A novel mechanism of radiation-induced lung injury: METTL3 mediates fibrogenesis through N6-methyladenosine modification of YY1 by Weiqiang Xu, Junxuan Yi, Xinfeng Wei, Mingwei Wang, Mingqi Zhao, Mengdie Zhao, Xinyan Wang, Yannan Shen, Zhicheng Wang, Shunzi Jin

“…We investigated the regulatory function of METTL3, a central m6A methyltransferase, in mediating m6A modification of YY1. …”
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Exploring the Molecular Mechanisms of Fisetin in Treating Periodontitis Through Multiomics and Network Pharmacology by Lingzhi Ma, Hongrong Zhang, Yali Liu, Yan Liu, Jing Zhou, Hefeng Yang, Biao Xu

“…Clinical relevance: By significantly reducing alveolar bone destruction and modulating fibroblast function, fisetin presents a novel therapeutic strategy for managing periodontitis. …”
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Comparative EEG study of neurodynamics upon olfactory stimulation in COVID-19 patients by Mariia Chernykh, Ihor Zyma, Bohdan Vodianyk, Bohdan Vodianyk, Yaroslav Subin, Ivan Seleznov, Ivan Seleznov, Anton Popov, Anton Popov, Ken Kiyono

“…Future studies incorporating direct cognitive measures are essential to validate EEG-based biomarkers of brain function.…”
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Impact of gut microbiota in chronic kidney disease: natural polyphenols as beneficial regulators by Cheng Li, Xulong Chen, Weiwei Zha, Sitian Fang, Jiangwen Shen, Lin Li, Hongli Jiang, PuXun Tian

“…Growing evidence links CKD with shifts in gut microbiota function and composition. Natural compounds, particularly polyphenols, have shown promise in CKD treatment due to their antioxidant and anti-inflammatory properties and their ability to modulate gut microbiota. …”
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MLKL‒OPTN axis regulates herpesvirus‐induced neurological sequelae by Ilina Bhattacharya, Rashmi Kadam, Tejabhiram Yadavalli, Chandrashekhar D. Patil, Hemant Borase, Ipsita Volety, Sergey Kalinin, Douglas L. Feinstein, Henry C. Tseng, Deepak Shukla

“…Methods and Results This study investigates new molecular dynamics following HSV‐1 infection, uncovering the pivotal role of the mixed lineage kinase domain‐like (MLKL) protein. Beyond its known function in necroptosis, MLKL was found to control HSV‐1 transport into the nucleus, tightly regulated by Optineurin (OPTN). …”
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Unraveling cysteinyl leukotrienes and their receptors in inflammation through the brain-gut-lung axis by Xiao-Ru Liu, Ming Li, Qian-Qian Hao, Ya-Jie Yu, Cai Liao, Rui Yu, De-Lei Kong, Yun Wang

“…However, However, the function of CysLT3R is unclear and lacks a network of cross-organ metabolite interactions, and the clinical use of leukotriene receptor antagonists (LTRAs) has certain limitations. …”
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Immunosenescence and cancer: molecular hallmarks, tumor microenvironment remodeling, and age-specific immunotherapy challenges by Qianwen Liu, Jingfeng Li, Xiuqiao Sun, Jiayu Lin, Zhengwei Yu, Yue Xiao, Dan Li, Baofa Sun, Haili Bao, Yihao Liu

“…Abstract Immunosenescence, the age-related decline in immune function, profoundly impacts cancer progression and therapeutic outcomes by fostering a tumor-promoting microenvironment and impairing immune surveillance. …”
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Immunotherapy resistance in non-small cell lung cancer: from mechanisms to therapeutic opportunities by Huiyu Wang, Xiaomin Niu, Zhenning Jin, Shaoxing Zhang, Rong Fan, Hua Xiao, Shen S. Hu

“…Therapeutic strategies to overcome resistance are also discussed, including combination approaches involving chemotherapy, radiotherapy, and antiangiogenic agents, as well as epigenetic modulators (HDAC and BET inhibitors). Moreover, the review explores bispecific antibodies, antibody-drug conjugates, and small-molecule agents that enhance T cell function or disrupt immunosuppressive signaling networks. …”
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Inhibition of stromal MAOA leading activation of WNT5A enhance prostate cancer immunotherapy by involving the transition of cancer-associated fibroblasts by Hui Li, Mengyao Li, Lijun Yang, Tong Lu, Zhite Zhao, Yaohua Hu, Xinglin He, Yifan Ma, Minli Huang, Changhong Shi

“…Furthermore, C57BL/6J mouse subcutaneous transplant tumor models and dual humanized mouse models were established to investigate the function of MAOA in vivo and the potential of its inhibitors for immunotherapy.Results Our study demonstrates that inhibiting MAOA in stromal cells facilitates the conversion of myofibroblastic cancer-associated fibroblasts (myCAFs), thereby improving the immunosuppressive environment of PCa. …”
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The CB1R of mPFC is involved in anxiety-like behavior induced by 0.8/2.65 GHz dual-frequency electromagnetic radiation by Bin Sun, Teng Xue, An-ning Gao, Xin-yu Wang, Shuang Wu, Xiao-man Liu, Li-hui Zhang, Meng-hua Li, Dong-fang Zou, Yan Gao, Chang-zhen Wang

“…In summary, our study demonstrates that anxiety induced by dual-frequency EMR is closely linked to the function of the ECS in the mPFC and BLA, and that CB1R expression in the mPFC plays a significant role in modulating emotional behavior in mice.…”
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Synergistic Probiotic–Postbiotic Therapy Ameliorates Hyperuricemia via Multi-Target Regulation of Purine Metabolism and Gut Microbiota by Lu Ren, Shiting Liu, Shangshang Wang, Zhenrui Li, Fuping Lu, Xuegang Luo

“…Additionally, T + GQ01 ameliorated kidney injury, as evidenced by reduced serum CRE and BUN levels, and improved liver function, indicated by decreased ALT and AST activities. …”
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RAU-Net for precise lung cancer GTV segmentation in radiation therapy planning by Huai-wen Zhang, Bo Hu, Jun Yang, Liang-li Xiong, Huan-huan Shi, Qi-liang Xiong, Chen Yi, Shao-feng Jiang

“…Ablation studies further confirmed the crucial role of the ROI extraction phase, attention mechanism, SE-Res module, and Combined Loss Function (CLoss) in enhancing segmentation performance. …”
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Emerging Roles of GDF15 in Metabolic and Cardiovascular Diseases by Tian Tian, Monan Liu, Peter J. Little, Hans Strijdom, Jianping Weng, Suowen Xu

“…The GFRAL receptor is central to its function, mediating the anorexigenic and metabolic effects of GDF15. …”
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Role of Rab10 in cocaine-induced behavioral effects is associated with GABAB receptor membrane expression in the nucleus accumbens by Zhuoxuan Yu, Qiang Fu, Tianyun Qiu, Caidi Yang, Mingfen Lu, Qinghua Peng, Jianhua Yang, Zhenzhen Hu

“…In this study, we showed that Rab10 in the nucleus accumbens (NAc) of male animals affects the development of cocaine-induced behavioral effects, which are associated with the plasma membrane expression of the GABAB heteroreceptor (GABABR).MethodsWe performed flow cytometry, immunoendocytosis, pHluorin activity analysis, electrophysiology analysis, and open-field testing to explore the role of Rab10 in modulating the membrane expression and function of GABABR and its regulatory effect on cocaine-induced behavioral effects.ResultsTranscriptomics analysis showed that Rab10 was elevated following acute cocaine treatment. …”
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A Compact Two-Wavelength Time-Domain NIRS System Based on SiPM and Pulsed Diode Lasers by Mauro Buttafava, Edoardo Martinenghi, Davide Tamborini, Davide Contini, Alberto Dalla Mora, Marco Renna, Alessandro Torricelli, Antonio Pifferi, Franco Zappa, Alberto Tosi

“…The system experimental characterization shows an instrument response function narrower than 300 ps (full-width at half maximum), with measurement stability better than ±1% over several hours of operation. …”
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Hepatocellular carcinoma and AIM2: Therapeutic potential through regulation of autophagy and macrophage polarization by Shuangshuang Xie, Cuiyun Wang, Xiaoyan Liu, Cheng Li, Jinhong Yu, Shumin Ma, Qiang Li, Wenjun Du

“…Conclusion The findings underscore AIM2's crucial function in modulating major biological processes in HCC, pointing to its potential as a therapeutic target. …”
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The role of probiotics in supporting celiac disease management - a review of current research and therapeutic perspectives by Aleksandra Cieplak, Zuzanna Czyżewicz, Aleksandra Kołodziej, Nadia Hornig, Wiktoria Zamirska

“…Description of the state of knowledge: The accumulated data suggest that probiotics may improve gut function and reduce inflammation in patients with celiac disease. …”
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Channel attention pyramid network for remote physiological measurement by Jing Zhang, Haixin Sun, Yuhao Hu, Guanghao Zhu, Fang Liu, Boyun Yan, Jiahao Pu, Xiaohui Du, Juanxiu Liu, Lin Liu, Ruqian Hao, Xingguo Wang, Yong Liu

“…The uniqueness of CAP-rPPG lies in its hybrid loss function, adeptly balancing the short-term characteristics, long-term characteristics of the signal and the correlation between the predicted HR and the ground-truth HR. …”
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Dihydromyricetin ameliorates lipopolysaccharide‒induced hepatic injury in chickens by activating the Nrf2/Keap1 pathway and regulating mitochondrial dynamics by Liang Yuan, Xinru Jiang, Yani Ren, Bingke Ma, Zhenghua Ji, Shibo Wang, Beili Hao, Changwen Li, Rui Li, Fangping Liu

“…Network pharmacology results showed that the effect of DHM on hepatic injury might be related to oxidative stress and mitochondrial function. Further experiments showed that DHM significantly reduced LPS‒elicited serum ALT and AST activities, promoted antioxidant enzyme activities and scavenged ROS in chicken liver or primary hepatocytes. …”
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Transcription factor ETV1 promotes angiogenesis after myocardial infarction via activation of the VEGFA/VEGFR2/eNOS pathway by Jinyu Wang, Chunxia Li, Feng Li, Sen Fang, Yuan Chen, Yuan Chen

“…Moreover, overexpression of Etv1 alleviated the deterioration of heart function, mitigated the fibrosis, reduced apoptosis, and promoted angiogenesis after MI. …”
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