Myometrial extracellular vesicles promoted endometrial mesenchymal stem/stromal cells to self-renewal via jag1-mediated notch signaling by Sisi Zhang, Ernest H. Y. Ng, William S. B. Yeung, Rachel W. S. Chan

“…We have demonstrated that the myometrial cells are candidate niche cells of the endometrial mesenchymal stem/stromal cells (eMSC) modulating their biological function. The Notch signaling pathway regulates the endometrial stem cell functions. …”
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Health-related quality of life in patients undergoing laparoscopic versus open hemihepatectomy: a secondary analysis of the ORANGE II PLUS randomised controlled, phase 3, superiori... by Bram Olij, Robert S. Fichtinger, Luca A. Aldrighetti, Mohammad Abu Hilal, Roberto I. Troisi, Robert P. Sutcliffe, Marc G. Besselink, Somaiah Aroori, Krishna V. Menon, Bjørn Edwin, Mathieu D’Hondt, Valerio Lucidi, Tom F. Ulmer, Rafael Díaz-Nieto, Zahir Soonawalla, Steve White, Gregory Sergeant, Francesca Ratti, Christoph Kuemmerli, Vincenzo Scuderi, Frederik Berrevoet, Aude Vanlander, Ravi Marudanayagam, Pieter J. Tanis, Maxime J.L. Dewulf, Zina B. Eminton, Ulf P. Neumann, Lloyd Brandts, Siân A. Pugh, Åsmund A. Fretland, Merel L. Kimman, John N. Primrose, Ronald M. van Dam, Ronald M. Van Dam, Luca A. Aldrighetti, Mohammed Abu Hilal, Roberto I. Troisi, Robert P. Sutcliffe, Marc G. Besselink, Somaiah Aroori, Krishna V. Menon, Bjørn Edwin, Mathieu D’Hondt, Valerio Lucidi, Tom F. Ulmer, Rafael Diaz-Nieto, Zahir Soonawalla, Steve White, Gregory Sergeant, Robert S. Fichtinger, Bram Olij, Francesca Ratti, Christoph Kuemmerli, Vincenzo Scuderi, Frederik Berrevoet, Aude Vanlander, Ravi Marudanayagam, Pieter J. Tanis, Maxime J.L. Dewulf, Zina B. Eminton, Ulf P. Neumann, Lloyd Brandts, Siân A. Pugh, Åsmund A. Fretland, Merel L. Kimman, John N. Primrose, Remon Korenblik, Michelle Lintforth, Burak Gorçek, Penelope Rogers, Viviane Van Laethem, Betsy Van Loo, Kathleen Segers, Celine Demeyere, Ane Zamalloa, Cornelis Dejong, Davit Aghayan, Katherine Gordon-Quayle, Tracy Ward, Jess Boxal, Beth Wedge

“…Interpretation: In this international randomised trial evaluating HRQoL, LH demonstrated better physical and social functioning, and less pain and appetite loss, compared to OH. …”
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The identification and validation of histone acetylation-related biomarkers in depression disorder based on bioinformatics and machine learning approaches by Lu Zhang, Lu Zhang, YuJing Lv, Mengqing Ma, Jile Lv, Jie Chen, Shang Lei, Yi Man, Guimei Xing, Yu Wang

“…We used weighted gene co-expression network analysis (WGCNA) to screen key module genes. Candidate genes were selected by intersecting DEGs, key module genes, and HAC-RGs, followed by functional analysis. …”
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Revolutionizing treatment for disorders of consciousness: a multidisciplinary review of advancements in deep brain stimulation by Yi Yang, Tian-Qing Cao, Sheng-Hong He, Lu-Chen Wang, Qi-Heng He, Ling-Zhong Fan, Yong-Zhi Huang, Hao-Ran Zhang, Yong Wang, Yuan-Yuan Dang, Nan Wang, Xiao-Ke Chai, Dong Wang, Qiu-Hua Jiang, Xiao-Li Li, Chen Liu, Shou-Yan Wang

“…It is imperative to further elucidate the precise modulatory effects of DBS on thalamo-cortical and cortico-cortical functional connectivity networks. Ultimately, by optimizing neuromodulation strategies, we aim to substantially enhance therapeutic outcomes and greatly expedite the process of consciousness recovery in patients.…”
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Metabotropic glutamate receptor 4-mediated glutamatergic signaling reshapes the tumor microenvironment by regulating dendritic cell maturation by Xiaoman Ju, Eva Maria Putz, Yaqi Liu, Dongchen Yuan, Guowei Sun, Stephane Koda, Zhuo Fu, Simin Shao, Chunrong Tong, Biping Deng, Jing Hu, Juming Yan

“…Single-cell RNA-sequencing and ex vivo assays show changes in the composition and functional state of the immune TME. Mechanistically, mGluR4 suppresses the adenyl cyclase/PKA signaling pathway, leading to metabolic reprogramming of DCs. …”
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Genomic locus of lncRNA-Gm26793 forms an inter-chromosomal interaction with Cubn to ensure proper stem cell differentiation in vitro and in vivo by Zhiwen Liu, Xin Wan, Jiehui Chen, Yongjian Ma, Yonggao Fu, Yingying Chen, Mingzhu Wen, Yun Yang, Yun Qian, Yong Zhang, Dahai Zhu, Jinsong Li, Naihe Jing, Xianfa Yang

“…Abstract Inter-chromosomal interactions play a crucial role in 3D genome organization, yet the organizational principles and functional significances remain elusive. In general, lncRNA loci and transcripts are frequently associated with transcriptional programs modulated by long-range chromatin interactions. …”
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Defect‐Engineered Multi‐Intermetallic Heterostructures as Multisite Electrocatalysts for Efficient Water Splitting by Xiang‐Feng Wu, Zi‐Yan Li, Hui Wang, Jun‐Chuan Wang, Guo‐Qiang Xi, Xiao‐Jin Zhao, Chen‐Xu Zhang, Wu‐Gang Liao, Johnny C. Ho

“…Advanced characterization techniques and density functional theory (DFT) reveal that the formation of defect sites and heterojunctions not only induces electronic modulation but also enhances intermetallic interactions and charge transfer from Ni and Mo to Cu and Co, facilitating intermediate formation and transformation, thereby boosting intrinsic activity. …”
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Mechanism of action, efficacy and adverse events of selected drugs used to treat irritable bowel syndrome (IBS): A Literature Review by Mikołaj Łabuda, Adrianna Bogucka, Oliwia Mentel, Teresa Sowińska, Agnieszka Szema, Jakub Sikora, Aleksandra Słojewska, Agata Kotkowiak, Klaudia Królikowska, Karolina Knychalska

“… Introduction and purpose: Irritable bowel syndrome (IBS) is a prevalent functional gastrointestinal disorder, affecting approximately 11% of the global population, with a higher prevalence in women. …”
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EGR1 Promotes Craniofacial Bone Regeneration via Activation of ALPL⁺PDGFD⁺ Periosteal Stem Cells by Yang Li, Dazhuang Lu, Fanqing Xu, Jun Yang, Dong Li, Chenlong Yang, Xin Chen, Xu Wang, Jia Qing, Hui Zhang, Yingfei Zhang, Fuchou Tang, Jie Qiao, Ophir D. Klein, Ping Zhang, Yongsheng Zhou

“…Abstract Oral and craniofacial bone regeneration remains challenging due to unique anatomical and functional demands. Rodent models have limited translational value because of significant structural differences from humans. …”
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Targeting a pathogenic cryptic exon that drives HLRCC to induce exon skipping by Siddhardha S. Maligireddy, Mariana D. Mandler, Judith C. Lunger, Madeline Yuen, Sneha Kulkarni, Alexendar R. Perez, Christina M. Fitzsimmons, Daniel R. Crooks, Raj Chari, W. Marston Linehan, Pedro J. Batista

“…These findings support the potential for splicing modulation as a therapeutic approach for HLRCC-associated non-coding loss-of-function mutations in FH.…”
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A searchable atlas of pathogen-sensitive lncRNA networks in human macrophages by Nils Schmerer, Harshavardhan Janga, Michelle Aillaud, Janina Hoffmann, Marina Aznaourova, Sarah Wende, Henrike Steding, Luke D. Halder, Michael Uhl, Fabian Boldt, Thorsten Stiewe, Andrea Nist, Lukas Jerrentrup, Andreas Kirschbaum, Clemens Ruppert, Oliver Rossbach, Evgenia Ntini, Annalisa Marsico, Chanil Valasarajan, Rolf Backofen, Uwe Linne, Soni S. Pullamsetti, Bernd Schmeck, Leon N. Schulte

“…We further uncover the function of ROCKI in repressing the messenger of the anti-inflammatory GATA2 transcription factor, thus promoting macrophage activation. …”
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Tailoring tetrahedral and pair-correlation entropies of glass-forming liquids for energy storage applications at ultralow temperatures by Meijia Qiu, Peng Sun, Yuxuan Liang, Jian Chen, Zhong Lin Wang, Wenjie Mai

“…The constructive EDGFL with a low T g of −128 °C and a high boiling point of +145 °C enables stable energy storage over an ultra-wide temperature range of −95~+120 °C, realizes superior AC linear filtering function at −95 °C, and helps improve the performance of aqueous Zn-ion batteries at ultralow temperatures. …”
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Exploring the promise of psychobiotics: Bridging gut microbiota and mental health for a flourishing society by Neel Kamal, Baljeet Singh Saharan, Joginder Singh Duhan, Ashwani Kumar, Payal Chaudhary, Chhaya Goyal, Mukesh Kumar, Nikita Goyat, Meena Sindhu, Priti Mudgil

“…A lot of studies have supported the function of gut microbiota in mood cognition and controlling anxiety. …”
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Natural Health Products in the Prevention and Management of Alzheimer’s Disease: A Systematic Review of Randomized Clinical Trials by Valeria Conti, Adele Zarrella, Danilo Donnarumma, Annarita Pagano, Ines Mazza, Alessandra De Stefano, Francesca Gallo, Valeria Di Landri, Domenico De Pascale, Valentina Manzo, Pasquale Pagliano, Graziamaria Corbi, Emanuela De Bellis, Amelia Filippelli

“…Out of the 34 RCTs analyzed, 50% reported improvements in cognitive function and reductions in neuroinflammatory markers following NHP supplementation, suggesting a potential but inconsistent therapeutic effect. …”
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Nutritional management of pediatric nephrotic syndrome regarding oxidative stress and antioxidant balance by Elena Jechel, Alin Horatiu Nedelcu, Felicia Dragan, Vasile Valeriu Lupu, Iuliana Magdalena Starcea, Adriana Mocanu, Solange Tamara Rosu, Violeta Streanga, Ruxandra Russu, Ginel Baciu, Ciprian Danielescu, Delia Lidia Salaru, Ionela Daniela Morariu, Olga Cirstea, Emil Anton, Ancuta Lupu

“…Recent evidence supports the involvement of redox imbalance in podocyte damage, impaired glomerular function, and systemic decline. All this suggests that antioxidant interventions can favorably modulate the course of the disease. …”
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Adipokines regulate the development and progression of MASLD through organellar oxidative stress by Ke Zhao, Heng Zhang, Wenyu Ding, Xiaoshuai Yu, Yanli Hou, Xihong Liu, Xinhua Li, Xiaolei Wang

“…These adipokines intricately orchestrate regulatory pathways that impact glucose and lipid metabolism, oxidative stress, and mitochondrial function, thereby influencing the evolution of hepatic steatosis and progression to metabolic dysfunction–associated steatohepatitis (MASH). …”
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Pharmacogenomics for neurodegenerative disorders - a focused review by S. Rehan Ahmad, Md. Zeyaullah, Mohammad Suhail Khan, Abdullah M. AlShahrani, Abdelrhman A. Galaleldin Altijani, Haroon Ali, Adam Dawria, Ali Mohieldin, Mohammad Shane Alam, Awad Osman Abdalla Mohamed

“…Neurodegenerative disorders such as Alzheimer’s disease (AD), Parkinson’s disease (PD), Huntington’s disease (HD), and amyotrophic lateral sclerosis (ALS) are characterized by the progressive degeneration of neuronal structure and function, leading to severe cognitive and motor impairments. …”
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The novelty of profilin 2 in regulating pyruvate kinase M2 nuclear translocation and promoting tumor angiogenesis in lung adenocarcinoma by Xiaohui Du, Chi Ma, Yingyan Wang, Mingxin Xu, Yanbin Kuang, Mengyun Li, Shuang Wen, Peipei He, Hui Zhao, Qi Wang

“…The nuclear translocation of PKM2 was observed to be dependent on PFN2 expression and their interaction, which functionally modulates angiogenesis in lung cancer. Conclusions Our study revealed oncogene PFN2 promoted tumor angiogenesis in LUAD through regulating PKM2 nuclear translocation, providing novel molecular therapy targets for LUAD treatment.…”
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A Multiscale Convolution SAR Image Target Recognition Method Based on Complex-Valued Neural Networks by Guangyu Hou, Zhihui Xin, Guisheng Liao, Penghui Huang, Yuhao Huang, Rui Zou

“…Specifically, first, the elements of CNN, including the input and output layers, the convolution layers, the activation functions, and the pooling layers, are extended to the complex-valued domain. …”
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A fishy gut feeling – current knowledge on gut microbiota in teleosts by Ingvill Tolas, Ingvill Tolas, Zhigang Zhou, Zhen Zhang, Zhen Zhang, Tsegay Teame, Tsegay Teame, Rolf Erik Olsen, Einar Ringø, Ivar Rønnestad

“…Elevated temperatures and salinity shifts alter microbial composition, and pollutants introduce toxins that compromise intestinal function and microbial diversity. Stress and pathogen infections further destabilize GM, often favoring pathogenic bacteria. …”
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