Exploring the Anti-PANoptosis Mechanism of Dachaihu Decoction Against Sepsis-Induced Acute Lung Injury: Network Pharmacology, Bioinformatics, and Experimental Validation by Yang Z, Kao X, Zhang L, Huang N, Chen J, He M

“…Then, protein-protein interaction (PPI) network, molecular docking, and functional enrichment analysis were conducted. In vivo, cecal ligation and puncture (CLP) was used to construct a sepsis mouse model, and the therapeutic effects of DCHD on SALI were evaluated using hematoxylin and eosin (H&E) staining, quantitative real-time PCR (qRT-PCR), and ELISA. …”
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Glial and immune dysregulation in glaucoma independent of retinal ganglion cell loss: a human post-mortem histopathology study by Akanksha Salkar, Viswanthram Palanivel, Devaraj Basavarajappa, Mehdi Mirzaei, Angela Schulz, Peng Yan, Vivek Gupta, Stuart Graham, Yuyi You

“…These findings highlight the need for further research into glial modulation as a potential therapeutic strategy.…”
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Scorpion venom peptides enhance immunity and survival in Litopenaeus vannamei through antibacterial action against Vibrio parahaemolyticus by Ling Zeng, Yulin Sun, Hualin Zhang, Xiangxi Yi, Ran Du, Ziming Chen, Qi Wang

“…The differential efficacy in immune regulation, such as BmKn2-7's broad pathway activation versus BmKn1's selective ROS induction, indicates structure-dependent functional divergence. These findings highlight the potential of tailored scorpion venom peptides as dual-action agents against bacterial infections and immune dysregulation…”
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Effects of different hormones on the color of tree peony leaves by Zihan Yang, Shuiyan Yu, Shanrong Dong, Chenxi Wei, Yingan Niu, Xiaoman Wang, Jianrang Luo

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Bioinformatics and Network Pharmacology Identify the Therapeutic Role of Guominkang in Allergic Asthma by Inhibiting PI3K/Akt Signaling by Zhang H, Zhang H, Wang L, Zhang Y, Hu L, Liu J, Zhou Y, Wang J

“…The aim of this study was to explored the mechanism of action through which GMK combats AA.Methods: Potential target genes for the compounds were identified from the database and subjected to functional enrichment analysis. Subsequently, a protein-protein interaction (PPI) network was constructed in order to screen the core target and confirmed by molecular docking. …”
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Network Analysis of Multidimensional Symptoms and Inflammatory Biomarkers in Chinese Patients with Glioma by Li H, Tong Y, Li J, Shi X, Nyalali AMK, Li F

“…Huayu Li,1 Yuanhao Tong,2 Jing Li,3 Xiaohan Shi,4 Alphonce MK Nyalali,3,5 Feng Li3 1Department of Social Medicine of School of Public Health and Department of Pharmacy of The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310058, People’s Republic of China; 2Department of Orthopedics, National Center for Orthopedics, Shanghai Sixth People’s Hospital Affiliated to Shanghai JiaoTong University School of Medicine, Shanghai, 200030, People’s Republic of China; 3Department of Neurosurgery, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, 250117, People’s Republic of China; 4School of Nursing and Rehabilitation, Shandong University, Jinan, 250014, People’s Republic of China; 5Department of Orthopedics and Neurosurgery, Mbeya Zonal Referral Hospital and Mbeya College of Health and Allied Sciences, University of Dar Es Salaam, Mbeya, TanzaniaCorrespondence: Feng Li, Department of Neurosurgery, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, People’s Republic of China, Email lidoc@163.comBackground: Patients with glioma experience multidimensional symptoms that reduce their functional status, quality of life, and survival, and these symptoms may be associated with inflammation. …”
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BALF editome profiling reveals A-to-I RNA editing associated with severity and complications of Mycoplasma pneumoniae pneumonia in children by Yun-Yun Jin, Yun Guo, Su-Wan Xiong, Na Zhang, Jian-Huan Chen, Feng Liu

“…The expression of adenosine deaminase acting on RNA (ADAR) significantly increased on SS compared to OS and positively correlated with the average RNA editing level and individual DRE events. Meanwhile, functional enrichment analysis showed that DRE was observed in genes primarily associated with the negative regulation of innate immune response, type I interferon production, and cytokine production. …”
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Effects of binocularity and eye dominance on visually-driven ocular tracking by Kimia Seyedmadani, Kimia Seyedmadani, Keith A. Tucker, Mark R. Anderson, Mark R. Anderson, Yasemin M. Akay, Metin Akay, Leland S. Stone

“…Our examination of spatial/directional tuning revealed largely isotropic enhancement due to binocularity, as well as several anisotropies in retinal functional processing: (1) a Nasal-Temporal asymmetry for pursuit latency and direction noise, and a Superior–Inferior asymmetry for latency, and (2) anisotropic enhancement in initial acceleration and direction noise (primarily for nasal retina) and speed noise (primarily for superior retina) when viewing through the dominant eye. …”
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Strawberry dietary intervention influences diversity and increases abundances of SCFA-producing bacteria in healthy elderly people by Franziska Meiners, Bernd Kreikemeyer, Patrick Newels, Ingmar Zude, Michael Walter, Alexander Hartmann, Daniel Palmer, Georg Fuellen, Israel Barrantes

“…Our study demonstrates that a 10-week dietary intervention with strawberries can beneficially modulate gut microbial composition and diversity in healthy elderly individuals. …”
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Lipopolysaccharide-binding protein (LBP): a prognostic biomarker for gastric cancer linked to immune infiltration by Hao Lv, Mei Lv, Xuyang Guo, Xiaoman Zhu, Yue Chao, Dandan Li

“…Additionally, immune infiltration and functional enrichment analyses revealed the involvement of LBP in pathways crucial to cancer development, such as immune response modulation and lipid metabolism. …”
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Anti-Inflammatory effects of Lactobacillus helveticus and Arthrospira platensis on colonic cells inflamed by Crohn’s disease-associated Escherichia coli by Samira Alipour, Hossein Halimi, Nastaran Asri, Mohammad Rostami-Nejad, Leila Pishkar, Hamidreza Houri

“…Signaling molecules (NF-κB, STAT3, NOD2) were analyzed via qPCR to capture pathway activation dynamics, while cytokines (TNF-α, IL-1β, IL-8, IL-10) were quantified by ELISA to assess secreted functional proteins. Results HA-A. platensis reduced E. coli adhesion by 68% (P < 0.001) and completely inhibited invasion. …”
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Engineered nanofiber scaffolds prime chromatin reorganization to sensitize cells for long-term and low-dose chemical hazard detection by Yupeng Zhang, Hang Zhao, Li Jiang, Qi Zhang, Tingbao Cao, Zesheng Wang, Yang Song, Kunpeng Qu

“…Mechanistic investigations revealed that this chromatin priming effect was mediated by reduced F-actin polymerization and increased nuclear height. To evaluate functional consequences, fibroblasts were challenged with 0.1% paraformaldehyde (PFA), a commonly encountered chemical with known long-term health risks. …”
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Mechanism of Salvia miltiorrhiza in the treatment of periodontitis: integrative analyses via network pharmacology, molecular dynamics, and cellular assays by Yabing Chen, Siyu Du, Yijing Guo, Yi Zheng, Lei Wang

“…Molecular docking indicated strong binding affinities between the bioactive compounds in S. miltiorrhiza and these critical targets. Functional enrichment analysis suggested that the anti-inflammatory action of S. miltiorrhiza in periodontitis may involve the regulation of pathways such as AGE-RAGE, TNF and PI3k/AKT1 pathways. …”
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Kinin B₁ Receptor Agonist Enhances Blood-Brain Barrier Permeability in Healthy and Glioblastoma Environments by Carolina Batista, João Victor Roza Cruz, Michele Siqueira, João Bosco Pesquero, Joice Stipursky, Fabio de Almeida Mendes

“…Kinin receptors play a crucial role in modulating BBB permeability, and their agonist analogs have been explored in preclinical animal models to enhance drug delivery to the brain. …”
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miR-627-5p inhibits malignant progression of cervical cancer by targeting ANGPTL4 by Xinghua Wu, Kai Lin, Chen Gao, Yinfang Ni, Li Zhang, Tailai Yang, Jinguo Chen

“…Further analysis confirmed that miR-627-5p negatively regulates ANGPTL4 by directly targeting its 3'-UTR. Functional assays demonstrated that miR-627-5p inhibits proliferation, invasion, migration, and epithelial-mesenchymal transition (EMT) while promoting apoptosis and S-phase arrest in C33A cells, effects that were reversed by ANGPTL4 overexpression. …”
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Features of management and treatment of elderly patients with type 2 diabetes mellitus by L. Yu. Morgunov, E. V. Zemskova

“…The elderly population varies greatly in functional and cognitive abilities. These factors, along with an increased risk of hypoglycemia, falls and concomitant diseases, complicate the development of treatment regimens, therefore it is necessary to use a personality-oriented approach, minimizing the risk of excessive or insufficient therapy of diabetes, since the use of antidiabetic drugs in the elderly is associated with significant risk. …”
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Platelet-derived HMGB1 induces NETosis, exacerbating brain damage in the photothrombotic stroke model by Sang-A. Oh, Song-I. Seol, Dashdulam Davaanyam, Seung-Woo Kim, Ja-Kyeong Lee

“…Therefore, targeting NETosis through modulation of HMGB1 presents a promising multipotent therapeutic strategy for mitigating ischemic brain damage.…”
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Analysis of mRNA Pentatricopeptide Repeat Domain 1 as a prospective oncogene in clear cell renal cell carcinoma that accelerates tumor cells proliferation and invasion via the Akt/... by Zhongbao Zhou, Yulong Li, Yumeng Chai, Yong Zhang, Pu Yan

“…Researchers studied how PTCD1 affects the functional behavior of tumor cells in vitro. Results PTCD1 expression was greater in ccRCC samples than in normal samples, and expression increased gradually as the stage increased. …”
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Tumor tissue-of-origin classification using miRNA-mRNA-lncRNA interaction networks and machine learning methods by Ankita Lawarde, Ankita Lawarde, Masuma Khatun, Prakash Lingasamy, Prakash Lingasamy, Andres Salumets, Andres Salumets, Andres Salumets, Vijayachitra Modhukur, Vijayachitra Modhukur

“…Furthermore, in silico validation revealed that many of the top miRNAs, including miR-21-5p, miR-93-5p, and miR-10b-5p, were not only highly central in the network but also correlated with patient survival and drug response. In addition, functional enrichment analyses indicated significant involvement of miRNAs in pathways such as TGF-beta signaling, epithelial-mesenchymal transition, and immune modulation. …”
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Genotoxic and Anti-Genotoxic Assessments of Fermented <i>Houttuynia cordata</i> Thunb. Leaf Ethanolic Extract and Its Anti-Cancer Effect in a Dual-Organ Carcinogenesis Model of Col... by Chonikarn Singai, Pornsiri Pitchakarn, Sirinya Taya, Rawiwan Wongpoomchai, Ariyaphong Wongnoppavich

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