Aberrant Tryptophan Metabolism Manipulates Osteochondral Homeostasis by Tingwen Xiang, Chuan Yang, Langlang Xie, Shiyu Xiao, Yong Tang, Gang Huang, Dong Sun, Yueqi Chen, Fei Luo

“…Accompanied by distinct alterations in immune function, inflammatory responses, endocrine balance, and other physiological aspects, their impact and efficacy in osteochondrogenic disorders have also been well documented. …”
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Pharmacological and pupillary evidence for the noradrenergic contribution to reinforcement learning in Parkinson’s disease by Claire O’Callaghan, Frank H. Hezemans, Naresh Subramaniam, Rong Ye, Kamen A. Tsvetanov, Alexander G. Murley, Negin Holland, Isabella F. Orlando, Ralf Regenthal, Roger A. Barker, Caroline H. Williams-Gray, Luca Passamonti, Trevor W. Robbins, James B. Rowe

“…However, noradrenergic function is also severely impaired by Parkinson’s disease, contributing to cognitive deficits. …”
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Nanoparticle technologies in precision oncology and personalized vaccine development: Challenges and advances by Saber Imani, Samaneh Moradi, Tola Abdulsattar Faraj, Pejman Hassanpoor, Nazanin Musapour, Soran K. Najmaldin, Anno Hashm Abdulhamd, Aliasghar Tabatabaei Mohammadi, Chnar Husam Taha, Sargol Aminnezhad

“…Nanoparticles (NPs) are changing the paradigm of precision oncology by providing means for targeted delivery, immune modulation, and personalized therapies for patients. …”
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Sex-specific perturbations of neuronal development caused by mutations in the autism risk gene DDX3X by Adele Mossa, Lauren Dierdorff, Jeronimo Lukin, Marta Garcia-Forn, Wei Wang, Fatemeh Mamashli, Yeaji Park, Chiara Fiorenzani, Zeynep Akpinar, Janine Kamps, Jörg Tatzelt, Zhuhao Wu, Silvia De Rubeis

“…Further, ablating Ddx3x conditionally in forebrain neurons is sufficient to yield sex-specific changes in developmental outcomes and motor function. Together, these findings pose Ddx3x as a mediator of sexual differentiation during neurodevelopment and open new avenues to understand sex differences in health and disease.…”
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From Chemistry to Pharmacology: Exploring the Anti-Inflammatory and Antioxidant Potential of Novel Dexketoprofen Amide Derivatives by Marko Karović, Miloš Nikolić, Nikola Nedeljković, Marina Vesović, Marina Nikolić, Marijana Anđić, Nevena Lazarević, Vladimir Jakovljević, Jelena Nedeljković, Sanja Đaković, Jelena Bošković, Vladimir Dobričić

“…The findings of this study underscore the therapeutic potential of the novel dexketoprofen amide derivatives as dual-function agents with the capacity to modulate both inflammatory responses and oxidative stress.…”
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Light extraction film for organic light-emitting diodes based on an eco-friendly template comprising cellulose and polyphenon 60 by Hyunjun Jang, Jooho Lee, Sora Han, Baeksang Sung, Chul Woong Joo, Hyunji Park, Jinhwa Kim, Hyerin Kang, Seoyeon Kim, Jae-Hyun Lee, Yong Hyun Kim, Jonghee Lee

“…The template surface exhibited randomly distributed microscale aggregates owing to the chemical interactions between HEC and P60, with their morphology varying as a function of the P60 concentration. The quantitative analysis utilizing fill factor calculations demonstrated that increased P60 concentration led to a higher aggregate density and larger structure sizes as the fill factor values increased from 21% at 1.5 wt% to 45% at 2.0 wt% and 86% at 2.5 wt%. …”
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Unraveling the effects of FLASH and conventional irradiation on retinal pigment epithelial cells: in vitro and in vivo studies by Beatrice Di Marco, Gabriele Sansevero, Beatrice D’Orsi, Elisa De Santis, Giulia Salamone, Andrea Cavalieri, Luigi Masturzo, Mariagrazia Celentano, Fabio Di Martino, Simone Capaccioli, Daniele Panetta, Fabiola Paiar, Alessandra Gonnelli, Giovanni Gadducci, Mario Costa, Enrica Strettoi

“…Abstract The retinal pigment epithelium (RPE) is a fundamental monolayer of pigmented cells that supports visual function, situated between the neural retina and choroidal blood vessels. …”
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scRNA-Seq reveals age-dependent microglial evolution as a determinant of immune response following spinal cord injury by Lufei Shao, Yueliang Chang, Jinfang Liu, Leilei Lin, Long Chang, Jialin Zhang, Zhibin Lan, Honglai Zhang, Xiaolei Chen

“…Spinal cord injury (SCI) is a debilitating condition of the central nervous system (CNS) that leads to severe impairments in sensory and motor functions. Previous studies have pointed out that patient age is a critical factor influencing SCI prognosis. …”
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Prebiotics in animal nutrition: Harnessing agro-industrial waste for improved gut health and performance by M. Cristina Ravanal, Carolina A. Contador, Wing-Tak Wong, Qile Zhang, Analese Roman-Benn, Kong Shun Ah-Hen, Pilar E. Ulloa, Hon-Ming Lam

“…However, further research is necessary to explore the interaction between prebiotics and probiotics in animal care and well-being, to establish systematic management of production and practical applications of these functional feed additives.…”
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Effects of feeding enriched-olive cake on milk quality, metabolic response, and rumen fermentation and microbial composition in mid-lactating Holstein cows by A. Amato, L. Liotta, C. Cavallo, C. L. Randazzo, A. Pino, S. Bonacci, M. Frisina, A. Procopio, F. Litrenta, V. Floridia, A. R. Di Rosa, M. Oteri, E. Trevisi, V. Lopreiato

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OPM-MEG reveals dynamics of beta bursts underlying attentional processes in sensory cortex by Gonzalo Reina Rivero, Zoe Tanner, Lukas Rier, Ryan M. Hill, Vishal Shah, Molly Rea, Cody Doyle, James Osborne, David Bobela, Peter G. Morris, Karen J. Mullinger, Elena Boto, Niall Holmes, Matthew J. Brookes

“…Abstract Human brain electrophysiology is dominated by rhythmic activity—neural oscillations—which play an important role in coordinating brain function. In the somatosensory cortices, the dominant oscillations occur in the beta (13–30 Hz) band and are thought to mediate top-down inhibition of primary cortices. …”
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Unveiling the immunological terrain of pancreatic ductal adenocarcinoma: strategies to prompt immunotherapy from Mendelian randomization by Peizan Ni, Lilin Li, KunPeng Du, Pengkhun Nov, Duanyu Wang, Changqian Wang, Qianzi Kou, Ying Li, Yangfeng Zhang, Chongyang Zheng, Wen Fu, Jiqiang Li

“…The bacterial trait associations, particularly with Collinsella and Ruminococcus torques, highlight the gut microbiome's influence on immune modulation and PDAC pathogenesis. Additionally, the traits concerning Interleukin-12 subunit beta levels and T-cell surface glycoprotein CD5 levels further indicate their function of this complex interaction. …”
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Research on soybean leaf disease recognition in natural environment based on improved Yolov8 by Chen Chen, Chen Chen, Xiaolei Lu, Lei He, Lei He, Ruoxue Xu, Ruoxue Xu, Yi Yang, Yi Yang, Jing Qiu, Jing Qiu

“…Lastly, the WIoUv3 loss function is employed to place greater emphasis on small targets and moderate-quality samples, thereby enhancing detection precision. …”
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TAS2R38 genotype and CRS severity in children with cystic fibrosis by Elena Cantone, Antonella Tosco, Angela Sepe, Valeria Raia, Rossella Negri, Alice Castaldo, Chiara Cimbalo, Paolo Pezzella, Mario Brandon Russo, Giusi Grimaldi, Claudio Di Nola, Luigi Greco

“…Background: Cystic fibrosis is a heterogeneous disease whose severity and symptoms largely depend on the functional impact of mutations in the cystic fibrosis transmembrane conductance regulator gene. …”
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mgr-mir-228-regulated transthyretin-like protein in Meloidogyne graminicola suppresses ROS generation and enhances parasitism by Zhongling Tian, Yixiao Cai, Mingming Zhu, Liang Wang, Qiannan Liu, Qinghong Li, Xiaoyi Gao, Jingwu Zheng, Borong Lin, Kan Zhuo, Shaojie Han

“…These findings suggest that MgTTL1, specifically regulated by the newly identified miRNA mgr-mir-228, functions as a negative regulator of ROS-mediated plant immunity and plays a pivotal role in modulating plant susceptibility to nematode infections.…”
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Oligodendrocyte precursor cell-derived exosomes combined with cell therapy promote clinical recovery by immunomodulation and gliosis attenuation by Sarah Ingrid Pinto Santos, Santiago José Ortiz-Peñuela, Alessandro de Paula Filho, Ana Laura Midori Rossi Tomiyama, Lilian de Oliveira Coser, Juliano Coelho da Silveira, Daniele dos Santos Martins, Adriano Polican Ciena, Alexandre Leite Rodrigues de Oliveira, Carlos Eduardo Ambrósio

“…Multiple sclerosis is a chronic inflammatory disease of the central nervous system characterized by autoimmune destruction of the myelin sheath, leading to irreversible and progressive functional deficits in patients. Pre-clinical studies involving the use of neural stem cells (NSCs) have already demonstrated their potential in neuronal regeneration and remyelination. …”
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Cross-feeding between beneficial and pathogenic bacteria to utilize eukaryotic host cell-derived sialic acids and bacteriophages shape the pathogen-host interface milieu by Darab Ghadimi, Regina Fölster-Holst, Sophia Blömer, Michael Ebsen, Christoph Röcken, Jumpei Uchiyama, Shigenobu Matsuzaki, Wilhelm Bockelmann

“…Changes in physiological, functional, and structural health markers of stimulated cocultured cells were evaluated. …”
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Genome-Wide Analysis of the EIN3/EIL Transcription Factors in <i>Osmanthus fragrans</i> and Their Stress Response to Azacytidine (AZA) and Ethylene (ETH) Treatment by Dou Pan, Chun Xu, Wanlu Ma, Xinyi Zhu, Qiangjun Yu, Yingting Zhang, Jie Yang, Xiangling Zeng, Xuan Cai, Jingjing Zou

“…Strikingly, <i>OfEIL7</i> exhibited dual regulatory roles, correlating strongly with natural flowering progression, AZA-induced demethylation, and ETH responses. Functional divergence was observed in petal senescence, with <i>OfEIL2–5</i> and <i>OfEIL7–9</i> showing stage-specific and tissue-specific expression patterns. …”
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Aminophylline suppresses chronic renal failure progression by activating SIRT1/AMPK/mTOR-dependent autophagy by Liao Xin, Lu Jieyi, Huang Zhifeng, Lin Jinai, Zhang Miao, Chen Huanru, Lin Xiaoqing, Gao Xia, Gong Sitang

“…Histological evaluations of renal tissues are performed by H&amp;E, Masson staining, and PAS staining. Functional protein expression is detected by western blot analysis or immunofluorescence microscopy. …”
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NEK2 Phosphorylates RhoGDI1 to Promote Cell Proliferation, Migration and Invasion Through the Activation of RhoA and Rac1 in Colon Cancer Cells by Jeewon Lim, Yo-Sep Hwang, Jong-Tae Kim, Hyang-Ran Yoon, Hyo-Min Park, Jahyeong Han, Taeho Kwon, Kyung-Ho Lee, Hee-Jun Cho, Hee-Gu Lee

“…Phosphorylation assays determined the site of NEK2-mediated phosphorylation on RhoGDI1. Functional assays were conducted using overexpression of the RhoGDI1 substitution mutant to assess their impact on cancer cell behavior. …”
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