Resveratrol as a Novel Therapeutic Approach for Diabetic Retinopathy: Molecular Mechanisms, Clinical Potential, and Future Challenges by Snježana Kaštelan, Suzana Konjevoda, Ana Sarić, Iris Urlić, Ivana Lovrić, Samir Čanović, Tomislav Matejić, Ana Šešelja Perišin

“…This review provides a comprehensive analysis of the molecular mechanisms by which RSV exerts protective effects in DR, including modulation of oxidative stress pathways, suppression of inflammatory cytokines, enhancement of mitochondrial function, promotion of autophagy, and inhibition of pathological neovascularisation. …”
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Effects of all-trans retinoic acid on glutamate receptor expression and dendritic spine density in the hypothalamus of rats by Yuan-Zhong Kai, Chun Xia, Qing-Hong Shan, Zheng-Quan Tang

“…These results suggest that ATRA may alter both synaptic structure and glutamatergic function in the hypothalamus, providing new insights into its potential role in stress-related disorders. …”
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SSMM-DS: A semantic segmentation model for mangroves based on Deeplabv3+ with swin transformer by Zhenhua Wang, Jinlong Yang, Chuansheng Dong, Xi Zhang, Congqin Yi, Jiuhu Sun

“…Finally, we optimized the loss function by combining cross-entropy loss and dice loss, addressing the issue of sampling imbalance caused by the small areas of mangroves. …”
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CMCD: A Consistency Model-Based Change Detection Method for Remote Sensing Images by Xiongjie Li, Weiying Xie, Jiaqing Zhang, Yunsong Li

“…Then, we introduce a novel joint loss function to prevent the training collapse of the consistency model caused by errors accumulated from exponential moving average updates. …”
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The Effect of Probiotics on the Prevention of Necrotizing Enterocolitis (NEC) in Low Birth Weight (LBW) and Very Low Birth Weight (VLBW) Infants by Reza Saeidi, Shamsollah Nouripour, Parinaz Alizadeh

“…The mechanisms of action are believed to involve modulation of the gut microbiome, enhancement of the gut barrier function, and immunomodulation. …”
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Evaluation of antioxidant–surfactant interactions using size distribution Taylor dispersion analysis: measuring antioxidant partitioning and size of native-state micelles by Erwann Durand, Théo Troncho, Pierre Villeneuve

“…The interactions between antioxidants and micelles can either enhance or impair antioxidant function. Despite this importance, methodologies to study these interactions in native-state micelles remain limited. …”
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Evaluating elexacaftor/tezacaftor/ivacaftor (ETI; Trikafta™) for treatment of patients with non-cystic fibrosis bronchiectasis (NCFBE): A clinical study protocol. by Colin E Swenson, William R Hunt, Candela Manfredi, Diana J Beltran, Jeong S Hong, Brian R Davis, Shingo Suzuki, Cristina Barillá, Andras Rab, Cynthia Chico, Joy Dangerfield, Ashleigh Streby, Erin Barton, Elizabeth M Cox, Arlene A Stecenko, Adrianna Westbrook, Rebecca Kapolka, Eric J Sorscher

“…ETI is currently prescribed solely for treatment of CF and has not been adequately tested or proposed for patients with NCFBE, many of whom exhibit decreased CFTR function. Accordingly, we are conducting a clinical trial of ETI in subjects carrying a diagnosis of NCFBE.…”
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Fecal Microbiota Transplantation Activity of <i>Floccularia luteovirens</i> Polysaccharides and Their Protective Effect on Cyclophosphamide-Induced Immunosuppression and Intestinal... by He Ma, Abdul Mueed, Yanxu Ma, Muhammad Ibrahim, Ling Su, Qi Wang

“…Moreover, FFLP1s mitigated oxidative stress by activating the Nrf2/Keap1 signaling pathway and strengthened the intestinal barrier function by upregulating the expression level of tight junction proteins (occludin, claudin-1, MUC-2, and ZO-1). …”
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Stem cell mechanoadaptation. I. Effect of microtubule stabilization and volume changing stresses on cytoskeletal remodeling by Vina D. L. Putra, Kristopher A. Kilian, Melissa L. Knothe Tate

“…Here, we report on the first part of a two-part experimental series to elucidate spatiotemporal cytoskeletal remodeling, which underpins the evolution of stem cell shape and fate, and the emergence of tissue structure and function. In Part I of these studies, we first develop protocols to stabilize microtubules exogenously using paclitaxel (PAX) in a standardized model murine embryonic stem cell line (C3H/10T1/2) to maximize comparability with previously published studies. …”
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Exploring possible hub genes of metabolic syndrome and type 2 diabetes mellitus: a systematic network biology study by Ashish Runthala, Srinivasa R. Vulichi, Sreya Kosanam, Rajeshwari Pasupula, Kakarla Ramakrishna, Monoj Sutradhar, Kumar Pranav Narayan

“…Interestingly, nine of these genes are influenced by metformin, suggesting its broader mechanism in modulating metabolic pathways. Additionally, scrutiny of transcription factors for the considered dataset shows that forkhead box protein O1 (FOXO1), sirtuin 1 (SIRT1), and peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC1α) play crucial roles in insulin signalling, mitochondrial function, and glucose metabolism, further elucidating the molecular complexity of T2DM. …”
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Exploring the Role of p53 in Radiosensitivity: A Key Player in Cancer Therapy by Tusher- Al-Arafat, Aihong Mao, Takanori Katsube, Bing Wang

“…Conversely, intact p53 function is associated with enhanced radiosensitivity due to its ability to promote cell cycle arrest and apoptosis in response to radiation-induced DNA damage. …”
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Fire and Smoke Detection Based on Improved YOLOV11 by Zhipeng Xue, Lingyun Kong, Haiyang Wu, Jiale Chen

“…In this paper, the core DCN2 (Deformable Convolutional Networks2) of the YOLOV11 Head is replaced with the DCN3 module to form a new detection head. In addition, the loss function CIOU in YOLOV11 is replaced with IOU to consider the irregular shape of fire and smoke and the problem of multi-scale targets. …”
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METTL3 mediates m6A methylation modification of ULBP2 and affects the progression of cervical cancer by Hongtao Ren, Yuting Wang, Jiao Yu, Lei An, Xiulong Ma, Jiyuan Pan

“…METTL3 influenced the expression of ULBP2 and impacted the biological function of the CC cells. Silencing ULBP2 reduced the radioresistance of CC in vivo. …”
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Evaluation of toll-like receptors 2 and 4 polymorphism and intestinal microbiota in children with food allergies by Mehmet Kılıç, Elif Beyazıt, Ebru Etem Önalan, Tuğçe Kaymaz, Erdal Taşkın

“…Future work in this area will be required to clarify the roles of different microbial strains that modulate gut microbiota composition and function in conjunction with TLR transcription pathways. …”
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Drugs of abuse drive neurotransmitter plasticity that alters behavior: implications for mental health by Marta Pratelli, Marta Pratelli, Nicholas C. Spitzer, Nicholas C. Spitzer

“…The ability of neurons to express multiple transmitters and/or switch them in response to environmental stimuli likely evolved to provide flexibility and complexity to neuronal circuit function in an ever-changing environment. However, this adaptability can become maladaptive when generating behavioral alterations that are unfit for the environment in which the animal lives or the tasks it needs to perform. …”
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MuSK is a substrate for CaMK2β but this interaction is dispensable for MuSK activation in vivo by Jakob J. Prömer, Sara Wolske, Perrine Castets, Geeske M. van Woerden, Cinzia Barresi, Kevin C. O’Connor, Ruth Herbst

“…Abstract The neuromuscular junction (NMJ) is the unique interface between lower motor neurons and skeletal muscle fibers and is indispensable for muscle function. Tight control of its localized formation at the center of every muscle fiber, and maintenance throughout lifetime are sustained by muscle-specific kinase (MuSK). …”
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OR-FCOS: an enhanced fully convolutional one-stage approach for growth stage identification of Oudemansiella raphanipes by Runze Fang, Huamao Huang, Nuoyan Guo, Haichuan Wei, Shiyi Wang, Haiying Hu, Ming Liu

“…Integrating the complete intersection over union (CIoU) loss function addresses standard IoU limitations by factoring in aspect ratio and bounding box center distance. …”
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Posttranscriptional RNA stabilization of telomeric RNAs FRG2, DBE-T, D4Z4 at human 4q35 in response to genotoxic stress and D4Z4 macrosatellite repeat length by Valentina Salsi, Francesca Losi, Monica Salani, Paul D. Kaufman, Rossella Tupler

“…Remarkably, the extent of this response is modulated by the copy number of the D4Z4 repeats, raising new hypotheses about their regulation and function in human biology and disease.…”
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Impact of perinatal hypertonic NaCl access on adult offspring’s sodium intake and angiotensin and vasopressin systems under hypertension model by Cintia Y Porcari, Cristina A Lencina, José L Amigone, José Antunes-Rodrigues, Ximena E Caeiro, Andrea Godino

“…This behavioral change was accompanied by a higher angiotensin type 1 receptor (Agtr1a) gene expression at brain level in the subfornical organ and the hypothalamic paraventricular nucleus of PM-NaCl, areas key to the modulation of salt appetite and autonomic function. …”
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Eeg-based detection of epileptic seizures in patients with disabilities using a novel attention-driven deep learning framework with SHAP interpretability by Tawfeeq Shawly, Ahmed A. Alsheikhy

“…We articulate the mathematical characteristics of feature selection driven by NAM, delineate the convergence attributes of the loss function, and present measures of explainability through Shapley Additive Explanations (SHAP). …”
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