Selecting Hub Genes and Predicting Target Genes of microRNAs in Tuberculosis via the Bioinformatics Analysis by Siqi Deng, Shijie Shen, Saeed El-Ashram, Huan Lu, Dan Luo, Guomin Ye, null Zhen feng, Bo Zhang, Hui Zhang, Wanjiang Zhang, Jiangdong Wu, Chuangfu Chen

“…The identification of novel target genes and main pathways would aid with our understanding of miRNA's function in tuberculosis progression.…”
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Integrative multi-omics and Mendelian randomization analysis reveal SPP1+ tumor-associated macrophage-driven prognostic signature for hepatocellular carcinoma by Kai Lei, Yichun Lei, Zeyao Wang, Zhixin Ye, Jiawei Liu, Wenhao Chen, Caihong Zhou, Jinmei Tan, Shuxian Chen, Yifan Zhang, Jiehui Tan

“…Kaplan-Meier survival analysis, receiver operating characteristic (ROC) curve analysis, and functional enrichment analysis were performed to assess the prognostic value of STRS.ResultsSPP1+ TAMs exhibited strong associations with immunosuppressive functions. 16 SPP1+ TAMs-related genes were used to construct STRS. …”
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Long non-coding RNA MIR22HG impedes the progression of anaplastic thyroid carcinoma via targeting miR-141-3p/PTEN/AKT axis by Junyu Cao, Peng Jiang, Songliang Jiang, Yuhan Zhao, Xin Jiang, Chuancheng Zhou, Jing Li, Kunxian Yang

“…In this study, we aimed to investigate the biological functions and underlying molecular mechanisms of MIR22HG in ATC. …”
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Zipper-interacting protein kinase mediates neuronal cell death and cognitive dysfunction in traumatic brain injury via regulating DEDD by Yingxue Mei, Fei She, Ling Zhang, Gamin Kim, Ruomeng Li, Xiuzhi Zheng, Zonghai Wang, Renxuan Chen, Long Wang, Dongmei Chen, Jungho Kim, Tao Zhang, Tae Ho Lee

“…Abstract Neuronal cell death is a causative process in traumatic brain injury (TBI)-induced structural and functional impairment of the central nervous system. …”
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Molecular cloning of TPM3 gene in qinchuan cattle and its effect on myoblast proliferation and differentiation by Juntao Guo, Jianfang Wang, Ke Zhang, Zhimei Yang, Bingzhi Li, Yueting Pan, Hengwei Yu, Shengchen Yu, Sayed Haidar Abbas Raza, Belete Kuraz Abebea, Linsen Zan

“…Expression patterns varied during different stages of myoblast differentiation. Functional studies that involved interference with TPM3 in Qinchuan cattle myoblasts revealed a very significantly decrease in S-phase cell numbers and EdU-positive staining (P < 0.01), and disrupted myotube morphology. …”
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Unveiling the Microbial Symphony of Amasi: A Targeted Metagenomic 16S rRNA, ITS, and Metabolites Insights Using Bovine and Caprine Milk by Betty Olusola Ajibade, Titilayo Adenike Ajayeoba, Saheed Sabiu, Konstantin V. Moiseenko, Sizwe Vincent Mbona, Errol D. Cason, Tatyana V. Fedorova, Oluwatosin Ademola Ijabadeniyi

“…This study investigated the microbial diversity in Amasi (produced from cow’s and goat’s milk) through targeted metagenomic bacterial 16S rRNA and fungal ITS sequencing, the metabolic functional prediction of Amasi samples using the Phylogenetic Investigation of Communities by Reconstruction of Unobserved States (PICRUSt) and profiled amino acids constituents using Liquid Chromatographic-Mass Spectrophotometry (LC-MS). …”
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Integrated Transcriptomic and Metabolomic Analysis Reveals Nitrogen-Mediated Delay of Premature Leaf Senescence in Red Raspberry Leaves by Qiang Huo, Feiyang Chang, Peng Jia, Ziqian Fu, Jiaqi Zhao, Yiwen Gao, Haoan Luan, Ying Wang, Qinglong Dong, Guohui Qi, Xuemei Zhang

“…Superoxide sismutase (SOD) and peroxidase (POD) activities in the middle and lower functional leaves of T150 were higher than in CK, while catalase (CAT) activity was lower. …”
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QKI-induced circ_0001766 inhibits colorectal cancer progression and rapamycin resistance by miR-1203/PPP1R3C/mTOR/Myc axis by Yulai Zhou, Yan Gao, Yinghui Peng, Changjing Cai, Ying Han, Yihong Chen, Gongping Deng, Yanhong Ouyang, Hong Shen, Shan Zeng, Yangfeng Du, Zemin Xiao

“…Our results showed that circ_0001766 is downregulated in CRC tissues and closely associated with patient survival and metastasis. Functional experiments demonstrated that circ_0001766 inhibits CRC cell proliferation, migration and invasion both in-vitro and in-vivo. …”
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The ETS transcription factor GABPA inhibits bladder cancer aggressiveness by repressing extracellular matrix deposition and mechanotransduction signaling by Mingkai Dai, Xiaotian Yuan, Chenxi Sun, Runyuan Han, Magnus Björkholm, Feng Kong, Shengtian Zhao, Dawei Xu

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BESW-YOLO: A Lightweight SAR Image Detection Model Based on YOLOv8n for Complex Scenarios by Xiao Tang, Kun Cao, Yunzhi Xia, Enkun Cui, Weining Zhao, Qiong Chen

“…Second, efficient multiscale convolution (EMSC) is introduced, which is combined with the C2f module in the YOLO model to form a new module, EMSC-C2f. …”
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A Cross-Stage Focused Small Object Detection Network for Unmanned Aerial Vehicle Assisted Maritime Applications by Gege Ding, Jiayue Liu, Dongsheng Li, Xiaming Fu, Yucheng Zhou, Mingrui Zhang, Wantong Li, Yanjuan Wang, Chunxu Li, Xiongfei Geng

“…Finally, to enhance the model’s robustness, WIoUv2 loss function was employed, ensuring a balanced treatment of positive and negative samples. …”
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A comparative study of the performance of ten metaheuristic algorithms for parameter estimation of solar photovoltaic models by Adel Zga, Farouq Zitouni, Saad Harous, Karam Sallam, Abdulaziz S. Almazyad, Guojiang Xiong, Ali Wagdy Mohamed

“…These algorithms are applied to solve four well-established photovoltaic models: the single-diode model, the double-diode model, the triple-diode model, and different photovoltaic module models. The study focuses on key performance metrics such as execution time, number of function evaluations, and solution optimality. …”
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Transceiver Design for Full-Duplex UAV Based Zero-Padded OFDM System With Physical Layer Security by Joarder Jafor Sadique, Shaikh Enayet Ullah, Md. Rabiul Islam, Raad Raad, Abbas Z. Kouzani, M. A. Parvez Mahmud

“…Numerical results demonstrate the effectiveness of the proposed system in terms of PLS for color image transmission at high order digital modulation (16-PSK and 16-QAM). At the complementary cumulative distribution function of probability level 1-6&#x0025;, the estimated PAPR is found to have value of 6 dB.The three users achieve BER <inline-formula> <tex-math notation="LaTeX">$= 1\times {10}^{-4}$ </tex-math></inline-formula> at signal-to-noise ratio of 1.5 dB, 4 dB and 6 dB under RA channel coding and 16-QAM digital modulation.…”
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Irisin regulates integrin αvβ5/FAK/ERK to inhibit neutrophil extracellular traps formation and reduce pancreatic beta-cells pyroptosis in type 2 diabetes mellitus by Anjun Tan, Tianrong Li, Jingjing Yang, Xiaolu Li, Wenqin Li, Jinwen Yu

“…These findings suggest that Irisin may serve as a therapeutic agent in managing T2DM by modulating NETs and preserving β-cell function.…”
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Phosphatidylcholine Ameliorates Palmitic Acid‐Induced Lipotoxicity by Facilitating Endoplasmic Reticulum and Mitochondria Contacts in Intervertebral Disc Degeneration by Shuangshuang Tu, Yijun Dong, Chuanfu Li, Mingxin Jiang, Liqun Duan, Wenzhi Zhang, Xi Chen

“…Conclusion Phosphatidylcholine emerges as a potential therapeutic agent to counteract lipotoxic stress by modulating organelle interactions and mitochondrial function. …”
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Web-SpikeSegNet: Deep Learning Framework for Recognition and Counting of Spikes From Visual Images of Wheat Plants by Tanuj Misra, Alka Arora, Sudeep Marwaha, Ranjeet Ranjan Jha, Mrinmoy Ray, Rajni Jain, A. R. Rao, Eldho Varghese, Shailendra Kumar, Sudhir Kumar, Aditya Nigam, Rabi Narayan Sahoo, Viswanathan Chinnusamy

“…The Spike counting module implements the &#x201C;Analyze Particle&#x201D; function of imageJ to count the number of spikes. …”
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SPIRRIG is required for BRICK1 stability and salt stress induced root hair developmental plasticity in Arabidopsis by Chi Zhang, Jingyu Zeng, Wenjuan Xie, Chuanseng Liu, Linyu Niu, Yanling Wang, Yali Wang, Muyang Shi, Jingxia Shao, Wenjia Wang, John Schiefelbein, Fei Yu, Lijun An

“…Moreover, based on biochemical analyses, we found BRK1 is unstable and SPI mediates BRK1 stability. Functional loss of SPI results in the accumulation of steady-state of BRK1.…”
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Anticancer activity of triterpene glycosides from the sea star Solaster pacificus by Sergey A. Dyshlovoy, Jessica Hauschild, Malte Kriegs, Konstantin Hoffer, Olga Y. Burenina, Nadja Strewinsky, Timofey V. Malyarenko, Alla A. Kicha, Natalia V. Ivanchina, Valentin A. Stonik, Markus Graefen, Carsten Bokemeyer, Gunhild von Amsberg

“…To explore the mechanism of anticancer activity of cucumarioside C1, we performed functional kinome profiling of treated 22Rv1 cells, predicting activation of kinases involved in stress response and survival (IKKα, IKKβ, IKKε), necroptosis (MLKL), metabolism (GCN2, PDK1), cytoskeletal dynamics (RHOK), mitophagy (PINK1), apoptosis and cell cycle regulation (PITSLRE), and immune modulation (COT). …”
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Bioinspired hydrogel for sustained minocycline release: A superior periodontitis solution by Shiyao Liu, Wenqian Zheng, Lina Wang, Yajie Zhang, Kang Feng, Yan Zhang, Haitao Yang, Yao Xiao, Chenxi Sun, Xiqiang Liu, Baoyang Lu, Xuemin Yin

“…The sustained release of minocycline, combined with the hydrogel's acidic microenvironment and the antioxidant functional groups, provides M@PP with excellent biocompatibility, potent antibacterial activity (98.1 % against P. gingivalis), and enhanced anti-inflammatory properties. …”
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Exploring the relationship between the androgen receptor and structural configuration of benzophenones: a combination of computational analysis and laboratory models by Da-Hyun Jeong, Rajesh Kumar Pathak, Da-Woon Jung, Jun-Mo Kim, Hee-Seok Lee

“…Key interactions with residues, such as Gln711 and Asn705, were identified. Density functional theory analysis revealed that BP-2 has a balanced energy gap, which contributes to its stability and reactivity. …”
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