The Effect of the Eighth Week of Intense Interval Training and Bee Pollen Consumption on Interleukin-1 Beta, Tumor Necrosis Factor Alpha, and C-Reactive Protein in the Hippocampus... by Masoud Kordi khondabi, Firuz Sharafi deharham, Vahid Valipour dehnou, Mehdi Roozbahani

“…Introduction: Studies have shown that chronic toxic cadmium modulates immune function and increases inflammatory responses. …”
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Taurine Transporter Gene Expression in Mononuclear Blood Cells of Type 1 Diabetes Patients by Zaleida Napoli, Giuseppe Seghieri, Loria Bianchi, Roberto Anichini, Alessandra De Bellis, Ilaria Campesi, Ciriaco Carru, Stefano Occhioni, Angelo Zinellu, Flavia Franconi

“…Taurine transporter gene expression (RNA-TauT) has a role in retinal cell function and is modulated in vitro and in vivo by hyperglycemia and/or oxidative stress. …”
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Apolipoprotein L1 (APOL1): Consideration of Molecular Evolution, Interaction with APOL3, and Impact of Splice Isoforms Advances Understanding of Cellular and Molecular Mechanisms o... by Razi Khalaila, Karl Skorecki

“…The Apolipoprotein L1 (APOL1) innate immunity gene product represents the sole member of the APOL gene family in humans capable of secretion into circulation, thereby mediating the trypanolysis of <i>T. brucei brucei</i>. Gain-of-function variants of the APOL1 gene originated and spread among human population groups to extend APOL1’s protective capacity to include also serum-resistant subspecies, such as <i>T. brucei gambiense</i> (S342G known as APOL1-G1) and <i>T. brucei rhodesiense</i> (N388_Y389del known as APOL1-G2). …”
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A dual-domain perception gate-controlled adaptive fusion algorithm for road crack detection by Ziyang Zhang, Yong’an Feng

“…In response to the persistent high-frequency signature identified within crack feature distributions, a dual-domain structural feature enhancement loss function is designed, which elevates the weighting of high-frequency information by leveraging a spectral weighting matrix, while complementarily enhancing crack edge texture features in the spatial domain through gradient map integration. …”
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Exercise orchestrates systemic metabolic and neuroimmune homeostasis via the brain–muscle–liver axis to slow down aging and neurodegeneration: a narrative review by Jianda Kong, Yingao Xie, Rao Fan, Qinglu Wang, Ying Luo, Panpan Dong

“…In the aging brain, exercise stimulates neurogenesis, suppresses neuroinflammation via NF-κB inhibition, and elevates BDNF levels, which synergistically enhance cognitive resilience. vitally, exercise modulates the neuro-immunometabolic axis by balancing pro- and anti-inflammatory cytokines (e.g., IL-6’s hormetic role), optimizing immune cell function, and enhancing autophagy-mediated clearance of toxic aggregates (Aβ, α-synuclein). …”
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Identifying Inhibitor-SARS-CoV2-3CL^pro Binding Mechanism Through Molecular Docking, GaMD Simulations, Correlation Network Analysis and MM-GBSA Calculations by Jianzhong Chen, Jian Wang, Wanchun Yang, Lu Zhao, Xiaoyan Xu

“…Our findings indicate that a CNA-identified node in domain II of 3CL^pro acts as a conduit, transferring conformational changes from the catalytic regions in domains I and II, triggered by the binding of inhibitors (7YY, 7XB, and Y6G), to domain III, thereby modulating 3CL^pro’s activity. Normal mode analysis (NMA) and principal component analysis (PCA) revealed that inhibitor binding affects the structural flexibility and collective movements of the catalytic sites and domain III, influencing 3CL^pro’s function. …”
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Fibrin clot structure and platelet aggregation in patients with aspirin treatment failure. by Søs Neergaard-Petersen, Ramzi Ajjan, Anne-Mette Hvas, Katharina Hess, Sanne Bøjet Larsen, Steen Dalby Kristensen, Erik Lerkevang Grove

“…<h4>Background</h4>Aspirin is a cornerstone in prevention of cardiovascular events and modulates both platelet aggregation and fibrin clot formation. …”
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The Impact of Mechanisms of Action on Adherence and Outcomes in Self-Guided Digital Mental Health Interventions: Protocol for a Randomized Controlled Trial With Mediation Analysis by Amit Baumel, Idan M Aderka

“…ConclusionsIdentifying conceptual scientific theories that draw a link between active ingredients embedded within a digital intervention function and their outcomes is crucial in advancing our understanding of what influences usage and outcomes. …”
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DFN-YOLO: Detecting Narrowband Signals in Broadband Spectrum by Kun Jiang, Kexiao Peng, Yuan Feng, Xia Guo, Zuping Tang

“…The deformable attention mechanism embedded in DCFFN adaptively focuses on critical signal regions, while the loss function is optimized to the focal scaled intersection over union (Focal_SIoU), improving detection accuracy under low-SNR conditions. …”
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CTLA-4 blockade and interferon-α induce proinflammatory transcriptional changes in the tumor immune landscape that correlate with pathologic response in melanoma. by Arjun Khunger, Erin Piazza, Sarah Warren, Thomas H Smith, Xing Ren, Andrew White, Nathan Elliott, Alessandra Cesano, Joseph M Beechem, John M Kirkwood, Ahmad A Tarhini

“…It was observed that neoadjuvant ipilimumab-HDI therapy demonstrated an upregulation of immune-related genes, chemokines, and transcription regulator genes involved in immune cell activation, function, or cell proliferation. Importantly, increased expression of baseline pro-inflammatory genes CCL19, CD3D, CD8A, CD22, LY9, IL12RB1, C1S, C7, AMICA1, TIAM1, TIGIT, THY1 was associated with longer OS (p < 0.05). …”
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Dendritic cell-intrinsic PTPN22 negatively regulates antitumor immunity and impacts anti-PD-L1 efficacy by Thomas F Gajewski, Emily F Higgs, Santiago Acero-Bedoya, Anna C Martinez, Ruxandra Tonea

“…Background Individuals with a loss-of-function single-nucleotide polymorphism in the gene encoding PTPN22 have an increased risk for autoimmune diseases, and patients with cancer with such alleles may respond better to checkpoint blockade immunotherapy. …”
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Multiomics analysis revealed the regulatory role of chenodeoxycholic acid in fatty acid metabolism and lipid homeostasis by Lishuang Li, Xing Ren, Xinyu Gao, Yujia Zhao, Yuman Ma, Junxiao Gong, Shuo Yang, Yanan Sun, Yi Wang

“…Multi-omics analyses revealed that CDCA modulated fatty acid biosynthesis and degradation, energy metabolism, mitochondrial function, and Peroxisome Proliferator-Activated Receptor Gamma (PPAR-γ) signaling. …”
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Comparative physiological and immunological impacts of Moringa oleifera leaf and seed water supplements on African catfish (Clarias gariepinus): effects on disease resistance and h... by Howyda G. Gaber, Nehal A. Younis, Sohair Y. Saleh

“…Fish treated with seed powder exhibited reduced growth performance (gain % 11.2), elevated stress markers (glucose: 113.3 ± 3.8 mg/dL; cortisol: 27.4 ± 1.3 μg/dL), and compromised liver function (ALT: 30.2 ± 1.1 U/L; AST: 53.0 ± 1.6 U/L), evident through histological changes. …”
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GPER Enhances Chronic Burn Pain via PKC-Mediated Mu-Opioid Receptor Phosphorylation in the Rostral Ventromedial Medulla by Zhu X, Zhang Y, Zhang Q, Zhang Z

“…This investigation examined GPER function in chronic pain modulation and its role in pain rehabilitation.Methods and Results: A murine model of burn injury-induced chronic pain was employed, wherein nociceptive paw withdrawal reflexes to both thermal and mechanical stimuli were evaluated. …”
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A non-dominated sorting based multi-objective neural network algorithm of ethylene glycol hydrogenation reactor in energy reduction by Fakhrony Sholahudin Rohman, Sharifah Rafidah Wan Alwi, Dinie Muhammad, Muhamad Nazri Murat, Ashraf Azmi

“…The intermediate points in the Pareto Front PF for various three-objective situations provide lower energy costs than the bi-objective function. While bi-objective optimization might seem more straightforward, the intermediate points on the Pareto Front in three-objective optimization can provide lower energy costs due to more effective balancing of trade-offs, richer exploration of the solution space, capturing complex interdependencies, and offering more robust and flexible solutions. …”
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Analysis of the CRK expressions in bottle gourd (Lagenaria siceraria) under Fusarium oxysporum f. sp. lagenariae stress by using genome-wide identification strategy by Preetinanda Sahoo, Ikram Ullah, Debarpita Sahoo, Chirasmita Bose, Muhammad Amir Zia, Sumaira Salahuddin Lodhi, Mahmoud F. Seleiman, Nawab Ali, Gagan Kumar, Suhail Asad, Satyabrata Nanda

“…Conclusions The present work explored and analyzed the LsCRKs in bottle gourd. Functional predictions and interaction network analysis suggested the roles of LsCRKs in modulating multiple physiological processes in bottle gourd. …”
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Parasitic infections during pregnancy in Gabon affect glycosylation patterns of maternal and child antibodies by Yabo J. Honkpehedji, Anna O. Kildemoes, Koen A. Stam, Dieu L. Nguyen, Tom Veldhuizen, Angela van Diepen, Meral Esen, Peter G. Kremsner, Manfred Wuhrer, Ayôla A. Adegnika, Cornelis H. Hokke, Maria Yazdanbakhsh

“…Abstract Antibody glycosylation patterns can affect antibody functionality and thereby contribute to protection against invading pathogens. …”
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FAM3C Regulates Glioma Cell Proliferation, Invasion, Apoptosis, and Epithelial Mesenchymal Transition via the Notch Pathway by Xiaochao Xia, Zihao Wang, Lvmeng Song, Yinchuan Cheng, Ping Xiong, Shun Li

“…Methods We utilized open‐source bioinformatics tools and platforms to analyze the transcriptional expression levels, prognosis, and correlation with clinical variables of FAM3C in gliomas, and subsequently, to hypothesize its potential molecular functions and possibly associated signaling pathways. …”
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SPINT1-AS1 promotes oxidative damage and apoptosis of gastric cancer cells via the miR-656-3p/PLCXD3 axis by Duo Xu, Tong Wu, Xin Zhao, ShaoHai Li, XiaoHui Wei

“…Abstract Background and objectives In the study of gastric cancer (GC), long non-coding RNAs (lncRNAs) have been identified and their functions have been partly characterized; however, the specific function of SPINT1 antisense RNA 1 (SPINT1-AS1) in GC remains unclear. …”
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Ras-PI3K pathway promotes osteosarcoma progression via regulating VRK1-mediated H2A phosphorylation at threonine 120 by Xianlun Xu, Hao Yu

“…H2AT120ph participated in the oncogenic functions of Ras-PI3K pathway on osteosarcoma by modulating the transcription of Ras-PI3K-targeted genes. …”
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