End-to-End Stroke Imaging Analysis Using Effective Connectivity and Interpretable Artificial Intelligence by Wojciech Ciezobka, Joan Falco-Roget, Cemal Koba, Alessandro Crimi

“…Neuroimaging data, with their rich structural and functional information, provide a fertile ground for biomarker discovery. …”
Get full text

Harnessing single-cell and multi-omics insights: STING pathway-based predictive signature for immunotherapy response in lung adenocarcinoma by Yang Ding, Dingli Wang, Dali Yan, Jun Fan, Zongli Ding, Lei Xue

“…We developed a STING pathway-related signature (STINGsig) using 101 machine learning frameworks. The functional significance of ERRFI1, a key component of STINGsig, was validated through mouse models and multicolor flow cytometry, particularly examining its role in enhancing antitumor immunity and potential synergy with α-PD1 therapy.ResultsOur single-cell analysis identified and characterized 15 distinct cell populations, including epithelial cells, macrophages, fibroblasts, T cells, B cells, and endothelial cells, each with unique marker gene profiles. …”
Get full text

Screening and Verification COPD-OSA Overlap Syndrome Core Genes Using Bioinformatics by Qiang S, Wan R, Wu J, Wang C, Cui X, Zhang Y

“…Through WGCNA analysis, 128 common key module genes for OSA and COPD were identified. By taking the intersection of the identified 9 DEGs and the 128 common key module genes from WGCNA, 5 key genes were determined. …”
Get full text

Multi-omics analysis reveals glutathione metabolism-related immune suppression and constructs a prognostic model in lung adenocarcinoma by Yuxiang Chi, Yuxiang Chi, Guoyuan Ma, Qiang Liu, Qiang Liu, Yunzhi Xiang, Yunzhi Xiang, Defeng Liu, Jiajun Du, Jiajun Du

“…Whole-transcriptome data from the TCGA database were analyzed for functional enrichment, immune infiltration, and immune functionality. …”
Get full text

Upregulated astrocyte HDAC7 induces Alzheimer-like tau pathologies via deacetylating transcription factor-EB and inhibiting lysosome biogenesis by Jinwang Ye, Suyue Zhong, Huali Wan, Xing Guo, Xuanbao Yao, Qiong Liu, Liming Chen, Jian-Zhi Wang, Shifeng Xiao

“…Genetic or pharmacological inhibition of HDAC7 effectively enhanced astrocytic clearance of tau with improved cognitive functions in PS19 mice. HDAC7 could modulate astrocytic uptake and lysosomal degradation of tau proteins through a transcriptional factor EB (TFEB) acetylation-dependent manner. …”
Get full text

Temporal Association Cortex Gates Sound‐Evoked Arousal from NREM Sleep by Haipeng Yu, Jincheng Wang, Ruiqi Pang, Penghui Chen, Tiantian Luo, Xuan Zhang, Yatao Liao, Chao Hu, Miaoqing Gu, Bingmin Luo, Zhiyue Shi, Mengyao Li, Yueting Zhang, Qiaoqian Wei, Wei Yuan, Hui Xie, Zhiyi Chen, Hongbang Liu, Shuancheng Ren, Xiaowei Chen, Yi Zhou

“…Further investigation reveals that the baseline excitability of TeA CaMKIIα+ neurons and the delta oscillations in the electroencephalogram are particularly important in regulating the evoked activity of TeA neurons. Anatomical and functional screening of downstream targets of TeA reveals that excitatory projections from TeA glutamatergic neurons to glutamatergic neurons in the basolateral/lateral amygdala are critical for modulating sound‐evoked arousal from NREM sleep. …”
Get full text

Assessing the prognostic and therapeutic value of cuproptosis-related genes in colon adenocarcinoma patients by Zhanhui Ye, Yixian Song, Mengqing Zhu, Fuying Zheng, Wenjie Qin, Wenjie Qin, Xue Li, Pei Wang, Zihua Li, Kequan Chen, Aimin Li

“…Using the Weighted Gene Co-expression Network Analysis (WGCNA) method, we identified the gene module most strongly linked to cuproptosis and conducted functional enrichment analysis to explore the roles of genes within this module in COAD tumorigenesis. …”
Get full text

Emotion regulation strategies and mental wellbeing among Chinese college students during COVID-19: the moderating roles of confinement and attentional bias by Mengqi Xiao, Mengqi Xiao, Yiran Wang, Yaling Zhuang, Yier Luo, Li Liu, Yingxin Lin, Dingguo Gao, Dingguo Gao, Dingguo Gao, Jiahua Xu

Get full text

Impaired Gal-9 Dysregulates the PBMC-Induced Th1/Th2 Imbalance in Abortion-Prone Matings by Mengzhou He, Ming Jiang, Yuan Zhou, Fanfan Li, Meitao Yang, Yao Fan, Yin Xie, Rajluxmee Beejadhursing, Ling Feng, Dongrui Deng

“…Galectin-9 (Gal-9) may modulate a variety of biologic functions and play an important role in Th1/Th2 immune deviation. …”
Get full text

Order–Disorder-Type Transitions Through a Multifractal Procedure in Cu-Zn-Al Alloys—Experimental and Theoretical Design by Constantin Plăcintă, Valentin Nedeff, Mirela Panainte-Lehăduş, Elena Puiu Costescu, Tudor-Cristian Petrescu, Sergiu Stanciu, Maricel Agop, Diana-Carmen Mirilă, Florin Nedeff

“…Consequently, since the thermal conductivity becomes a function of the observation scale, and heat transfer is modified to reflect the multifractal, non-differentiable paths in the material, it leads to anomalous diffusion and complex thermal behaviors.…”
Get full text

Regulatory roles of NAMPT and NAD+ metabolism in uterine leiomyoma progression: Implications for ECM accumulation, stemness, and microenvironment by Yi-Fen Chiang, Ko-Chieh Huang, Tsui-Chin Huang, Hsin-Yuan Chen, Mohamed Ali, Ayman Al-Hendy, Pei-Shen Huang, Shih-Min Hsia

“…This study sought to elucidate the regulatory functions of NAMPT and NAD+ metabolism, in conjunction with redox signaling, in the progression of UL, and to explore potential therapeutic strategies targeting these pathways. …”
Get full text

Long non-coding RNA transcripts in Mycobacterium tuberculosis-host interactions by Mahalakshmi Vijayaraghavan, Shrikanth S. Gadad, Subramanian Dhandayuthapani

“…Mtb is an intracellular pathogen capable of subverting the defensive functions of the immune cells, and it can survive and multiply within humans' mononuclear phagocytes. …”
Get full text

Nerve Growth Factor in Pediatric Brain Injury: From Bench to Bedside by Lorenzo Di Sarno, Serena Ferretti, Lavinia Capossela, Antonio Gatto, Valeria Pansini, Anya Caroselli, Luigi Manni, Marzia Soligo, Antonio Chiaretti

“…Clinical studies, including case reports of pediatric patients treated with intranasal NGF, reported improvements in motor and cognitive function, neuroimaging findings, and electrophysiological parameters, with no significant adverse effects observed. …”
Get full text

The impact of aberrant lipid metabolism on the immune microenvironment of gastric cancer: a mini review by Shuangyu Chen, Wenqian Chen, Tinghui Xu, Jiayang Li, Jianghao Yu, Yibo He, Shengliang Qiu

“…Among various metabolic abnormalities in the TIME, dysregulated lipid metabolism has emerged as a critical determinant of immune cell fate, differentiation, and function. In this review, we comprehensively summarize the current understanding of the immune landscape in GC, focusing on how altered lipid metabolism reshapes immune cell populations—including tumor-associated macrophages (TAMs), dendritic cells (DCs), regulatory T cells (Tregs), myeloid-derived suppressor cells (MDSCs), and cytotoxic CD8+ T cells. …”
Get full text

Permissive immunosuppression facilitates the expansion of ex vivo administered regulatory T cells in the lung allograft by Akihiro Takahagi, Ei Miyamoto, Christina Lam, Mingyao Liu, Betty Joe, Xiaomin Wang, David Hwang, Tereza Martinu, Marcelo Cypel, Shaf Keshavjee, Stephen Juvet

“…We combined IL-2 C and Tac with pre-transplant Treg administration during EVLP in a Fischer 344 to Wistar Kyoto rat LT model, to test the hypothesis that this strategy would facilitate intragraft Treg expansion and function. Recipients were given no treatment, Tac alone, IL-2 C/Tac alone, Treg alone, or Treg/IL-2 C/Tac. …”
Get full text

Thermosensitive hydrogel composite with si-Cx43 nanoparticles and anti-VEGF agent for synergistic treatment of diabetic retinopathy by Lihui Wen, Mengxin Gan, Siying Xiong, Li Dai, Wen Chen, Wen Shi

“…In vivo, the hydrogel composite reduced neovascularization, inflammation, and apoptosis, restoring retinal structure and function more effectively than either single-agent treatment alone. …”
Get full text

LRP1 Mediates Endocytosis Activity and Is a Potential Therapeutic Target in Osteoarthritis by Yuangang Wu, Kaibo Sun, Mingyang Li, Yang Yang, Yuan Liu, Limin Wu, Yang Ding, Yi Zeng, Bin Shen

“…Emerging therapies targeting LRP1, such as gene interventions, exosome‐based therapies, and small‐molecule modulators, show potential in restoring LRP1 function, reducing cartilage degradation, and promoting joint repair. …”
Get full text

Physiological and psychological determinants of cardiovascular autonomic response in experienced Cold-Water Swimmers by Josefa Lillo Bobadilla, Aline Fieldhouse Sandoval, Pedro Fernández Fredes, Paula Bravo Sepúlveda, Matías Castillo-Aguilar, Michele Macedo Moraes, Thiago Teixeira Mendes, Cristian A. Núñez Espinosa

“…Results: Cold-water immersion triggered significant reductions in HRV, particularly in RMSSD and SDNN (p < 0.01), indicating elevated sympathetic activity and decreased parasympathetic modulation. Notably, overall autonomic function, reflected by a decline in the PNS index (β = -0.73, p < 0.01), was inversely associated with anxiety (β = -0.64, p < 0.01) and depression levels (β = -0.49, p < 0.05). …”
Get full text

YOLOv8n-WSE-Pest: A Lightweight Deep Learning Model Based on YOLOv8n for Pest Identification in Tea Gardens by Hongxu Li, Wenxia Yuan, Yuxin Xia, Zejun Wang, Junjie He, Qiaomei Wang, Shihao Zhang, Limei Li, Fang Yang, Baijuan Wang

“…Taking into account the pest image data collected from organic tea gardens in Yunnan, this study utilizes the YOLOv8n network as a foundation and optimizes the original loss function using WIoU-v3 to achieve dynamic gradient allocation and improve the prediction accuracy. …”
Get full text

Prognostic and immune modulatory effects of ammonia-induced cell death in head and neck squamous cell carcinoma by Qian Chengqun, Wang Xijun, Fan Yangyang, Yang Xiaoqin, Cheng Min, Xu Jun

“…Immune profiling showed that high ADS correlated with an immunosuppressive microenvironment, reduced immune infiltration, and impaired immune function. Glutaminase (GLS) was identified as a key ACD-related gene with high diagnostic accuracy and prognostic relevance. …”
Get full text