The cardiac microenvironment uses non‐canonical WNT signaling to activate monocytes after myocardial infarction by Ingmar Sören Meyer, Andreas Jungmann, Christoph Dieterich, Min Zhang, Felix Lasitschka, Susann Werkmeister, Jan Haas, Oliver J Müller, Michael Boutros, Matthias Nahrendorf, Hugo A Katus, Stefan E Hardt, Florian Leuschner

“…Next, we induced AAV‐mediated cardiomyocyte‐specific WIF1 overexpression, which attenuated the monocyte response and improved cardiac function after MI, as compared to control‐AAV‐treated animals. …”
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Exploring the role of Cdk5 on striatal synaptic plasticity in a 3-NP-induced model of early stages of Huntington’s disease by Elizabeth Hernández-Echeagaray, Jorge A. Miranda-Barrientos, Elizabeth Nieto-Mendoza, Francisco Miguel Torres-Cruz

“…Impaired mitochondrial function has been associated with the onset of neurodegenerative diseases. …”
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Non-rhizobial endophyte recruitment and diversity in Pisum sativum are strongly shaped by phosphorus fertilizer form by Stefanie Katharina Thaqi, Natalia Hensel, Nora Vitow, Christel Baum, Lisa-Marie Streb, Susanne Kublik, Peter Leinweber, Kerstin Panten, Michael Schloter, Stefanie Schulz

“…Abstract Background Non-rhizobial endophytes (NREs) support plant health and nodule function by enhancing symbiotic interactions and nitrogen fixation. …”
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Regulation of intestinal flora by Suaeda salsa extract ameliorates hyperglycemia in a mouse model of type 2 diabetes mellitus by Xuemei Yin, Yinzi Sui, Zhengyan Chu, Suqing Han, Xiaodong Ge, Tingting Liu, Feng Zeng, Ligen Chen, Rong Shao, Wei Xu

“…The aim of this study was to analyze the regulatory effect of Suaeda salsa extract (SSE) on T2DM and its effect on the intestinal flora of mice.ResultsThe results showed that SSE could significantly improve the body weight, fasting blood glucose (FBG), area under the curve (AUC) of the oral glucose tolerance test (OGTT), glycosylated serum protein (GSP) and islet function index. Moreover, 4-week body weight, FBG, AUC of OGTT, GSP, as well as intestinal acetic and butyric acid were significantly better in the SSE-L than in the MET group (p < 0.05). …”
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Efficacy and Safety of Visible and Near-Infrared Photobiomodulation Therapy on Astenospermic Human Sperm: Wavelength-Dependent Regulation of Nitric Oxide Levels and Mitochondrial E... by Matilde Balbi, Rachele Lai, Sara Stigliani, Claudia Massarotti, Matteo Bozzo, Paola Scaruffi, Silvia Ravera, Andrea Amaroli

“…At longer wavelengths (940 nm and 1064 nm), interactions with water and lipids may introduce additional variables that affect membrane fluidity and mitochondrial function differently from shorter wavelengths.…”
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Negative Regulation of <i>GmNAC35</i> by miR164 Enhances Drought Tolerance in Soybean by Wentao Hu, Man Zhang, Jie Lu, Miaomiao Zhang, Reqing He, Youlin Zhu, Dong Wang, Liyun Jiang

“…The miR164 family is highly conserved across plant species and has been shown to participate in drought responses in a range of plants, yet the function of miR164 in soybean remains unclear. In this study, we identified <i>GmNAC35</i> as a direct target of miR164 through published degradome sequencing data and 5′ RLM-RACE assays. …”
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MicroRNA: unveiling novel mechanistic and theranostic pathways in diabetic cardiomyopathy by Akash De, Arnab Sarkar, Tanmoy Banerjee, Rudranil Bhowmik, Shuvam Sar, Md. Adil Shaharyar, Sanmoy Karmakar, Nilanjan Ghosh

“…In diabetic patients, it is a chronic condition that is characterized by ventricular hypertrophy (VH), diastolic dysfunction, alteration of systolic function, and reduced ejection fraction, ultimately leading to heart failure (HF). …”
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Oral andrographolide loaded lipid nanocarriers alleviate stress behaviors and hippocampal damage in TNF alpha induced neuroinflammatory mice by Sarawut Lapmanee, Natchanon Rimsueb, Phichaporn Bunwatcharaphansakun, Katawut Namdee, Prapimpun Wongchitrat, Sakkarin Bhubhanil, Nattapon Supkamonseni, Natthawut Charoenphon, Anjaree Inchan, Rattaporn Saenmuangchin, Mattaka Khongkow

“…These changes included weight loss and compensatory responses to inflammation, as indicated by increased immune- and stress-modulated organ weights, elevated serum corticosterone levels, altered liver function markers, and higher levels of hippocampal IL-6 and TNF-alpha. …”
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Seasonal expression of reproductive axis-related neuroendocrine genes and their relation with ovarian maturation in captive yellowtail kingfish (Seriola lalandi) by Jaime Palomino, Ayleen Olea, Stevanie Ramírez, Phillip Dettleff, Ricardo D. Moreno

“…Notably, the elevated expression of drd2a in winter suggests that modulation of GnRH action on pituitary function may not rely solely on dopaminergic inhibition. …”
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Dynamic Error Modeling and Predictive Compensation for Direct-Drive Turntables Based on CEEMDAN-TPE-LightGBM-APC Algorithm by Manzhi Yang, Hao Ren, Shijia Liu, Bin Feng, Juan Wei, Hongyu Ge, Bin Zhang

“…Our methodology comprises four key stages: Complete Ensemble Empirical Mode Decomposition with Adaptive Noise (CEEMDAN)-based decomposition of historical error data, development of component-specific prediction models using Tree-structured Parzen Estimator (TPE)-optimized Light Gradient Boosting Machine (LightGBM) algorithms for each Intrinsic Mode Function (IMF), integration of component predictions to generate initial values, and application of the Adaptive Prediction Correction (APC) module to produce final predictions. …”
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Hydroxyurea mitigates diabetic kidney disease through mTOR-S6K signaling pathway in STZ-induced diabetic mice by Wanying Cheng, Cenzhu Wang, Meican Ma, Yu Zhou

“…Serum creatinine and blood urea nitrogen levels reflecting renal function were evaluated. Histology was used to evaluate pathological changes. …”
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Adaptive cognitive control in 4 to 7-year-old children and potential effects of school-based yoga-mindfulness interventions: an exploratory study in Italy by Lisa Toffoli, Giulia Stefanelli, Giulia Manca, Fiorella Del Popolo Cristaldi, Gian Marco Duma, Michele Guidi, Francesca Incagli, Luca Sbernini, Luca Sbernini, Vincenza Tarantino, Giovanni Mento, Giovanni Mento

“…Moreover, they successfully modulate interference control as a function of environmental contingencies, displaying more optimal conflict resolution when proactive control is engaged. …”
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Effects of off-line auricular transcutaneous vagus nerve stimulation (taVNS) on a short-term memory task: a pilot study by Francesco Fisicaro, Francesco Fisicaro, Klizia Cortese, Rita Bella, Manuela Pennisi, Giuseppe Lanza, Giuseppe Lanza, Kaoru Yuasa, Yoshikazu Ugawa, Yasuo Terao

“…Although further studies are needed to better clarify the optimal stimulation parameters, findings from this study could support the use of taVNS as a safe neuromodulation technique to improve cognitive function.…”
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Multi-input PINN Surrogate Model for Digital Twin of Lead-cooled Fast Reactor Main Pump by GUO Yiwen, LI Liangxing, XIANG Zutao, GUI Jiabin, SHI Shang, LEI Zhenxin, XU Xiangyang

“…First, the flow field within an axial lead-bismuth eutectic (LBE) pump was modeled and the loss function for training the multi-input PINN surrogate model based on the governing equations of the pump was derived. …”
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LGVM-YOLOv8n: A Lightweight Apple Instance Segmentation Model for Standard Orchard Environments by Wenkai Han, Tao Li, Zhengwei Guo, Tao Wu, Wenlei Huang, Qingchun Feng, Liping Chen

“…The proposed model integrates three key improvements: (1) the GSConv module, which enhances feature interaction and reduces computational cost; (2) the VoVGSCSP module, which optimizes multi-scale feature representation for small objects; and (3) the <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><mi>M</mi><mi>P</mi><mi>D</mi><mi>I</mi><mi>o</mi><mi>U</mi></mrow></semantics></math></inline-formula> loss function, which improves target localization accuracy, particularly for occluded fruits. …”
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Palmitoylation Transduces the Regulation of Epidermal Growth Factor to Organic Anion Transporter 3 by Zhou Yu, Jinghui Zhang, Jiaxu Feng, Guofeng You

“…<b>Conclusions:</b> In summary, we provided the first evidence that palmitoylation transduces the EGF/PKA signaling pathway to the modulation of OAT3 expression and function. Our study also provided an important implication that during comorbidity therapies, EGFR inhibitor drugs could potentially decrease the transport activity of renal OAT3, which would subsequently alter the therapeutic efficacy and toxicity of many co-medications that are OAT3 substrates.…”
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The subtle red line between combating and resolving inflammation in the cardiovascular disease, a “silent sniper” by Ciarán Kennedy, Luke J Conroy, Braden Millar, Monica de Gaetano

“…Recent evidence suggests that glucose-lowering medications, including SGLT2 inhibitors and GLP-1 receptor agonists, confer cardiovascular benefits beyond glycaemic control by reducing inflammation, improving endothelial function, and promoting macrophage phenotype switching. …”
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MSFA-YOLO: A Multi-Scale SAR Ship Detection Algorithm Based on Fused Attention by Zhao Liangjun, Ning Feng, Xi Yubin, Liang Gang, He Zhongliang, Zhang Yuanyang

“…Furthermore, the Wise-IoU loss function is adopted, and a dynamic non-monotonic focusing mechanism is employed for bounding box loss, significantly enhancing the model&#x2019;s ability to handle low-quality images. …”
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Rasal2 inhibits autophagic-exosomes secretion via regulating Rab27a in triple-negative breast cancer progression by Xuan Wang, Guocui Qi, Kunning Yang, Linlin Ma, Yuansai Kang, Xiaojing Tang, YanTao Han

“…We have demonstrated that the function of Rasal2 in the modulation of breast cancer progression is exos-mediated, but the relationship between Rasal2 and exosome secretion remains elusive. …”
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YOLO-MECD: Citrus Detection Algorithm Based on YOLOv11 by Yue Liao, Lerong Li, Huiqiang Xiao, Feijian Xu, Bochen Shan, Hua Yin

“…At last, the MPDIoU loss function was employed, resulting in improved bounding box detection accuracy and accelerated model convergence. …”
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