Success: the synergy of off-pump coronary artery bypass and living donor liver transplantation—a two-case report by Sinan Efe Yazici, Ahmet Atasever, Ozge Cetinarslan, Ebru Turan, Ertan Sagbas, Yıldıray Yuzer

“…Both patients were extubated on postoperative day one, discharged with triple immunosuppression, and followed for 6–12 months with preserved cardiac and graft function. A bile leak from the cystic duct anastomosis was encountered in one case.ConclusionSimultaneous OPCAB and LDLT is a feasible and safe approach in carefully selected ESLD patients with CAD when performed by experienced multidisciplinary teams. …”
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Electroacupuncture at ST25 mediated glial cells pruning of pancreatic TRPV1 neural synapse responds to neuropathy-associated beta cell dysfunction by Yun Liu, Jiahui Xie, Zhi Yu, Meirong Gong, Qian Li, Guanhu Yang, Bin Xu, Tiancheng Xu

“…Abstract Electroacupuncture (EA) is verified to modulate glycemic changes in T2DM, and this is partially related to sensory neurotransmitters. …”
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The Anti-Inflammatory Potential of Tricyclic Antidepressants (TCAs): A Novel Therapeutic Approach to Atherosclerosis Pathophysiology by Majid Eslami, Marzieh Monemi, Mohammad Ali Nazari, Mohammad Hossein Azami, Parand Shariat Rad, Valentyn Oksenych, Ramtin Naderian

“…By inhibiting the NLRP3 inflammasome and suppressing pathways including JAK/STAT, MAPK, and PI3K, these effects are produced, improving endothelial function and reducing oxidative stress. The intricacy of TCAs’ anti-inflammatory actions has demonstrated by the existence of contradictory findings about how they alter IL-6 levels. …”
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Unraveling environmental influences on the spatial and temporal dynamics of cyanobacterial blooms in Lake Erhai during its early stage of eutrophication by Shangbo Yang, Jianzhong Lu, Xiaoling Chen, Xuejiao Hou, Zushuai Wei, Jinru Wu

“…We investigated the cyanobacterial phycocyanin concentration variability based on satellite observations from 2003 to 2019, by using the empirical orthogonal function analysis. We observed a decrease in the coverage of the dominant mode of variability in phycocyanin magnitudes compared to the period 2003 to 2011, with variations primarily occurring in the northern bays. …”
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Brain stimulation enhances dispositional mindfulness in PTSD: an exploratory sham-controlled rTMS trial by Kaveh Rayani, Andrea Grabovac, Peter Chan, Peter Chan, Stefanie Montgomery, Mohammad-Reza Ghovanloo, Matthew D. Sacchet

“…Therapies involving mindfulness have been shown to reduce PTSD symptoms and modulate brain function. Pharmacological and brain stimulation interventions are also effective for treating PTSD. …”
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Effect of the Several Herbal Medicines Mixture on BMI and Lipid Profile -The Animal Study by Mozhgan Mohammadzadeh, Ali Shamsizadeh, Mohammad Reza Memarzadeh, Jalal Hassanshahi, Ayat Kaeidi, Morteza Khademalhosseini, Mohammad-Reza Shafiepour

“…Furthermore, GUTAC enhanced renal function markers (BUN and creatinine) and mitigated hepatic steatosis, as evidenced by histological analysis. …”
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A randomized controlled study on intermittent theta pulse stimulation for improving cognitive impairment after stroke by Fei Li, Fengxia Hu, Yi Liang, Fen Liang, Huiqun Tan, Sisi Xing

“…ObjectiveThis study evaluates the efficacy and underlying mechanisms of intermittent theta-burst stimulation (iTBS) in improving cognitive function and quality of life in post-stroke patients.MethodsA total of 80 subacute stroke patients with cognitive deficits were randomly assigned to a control group (n = 40) receiving conventional treatment plus sham stimulation and an experimental group (n = 40) receiving conventional treatment plus iTBS over the left dorsolateral prefrontal cortex for 4 weeks.ResultsBaseline characteristics were comparable between groups. …”
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The effect of Jian Gan powder on the proliferation, migration and polarization of macrophages and relative mechanism by Kun Li, Xue Zheng, Jian Zhang, Zhanpeng Yan, Yu Ji, Fei Ge, Fangshi Zhu

“…Furthermore, it inhibited macrophage M1 polarization, promoting M2 polarization.Discussion and conclusions JGP effectively suppressed the cellular function of RAW264.7 cells by down-regulating the IL-6/STAT3 signaling pathway and modulating macrophage M1/M2 polarization. …”
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<i>Persea americana</i> Peel: A Promising Source of Nutraceutical for the Mitigation of Cardiovascular Risk in Arthritic Rats Through the Gut–Joint Axis by Doha A. Mohamed, Asmaa A. Ramadan, Hoda B. Mabrok, Gamil E. Ibrahim, Shaimaa E. Mohammed

“…Treatment with APN was favorable in restoring eubiosis in the gut by modulating RA-associated bacterial taxa linked to impaired immune function and cardiometabolic diseases. …”
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The treatment of primary CoQ deficiency requires the targeting of multiple pathogenic mechanisms by Pilar González-García, Laura Jiménez-Sánchez, Julia Corral-Sarasa, Sergio López-Herrador, Sara Torres-Rusillo, María Elena Díaz-Casado, Luis C. López

“…Results In Coq9 R239X mice, we demonstrate that co-administration of CoQ10 and VA significantly extends lifespan and improves motor function beyond the effects observed with either compound alone. …”
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Exploring the Therapeutic Potential of <i>Rehmannia glutinosa</i>: A Network Pharmacology and Molecular Docking Analysis Across Multiple Diseases by Jinyoung Park, Muhammad Yasir, Eun-Taek Han, Jin-Hee Han, Won Sun Park, Jongseon Choe, Wanjoo Chun

“…<i>Rehmannia glutinosa</i> (RG), a fundamental herb in traditional Chinese medicine belonging to the Orobanchaceae family, has been widely used for centuries due to its diverse therapeutic properties, including promoting blood circulation, enhancing immunity, managing diabetes, reducing inflammation, and supporting kidney function. Despite its traditional significance, scientific studies on RG’s therapeutic mechanisms remain limited, and its underlying pharmacological pathways are not extensively elucidated. …”
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Conformational Propensities of a DNA Hairpin with a Stem Sequence from the c-MYC Promoter by Arees Garabet, Iztok Prislan, Nataša Poklar Ulrih, James W. Wells, Tigran V. Chalikian

“…We used our CD-based procedure to quantify the distribution of conformational states sampled by the hairpin at pH 5.0 and 7.0 as a function of temperature and the concentration of KCl. …”
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Assessing inflammatory protein biomarkers in COPD subjects with and without alpha-1 antitrypsin deficiency by Matthew Moll, Brian D. Hobbs, Katherine A. Pratte, Chengyue Zhang, Auyon J. Ghosh, Russell P. Bowler, David A. Lomas, Edwin K. Silverman, Dawn L. DeMeo

“…PPI networks implicated regulation of immune system function, cytokine and interleukin signaling, and matrix metalloproteinases. …”
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The Effect of Dapagliflozin, a Sodium–Glucose Co-Transporter 2 Inhibitor, on Vancomycin-Induced Nephrotoxicity in Rats by Seyhmus Tan, Bulent Kaya, Ercan Akburak, Cagri Avci, Kivilcim Eren Ates, Gulfiliz Gonlusen, Tugce Sapmaz Ercakalli, Burak Mete

“…<b>Methods</b>: Rats were randomly assigned to four groups: control, VA (vancomycin), DAPA (dapagliflozin), and VA+DAPA. Renal function was assessed by measuring serum urea and creatinine. …”
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SCL-YOLOv11: A Lightweight Object Detection Network for Low-Illumination Environments by Shulong Zhuo, Hao Bai, Lifeng Jiang, Xiaojian Zhou, Xu Duan, Yiqun Ma, Zihan Zhou

“…Meanwhile, the Minimum Point Distance based IoU(MPDIoU) loss function is adopted to mitigate gradient explosion risks while enhancing detection precision. …”
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The mechanism of Ningxin-Tongyu-Zishen formula regulating probdnf/mbdnf balance through PAI-1/tPA signaling pathway in the treatment of premature ovarian insufficiency by Jiawen Ma, Chaofan Zhu, Lifang Xie, Shuaiqi An, Zaiyang Zhang, Keying Wang, Yizhou Zhang

“…Results NTZF composition was characterized and shown to improve ovarian function in POI rats. Its mechanism involves correcting proBDNF/mBDNF imbalance in both brain and ovarian tissues. …”
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Multiparametric Investigation of Chemically Treated and Untreated Sugarcane Bagasse Fiber-Reinforced Epoxy Composites With Wood Apple Shell as Filler: From Waste to Green Composite by Vinita Sharma, null Priyanka, Minakshi Verma, Deepak Kumar, Anu Gupta

“…In addition, we report an increase in water absorption as a function of filler loading for both treated and untreated specimens, whereas untreated composites exhibit a higher rate of water absorption with respect to treated ones at a fixed loading value. …”
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Signaling via class IA Phosphoinositide 3-kinases (PI3K) in human, breast-derived cell lines. by Veronique Juvin, Mouhannad Malek, Karen E Anderson, Carine Dion, Tamara Chessa, Charlotte Lecureuil, G John Ferguson, Sabina Cosulich, Phillip T Hawkins, Len R Stephens

“…These results indicate that; p110α is required for EGF signaling to PKB and chemokinesis, but not chemotaxis; onco-mutant alleles of p110α augment signaling in the absence of EGF and may increase motility, in part, via acutely modulating PI3K-activity-independent mechanisms. Finally, we demonstrate that there is not a universal mechanism that up-regulates p110β function in the absence of PTEN.…”
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An interpretable physics-informed deep learning model for estimating multiple air pollutants by Binjie Chen, Jiacong Hu, Yumiao Wang, Tian Feng, Weiwei Sun, Zunlei Feng, Gang Yang, Huiqiong Wang

“…To ensure consistency with physical laws, a physics-constrained loss function was incorporated. Finally, layer-wise relevance propagation was employed to interpret the model results. …”
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Assessment of binary prediction of fraudulent advertisements in ATS candidate tracking cloud systems by V. V. Ligi-Goryaev, G. A. Mankaeva, T. B. Goldvarg, S. S. Muchkaeva, E. N. Dzhakhnaeva

“…Then, after reducing the dimensionality of the data, the data was reloaded, and both the model and vectorizer were retrained before being used for prediction. The tkinter module was used for the graphical interface. The predict() function utilizes the trained model for predictions based on the feature vector.…”
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