Epigenetic targeting of MECOM/KRAS axis by JIB-04 impairs tumorigenesis and cisplatin resistance in MECOM-amplified ovarian cancer by Ibha Singh, Amarnath Karna, Anita Prajapati, Ujjawal Solanki, Archana Mukherjee, Sheetal Uppal, Pawan Malhotra, Manoj Kumar, Pallavi Agarwal

“…MDS1 and EVI1 Complex locus (MECOM) gene is copy number amplified and overexpressed in aggressive epithelial ovarian cancers. The biological function and precise molecular mechanism of MECOM in the progression and drug resistance of ovarian cancer remain unclear. …”
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Introducing a Novel Personalized Microbiome-Based Treatment for Inflammatory Bowel Disease: Results from NostraBiome’s Internal Validation Study by Adrian Goldiș, Radu Dragomir, Marina Adriana Mercioni, Christian Goldiș, Diana Sirca, Ileana Enatescu, Oana Belei

“…Primary outcomes included stool frequency and consistency as well as inflammatory markers (C-reactive protein and fecal calprotectin), while secondary outcomes assessed nutritional status, metabolic function, and quality of life. Statistical analyses included paired t-tests and repeated measures ANOVA to determine significant changes over time. …”
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Human umbilical cord-derived mesenchymal stem cells attenate histaminergic effect of intestinal mucosa through bax/bcl-2 pathway in food allergic enteritis by Yuan Zhao, Weipeng Liu, Yabing Ding, Jie Zhou, Fan Zhang, Zhaoyan Wang, Qian Wang, Zuo Luan

“…These results reveal novel therapeutic potential for hUC-MSCs in maintaining epithelial homeostasis and intestinal barrier function in food allergy-associated enteritis, suggesting promising clinical applications for this disorder.…”
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Consumer-Grade Neurofeedback With Mindfulness Meditation: Meta-Analysis by Isaac Treves, Zia Bajwa, Keara D Greene, Paul A Bloom, Nayoung Kim, Emma Wool, Simon B Goldberg, Susan Whitfield-Gabrieli, Randy P Auerbach

“…Effects were categorized outcomes (ie, psychological distress, cognitive function, and physiological health) and process variables (ie, state mindfulness and brain measures). …”
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Mediation Mendelian randomization analysis of immune cell phenotypes and glioma risk: unveiling the regulation of cerebrospinal fluid metabolites by Siyuan Zhao, Jinghao Jiang, Jianwu Zhang, Xiaoqing Jin

“…The potential mediating effects of cerebrospinal fluid metabolites were investigated to explore the underlying mechanisms linking immune cell function and glioma. The GWAS data for immune cells, cerebrospinal fluid metabolites, and glioma used in this study were sourced from public databases. …”
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The pig pose recognition method based on pig body semantic segmentation by Nuonan Huang, Deli Zhu, Liang He, Yi Li

“…Furthermore, the Mish activation function is introduced to improve training stability and accelerate convergence. …”
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Nicotinamide Mononucleotide Restores NAD⁺ Levels to Alleviate LPS-Induced Inflammation via the TLR4/NF-κB/MAPK Signaling Pathway in Mice Granulosa Cells by Mehboob Ahmed, Umair Riaz, Haimiao Lv, Muhammad Amjad, Sohail Ahmed, Shaokat Ali, Muhammad Usman Ghani, Guohua Hua, Liguo Yang

“…Inflammation disrupts the normal function of granulosa cells (GCs), which leads to ovarian dysfunction and fertility decline. …”
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Lightweight blasthole image detection and positioning method by Shan PAN, Ting YU, Zhongwen YUE, Zijian TIAN, Qingyu JIN

“…Finally, the loss function is optimized to improve the accuracy of blasthole bounding box regression. …”
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Research on SeaTreasure Target Detection Technology Based on Improved YOLOv7-Tiny by Xiang Shi, Yunli Zhao, Jinrong Guo, Yan Liu, Yongqi Zhang

“…First, based on the YOLOv7-Tiny network, the MAFPN neck structure is used to replace the ELAN structure to achieve the multi-scale capture of semantic information of underwater sea treasures, and to enhance the UPA-YOLO model to accurately locate the targets of underwater sea treasures; second, the P2ELAN module is constructed and added to the backbone network, which makes use of the redundancy information in the feature map and dynamically adjusts the convolution kernel to adapt to data The P2ELAN module is added to the backbone network, using the redundant information in the feature map, dynamically adjusting the convolutional kernel to adapt to the lack of data, reducing the number of parameters in the model, and introducing the MSCA attention mechanism to inhibit the complex and changeable background features underwater, to improve the semantic feature extraction ability of the UPA-YOLO model for underwater targets, adding the MPDiou loss function to the improved algorithm model and completing the data validation of the detection model; finally, based on the TensorRT acceleration framework, the optimisation of the target detection Finally, based on the TensorRT acceleration framework, the target detection model is optimised, and the Jetson Nano edge device is used to complete the localisation deployment and realise the real-time target detection task of underwater sea treasures. …”
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Identification of SETD4 as an Onco‐Immunological Biomarker Encompassing the Tumor Microenvironment, Prognoses, and Therapeutic Responses in Various Human Cancers by Yuyun Zhong, Ruiqi Wang, Zijie Huang, Zhaoting Hu, Bin Peng, Bin Chen, Liyue Sun

“…Previous reports have demonstrated its function in the quiescence of cancer stem cells as well as drug resistance in several cancers. …”
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Effects of exercise training on the nigrostriatal glutamatergic pathway and receptor interactions in Parkinson’s disease: a systematic review by Shahid Ishaq, Iqbal Ali Shah, Shin-Da Lee, Shin-Da Lee, Bor-Tsang Wu

“…It also improved motor function, including balance, coordination, and gait parameters.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/#recordDetails, identifier CRD42024564127…”
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HGCS-Det: A Deep Learning-Based Solution for Localizing and Recognizing Household Garbage in Complex Scenarios by Houkui Zhou, Chang Chen, Zhongyi Xia, Qifeng Ding, Qinqin Liao, Qun Wang, Huimin Yu, Haoji Hu, Guangqun Zhang, Junguo Hu, Tao He

“…Finally, the Slide Loss function is applied to dynamically weight hard samples arising from the complex detection environments to improve the recognition accuracy of hard samples. …”
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Anti-inflammatory therapy for tendinopathy using Il1rn mRNA encapsulated in SM102 lipid nanoparticles by Yuan Zhang, Yuan Zhang, Xu Li, Hao Li, Ruiyang Zhang, Ti Zhang, Talante Juma, Yongfei Zhou, Quanyi Guo, Hui Zhao, Yongping Cao

“…By 4 weeks, treated tendons exhibited functional recovery with normalized gait patterns. Transcriptomics revealed dual modulation of IL-1 signaling and extracellular matrix (ECM) remodeling pathways, alongside macrophage polarization and oxidative stress regulation. …”
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Pitolisant alleviates brain network dysfunction and cognitive deficits in a mouse model of Alzheimer’s disease by Yang Zou, Linhan Yang, Jiahui Zhu, Jihua Fan, Hanrun Zheng, Xiang Liao, Zhiqi Yang, Kuan Zhang, Hongbo Jia, Arthur Konnerth, Yan-jiang Wang, Chunqing Zhang, Yun Zhang, Sunny C. Li, Xiaowei Chen

“…Abstract Histamine H3 receptor (H3R) antagonists regulate histamine release that modulates neuronal activity and cognitive function. …”
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Reduced lung metastasis in endothelial cell-specific transforming growth factor β type II receptor-deficient mice with decreased CD44 expression by Kako Hanada, Yuki Saito, Takahiro Takagi, Mitsuki Go, Yota Nakano, Toshihiko Inagawa, Hideyo Hirai, Marcus Fruttiger, Susumu Itoh, Fumiko Itoh

“…These findings highlight TGF-β′s role in promoting metastasis by modulating EC function.…”
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The Impact of Caffeine on Anxiety Levels and Stress Responses - a literature review by Karolina Knychalska, Jakub Sikora, Mikołaj Łabuda, Klaudia Królikowska, Aleksandra Słojewska, Agata Kotkowiak, Teresa Sowińska, Oliwia Mentel, Adrianna Bogucka, Agnieszka Szema

“…State of Knowledge: Previous research indicates that caffeine modulates nervous system function by affecting neurotransmission, particularly by increasing the release of dopamine, noradrenaline, and serotonin. …”
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Clinical Trial: Effects of Autologous Dendritic Cell Administration on Renal Hemodynamics and Inflammatory Biomarkers in Diabetic Kidney Disease by Endang Drajat, Aziza Ghanie Icksan, Jonny Jonny, Aditya Pratama Lokeswara, Bhimo Aji Hernowo, Elvita Rahmi Daulay, Terawan Agus Putranto

“…Hyperglycemia in DKD induces inflammation, contributing to glomerular hyperfiltration, fibrosis, and impaired renal function. Current therapies, including SGLT2 inhibitors, ACE inhibitors, and ARBs, show limited efficacy. …”
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How does medication-related osteonecrosis of the jaw (MRONJ) influence the health-related quality of life after surgery? by Oliver Bissinger, Josefa Greiser, Elisabeth Maier, Philipp Ehrmann, Tamara Kakoschke, Klaus-Dietrich Wolff, Carolin Götz

“…It was demonstrated that MRONJ causes an even further negative impact, particularly on role and social function. Amongst the MRONJ patients certain factors such as female sex, breast cancer as underlying disease, hypothyroidism, denture, nicotine abuse and multiple surgeries of the MRONJ were associated with worse QoL. …”
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The expression of Aldo-keto reductase gene OsKOB1 coordinates ABA homeostasis and antioxidant defense to maintain seed vigor under osmotic stress by Jianhong Tian, Mengqi Yin, Kerui Huang, Shiqi Zhou, Ting Chen, Niwen Tang, Yan Liu, Jing Wang, Yan Wang, Xiaocheng Jiang

“…In this paper, we investigated the function of the rice AKR gene OsKOB1 under osmotic stress. …”
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Targeted M‐Channel Activation in the Left Stellate Ganglion Protects Against Ischemia‐Induced Ventricular Arrhythmias in Canines by Jin‐qiang Peng, Ming‐min Zhou, Liao Xu, Xi Wang, Yan‐hong Tang, Yu Liu

“…These findings highlight ganglionic M‐channel modulation as a translatable strategy to suppress neurogenic arrhythmogenesis in AMI.…”
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