injury in Renal Tubular Cells in Diabetic Kidney Disease by Hongtu Hu, Jijia Hu, Zhaowei Chen, Keju Yang, Zijing Zhu, Yiqun Hao, Zongwei Zhang, Weiwei Li, Zhuan Peng, Yun Cao, Xiaoling Sun, Fangcheng Zhang, Qingjia Chi, Guohua Ding, Wei Liang

“…The interaction between RBBP6 and ERRα opens new therapeutic avenues, suggesting that modulating RBBP6‐ERRα interactions could be a strategy for preserving mitochondrial function and slowing DKD progression.…”
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Structural characterization and alleviation on osteoporotic of polysaccharide purified from Psidium guajava L. leaves by Meng Meng, Rui Zhang, Fang Ning, Ying Sun, Yinyin Feng, Xiaoyang He, Ran Han, Qinghua Liu, Huiqing Sun

“…These findings suggest that GLP not only modulates bone metabolism and inflammation but also may serve as an innovative natural therapeutic agent or functional food ingredient for the prevention and management of osteoporosis, highlighting the potential of valorizing guava leaf by-products in industrial applications.…”
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In situ growing of ZIF-8 crystals into TiO2 micro columnar films by Juan J. Romero-Guerrero, Francisco G. Moscoso, Said Hamad, Gloria P. Moreno, Víctor Rico, Ángel Barranco Quero, Tânia Lopes-Costa, José M. Pedrosa

“…Additionally, a density functional theory (DFT) study as well as Fourier-transform infrared spectroscopy (FTIR) and GAXRD experiments were conducted to elucidate the nucleation process. …”
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GULP1 as a novel diagnostic and predictive biomarker in hepatocellular carcinoma by Hyung Seok Kim, Jung Hwan Yoon, Ji Yi Choi, Moon Gyeong Yoon, Geum Ok Baek, Minji Kang, Se Ha Jang, Won Park, Yunjin Go, Jestlin Tianthing Ng, Suk Woo Nam, Jee-Yeong Jeong, Ji Eun Han, Hyo Jung Cho, Su Bin Lim, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun

“…Using clinical cohorts and patient sera, GULP1 roles were examined, and functional assays in vitro and in vivo were used to evaluate its effects on cell growth, epithelial–mesenchymal transition (EMT), ADP-ribosylation factor 6 (ARF6) activation, and β-catenin signaling. …”
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Knockout of thyroid hormone receptor alpha a (thraa) enhances cardiac regeneration in zebrafish through metabolic and hypoxic regulation by Man Yee Cheung, Chunmei Jiang, Imtiaz Ul Hassan, Hui Wang, Donghao Guo, Daniel Wuyang Dio, Huan Yan, Jianmin Sun, Xufeng Qi, Dongqing Cai, Wei Ge, Sheue-yann Cheng, Wai-Yee Chan, Hui Zhao

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Interplay Between Insulin Resistance and Immune Dysregulation in Type 2 Diabetes Mellitus: Implications for Therapeutic Interventions by Berbudi A, Khairani S, Tjahjadi AI

“…Beyond regulating glucose homeostasis, insulin plays a pivotal role in modulating immune cell function, linking metabolic dysregulation with immune responses. …”
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Lack of an atypical PDR transporter generates an immunogenic Cryptococcus neoformans strain that drives a dysregulated and lethal immune response in murine lungs by Christopher J. Winski, Peter V. Stuckey, Armando M. Marrufo, Georgina Agyei, Robbi L. Ross, Tamanna Urmi, Sarah Chapman, Felipe H. Santiago-Tirado

“…In this study, we expand our knowledge of the biological function of the PDR6 gene, particularly its effect on modulating the host’s immune response. …”
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Kv3 channel agonist ameliorates the phenotype of a mouse model of amyotrophic lateral sclerosis by Manuela Marabita, Caterina Marchioretti, Aishwarya Aravamudhan, Simona Zito, Antonella Falconieri, Emanuela Zuccaro, Roberta Andreotti, Lisa Gambarotto, Samuele Metti, Marika Tonellato, Valentina Adami, Kyung Ho Park, Martin J. Gunthorpe, Charles H. Large, Agostino Marasco, Sara Vianello, Jessica Rosati, Elisa Belluzzi, Assunta Pozzuoli, Carlo Biz, Pietro Ruggieri, Manuela Basso, Angelo Poletti, Giuseppe Alvaro, Gianni Sorarù, Paolo Bonaldo, Ornella Rossetto, Nadia Pilati, Maria Pennuto

“…Little is known about the expression and function of Kv3 channels in skeletal muscle. We show that these channels are expressed in type IIa/IIx fibers, and their transcript levels progressively increase from postnatal age to adulthood in physiological context. …”
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Unveiling the Cuproptosis in Colitis and Colitis-Related Carcinogenesis: A Multifaceted Player and Immune Moderator by Jingwen Liu, Hairuo Huang, Xiaojie Zhang, Yang Shen, DeMing Jiang, Shurong Hu, Shuyan Li, Zelin Yan, Wen Hu, Jinhua Luo, Haibo Yao, Yan Chen, Bufu Tang

“…This review emphasizes the dual function of copper metabolism and cuproptosis in the progression of IBD and CRC, while also exploring the potential application of copper-based therapies in disease treatment. …”
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Recovery of Lysosomal Acidification and Autophagy Flux by Attapulgite Nanorods: Therapeutic Potential for Lysosomal Disorders by Yuanjing Hao, Xinru Fan, Xiaodan Huang, Zhaoying Li, Zhiyuan Jing, Guilong Zhang, Yuxue Xu, Na Zhang, Pengfei Wei

“…Attapulgite (ATT), a natural nanomaterial with excellent adsorption capacity and biocompatibility, herein demonstrated a novel biological function in regulating the lysosomal and autophagy–lysosome pathway. …”
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Advances in A-to-I RNA editing in cancer by Yi Zhang, Lvyuan Li, Juana Jessica Mendoza, Dan Wang, Qijia Yan, Lei Shi, Zhaojian Gong, Zhaoyang Zeng, Pan Chen, Wei Xiong

“…These modifications can either promote or suppress cancer progression through several mechanisms, including inducing non-synonymous amino acid mutations, altering the immunogenicity of dsRNAs, modulating mRNA interactions with microRNAs (miRNAs), and affecting the splicing of circular RNAs (circRNAs) as well as the function of long non-coding RNAs (lncRNAs). …”
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Inhibition of FAK promotes pancreatic cancer immunotherapy by mediating CXCL10 secretion to enhance CD8+ T cell infiltration by Yu-Chen Shi, Qingling An, Na Tang, Yong-Qiang Zhang, Shu-Qiao Xing, Fan Song, Xiao-Qiang Li

“…Additionally, mouse PC models and dual humanized models are established to investigate the in vivo function of FAK and the potential of its inhibitors for immunotherapy. …”
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