Clinical characteristics of obsessive-compulsive disorder comorbid with obsessive -compulsive personality disorder: subtype implications by Ayse Dondu, Levent Sevincok

“…BackgroundObsessive-compulsive disorder (OCD) is a psychiatric condition characterized by persistent obsessions and compulsions that lead to significant distress and functional impairment. Obsessive-compulsive personality disorder (OCPD) frequently co-occurs in individuals with OCD and has been identified in several studies as the most prevalent personality disorder within this population. …”
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Integrative single-cell and spatial transcriptomics uncover ELK4-mediated mechanisms in NDUFAB1+ tumor cells driving gastric cancer progression, metabolic reprogramming, and immune... by Yuwei Sun, Wenyang Nie, Zhikai Xiahou, Xiaojing Wang, Wenjia Liu, Zongkai Liu, Zhiheng Lin, Zhaidong Liu

“…CellChat was used to analyze the interactions between key cell subtypes and other cells, and the “StLearn” package was employed to investigate spatial cell communication in depth. Additionally, the functional role of the key molecule ELK4 was validated through in vitro experiments.ResultsThis research utilized scRNA-seq combined with spatial transcriptomics to comprehensively analyze GC, identifying the C1 NDUFAB1+ subtype, which exhibited high proliferative activity, metabolic reprogramming capabilities, and immune evasion properties. …”
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Comprehensive single-cell transcriptomic analysis reveals fibroblast subpopulations and the prognostic association of COMT in prostate cancer progression全面的单细胞转录组分析揭示了成纤维细胞亚群，并探讨了... by Weimin Shan, Bo Guan, Weiwei Ma, Runzhe Fan, Di Cui, Zongyao Hao

“…Fibroblast subpopulations were identified through clustering, and functional gene signatures for each subgroup were characterized. …”
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LncRNA H19 acts as a ceRNA to promote glioblastoma malignancy by sponging miR-19b-3p and upregulating SERPINE1 by Wonyi Jang, Mijung Im, Goeun Yoon, Jungwook Roh, Wanyeon Kim

“…Experimental validation demonstrated that H19 upregulates SERPINE1 expression, while miR-19b-3p directly binds to both H19 and SERPINE1, suppressing SERPINE1 expression. Functional assays further confirmed that H19 promotes cell survival, migration, and invasion, whereas miR-19b-3p inhibits these processes by downregulating SERPINE1. …”
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A telomere-associated molecular landscape reveals immunological, microbial, and therapeutic heterogeneity in colorectal cancer by Yinmeng Zhang, Jiawei Fan, Jiahui Zhao, He Zhu, Yan Xia, Hong Xu

“…Finally, scRNA analysis highlighted profound cellular and functional divergence between TELscore subgroups. We identified intensified intercellular communication between inflammatory macrophages and fibroblasts, reinforcing the presence of an immunosuppressive niche.ConclusionTELscore is a robust stratification tool that captures the interplay between tumor biology, immune characteristics, and microbial ecology in colorectal cancer. …”
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Bacterial Adhesion on Soft Surfaces: The Dual Role of Substrate Stiffness and Bacterial Growth Stage by René Riedel, Garima Rani, Anupam Sengupta

“…Our results suggest how bacteria could leverage stiffness-dependent adhesion and the diversity therein as functional traits to modulate their initial attachment to, colonization of, and proliferation on soft substrates during the early stages of biofilm development.…”
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Structure and mechanism of a mycobacterial isoniazid efflux pump MsRv1273c/72c with a degenerate nucleotide-binding site by Jing Yu, Yuhui Lan, Chen Zhu, Zhendong Chen, Junyi Pan, Yanfeng Shi, Lan Yang, Tianyu Hu, Yan Gao, Yao Zhao, Xiaobo Chen, Xiuna Yang, Shuihua Lu, Luke W. Guddat, Haitao Yang, Zihe Rao, Jun Li

“…Using these intermediate states, the D-WalkerB loop and X-signature loop of MsRv1272c modulate and couple the function of both NBSs through conformational changes. …”
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Advances in nanocarrier-mediated cancer therapy: Progress in immunotherapy, chemotherapy, and radiotherapy by Yue Peng, Min Yu, Bozhao Li, Siyu Zhang, Jin Cheng, Feifan Wu, Shuailun Du, Jinbai Miao, Bin Hu, Igor A Olkhovsky, Suping Li, Yuanyuan Ji

“…By assessing structure-function correlations and clinical translation barriers, this work establishes mechanistic and translational references to advance oncological nanomedicine development.…”
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Essential Role of the Anterior Piriform Cortex in Mediating Social Novelty Output via a Top–Down Circuit by Jingwei Zhou, Zhaoyang Yin, Zhiyun Chen, Hanyu Fu, Qun Li, Shan Li, Ying Zhang, Xianzhi Zhang, Dewei Tang, Anan Li, Dejuan Wang

“…Moreover, the APC inherits social cues from the mPFC and sends feedback projections to the olfactory bulb (OB) to modulate social novelty. These findings unveil the APC's role as extending well beyond olfaction, encompassing a specialized function in social novelty recognition in male mice.…”
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The glycolytic reaction PGAM restrains Th17 pathogenicity and Th17-dependent autoimmunity by Chao Wang, Allon Wagner, Johannes Fessler, David DeTomaso, Sarah Zaghouani, Yulin Zhou, Kerry Pierce, Raymond A. Sobel, Clary Clish, Nir Yosef, Vijay K. Kuchroo

“…Summary: Glucose metabolism is a critical regulator of T cell function, largely thought to support their activation and effector differentiation. …”
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Algae-Mamba: A Spatially Variable Mamba for Algae Extraction From Remote Sensing Images by Yaoteng Zhang, Shuaipeng Wang, Yanlong Chen, Shiqing Wei, Mingming Xu, Shanwei Liu

“…Furthermore, the model addresses class imbalances by employing a hybrid cross-entropy and Lovász-Softmax loss function, ensuring balanced and robust training. Unlike other methods that depend on extensive spectral information, Algae-Mamba achieves precise differentiation of sargassum and ulva with just 4-band spectral imagery, offering a powerful tool for monitoring marine ecological security. …”
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IACGAN-ST: A Fault Diagnosis Method for Scraper Conveyor Bearings Under Imbalanced Data Conditions by Hongwei Wang, Shengyu Guan, Xuesong Wang, Lijie Wang, Qun Zhang, Kaiman Liu, Zhiwen Fang, Hongli Wang

“…Moreover, a gradient penalty term is added to the discriminator’s loss function to improve training stability and mitigate mode collapse. …”
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Autoimmunity and clinical pathology amelioration in SLE by dexamethasone primed mesenchymal stem cell derived conditioned media by Khushbu Priya, Sonali Rawat, Doli Das, Manaswi Chaubey, Hiral Thacker, Kiran Giri, Shambhavi Singh, Madhukar Rai, Sujata Mohanty, Geeta Rai

“…Dex and DW treatments were evaluated for autoantibody production, proteinuria, immunomodulation of immune cells, organ function, and histopathology. In vivo imaging of internal organs was done using VevoLAZR-X photoacoustic imaging system. …”
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Evidence of focusing the MHC class I immunopeptidome by tapasin by Rachel Darley, Patricia T. Illing, Patrick Duriez, Alistair Bailey, Anthony W. Purcell, Andy van Hateren, Tim Elliott

“…Here, we independently investigated the peptide focusing function of tapasin by introducing a point mutation into a tapasin independent MHC-I allotype that dramatically increased its tapasin dependence without substantially altering its peptide binding specificity. …”
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STar-DETR: A Lightweight Real-Time Detection Transformer for Space Targets in Optical Sensor Systems by Yao Xiao, Yang Guo, Qinghao Pang, Xu Yang, Zhengxu Zhao, Xianlong Yin

“…Finally, the minimum points distance scylla intersection over union (MPDSIoU) loss function is developed to enhance regression accuracy and expedite model convergence. …”
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Individual-Specific Effects of Transcranial Electrical Stimulation on 40-Hz Auditory Steady-State Responses by Aurimas Mockevicius, Xiaojuan Wang, Jovana Bjekic, Marko Zivanovic, Sasa R. Filipovic, Inga Griskova-Bulanova

“…Transcranial electrical stimulation (tES) has shown promise for modulating brain function and related behavioral performance, but evidence has been mixed thus far. …”
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MCL-1 as a molecular switch between myofibroblastic and pro-angiogenic features of breast cancer-associated fibroblasts by Chloé C. Lefebvre, Philippine Giowachini, Jennifer Derrien, Maxime Naour, Isabelle Corre, Laura Thirouard, Elise Douillard, David Chiron, François Guillonneau, Lucas Treps, Mario Campone, Philippe P. Juin, Frédérique Souazé

“…Overall, these findings uncover a novel regulatory function of MCL-1 in determining bCAF subpopulation differentiation and highlight its role in modulating their pro-angiogenic properties, in response to treatment in particular.…”
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Assessing Chlorophyll-a Variability and Its Relationship with Decadal Climate Patterns in the Arabian Sea by Muhsan Ali Kalhoro, Veeranjaneyulu Chinta, Muhammad Tahir, Chunli Liu, Lixin Zhu, Zhenlin Liang, Aidah Baloch, Jun Song

“…Empirical orthogonal function (EOF) analysis revealed distinct spatial patterns in Chl-a and SST, indicating dynamic regional variability. …”
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The role of epigenetic modifications in the formation of heterogeneous phenotypes in diabetes mellitus (a literature review) by O.V. Zinych, A.A. Shuprovych, O.M. Trofymenko, K.P. Komisarenko

“…For example, S-adenosylmethionine, through participation in methylation reactions, can modulate the folate cycle function and production of homocysteine, an endothelium-toxic substance. …”
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Renoprotective effects of GHRH agonist MR409 is associated with reduced oxidative stress and ferroptosis in diabetic mice by Yueyang Liu, Rong Fu, Qi Tang, Yaoxia Zhang, Ruiping Cai, Limin Liu, Hui Jia, Junjia Gao, Ming-Sheng Zhou

“…Treatment with MR409 significantly improved renal function, reduced the renal injury and fibrosis in both db/db and STZ-induced diabetic mice. …”
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