Differential Strain-Specific Responses of <i>Trichoderma</i> spp. in Mycoparasitism, Chitinase Activity, and Volatiles Production Against <i>Moniliophthora</i> spp. by María F. Garcés-Moncayo, Christian A. Romero, Simón Pérez-Martínez, Carlos Noceda, Luís L. Galarza, Daynet Sosa del Castillo

“…In 90% of dual-culture with MR and MP, HDA was detected as the most abundant. Functional specialization was evident. C4A and C1 prioritized chitinase production growing on MR and MP cell walls (respectively), whereas C9 excelled in antifungal hexadecanoic acid synthesis in confrontation with both pathogens. …”
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Ceramic-based piezoelectric material reinforced 3D printed polycaprolactone bone tissue engineering scaffolds by Duo Meng, Yanhao Hou, Hareem Zubairi, Mustafa Tugrul Ucan, David A Hall, Antonio Feteira, Paulo Bartolo, Ge Wang, Weiguang Wang

“…., generating local electrical stimulation under mechanical stress, or generating mechanical response under external electrical stimulation, thereby modulating cellular activity, accelerating cell proliferation and differentiation, ultimately speeding up the regeneration process. …”
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Determination of trunk neural crest cell fate and susceptibility to splicing perturbation by the DLC1-SF3B1-PHF5A splicing complex by Zhengfan Zheng, Suisui Guo, Hoi Yau Tam, Jingkai Wang, Yanxia Rao, Man-Ning Hui, May Pui Lai Cheung, Alan Wai Lun Leung, Kelvin K. W. Wong, Rakesh Sharma, Jessica Aijia Liu, Martin Cheung

“…Mechanistically, SF3B1-PHF5A binds to the intronic branch site (BS) sequences of all factors, while DLC1 interacts with a specific motif near the BS sequences of SOX9 and SNAI2, thereby determining their functional specificity in NC specification. Moreover, DLC1 increases NC cells’ vulnerability to splicing modulator pladienolide B (PB) by reducing the binding capacity of the SF3B1-PHF5A splicing complex to the shorter length of both SOX9 intron 2 and SNAI2 intron 1, which possess weaker polypyrimidine tract 3’ of the BS sequence, resulting in intron retention and loss of NC progenitors. …”
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RuO2 sub‐nanocluster decorated Co3O4 as efficient and pH‐universal oxygen evolution electrocatalyst by Ziye Li, Yangfan Liu, Jiandong Hu, Wenhui Luo, Yang Wang, Zhao Xin, Yanlin Jia, Yong Pang, Hong Zhang, Zhi Liang Zhao, Yejun Li, Qi Wang

“…This electronic modulation enhances –OH adsorption and accelerates OER kinetics. …”
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A fish-specific antimicrobial peptide MsPiscidin2 inactivates MSRV and confers protection in largemouth bass by Chenjie Fei, Chenjie Fei, Chenjie Fei, Ziwen Wang, Ziwen Wang, Yang Hu, Yang Hu, Yang Hu, Li Nie, Li Nie, Li Nie, Jiong Chen, Jiong Chen, Jiong Chen

“…Computational prediction and expression profiling revealed inducible expression of MsPiscidins upon MSRV infection, with distinct tissue-specific patterns. Functional assays demonstrated that while MsPiscidin1 and MsPiscidin3 primarily modulated host antiviral responses, MsPiscidin2 exhibited direct virucidal activity against MSRV. …”
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Next generation bioelectronic medicine: making the case for non-invasive closed-loop autonomic neuromodulation by Imanuel Lerman, Yifeng Bu, Rahul Singh, Harold A. Silverman, Anuj Bhardwaj, Alex J. Mann, Alik Widge, Joseph Palin, Christopher Puleo, Hubert Lim

“…Today, invasive or non-invasive closed-loop systems have yet to be developed that dynamically modulate autonomic nervous system function by responding to real-time physiological and molecular signals; it represents a transformative approach to therapeutic interventions and major opportunity by which the bioelectronic field may advance. …”
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Affective state-dependent effects of prefrontal rTMS on the cognitive control of negative stimuli in healthy and depressed individuals by Jasmina Paneva, Teresa Schuhmann, Stefanie De Smet, Terence De Meza, Felix Duecker, Alexander T. Sack

“…HF-rTMS produced distinct performance changes dependent on baseline BDI-II scores. As a function of BDI-II scores, we observed either increased or decreased response times on the task. …”
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Feeding regime synchronizes circadian clock in choroid plexus - insight into a complex mechanism by Tereza Dočkal, Pavel Houdek, Kateryna Semenovykh, Revan Rangotis, Martin Sládek, Alena Sumová

“…Abstract The circadian clock in choroid plexus (ChP) controls processes involved in its physiological functions, but the signals that synchronize the clock have been sparsely studied. …”
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Bioinformatics analysis identifies ZBTB16 as a potential immune biomarker for lung cancer and pan-cancer by Danfei Shi, Yunxiang Cai, Di Zhu, Xinmin Li, Yong Li

“…We conducted a comprehensive bioinformatics analysis of these differentially expressed genes, aiming to explore their enrichment functions and pathways, relative expression levels, interaction networks, and weighted gene co expression network (WGCNA) module analysis. …”
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Nanomedicine-Driven Approaches for Kartogenin Delivery: Advancing Chondrogenic Differentiation and Cartilage Regeneration in Tissue Engineering by Bhuyan S, Swain S, Misra RDK, Rautray TR

“…On top of that, it preserves the equilibrium between cartilage catabolism and anabolism, while also mitigating inflammation and alleviating pain by preventing damage induced by cytokines. To modulate tissue function and cellular behaviour, it is crucial to have sustained release of ketogenic through an appropriate delivery system. …”
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Latest Advancements in Transcutaneous Electrical Nerve Stimulation (TENS) and Electronic Muscle Stimulation (EMS): Revisiting an Established Therapy with New Possibilities by Patel P, Green M, Tram J, Wang E, Murphy M, Abd-Elsayed AA, Chakravarthy K

“…Additionally, TENS may influence autonomic functions, such as micro-perfusion and sympathetic tone, further broadening its therapeutic potential. …”
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Curcumin preserves bone health compromised by diabetes by inhibiting osteoporosis through regulation of the SIRT3/FoxO3a signalling pathway by Osama H. Mohammad, Shuaijie Yang, Wei Ji, Hongdong Ma, Ran Tao

“…The beneficial effects of curcumin were abolished upon SIRT3 silencing, suggesting that SIRT3/FoxO3a is the principal pathway through which curcumin modulates cellular functions. Based on a rat model of DO, curcumin increased the level of SIRT3 and enhanced bone mineral density and trabecular number in a dose-dependent manner. …”
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Triplane generator-based NeRF-GAN framework for single-view ship reconstruction by Tao Liu, Shiqi Geng, Yucheng Fu, Zhengling Lei, Yuchi Huo, Xiaocai Zhang, Fang Wang, Bing Han, Mei Sha, Zhongdai Wu

“…Plus, discriminator and encoder networks, coupled with a tailored loss function, are formulated to direct model optimization. …”
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Cathelicidin regulates goblet cell mucus secretion and mucus-associated proteins in Citrobacter rodentium-induced colitis by Niloofar Mirzadzare, Graham A. D. Blyth, Rita Hannawayya, Karina M. Cirone, Geeta Kilari, Priyoshi Lahiri, Yi Lin Tan, Aydin Ivan Herik, Yongpeng Fu, Hayley Gorman, Björn Petri, Kris Chadee, Eduardo R. Cobo

“…In this study, we used cathelicidin-deficient (Camp-/-) littermates, colonoids, and human LS174T goblet-like cells to investigate how cathelicidin modulates goblet cell function and mucosal defense against attaching/effacing enteropathogen Citrobacter rodentium. …”
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Glial Cells in Spinal Muscular Atrophy: Speculations on Non-Cell-Autonomous Mechanisms and Therapeutic Implications by Andrej Belančić, Tamara Janković, Elvira Meni Maria Gkrinia, Iva Kristić, Jelena Rajič Bumber, Valentino Rački, Kristina Pilipović, Dinko Vitezić, Jasenka Mršić-Pelčić

“…Oligodendrocytes exhibit impaired differentiation and metabolic support, while Schwann cells display abnormalities in myelination, extracellular matrix composition, and neuromuscular junction maintenance, further compromising motor function. Dysregulation of pathways such as NF-κB, Notch, and JAK/STAT, alongside the upregulation of complement proteins and microRNAs, reinforces the non-cell-autonomous nature of SMA. …”
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Interferon-β and interleukin-6 exert opposing effects on Foxp3 acetylation to control regulatory T cell induction by Mehek Ningoo, Mehek Ningoo, Francisco Fueyo-González, Cayetana Gisbert-Vilanova, Cayetana Gisbert-Vilanova, Laura Espinar-Barranco, Laura Espinar-Barranco, Nada Marjanovic, Miguel Fribourg, Miguel Fribourg

“…Mechanistically, we demonstrate that IFNβ and IL-6 signal independently to promote opposing effects on the acetylation of Foxp3, an essential transcription factor governing Treg differentiation, stability, and function. We further show that this mechanism is conserved in both murine and human T cells, highlighting the broad relevance of this finding in immune regulation. …”
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Gully-ERFNet: a novel lightweight deep learning model for extracting erosion gullies in the black soil region of Northeast China by Qingyao Li, Jiuchun Yang, Jiaqi Wang, Zhi Li, Jianwei Fan, Liwei Ke, Xue Wang

“…We employed the Adaptive Correction Loss function to reduce the impact of incorrect labels on model performance. …”
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Faberidilactone A, a Sesquiterpene Dimer, Inhibits Hepatocellular Carcinoma Progression Through Apoptosis, Ferroptosis, and Anti-Metastatic Mechanisms by Ruyu Cao, Yuhui Liu, Jiahe Bao, Mingming Rong, Jing Xu, Haibing Liao, Yuanqiang Guo

“…In vitro studies using HepG2 cells revealed that faberidilactone A induces apoptosis and ferroptosis, causes cell cycle arrest, enhances the production of intracellular reactive oxygen species (ROS), and disrupts mitochondrial function. Mechanistic investigations via Western blot analysis indicated that faberidilactone A impedes HepG2 cell proliferation by modulating the signal transducer and activator of the transcription 3 (STAT3) signaling pathway and inhibits metastasis by affecting the focal adhesion kinase (FAK) pathway. …”
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WCMU-net: An Effective Method for Reducing the Impact of Speckle Noise in SAR Image Change Detection by Yu Duan, Kaimin Sun, Wangbin Li, Jinjiang Wei, Song Gao, Yingjiao Tan, Wanghui Zhou, Jun Liu, Junyi Liu

“…In this study, we introduce a focal loss function to enhance the robustness of the network, allowing for high-precision change detection of SAR images with different noise levels through parameter adjustment. …”
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Zika virus and the fetal-maternal interface: deciphering the mechanisms of placental infection and implications for pregnancy outcomes by Sam Chak Sum Wong, Joshua Fung, Pak-Ting Hau, Yanjie Guo, Philip C. N. Chiu, Hong Wa Yung, Gilman Kit Hang Siu, Franklin Wang-Ngai Chow, Cheuk-Lun Lee

“…ZIKV's ability to breach the fetal-maternal interface and compromise placental function distinguishes it from other arboviruses. This mini-review explores how ZIKV targets key placental cells, including cytotrophoblasts, extravillous trophoblasts, syncytiotrophoblasts, and Hofbauer cells, to establish infection in the placenta. …”
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