Oxytocin signaling in the ventral tegmental area mediates social isolation-induced craving for social interaction by Hsin-Tzu Chang, Kuan-Hsiang Cheng, Yu-Chieh Hung, Kuei-Sen Hsu

“…Social experiences, especially in early-life stages, strongly influence brain function and social behavior later in life. Acute social isolation (SI) increases motivation to seek social interaction, but little is known about its underlying neuronal and circuitry mechanisms. …”
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Prognosticators of hepatocellular carcinoma with intrahepatic vascular invasion by Yuan-Chen Lo, Feng-Chun Hsu, Shih-Kai Hung, Kuo-Chih Tseng, Yu-His Hsieh, Moon-Sing Lee, Chih-Wei Tseng, Hon-Yi Lin, Liang-Cheng Chen, Wen-Yen Chiou

“…Prognostic factors, including treatment modalities, liver function, and comorbidities, were analyzed using univariate and multivariate analysis with the Cox model. …”
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The Yin and Yang of Microglia-Derived Extracellular Vesicles in CNS Injury and Diseases by Mousumi Ghosh, Damien D. Pearse

“…Their cargo often contains pro-inflammatory cytokines, molecules involved in oxidative stress, and neurotoxic proteins, which can exacerbate neuroinflammation, contribute to neuronal damage, and impair synaptic function, hindering neurorepair processes. The role of MGEVs in neurodegeneration and injury—whether beneficial or harmful—largely depends on how they modulate inflammation through the pro- and anti-inflammatory factors in their cargo, including cytokines and microRNAs. …”
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The impact of Nrf2/HO-1, PD-L1/Bax/Bcl-2 and TNF-α/Il-6 signaling pathways in the ameliorative role of cordycepin against acrylamide-induced cardiac toxicity in rats by Ahmed A. Sedik, Soha A. Hassan, Mona S. O. Gouida, Eman Khalifa

“…In conclusion, Cor provides cardiac protection by inhibiting ACR-induced Nrf2/HO-1 and Bax/Bcl2 signaling failure, hence maintaining heart function. These findings suggest that Cor could be a promising treatment candidate for reducing ACR-induced cardiac damage.…”
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Mixed pastures and biological efficiency in buffalo production systems: determinants for a sustainable livestock by Juan Pablo Uzcátegui-Varela, Martha Gloribet Ceballos Ramírez

“…The analysis of biological systems is characterized by the use of basic calculations during the production process that define the complex dynamics of natural capital, which is directly managed by human activities with a simplification and selection of biodiversity to support ecosystem function while generating products of agri-food interest. …”
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Impact of probiotic supplementation on serum levels of brain-derived neurotrophic factor: GRADE-based dose-response meta-analysis by Reza Hashemi, Mohammad M. Hussein M. Raouf, Tanya S. Salih, Marzieh Feyzpour, Maryam Eskandarioun, Najmeh Nezamabadipour, Hossein Gandomkar

“…Abstract Background Brain-derived neurotrophic factor (BDNF) is a key neurotrophin involved in neuroplasticity and cognitive function, with its dysregulation linked to neurodegenerative and psychiatric disorders. …”
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Behavioral Fever in Lined Seahorse (<i>Hippocampus erectu)</i> Enhances the Immune Response to <i>Vibrio harveyi</i> Infection by Siping Li, Xin Liu, Tingting Lin, Dong Zhang

“…To explore an eco-friendly approach for managing Vibrio-induced enteritis in lined seahorse (<i>Hippocampus erectus</i>) aquaculture, we investigated whether <i>Vibrio harveyi</i> infection triggers behavioral fever and enhances immune function. Seahorses were intraperitoneally injected with <i>V. harveyi</i> (1 × 10⁷ cfu/fish) and placed in a thermal gradient tank (19–31 °C), allowing free movement between chambers. …”
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MicroRNA miR-34 inhibits human pancreatic cancer tumor-initiating cells. by Qing Ji, Xinbao Hao, Min Zhang, Wenhua Tang, Meng Yang, Ling Li, Debing Xiang, Jeffrey T Desano, Guido T Bommer, Daiming Fan, Eric R Fearon, Theodore S Lawrence, Liang Xu

“…<h4>Conclusions/significance</h4>Our results demonstrate that miR-34 may restore, at least in part, the tumor suppressing function of the p53 in p53-deficient human pancreatic cancer cells. …”
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Embryonal biliary rhabdomyosarcoma in a 4-year-old female: a case report by Abdullah Nofal, Somaya Al Kiswani, Zaid Sawaftah, Nader Sarhan, Ali Bani Odah, Humam Emad Rajha

“…She also underwent intensity-modulated radiotherapy (41.4 Gy). She achieved complete tumor regression, normalization of liver function, and long-term remission. …”
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Influence of atmospheric and oceanic circulation patterns on precipitation variability in North Africa with a focus on Morocco by Oualid Hakam, El Houssaine Bouras, Abdelhakim Amazirh, Victor Ongoma, Siham Eddamiri, Lamiae Saidi, Abdelaziz Zerouali, Abdelghani Chehbouni

“…We identify the dominant teleconnections and examine their seasonal and regional impacts across Morocco using regression analyses, empirical orthogonal function (EOF) analysis, and wavelet coherence. Linear regression of sea surface temperature (SST) and geopotential height fields onto three identified precipitation zones reveals varying patterns of oceanic and atmospheric variability, with significant differences between winter and spring. …”
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Targeted Therapy for Skeletal Muscle Fibrosis: Regulation of Myostatin, TGF-&beta;, MMP, and TIMP to Maintain Extracellular Matrix Homeostasis by Dewi NM, Meiliana A, Defi IR, Amalia R, Sartika CR, Wijaya A, Barliana MI

“…Despite muscle’s inherent regenerative potential, severe or chronic injuries often result in fibrosis, which compromises muscle function and impedes healing. This review explores a range of therapeutic strategies aimed at modulating the molecular pathways involved in muscle fibrosis, with a focus on the inhibition of myostatin and transforming growth factor-β (TGF-β), as well as the regulation of matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs). …”
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Interleukin‐37 promotes DMBA/TPA skin cancer through SIGIRR‐mediated inhibition of glycolysis in CD103+DC cells by Fan‐lian Zeng, Xiao‐yan Wang, Ya‐wen Hu, Zhen Wang, Ya Li, Jing Hu, Jia‐dong Yu, Pei Zhou, Xiu Teng, Hong Zhou, Hua‐ping Zheng, Fu‐lei Zhao, Lin‐na Gu, Cheng‐cheng Yue, Shu‐wen Chen, Juan Cheng, Yan Hao, Qi‐xiang Zhao, Chen Zhang, Song Zou, Zhong‐lan Hu, Xiao‐qiong Wei, Xiao Liu, Guo‐lin Li, Nong‐yu Huang, Wen‐ling Wu, Yi‐fan Zhou, Wei Li, Kaijun Cui, Jiong Li

“…Here, we report that IL‐37b‐transgenic mice (IL‐37tg) treated with the carcinogenic 7,12‐dimethylbenzoanthracene (DMBA)/12‐o‐tetradecylphorbol‐13‐acetate (TPA) exhibited enhanced skin cancer and increased tumor burden in the skin by inhibiting the function of CD103+ dendritic cells (DCs). Notably, IL‐37 induced rapid phosphorylation of adenosine 5‘‐monophosphate (AMP)‐activated protein kinase (AMPK), and via single immunoglobulin IL‐1‐related receptor (SIGIRR), inhibited the long‐term Akt activation. …”
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Hair Follicle Dermal Sheath Derived Cells Improve Islet Allograft Survival without Systemic Immunosuppression by Xiaojie Wang, Jianqiang Hao, Gigi Leung, Trisia Breitkopf, Eddy Wang, Nicole Kwong, Noushin Akhoundsadegh, Garth L. Warnock, Jerry Shapiro, Kevin J. McElwee

“…DSCC reduced T cell activation in the renal lymph node, prevented graft infiltrates, modulated inflammatory chemokine and cytokine profiles, and preserved better beta cell function in the islet allografts, but no systemic immunosuppression was observed. …”
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miR-363-5p regulates liver disease via the MAPK/ERK signaling pathway by targeting CPEB2 in chicken by Jialin Xiang, Bangsheng Jia, Zixiang Luo, Haorong He, Yao Zhang, Can Cui, Huadong Yin, Shunshun Han, Chang Liu

“…MicroRNAs (MiRNAs) serve as central hepatic regulators, particularly influencing egg-laying efficiency through metabolic pathway control, detoxification modulation, and vitellogenesis. While miR-363-5p is implicated in liver metabolism and development across species, its specific roles in avian hepatic function remain underexplored. …”
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Variations of rumen metagenome and metabolome in dairy cows with different feed intake levels during the postpartum period by Shuai Huang, Yikui Shang, Lan Wang, Shang Wang, Gang Zheng, Dongxing Wang, Musen Wang, Shengli Li

“…The feed intake variation explained by the rumen microbiome, functions, and metabolites were 29.63%, 27.30%, and 33.50%, respectively. …”
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Decoding mechanisms and protein markers in lung-brain axis by Shiqian Huang, Yuxi Zhou, Haipeng Ji, Tianhao Zhang, Shiya Liu, Lulin Ma, Daling Deng, Yuanyuan Ding, Linlin Han, Shaofang Shu, Yu Wang, Xiangdong Chen

“…Specifically, we highlight the role of the vagus nerve in modulating the central nervous system response to pulmonary stimuli; Additionally, the regulatory function of the immune system is underscored, with evidence suggesting that lung-derived immune mediators can traverse the blood-brain barrier, induce neuroinflammation and cognitive decline; Furthermore, we discuss the potential of lung microbiota to influence brain diseases through microbial translocation and immune activation; Finally, the impact of hypoxemia is examined, with findings indicating that it can exacerbate cerebral injury via oxidative stress and impaired perfusion. …”
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The metabolic dialogue between intratumoural microbes and cancer: implications for immunotherapy by Yingheng Situ, Pengpeng Zhang, Cangang Zhang, Aimin Jiang, Nan Zhang, Lingxuan Zhu, Weiming Mou, Zaoqu Liu, Hank Z.H. Wong, Jian Zhang, Quan Cheng, Anqi Lin, Peng Luo

“…We systematically analyse how microbial-derived glucose, amino acid, and lipid metabolites modulate immune cell function, cytokine secretion, and tumour growth. …”
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tRNA-derived small RNA 3’ tRF-Ala CGC obstructs NK cytotoxicity via cleavage of membrane protein MICA in colorectal cancer by Jing Zhang, Chunlin Ou, Xin Li, Li Fu, Qizhi Luo, Jie Wang, Yizhou Zou

“…These tsRNAs exhibit diverse biological functions, including immune modulation, metabolic disorders, and cell death. …”
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lncRNA RP11-34D15.2 sponges miR-223 to promote the PGC-1α/irisin signaling pathway, contributing to increased FFA and insulin resistance in obese children by Shuang Guo, Mengnan Lu, Yuesheng Liu, Hongai Zhang, Biyao Lian, Yanfeng Xiao, Chunyan Yin

“…Conclusion: lncRNA RP11-34D15.2 functions as a ceRNA sponging miR-223 to activate PGC-1α/irisin-mediated mitochondrial β-oxidation and FFA clearance, identifying therapeutic targets for childhood obesity.…”
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Rhein Alleviates Cisplatin-Induced Acute Kidney Injury via Downregulation of NOX4-COX2/PGFS Signaling Pathway by Yuan X, Long L, Wang M, Chen W, Liang B, Xu L, Wang W, Li C

“…Protein-protein interaction (PPI) network analysis prioritized 16 hub genes functionally enriched in oxidative stress (GO) and inflammatory/apoptotic pathways (HALLMARK). …”
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