FTO-mediated SMAD2 m6A modification protects cartilage against Osteoarthritis by Hongyi Zhou, Ziang Xie, Yu Qian, Weiyu Ni, Lei Cui, Xiangqian Fang, Shuanglin Wan, Xiangde Zhao, An Qin, Shunwu Fan, Yizheng Wu

“…Collectively, these findings reveal the function and mechanism of the m6A family member FTO in OA progression. …”
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Gambogic acid targets HSP90 to alleviate DSS-induced colitis via inhibiting the necroptosis of intestinal epithelial cells by Yuanyuan Wang, Yuanyuan Wang, Siqi Liu, Siqi Liu, Keyi Lu, Keyi Lu, Erping Xu, Erping Xu, Zhibin Wang

“…GA was observed to significantly ameliorate DSS-induced enteritis and enhance intestinal barrier function. Concurrently, it reduced the phosphorylated expression levels of RIPK1/3 and MLKL. …”
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Bacterial Outer Membrane Vesicles: From Physics to Clinical by Jun Zhou, Shuang Zou, Derong Dai, Liqing He, Xingyu Mou, Ninglin Zhao, Hong Li, Rui Bao

“…This review aims to provide a comprehensive overview of OMVs biogenesis, composition, function, and association with human disease, while also exploring current challenges and future development directions for clinical application.…”
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Bifidobacterium animalis subsp. lactis genome resources and metabolite profiling at the strain level and their ability to alleviate anxiety-like behavior in a sleep-deprived mouse... by Yao-Kun Zhang, Liang Zhang, Xue Ni, Shu-Wen Zhang, Min-Zhi Jiang, Si-Lu Zhang, Guo-Xun Xiao, He Jiang, Ming-Xia Bi, Yu-Lin Wang, Chang Liu, Shuang-Jiang Liu

“…In vivo, WLBA3 reduced inflammation and oxidative stress by inhibiting the NLRP3 inflammasome pathway and modulating gut microbiota (e.g., Lactobacillus and Alistipes), which in turn significantly improved weight gain and fatigue resistance, attenuated cognitive function, and anxiety-like behavior. …”
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Gut microbiota contribute to high-altitude adaptation in tree sparrows by Tingbei Bo, Gang Song, Mengru Zhang, Xiaoming Xu, Jundong Duan, Huishang She, Yun Fang, Wenting Li, Jing Wen, Jingsong Liu, Dehua Wang, Fumin Lei

“…ABSTRACT The intricate relationship between gut microbiota and various physiological functions in animals has emerged as a focal point in understanding host adaptability. …”
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Leech Extract Enhances the Pro-Angiogenic Effects of Endothelial Cell-Derived Exosomes in a Mouse Model of Ischemic Stroke by Yushuang Cao, Jin Sun, Lichen Guo, Meng Wang, Linlin Su, Tong Zhang, Shaoxia Wang, Lijuan Chai, Qing Yuan, Limin Hu

“…Leech extract significantly reduces ischemia–reperfusion injury, promotes angiogenesis, and improves neurological function in mice with stroke. However, further investigation is required to determine whether leech promotes angiogenesis through EC-Exo. …”
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Nitazoxanide mitigates methotrexate hepatotoxicity in rats: role in inhibiting apoptosis and regulating endoplasmic reticulum stress by Nevertyty Mohamed Mahmoud, Shimaa M. Elshazly, Fatma El-shaarawy, Sawsan A. Zaitone, Sawsan A. Zaitone, Afaf A. Aldahish, Gehan A. Ahmed, Manal S. Fawzy, Manal S. Fawzy, Sheka Yagub Aloyouni, Sally Y. Abed, Tahani Saeedi, Shaimaa S. El-Sayed

“…Groups were assigned as MTX-vehicle, NTZ-100, and NTZ-200 groups (at 100 and 200 mg/kg/day, gavage, respectively), N-acetyl cysteine (NAC) group (500 mg/kg), and 4-phenyl butyric acid (4-PBA) group (150 mg/kg, i.p). Liver function enzymes in serum, hepatic oxidative stress, proinflammatory cytokines, apoptosis, and ER-stress biomarkers were assessed. …”
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Targeting natural antioxidant polyphenols to protect neuroinflammation and neurodegenerative diseases: a comprehensive review by Maroua Jalouli, Md Ataur Rahman, Partha Biswas, Hasanur Rahman, Abdel Halim Harrath, In-Seon Lee, In-Seon Lee, Sojin Kang, Jinwon Choi, Moon Nyeo Park, Bonglee Kim, Bonglee Kim

“…Additionally, polyphenols have shown promise in modulating various cellular signaling pathways associated with neuronal viability, synaptic plasticity, and cognitive function. …”
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THE EFFECT OF SPLEEN LYMPHOCYTES TREATED WITH AN ORIGINAL ANTICONVULSANT ON HEMATOPOIESIS DURING LONG-TERM ALCOHOL CONSUMPTION by Irina Orlovskaya, Evgeniya Markova, Ivan Savkin, L. Toporkova, M. Knyazheva, E. Serenko, A. Smyk, E. Goiman

“…Chronic alcohol consumption also has a suppressive effect on the production and function of white blood cells, resulting in a poor ability to resist bacterial infection. …”
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The Role of Adenosine A1 and A2a Receptors in Cerebral Blood Vessel Reactivity of Sprague Dawley Rats Exposed to Hyperbaric Oxygenation by Vedran Đambić, Zrinka Mihaljević, Ines Drenjančević, Ivana Jukić, Petar Šušnjara, Aleksandar Kibel

“…Hyperbaric oxygenation (HBO₂) can modify gene and protein expression, signaling pathways, and vascular function, leading to altered vasomotor responses. Adenosine receptors (ARs) may mediate these effects by modulating vasoactivity. …”
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Sistem Pendeteksi Banjir dan Badai Angin serta Monitoring Cuaca Berbasis Internet of Things by Ida Bagus Made Lingga Pradirta, I Nyoman Piarsa, I Putu Arya Dharmaadi

“…Perangkat yang digunakan yaitu seperti mikrokontroler Arduino Mega 2560, sensor ultrasonik, sensor anemometer, sensor suhu dan kelembaban, sensor intensitas cahaya, sensor hujan, buzzer, Liquid Crystal Display (LCD), modul Wi-Fi ESP8266, modul SIM800L V2, stepdown LM2596 DC-DC, modul GPS NEO-6M, baterai 18650, dan switch on off dengan 3 pin. …”
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Toxoplasma gondii-Derived Exosomes: A Potential Immunostimulant and Delivery System for Tumor Immunotherapy Superior to Toxoplasma gondii by Zhao LX, Sun Q, Wang C, Liu JJ, Yan XR, Shao MC, Yu L, Xu WH, Xu R

“…This review proposes that T. gondii-derived exosomes may serve as a novel tool for tumor immunotherapy owing to their ability to activate host immune function and properties such as high modifiability, stability, and low toxicity. …”
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The dual GLP-1 and GIP receptor agonist tirzapetide provides an unintended interaction with the β-adrenoceptors and plays a role in glucose metabolism in hyperglycemic or senescent... by Dunya Aydos, Zeynep Busra Aksoy, Mehmet Altay Unal, Kamil Can Akcali, Ceylan Verda Bitirim, Belma Turan

“…Methods To establish the multifaceted cardioprotective function and underlying mechanisms of TZPD against hyperglycemia (HG)—or senescence (SC)-induced cardiac dysfunction, H9c2 cells were treated with and without TZPD. …”
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Low, but Not High, Pulsating Fluid Shear Stress Affects Matrix Extracellular Phosphoglycoprotein Expression, Mainly via Integrin β Subunits in Pre-Osteoblasts by Jianfeng Jin, Behrouz Zandieh-Doulabi

“…Therefore, we aimed to test whether low and/or high PFSS affects Mepe expression via modulation of integrin α and/or β subunit expression. …”
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Lightweight rice leaf spot segmentation model based on improved DeepLabv3+ by Jianian Li, Long Gao, Xiaocheng Wang, Jiaoli Fang, Zeyang Su, Yuecong Li, Shaomin Chen

“…Meanwhile, the PagFm-Ghostconv Feature Fusion (PGFF) module was proposed to significantly reduce the computational overhead of the model. …”
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Nano‐Anesthetics Regulate Neuro‐Immune Interaction for Treating Neuropathic Pain by Yue Wang, Xiuru Ji, Yu Sun, Han Wang, Ting Wang, Tao Luo, Yanyong Cheng, Jia Yan, Dalong Ni, Hong Jiang

“…Conventional treatments primarily focus on general pain modulation, which fail to address specific underlying mechanisms, leading to limited efficacy and infinite side effects. …”
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Rice bran oil rescues cognitive decline in D-galactose-induced aging mice by inhibiting Aβ accumulation and Tau hyperphosphorylation induced oxidative stress and neuroinflammation by Yadan Zhang, Diya Xu, Xiaoyu Zhang, Wenhua Zhou, Lin Zhang, Qinlu Lin

“…Thus, RBO can be considered as a potential functional food to attenuate AD owing to its multicomponent and multitarget effects.…”
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Exploratory study of associations between monetary reward anticipation brain responses and mu-opioid signalling in alcohol dependence, gambling disorder and healthy controls by Samuel Turton, Louise M. Paterson, James FM. Myers, Inge Mick, Chen-Chia Lan, John McGonigle, Henrietta Bowden-Jones, Luke Clark, David J. Nutt, Anne R. Lingford-Hughes

“…We explored associations between reward anticipation responses, using the Monetary Incentive Delay (MID) functional magnetic resonance imaging (fMRI) task, and mu-opioid receptor (MOR) availability and endogenous opioid release capacity using [11C]carfentanil positron emission tomography (PET), in 13 AD, 15 GD and 14 heathy control (HC) participants. …”
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Ruxolitinib and oHSV combination therapy increases CD4 T cell activity and germinal center B cell populations in murine sarcoma by Ravi Dhital, Yeaseul Kim, Doyeon Kim, Ilse Hernandez-Aguirre, Jack Hedberg, Alexia Martin, Kevin A. Cassady

“…Here, we illustrate the utility of a high-dimensional spectral flow cytometry panel that permits simultaneous evaluation of intratumoral CD4/CD8 T cell, Treg, γδ-T cell, natural killer T (NKT) cell, B cell, NK cell, monocyte, macrophage, granulocyte, myeloid-derived suppressor cell (MDSC), and dendritic cell functional changes from RUX+oHSV-treated MPNSTs.…”
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Cdc48 plays a crucial role in redox homeostasis through dynamic reshaping of its interactome during early stationary phase by Meytal Radzinski, Tal Oppenheim, Ohad Yogev, Adi Levy, Melamed-Book Naomi, Assaf Kacen, Yifat Merbl, Tommer Ravid, Dana Reichmann

“…Here, we show that entry to the stationary phase in yeast is accompanied by increased cytosolic and mitochondrial oxidation, imposing stress on the proteostasis network. We establish a functional link between redox and protein homeostasis, mediated by a key protein quality control member, Cdc48/p97/VCP.Comparative proteomic analysis of post-mitotic yeast cells reveals that while the global proteome remains largely stable during the first stages of stationary phase, the Cdc48 interactome undergoes significant remodeling, including altered interactions with antioxidants and its cofactors Shp1/Ubx1 and Ubx2.To challenge yeast Cdc48's capacity as a redox-switch protein during the early stages of the stationary phase, we utilized redox proteomics to map changes in reversible oxidation modification on Cdc48's cysteines upon entry to the stationary phase. …”
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