Targeting the complement-mTOR-autophagy axis: the role of apolipoprotein E in depression by Yong Li, Chengyuan Xu, Jing Liu, Mengru Guo, Jia Wang, Xianbing Bai, Yujie Cheng, Xinyue Luan, Huailong Pei, Chenlei Zhang, Huan Liu, Ming Chen, Binliang Tang

“…Abstract Background Depression is a highly prevalent and debilitating psychiatric disorder, and while Apolipoprotein E (ApoE), a critical regulator of lipid transport and neuronal function, has been implicated in regulating depressive behaviors, the underlying mechanisms remain insufficiently understood. …”
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TcMYB73, a salicylic acid-responsive R2R3-MYB transcription factor, positively regulates paclitaxel biosynthesis in Taxus chinensis in direct and indirect ways by Yifei Ren, Donglin Liu, Weicheng Zhao, Xinran Wang, Xiaoying Cao, Wen Wan

“…Both overexpression and RNA interference (RNAi) of TcMYB73 demonstrated its regulatory function in modulating key paclitaxel biosynthetic genes, including taxadiene synthase (TASY), 10-deacetylbaccatin III-10-O-acetyltransferase (DBAT), and 3’-N-debenzoyl-2’-deoxytaxol-N-benzoyltransferase (DBTNBT). …”
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Real-time cortical activity during virtual reality practice in people with multiple sclerosis: a pilot fNIRS study by Rotem Lavi, Massimiliano Pau, Sapir Dreyer-Alster, Tali Drori, Eleonora Cocco, Alon Kalron

“…Abstract Background Multiple sclerosis (MS) is a neuroinflammatory disorder affecting motor and cognitive functions. Virtual reality (VR) is increasingly used in rehabilitation, offering controlled environments for motor training and for integrating cognitive challenges into physical tasks through dual-task paradigms. …”
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Control of Clostridioides difficile virulence and physiology by the flagellin homeostasis checkpoint FliC-FliW-CsrA in the absence of motility by Duolong Zhu, Katherine J. Wozniak, Firas Midani, Shaohui Wang, Xingmin Sun, Robert A. Britton

“…This work highlights that key proteins involved in flagellar biosynthesis retain their regulatory roles in C. difficile pathogenesis and physiology independent of their functions in motility.IMPORTANCEClostridioides difficile is a leading cause of nosocomial antibiotic-associated diarrhea in developed countries with many known virulence factors. …”
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The significance of notch signaling in the regulation of Тreg-lymphocyte differentiation in patients with infiltrative pulmonary tuberculosis by A. E. Sanina, V. A. Serebryakova, O. I. Urazova, A. A. Gadzhiev, Т. E. Kononova

“…The overwhelming effect of Treg cells on the proliferation, functional activity of Th1 lymphocytes and antigen-presenting cells allows to consider this population as a possible target of modulation of the immune response in patients with tuberculosis. …”
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Analysis and Optimization of Operating Modes of Mini-CHP on Local Fuels in Conditions of Surplus Electric Power Capacities in the Unified Energy System of Belarus. Part 1 by R. S. Ignatovich, V. A. Sednin, Ye. S. Zuyeva

“…During the study, an analysis of the functioning of the ORC-installation Turboden 14 CHP ORC-installation operating as part of a mini-CHP using LFT was carried out. …”
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Perinatal SSRI exposure impacts innate fear circuit activation and behavior in mice and humans by Giulia Zanni, Milenna T. van Dijk, Martha Caffrey Cagliostro, Pradyumna Sepulveda, Nicolò Pini, Ariel L. Rose, Alexander L. Kesin, Claudia Lugo-Candelas, Priscila Dib Goncalves, Alexandra S. MacKay, Kiyohito Iigaya, Praveen Kulkarni, Craig F. Ferris, Myrna M. Weissman, Ardesheer Talati, Mark S. Ansorge, Jay A. Gingrich

“…Abstract Before assuming its role in the mature brain, serotonin modulates early brain development across phylogenetically diverse species. …”
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Exploration of the pathogenesis of nephrotic syndrome and traditional Chinese medicine intervention based on gut microbiota by Jing Li, Yupei Xu, Tianhao Sun, Xiaotian Zhang, Huimin Liang, Wei Lin, Hangxing Yu, Bo Yang, Hongtao Yang

“…In addition, it strengthens the stability of the intestinal barrier while controlling the metabolic function of the body through its efficient modulation of the gut microbiota. …”
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Cellulose Ether/Citric Acid Systems Loaded with SrTiO₃ Nanoparticles with Solvent-Tailored Features for Energy-Related Technologies by Raluca Marinica Albu, Mihaela Iuliana Avadanei, Lavinia Petronela Curecheriu, Gabriela Turcanu, Iuliana Stoica, Marius Soroceanu, Daniela Rusu, Cristian-Dragos Varganici, Victor Cojocaru, Andreea Irina Barzic

“…In this case, citric acid can act as a crosslinking agent for the polymer but also can react differently with the other counterparts from the composite as a function of the solvent used (H₂O and H₂O₂). …”
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Transcriptional and neurotransmitter signatures of cerebral spontaneous neural activity in nurses with burnout by Chun-Mei Song, Chun-Mei Song, Jian-Ping Liu, Hu-Cheng Yang, Qing-He Li, Shu Wang, Hai-Juan Chen, Shu-Fang Wang, Li Chen, Si-Yu Gu, Feng Zhang, Ping-Lei Pan

“…We analyzed fractional amplitude of low-frequency fluctuations (fALFF) and seed-based functional connectivity (FC), correlating findings with burnout (emotional exhaustion [EE], depersonalization [DP], and personal accomplishment [PA]). …”
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Evaluating the safety and efficacy of Lacticaseibacillus paracasei TISTR 2593 as a therapeutic probiotic for obesity prevention by Jaruwan Sitdhipol, Kanidta Niwasabutra, Neungnut Chaiyawan, Kamonsri Nuankham, Thanaphol Thanagornyothin, Somboon Tanasupawat, Wasaporn Preteseille Chanput, Pongsathon Phapugrangkul, Chaivarakun Chaipanya, Sukanya Phuengjayaem, Saranporn Poothong, Engkarat Kingkaew

“…These findings suggest that L. paracasei TISTR 2593 possesses probiotic and functional properties, including antiadipogenic activity, supporting its potential as a therapeutic probiotic supplement for preventing obesity. …”
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Integrating eQTL and genome-wide association studies to uncover additive and dominant regulatory circuits in pig uterine capacity by Z. Xu, H. Zeng, J. Teng, X. Ding, J. Li, Z. Zhang

“…Our results not only fill the knowledge gap regarding dominant genetic regulation mechanisms of uterine capacity but also provide a key theoretical foundation for the subsequent functional validation and breeding applications.…”
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Sugar lowering in fermented apple-pear juice orchestrates a promising metabolic answer in the gut microbiome and intestinal integrity by Ali Zein Alabiden Tlais, Andrea Polo, Lena Granehäll, Pasquale Filannino, Olimpia Vincentini, Francesca De Battistis, Raffaella Di Cagno, Marco Gobbetti

“…The impact of newly developed apple-pear juices on gut microbiome composition and functionality was evaluated in vitro using the Simulator of the Human Intestinal Microbial Ecosystem (SHIME). …”
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Development of the ultrasonic sensor based modification coordination test device. by Widiastuti Widiastuti, Muhamad Syamsul Taufik, Yasep Setiakarnawijaya, Kuswahyudi Kuswahyudi, Muhammad Zulqarnain Mohd Nasir, Hendro Wardoyo, Karisdha Karisdha, Adi Wijayanto, Sunanto Sunanto, Nur Ahmad Muharram, Heni Yuli Handayani, Abdul Hafidz, Rivan Saghita Pratama, Septyaningrum Putri Purwoto

“…The function of the sensor is to detect objects around the sensor. …”
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Biofeedback for Motor and Cognitive Rehabilitation in Parkinson’s Disease: A Comprehensive Review of Non-Invasive Interventions by Pierluigi Diotaiuti, Giulio Marotta, Salvatore Vitiello, Francesco Di Siena, Marco Palombo, Elisa Langiano, Maria Ferrara, Stefania Mancone

“…(1) Background: Biofeedback and neurofeedback are gaining attention as non-invasive rehabilitation strategies in Parkinson’s disease (PD) treatment, aiming to modulate motor and non-motor symptoms through the self-regulation of physiological signals. (2) Objective: This review explores the application of biofeedback techniques, electromyographic (EMG) biofeedback, heart rate variability (HRV) biofeedback, and electroencephalographic (EEG) neurofeedback in PD rehabilitation, analyzing their impacts on motor control, autonomic function, and cognitive performance. (3) Methods: This review critically examined 15 studies investigating the efficacy of electromyographic (EMG), heart rate variability (HRV), and electroencephalographic (EEG) feedback interventions in PD. …”
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Pedagogical support for professional self-determination of high school students in IT professions by E. K. Khenner

“…It is shown that the main reasons for the low level of formation of the professional self-determination of high school students in the IT profession are the following factors: insufficient attention paid in the school Computer Science course to the technological aspects that underlie most of the IT professions; lack of awareness of labour functions in IT professions; lack of awareness of the content of training in various areas of higher IT education and the focus of these areas on specific IT professions; ignorance of the real demand for the country’s economy in various IT professions.The school course in Computer Science can become a system-forming beginning in the formation of professional self-determination of high school students in the IT profession, but in its current state, it does not fully fulfill this function. …”
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Hyperpiliation, not loss of pilus retraction, reduces Pseudomonas aeruginosa pathogenicity by Sara L. N. Kilmury, Katherine J. Graham, Ryan P. Lamers, Lesley T. MacNeil, Lori L. Burrows

“…A better understanding of how T4aP modulate interaction of bacteria with target cells will improve the design of therapeutics targeting components involved in the regulation of T4aP expression and function to reduce the clinical burden of P. aeruginosa and other T4aP-expressing bacteria.…”
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Antiangiogenic Potential of Pomegranate Extracts by Riccardo Tornese, Anna Montefusco, Rocco Placì, Teodoro Semeraro, Miriana Durante, Monica De Caroli, Gianpiero Calabrese, Anna Eleonora Caprifico, Marcello Salvatore Lenucci

“…We explore the impact of pomegranate polyphenols, including ellagic acid, punicalagin, anthocyanins, punicic acid and bioactive polysaccharides on key angiogenesis-related pathways and endothelial cell function. Emphasis is placed on the effects of these extracts as phytocomplexes rather than isolated compounds. …”
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The Bidirectional Relationship between Sleep and Immunity against Infections by Elizabeth G. Ibarra-Coronado, Ana Ma. Pantaleón-Martínez, Javier Velazquéz-Moctezuma, Oscar Prospéro-García, Mónica Méndez-Díaz, Mayra Pérez-Tapia, Lenin Pavón, Jorge Morales-Montor

“…Sleep is considered an important modulator of the immune response. Thus, a lack of sleep can weaken immunity, increasing organism susceptibility to infection. …”
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Novel ultraflexible transparent self-heating composite films for nanoimprint lithography by Zhiwei Yang, Haitao Zhao, Xugang Qi, Chuangye Yao, Rui Ma, Jinsong Song, Yuanxun Cao, Dayong Ma, Haiming Li, Guangxu Cui, Jie Zhang

“…After curing, they are peeled off from the patterned substrates to form composite films with self-heating function (AgNWs/PVA). The films can generate heat when a voltage is applied by introducing positive and negative electrodes, simplifying the design of the heating module in nanoimprint lithography equipment and achieving rapid and accurate heat transfer to the target substrates. …”
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