Analyzation of the Peripheral Blood Mononuclear Cells Atlas and Cell Communication of Rheumatoid Arthritis Patients Based on Single-Cell RNA-Seq by Xinqiang Song, Yu Zhang, Lijun Zhao, Jinke Fan, Tao Peng, Ying Ma, Nailiang Guo, Xiaotong Wang, Xudong Liu, Zhe Liu, Lei Wang

“…Redimensional clustering analysis of four major immune cells (T cells, monocytes, B cells, and natural killer cells) revealed that double-negative T (DNT) cells were significantly altered in abundance and function. And a number of genes (including SOCS3, cAMP-responsive element modulator (CREM), B2M, MTFP1, RSRP1, and YWHAB) were specifically downregulated in DNT cells. …”
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Research on anti-occlusion tracking method for underground mine personnel based on adaptive link optimization by LU Yang, DONG Lihong, YE Ou

“…This score was combined with the total cost function of the Kalman filter in the original matching cascade stage to optimize matching decisions, effectively alleviating the issue of incorrect matching during the trajectory matching process. …”
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Lightweight Detection Algorithm for Breast-Mass Features in Ultrasound Images by Taojuan Li, Wen Liu, Mingxian Song, Zheng Gu, Ling Hai

“…Finally, a weighted intersection-over-union (WIoU) loss function is integrated to better capture the complex boundaries of malignant masses. …”
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Acupuncture Ameliorates Alzheimer’s-Like Cognitive Impairment and Pathological Changes via Regulating the Intestinal Fungal Community in APP/PS1 Mice by Hao X, Ding N, Zhang Y, Wu M, Tao Y, Li Z

“…The beneficial effects of acupuncture on Aβ deposition and cognitive function in APP/PS1 mice may be achieved by regulating the intestinal fungal community.Keywords: Alzheimer’s disease, acupuncture, intestinal fungal community, β-amyloid, probiotics…”
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Potential ability of circulating INSL3 level for the prediction of ovarian reserve and IVF success as a novel theca cell–specific biomarker in women with unexplained infertility an... by Pinar Ozcan, F. Sezer, A. Altun, C. Yildiz, H. T. Timur, E. C. Keles, O. Dural, H. S. Taha, E. Saridogan

“…It is hypothesized that INSL3 is integral to the initial development and function of antral follicles, specifically through its regulatory effect on androgen biosynthesis in the thecal cells of these follicles. …”
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Effector Responses Induced by Pattern Recognition Receptors (PRRs) for Disease Protection by L. Chi, Ya. Chi

“…PRRs also play crucial regulatory roles, preventing hyperinflammation and promoting immune tolerance. Conclusions. PRRs function as master regulators of immune responses, serving not only as pathogen detectors but also as sophisticated coordinators of immune activation, tolerance, and resolution. …”
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Unveiling SSR4: a promising biomarker in esophageal squamous cell carcinoma by Jiaqi Zhang, Fang Jia, Chuqiao Li, Shunzhe Song, Aixia Gong

“…The ESCC cell subsets with the highest gene expression levels were identified with single-cell data. Gene function and enrichment, immune infiltration, cell communication, and molecular docking analyses were performed.ResultsUnlike adjacent non-cancerous tissues, SSR4 was overexpressed in ESCC tissues, validated by both reverse transcription-qPCR and IHC staining. …”
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A full-spectrum Boswellia serrata extract with enhanced bioavailability, and its co-delivered system with curcumin alleviate pain and stiffness associated with moderate spondylitis... by K. Mamatha, Prathibha Prabhakaran, S. Syam Das, Manu Kanjoormana Aryan, Jestin Thomas

“…These outcomes suggest that the combined administration of curcuminoids and boswellic acids with improved bioavailability modulates inflammatory pathways, thus contributing to symptom relief and improved function.ConclusionBoth F-BSE and C-BSE reduced pain and stiffness issues by day 14, which continued to progress through day 28. …”
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Improved CSW-YOLO Model for Bitter Melon Phenotype Detection by Haobin Xu, Xianhua Zhang, Weilin Shen, Zhiqiang Lin, Shuang Liu, Qi Jia, Honglong Li, Jingyuan Zheng, Fenglin Zhong

“…Finally, WIoUv3 was introduced as the bounding box loss function to improve the model’s convergence speed and positioning capabilities. …”
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The Pathogenic Aspects of Human Parvovirus B19 NS1 Protein in Chronic and Inflammatory Diseases by Sedigheh Jalali, Ali Farhadi, Gholamreza Rafiei Dehbidi, Shirin Farjadian, Sedigheh Sharifzadeh, Reza Ranjbaran, Noorossadat Seyyedi, Sepide Namdari, Abbas Behzad-Behbahani

“…Therefore, hPVB19 NS1 function may play a role in the progression of some chronic and inflammatory diseases.…”
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Liver failure diagnosis: key diagnostic biomarkers discovery and bioinformatic validation by Quan Ye, Kai Wang, Hong Ye

“…The Comparative Toxicogenomics Database was used to predict the function of GPX3. In addition, in our study, we verified the target gene mRNA expression level in 40 patients with acute or chronic acute liver failure (ACHBLF) by RT-QCPR experiment and detect the methylation status of GPX3 promoter of ACHBLF patients with methylation specific PCR (MSP).ResultsThe results demonstrate that GPX3 drives pathogenic mechanisms in liver failure through oxidative stress-related pathways (e.g., collagen cross-linking, extracellular matrix remodeling) and immune dysregulation (e.g., macrophage activation, PD-1/CTLA-4 signaling). …”
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Arginine intervention mitigates growth retardation and gut antioxidant stress in orange-spotted groupers (Epinephelus coioides) fed high soybean meal diets by Cong Huo, Ruyi Xiao, Kun Wang, Yunzhang Sun, Jidan Ye

“…These results indicate that 0.5 % Arg supplementation effectively mitigates SBM-induced growth retardation and enteritis in juvenile groupers by enhancing gut antioxidant capacity, digestive function, and mucosal integrity while suppressing inflammatory responses.…”
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Phytobiotics in poultry: revolutionizing broiler chicken nutrition with plant-derived gut health enhancers by Uchechukwu Edna Obianwuna, Xinyu Chang, Vivian U. Oleforuh-Okoleh, Patience N. Onu, Haijun Zhang, Kai Qiu, Shugeng Wu

“…The focus is on elucidating the key mechanisms through which phytobiotics improve gut health, including their effects on gut morphology, integrity, microflora composition, antioxidant capacity, and immune function. The review highlights the potential of phytobiotics to revolutionize broiler nutrition by acting as natural enhancers of gut health. …”
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Maternal high-fat diet orchestrates offspring hepatic cholesterol metabolism via MEF2A hypermethylation-mediated CYP7A1 suppression by Ling Zhang, Wenyu Zou, Shixuan Zhang, Honghua Wu, Ying Gao, Junqing Zhang, Jia Zheng

“…The potential regulator of cholesterol metabolism in the offspring’s liver was identified, and the function of the targeted transcription factor was evaluated through in vitro experiments. …”
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Berberine in cardiovascular therapy: bridging modern pharmacology with the traditional Chinese botanicals Huanglian (黄连), Huangbai (黄柏), Amur Cork Tree (黄檗), and Gong Lao Mu (亮叶十大功... by Seema Sharma, Sampat Singh Tanwar

“…These include lipid-lowering effects by upregulating LDL receptors and inhibiting PCSK9, antihypertensive effects via vasodilation and modulation of the renin-angiotensin-aldosterone system, antiarrhythmic properties by affecting ion channels, and improvement in cardiac function in heart failure models. …”
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Hormonal Fluctuation and Ankle Instability in Women – Is There a Correlation? by Vanessa Boggiano, Hayden Hartman BS, Shannon Fehr DO, Arianna Gianakos DO

“…Articles were excluded if they evaluated patients that were injured or experiencing other associated pathological processes impacting ankle function or stability. Results: Fourteen articles were included, composed of 2 clinical trials, 5 cohort studies, 5 case series, and 2 cross-sectional studies. …”
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TRPM2 deficiency contributes to M2b macrophage polarization via the PI3K/AKT/CREB pathway in murine sepsis by Yanping Shen, Rana Dhar, Jujun Liu, Shenghui Hong, Huifang Tang, Xiaowei Qian

“…This effect is mediated through the modulation of macrophage phenotypic changes, which strengthen the immune response against infection. …”
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Deubiquitinase OTUD7B stabilizes HNF4α to alleviate pressure overload-induced cardiac hypertrophy by regulating fatty acid oxidation and inhibiting ferroptosis by Rujie Zheng, Wenjuan Song, Che Wang, Xiaoyu Du, Chunlei Liu, Xiaotong Sun, Chengzhi Lu

“…Deubiquitinating enzymes (DUBs) are critical in cardiac pathophysiology by regulating protein stability, function, and degradation. Here, we investigated the role and regulating mechanism of ovarian tumor domain-containing 7B (OTUD7B) in cardiac hypertrophy by modulating fatty acid metabolism. …”
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Association between Capillaria hepatica infection-induced alterations in gut microbiota and estrogen expression in Brandt’s voles (Lasiopodomys brandtii) by Bin Hu, Kening Yue, Daibao Zhang, Shengyong Feng, Ning Zhao, Gaojian Li, Sichao Gao, Yanan Xing, Shuyi Han, Hongxuan He

“…This indirect effect on hormone expression can subsequently impact the reproductive function of the host. By investigating the changes in specific gut microbiota, this study sheds light on the mechanisms through which parasites regulate population fluctuations in Brandt’s voles.…”
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Interactive Computer-Adaptive Chronic Kidney Disease (I-C-CKD) Education for Hospitalized African American Patients: Protocol for a Randomized Controlled Trial by Akilah King, Tayo Omoniyi, Lindsay Zasadzinski, Cynthia Gaspard, Denesha Gorman, Milda Saunders

“… BackgroundEnd-stage kidney disease (ESKD) or kidney failure is a condition where the kidneys lose the ability to function. African American individuals are 4 times as likely to develop ESKD compared to White American individuals. …”
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