RhoB regulates prostate cancer cell proliferation and docetaxel sensitivity via the PI3K-AKT signaling pathway by Tiantian Sheng, Hang Su, Lu Yao, Zhen Qu, Hui Liu, Wenjuan Shao, Xiangyu Zhang

“…To investigate RhoB’s function in prostate cancer, CRISPR/Cas9 gene editing technique was utilized to knock out the RhoB gene in prostate cancer cells. …”
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Comprehensive Assessment of Cannabidiol and HU308 in Acute and Chronic Colitis Models: Efficacy, Safety, and Mechanistic Innovations by Dinesh Thapa, Mohan Patil, Leon N Warne, Rodrigo Carlessi, Marco Falasca

“…The ability of HU308 to modulate GLP-1, a biomarker of gut endocrine function, further underscores its promise as a novel treatment option.…”
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Metabolic Reprogramming in HIV+ CD4⁺ T-Cells: Implications for Immune Dysfunction and Therapeutic Targets in <i>M. tuberculosis</i> Co-Infection by Suheena Ayrga, Gerrit Koorsen

“…This study aims to investigate the immunometabolic response of CD4⁺ and CD8⁺ T cells to <i>M.tb</i> antigens, analysed using metabolomics, to elucidate metabolic shifts that may influence immune function in an HIV+ environment. <b>Methods:</b> Whole blood samples from newly diagnosed, treatment-naïve HIV+ individuals were stimulated with <i>M.tb</i> antigens early secreted antigenic target 6 (ESAT-6) and culture filtrate protein 10 (CFP-10) using the QuantiFERON^® (QFT) Gold Plus assay. …”
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Lightweight and robust ship detection method driven by self-attention mechanism by Feng MA, Zihui SHI, Jie SUN, Chen CHEN, Xianbin MAO, Xinping YAN

“…Moreover, the method employs the SCYLLA-IoU (SIoU) loss function to constrain the detection heads, thereby reducing regression freedom and improving detection accuracy and robustness. …”
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Investigating the differential microRNAs expression in young and aged Drosophila melanogaster following Flock House Virus infection by Amber Thibeaux, Max Yang Lu, Marshall Martin, Michael Rodwell, Victoria Faber, Lakbira Sheffield, Janna L. Fierst, Stanislava Chtarbanova

“…In Drosophila melanogaster, the role of miRNAs has mostly been studied in regard to bacterial infection, yielding insights about their regulatory function in innate immunity. However, fewer studies have focused on viral infections, and importantly, how miRNAs modulate aging immune responses is not fully understood. …”
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Targeting super-enhancers in liver cancer: from pathogenic mechanisms to clinical applications by Chang-Lei Li, Zhi-Yuan Yao, Ao Sun, Jing-Yu Cao, Zu-Sen Wang

“…Therapeutic strategies, such as using small inhibitors that disrupt the function of key components in SE-mediated transcriptional complexes, have shown promise in pre-clinical studies. …”
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New domestic intraocular lenses. Resistance to biodegradation processes in comparison with foreign analogues by K.G. Khliyan, I.R. Omarieva, S.Yu. Kopaev

“…Before the experiment, the optical parameters of the studied IOLs were measured: optical power, modulation transmission function (MTF), Strel number. …”
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Hispidulin: a potential alternative to vorinostat against HDAC1 for acute myeloid leukemia by Sathyanarayan Balaji, Suvitha Anbarasu, Sudha Ramaiah, Anand Anbarasu

“…AML is characterized by failure of bone marrow function to produce healthy blood cells resulting in significant clinical symptoms such as anemia, shortness of breath, and paleness of skin. …”
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Circulating adiponectin mediates the association between omentin gene polymorphism and cardiometabolic health in Asian Indians. by Karani Santhanakrishnan Vimaleswaran, Dhanasekaran Bodhini, Juanjie Jiang, Kandaswamy Ramya, Deepa Mohan, Coimbatore Subramanian Shanthi Rani, Nagarajan Lakshmipriya, Vasudevan Sudha, Rajendra Pradeepa, Ranjit Mohan Anjana, Viswanathan Mohan, Venkatesan Radha

“…<h4>Conclusions</h4>Our findings show that adiponectin might function as a mechanistic link between omentin SNP and increased risk of cardiometabolic diseases independent of common and central obesity in Asian Indians. …”
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Tapping line detection and rubber tapping pose estimation for natural rubber trees based on improved YOLOv8 and RGB-D information fusion by Yaya Chen, Hui Yang, Junxiao Liu, Zhifu Zhang, Xirui Zhang

“…Firstly, YOLOv8n was improved by introducing the CFB module into the backbone, adding an output layer into the neck, fusing the EMA attention mechanism into the neck, and modifying the loss function as NWD to realize multi-object detection and segmentation. …”
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AC-YOLO: citrus detection in the natural environment of orchards by Xu Xiao, Yaonan Wang, Yiming Jiang, Haotian Wu, Zhe Zhang, Rujing Wang

“…At the same time, a self-attention mechanism is introduced to suppress the impact of complex backgrounds and underlying noise, improving the detection ability of small target citrus; Finally, the Mish activation function is used to replace Leaky Re LU, improving the generalization ability of the model and improving the accuracy of citrus detection. …”
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Detection Model for Cotton Picker Fire Recognition Based on Lightweight Improved YOLOv11 by Zhai Shi, Fangwei Wu, Changjie Han, Dongdong Song, Yi Wu

“…To further improve localization performance and accelerate convergence, the loss function is also modified. These improvements enable the model to achieve higher precision in fire detection while ensuring fast and accurate localization. …”
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YOLOLS: A Lightweight and High-Precision Power Insulator Defect Detection Network for Real-Time Edge Deployment by Qinglong Wang, Zhengyu Hu, Entuo Li, Guyu Wu, Wengang Yang, Yunjian Hu, Wen Peng, Jie Sun

“…Additionally, an auxiliary bounding box mechanism is incorporated into the CIoU loss function, improving both convergence speed and localization precision. …”
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The Impact of Vaginal Dilator Use on the Quality of Life in Women Treated with Adjuvant Radiotherapy for Cervical Cancer by Liujuan Shao, Xiaoli Chen, Xiaoyan Zhang, Min Zhu, Peijian Jin, Min Hu

“…The vaginal diameter and length were significantly different between the two groups during the follow-up period. Sexual/vaginal function, sexual worry, sexual activity, and sexual enjoyment were also significantly different after radiotherapy in groups A and B (p < 0.05). …”
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Implementation of a Digital Model of Thermal Characteristics Based on the Temperature Field by V. V. Pozevalkin, A. N. Polyakov

“…For the analytical solution, a computer model of thermal characteristics developed on the basis of the state-space method, implemented in the ANSYS Twin Builder module, was used. The state-space model was matched to the behavior of the original thermal model through approximating the transfer function to the stepwise response of the thermal load using the time domain vector approximation method. …”
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SRW-YOLO: A Detection Model for Environmental Risk Factors During the Grid Construction Phase by Yu Zhao, Fei Liu, Qiang He, Fang Liu, Xiaohu Sun, Jiyong Zhang

“…Finally, a dynamic non-monotonic focusing mechanism WIoU v3 loss function is employed to reweigh low-quality annotations, thereby improving small-object localization accuracy. …”
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The background of mitochondrial DNA haplogroup J increases the sensitivity of Leber's hereditary optic neuropathy cells to 2,5-hexanedione toxicity. by Anna Ghelli, Anna Maria Porcelli, Claudia Zanna, Sara Vidoni, Stefano Mattioli, Anna Barbieri, Luisa Iommarini, Maria Pala, Alessandro Achilli, Antonio Torroni, Michela Rugolo, Valerio Carelli

“…Therefore, we here investigate the effect of the n-hexane neurotoxic metabolite 2,5-hexanedione (2,5-HD) on cell viability and mitochondrial function of different cell models (cybrids and fibroblasts) carrying the LHON mutations on different mtDNA haplogroups. …”
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Low-light image enhancement method for underground mines based on an improved Zero-DCE model by WANG Yiwei, LI Xiaoyu, WENG Zhi, BAI Fengshan

“…The ReLU activation function in the Zero-DCE model was replaced with Leaky ReLU to accelerate model convergence and improve the efficiency of low-light image feature learning. …”
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Nuclear ubiquitin C-terminal hydrolase L5 expression associates with increased patient survival in pancreatic ductal adenocarcinoma by Leena Arpalahti, Kapo Saukkonen, Jaana Hagström, Harri Mustonen, Hanna Seppänen, Caj Haglund, Carina I Holmberg

“…In conclusion, UCHL5 expression could function as a prognostic marker in pancreatic ductal adenocarcinoma, particularly at disease stages IIB to III. …”
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CsLOB1 impairs kumquat immunity to citrus canker by reprogramming cell development and defense responses by Juanjuan Ma, Renhao Jiang, Xiaolong Tao, Xingru Guo, Lanzhen Xu, Xiuping Zou

“…In this study, transgenic kumquat plants with either Citrus sinensis LOB1 (CsLOB1) overexpression or RNAi-mediated silencing were obtained to investigate the function and molecular basis of LOB1 in kumquat resistance to Xcc. …”
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