Rg3-enriched Korean Red Ginseng enhances blood pressure stability in spontaneously hypertensive rats by Harsha Nagar, Sujeong Choi, Saet-byel Jung, Byeong Hwa Jeon, Cuk-Seong Kim

“…In particular, ginsenoside Rg3 is thought to be a potent modulator of vascular function. The present study was performed to examine the antihypertensive efficacy of Korean Red Ginseng (KRG) extract and Rg3-enriched KRG (REKRG) extract. …”
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Identification of intestinal microbial population structure of Penaeus vannamei supplemented with chitosan oligosaccharide using 2bRAD-M by Chunpeng Fu, Xiaopeng Fu, Zongzhen Li, Chengjiang Xu, Fajun Li, LiXin Wang, Lifang Wang

“…This shift enhances nutrient absorption, immune function, and disease resistance in shrimp. COS thus offers a sustainable alternative to antibiotics in aquaculture, promoting healthy growth and reducing environmental impact.…”
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Alveolar epithelial cells in bacterial sepsis-associated acute lung injury: mechanisms and therapeutic strategies by Guiyang Jia, Guiyang Jia, Erqin Song, Zhiyou Zheng, Mingjiang Qian, Guoyue Liu

“…Furthermore, therapeutic strategies for AEC injury are comprehensively analyzed from multiple perspectives, such as AEC repair and regeneration, modulation of inflammatory responses, restoration of barrier function, and exosome-based therapies. …”
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Examining the role of novelty detection in 20- and 40-Hz auditory steady-state responses by Kentaro Takai, Shunsuke Sugiyama, Koji Inui, Yuka Ikegame, Hirohito Yano, Jun Shinoda, Makoto Nishihara, Kazutaka Ohi, Toshiki Shioiri

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Protein arginine methyltransferase 7 linked to schizophrenia through regulation of neural progenitor cell proliferation and differentiation by Ting Shen, Jing Yu, Bin Xie, Cuiping Huang, Jingjie Cui, Kefu Liu, Chunyu Liu, Chao Chen

“…Together, the results of this study reveal that PRMT7 is a functional gene at 16q22.1, contributing to the etiology of SCZ by modulating NPC proliferation and differentiation as an epigenetic regulator.…”
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Understanding the dynamics of TKI-induced changes in the tumor immune microenvironment for improved therapeutic effect by Jie Zheng, Yihui Liu, Yong He, Chen Hu, Di Wu, Tao Peng, Chao He, Rui Han, Conghua Lu, Ziyuan Gao, Daijuan Huang, Caiyu Lin, Yuanyao Dou, Yimin Zhang, Fenfen Sun, Weiling Jiang, Guoqing Yin

“…Background The dynamic interplay between tyrosine kinase inhibitors (TKIs) and the tumor immune microenvironment (TME) plays a crucial role in the therapeutic trajectory of non-small cell lung cancer (NSCLC). Understanding the functional dynamics and resistance mechanisms of TKIs is essential for advancing the treatment of NSCLC.Methods This study assessed the effects of short-term and long-term TKI treatments on the TME in NSCLC, particularly targeting epidermal growth factor receptor (EGFR) and anaplastic lymphoma kinase (ALK) mutations. …”
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Flexible retinomorphic vision sensors with scotopic and photopic adaptation for a fully flexible neuromorphic machine vision system by Lei Shi, Ke Shi, Zhi‐Cheng Zhang, Yuan Li, Fu‐Dong Wang, Shu‐Han Si, Zhi‐Bo Liu, Tong‐Bu Lu, Xu‐Dong Chen, Jin Zhang

“…However, the large intensity range of natural lights and complex illumination conditions in actual scenarios always require the NMVS to dynamically adjust its sensitivity according to the environmental conditions, just like the visual adaptation function of the human retina. Although some opto‐sensors with scotopic or photopic adaption have been developed, NMVSs, especially fully flexible NMVSs, with both scotopic and photopic adaptation functions are rarely reported. …”
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FL3 mitigates cardiac ischemia-reperfusion injury by promoting mitochondrial fusion to restore calcium homeostasis by Zikan Zhong, Yutong Hou, Changzuan Zhou, Jiahui Wang, Longzhe Gao, Xiaoyu Wu, Genqing Zhou, Shaowen Liu, Yingjie Xu, Wen Yang

“…Mechanistically, FL3 promoted mitochondrial fusion in a mitofusin1 (MFN1)-dependent manner, preserving mitochondrial function under stress conditions and enhancing cellular resilience. …”
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Effects of estradiol exposure on lipid metabolism in male and female sea cucumber Apostichopus japonicus by Shuangyan Zhang, Libin Zhang, David Gonçalves, Jialei Xu

“…The study confirms that sex steroids play a significant role in regulating physiological functions in echinoderms and, in particular, that E2 might modulate lipid metabolism, as described for vertebrates. …”
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Elucidation of Mechanisms by Which Microplastics (PET) Facilitates the Rapid Growth of Benthic Cyanobacteria and Toxin Production in Aquatic Ecosystems by Rashid Mir, Shrooq Albarqi, Wed Albalawi, Ghaida Alanazi, Shouq S. Alsubaie, Razan I. Alghaban, Hanadi Saud Alanazi, Nora Taleb Alsharif, Manal M. Aljammaz, Nouf Faisal Alghabban, Wafaa Seluman Alhwiti, Alaa Albogmi, Faras Falah Alblwi

“…We explore how PET-derived compounds serve as carbon and energy sources or signaling molecules, possibly affecting photosynthesis, nitrogen fixation, or stress response pathways through changes in gene expression. Moreover, the function of PET leachates as environmental modulators of microbial community structure, generators of reactive oxygen species (ROS), and disruptors of hormonal and quorum sensing networks are also outlined. …”
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Terahertz photoneuromodulation of lateral orbitofrontal cortex neurons ameliorates stress-induced depression and cognitive impairment by Yuanyuan He, Jing Ma, Yun Yu, Junkai Yin, Ge Gao, Yifang Yuan, Hao Ruan, Xueqing Yan, Zihua Song, Chao Chang

“…This led to marked improvements in depressive-like behaviors and cognitive function. Furthermore, THz modulation of OFC activity recapitulated the effects of chemogenetic inhibition, underscoring the OFC's pivotal role in regulating depressive states. …”
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Gain of bipolar disorder-related lncRNA AP1AR-DT in mice induces depressive and anxiety-like behaviors by reducing Negr1-mediated excitatory synaptic transmission by Shufen Li, Hongyu Ni, Yaping Wang, Xiaohui Wu, Jianqiang Bi, Haiyan Ou, Zhongwei Li, Junjiao Ping, Zhongju Wang, Renhao Chen, Qiong Yang, Meijun Jiang, Liping Cao, Tingyun Jiang, Siqiang Ren, Cunyou Zhao

“…Conclusions The epigenetic and pathophysiological mechanism linking AP1AR-DT to the modulation of depressive and anxiety-like behaviors and excitatory synaptic function provides etiological implications for bipolar disorder.…”
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Preliminary Assessment of Hematopoietic Cell Kinase Gene Expression in Wistar Rats Fed SAMPEA-11 and SAMPEA 20T Diets by Stephen Dio Titus, Salisu Muhammed, Priscila Benjamin, Achilus Francis, Samuel Gadzama Ishaya, Christian Nelson, Kennedy Banja Samuel, Shuaibu M. Bala

“…This study contributes to the growing body of knowledge on the dietary modulation of immune function and underscores the potential health benefits of SAMPEA-11 and SAMPEA 20T in immune regulation.…”
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Oral cannabidiol did not impair learning and memory in healthy adults by Hanna H. Gebregzi, Joanna S. Zeiger, Jeffrey P. Smith, Libby Stuyt, Luann Cullen, Jim Carsella, Daniel C. Rogers, Jordan Lafebre, Jennah Knalfec, Alfredo Vargas, Moussa M. Diawara

“…However, age might influence CBD related modulation of proactive interference during human L&M. …”
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Muscarinic acetylcholine receptor activated effectors in principal neurons of the rat basolateral amygdala by Todd J. Sahagian, Scott W. Harden, Jennifer L. Bizon, Jennifer L. Bizon, Barry Setlow, Barry Setlow, Charles J. Frazier, Charles J. Frazier

“…Cholinergic signaling systems modulate neural excitability to influence information processing in the BLA. …”
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Preparation, structural property, and antioxidant activities of a novel pectin polysaccharide from the flowers of Hibiscus syriacus Linn. by Jialong Chen, Chaojun Ye, Lu Zhang, Zhiliang Xie, Jianjun Zhu, Zhi Zhang

“…These findings suggest that HFPS exerts its antioxidant effects by modulating the Nrf2/HO-1 pathway and redox homeostasis.DiscussionThis study contributes to the understanding of the structure-function relationships and antioxidant mechanisms of HFPS, highlighting its potential applications as a natural antioxidant in various fields.…”
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Robust Infrared–Visible Fusion Imaging with Decoupled Semantic Segmentation Network by Xuhui Zhang, Yunpeng Yin, Zhuowei Wang, Heng Wu, Lianglun Cheng, Aimin Yang, Genping Zhao

“…Additionally, we design a refined loss function that employs the decoupling network to constrain the pixel distributions in the fused images and produce more-natural fusion images. …”
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Structure-guided deep learning for back acupoint localization via bone-measuring constraints by Yulong Wang, Tian Lan, Wenjian Dou, Zhi Chen, Song Zhang, Gong Chen, Gong Chen

“…The method employs an HRFormer backbone network combined with a Structure-Guided Keypoint Estimation Module (SG-KEM) and a structure-constrained loss function, ensuring anatomically consistent predictions within a standardized spatial coordinate system to improve accuracy across diverse body types. …”
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DMFFNet: Dual-Mode Multiscale Feature Fusion-Based Pedestrian Detection Method by Ruizhe Hu, Ting Rui, Yan Ouyang, Jinkang Wang, Qunyan Jiang, Yinan Du

“…Finally, we optimize the loss function to reflect the distance between the predicted box and the real box more realistically as well as to enhance the ability of the network toward predicting difficult samples. …”
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Development and Experiment of Adaptive Oolong Tea Harvesting Robot Based on Visual Localization by Ruidong Yu, Yinhui Xie, Qiming Li, Zhiqin Guo, Yuanquan Dai, Zhou Fang, Jun Li

“…Our algorithm leverages prior knowledge about tea bush stem characteristics, uses the Tukey loss function to enhance robustness to outliers, and incorporates workspace constraints to ensure that the cutting tool remains within feasible operational limits. …”
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