Antiviral effects and mechanism of Ma-Xing-Shi-Gan-San on porcine reproductive and respiratory syndrome virus by Miao Zhang, Jiankun Huang, Qingan Chi, Xuhua Ran, Xiaobo Wen

“…Furthermore, pathway and functional enrichment analysis revealed that the impact of MXSGS on PRRSV mainly involved Toll-like receptor signaling pathway, typical NF-κB signaling, positive regulation of interleukin-6 production, Th17 cell differentiation, inflammatory response, and viral defense response. …”
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Deciphering the role of Hashimoto's Thyroiditis-related key genes in thyroid cancer via detailed in silico analysis followed by the experimental validation by Mostafa A. Abdel-Maksoud, Taghreed N. Almana, Saeedah Almutair, Abdulaziz Alamri, Ibrahim A. Saleh, Mohamed Y. Zaky, Wahidah H. Al-Qahtani, Yasir Hameed

“…The impact of BRAF overexpression on SW579 cells was assessed through various functional assays. Overexpression of BRAF resulted in reduced cell proliferation, colony formation, and wound healing, which may reflect context-dependent effects. …”
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Lactoferrin-derived peptide PXL01 impacts nerve regeneration after sciatic nerve reconstruction in healthy and diabetic rats by Derya Burcu Hazer Rosberg, Derya Burcu Hazer Rosberg, Margit Mahlapuu, Raquel Perez, Raquel Perez, Lars B. Dahlin, Lars B. Dahlin, Lars B. Dahlin

“…IntroductionAlthough advanced surgical techniques are available, satisfactory functional outcomes after peripheral nerve injuries are uncommon. …”
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Quantitative proteomic analysis of the protective effect exerted by alliin on ox-LDL-injured HUVECs by Yuan-yuan Tang, De Lv

“…Among the quantified proteins, a statistical t-test with P < 0.05 was used as a threshold for significance regarding a 1.5-fold change in differential expression. Finally, functional enrichment analysis of the differential proteins in the Alliin/Mod group was performed using Gene Ontology (GO) enrichment and KEGG pathway analysis. …”
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Profiling of Circulating Cell-free DNA Methylation Patterns Identifies Aberrant Methylated CTBP1 Promotor Sites for Prediction of Alzheimer’s Disease by Zhiwu Dong, Kewen Zhao, Hongjun Gu, Wenwei Yang, Xin Zhang

“…Results: A unique DNA methylation landscape in peripheral blood was characterized for AD patients and 4335 MVPs showed significant differential methylation (p < 0.01). Functional annotation and pathway enrichment analysis underscored processes and pathways inherent in the nervous system. …”
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The role of the gut microbiome in cardiovascular disease by Mateusz Świątko, Paweł Sosnowski, Joanna Rybak, Marcin Grzebyk, Anna Tokarska, Aleksandra Arnista, Katarzyna Gawrońska, Agnieszka Waszczuk, Aleksandra Kołodziejczyk, Piotr Łapiński

“… In recent years, the gut microbiome has gained increasing recognition as a crucial modulator of physiological homeostasis, including cardiovascular function. …”
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Terpenoids: A promising traditional chinese medicine for neuropathic pain relief by Hui-Si Yang, David H. Mauki, Yue-Xiang Zheng, Ting-Hua Wang, Xiu-Ying He

“…These compounds alleviate NPP by: inhibiting neuroinflammation and oxidative stress, regulating mitochondrial function, modulating ion channels, and influencing the cannabinoid and opioid receptor systems. …”
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The significance of reactive oxygen species in the formation of calcium oxalate stones and the protective effects of antioxidants on the kidneys by XiaoLong Ying, XiaoLong Ying, XiaoLong Ying, Yang Chen, Yang Chen, Yang Chen, ZongYao Hao, ZongYao Hao, ZongYao Hao, HaoRan Liu, HaoRan Liu, HaoRan Liu

“…In this review, we endeavor to elucidate the contributory role of ROS in kidney stone and explore the protective mechanisms by which certain antioxidants safeguard renal function.…”
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Fatty acid amide hydrolase levels in brain linked with threat-related amygdala activation by Duncan GJ. Green, Duncan J. Westwood, Jinhee Kim, Laura M. Best, Stephen J. Kish, Rachel F. Tyndale, Tina McCluskey, Nancy J. Lobaugh, Isabelle Boileau

“…Methods: Twenty-eight healthy participants completed a positron emission tomography (PET) scan with the radiotracer for FAAH, [11C]CURB, as well as a block-design functional magnetic resonance imaging session during which angry and fearful faces meant to activate the amygdala were presented. …”
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Reduced Levels of miR-145-3p Drive Cell Cycle Progression in Advanced High-Grade Serous Ovarian Cancer by Eva González-Cantó, Mariana Monteiro, Cristina Aghababyan, Ana Ferrero-Micó, Sergio Navarro-Serna, Maravillas Mellado-López, Sarai Tomás-Pérez, Juan Sandoval, Antoni Llueca, Alejandro Herreros-Pomares, Juan Gilabert-Estellés, Vicente Pérez-García, Josep Marí-Alexandre

“…Further investigation confirmed that DNA methylation controls <i>MIR145</i> expression. Functional assays showed that overexpression of miR-145-3p significantly reduced cell migration and induced G0/G1 cell cycle arrest by modulating the cyclin D1-CDK4/6 pathway. …”
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Identification and validation of a prognostic risk model based on radiosensitivity-related genes in nasopharyngeal carcinoma by Yi Li, Xinyi Hong, Wenqian Xu, Jinhong Guo, Yongyuan Su, Haolan Li, Yingjie Xie, Xing Chen, Xiong Zheng, Sufang Qiu

“…Additional analyses included functional pathway, immune infiltration, and drug sensitivity. …”
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Chitinase-1 inhibition attenuates metabolic dysregulation and restores homeostasis in MASH animal models by Katarzyna Drzewicka, Katarzyna M. Głuchowska, Michal Mlącki, Bartłomiej Hofman, Irina Tuszyńska, Tristram A. J. Ryan, Katarzyna Piwowar, Bartosz Wilczyński, Dorota Dymkowska, Marcin M. Grzybowski, Barbara Dymek, Tomasz Rejczak, Kamil Lisiecki, Adam Gołębiowski, Adam Jagielski, Angelika Muchowicz, Dylan Ryan, Krzysztof Zabłocki, Luke A. J. O’Neill, Zbigniew Zasłona

“…In addition to reducing inflammation and fibrosis observed in the rat model, RNA-Seq demonstrated that OATD-01 regulated key metabolic processes such as acetyl-CoA metabolism, triglyceride metabolism, cholesterol synthesis, cholesterol flux, and glycolysis. Using functional assay performed on bone marrow-derived macrophages (BMDMs) we demonstrated that both genetic and pharmacological inactivation of CHIT1 resulted in inhibition of glucose uptake. …”
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Enhanced spin polarization in GQDs/TiO2 fibers via magnetic field and oxygen vacancies for photocatalysis by Yu-Ze Sun, Jin-Hua Liu, Zhi Li, Li-Peng Qiu, Jia-Bin Song, Shuai-Jie Wang, Zhen Zhang, Ru Li, Hong-Di Zhang, Wen-Peng Han, Jun Zhang, Yun-Ze Long

“…Oxygen vacancies, as key active sites, enabled spin polarization during the photocatalytic reaction, and the material’s spin polarization was verified by X-ray Absorption Spectroscopy (XAS) and Density Functional Theory (DFT). For the first time, the effects of high magnetic fields (1000–5000 mT) on photocatalytic performance were systematically explored. …”
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Copper ion diffusion by solid solution treatment advancing GeTe-based thermoelectrics by Yongqi Chen, Meng Li, Xiaodong Wang, Wenyi Chen, Siqi Liu, Min Zhang, Wanyu Lyu, Nanhai Li, Han Gao, Weidi Liu, Xiao-Lei Shi, Zhi-Gang Chen

“…This work not only explains the kinetics behind dynamic doping behaviours, but also provide an original method to achieve high-quality functional materials with less lattice defects and a high carrier mobility.…”
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Preliminary analysis of wave retrieval from Chinese Gaofen-3 SAR imagery in the Arctic Ocean by Wei-Zeng Shao, Chi Zhao, Xing-Wei Jiang, Wei-Li Wang, Wei Shen, Jun-Cheng Zuo

“…A comparison of the HY-2B winds with the wind speeds generated by the geophysical model function (GMF) CMOD5.N showed a 3.36 m/s root mean square error (RMSE) with a correlation (COR) of 0.66. …”
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Unlocking the epigenetic code: new insights into triple-negative breast cancer by Gowthami Mahendran, Ann Dharshika Shangaradas, Ricardo Romero-Moreno, Nadeeshika Wickramarachchige Dona, S. H. G. Sumudu Sarasija, Sumeth Perera, Gayathri N. Silva

“…We explore the efficacy of histone deacetylase inhibitors (HDACi), which have shown promise in reversing aberrant histone deacetylation patterns, thereby restoring normal gene function, and suppressing tumor growth. Furthermore, the review highlights the dual role of miRNAs in TNBC as both oncogenes and tumor suppressors and discusses the therapeutic potential of miRNA mimics and inhibitors in modulating these regulatory molecules to inhibit cancer progression. …”
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Comparing the effect of transcranial random noise stimulation and transcranial direct current stimulation over the motor cortex on motor performance in men vs. women: a randomized... by Elchanan Frankel, Jason Friedman, Jason Friedman, Silvi Frenkel-Toledo, Silvi Frenkel-Toledo

“…Non-invasive Brain Stimulation may modulate motor function. One commonly investigated method is transcranial direct current stimulation (tDCS). …”
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Effects of Lactic Acid and Glyceryl Lactate on Growth Performance, Antioxidant Capacity, and Intestinal Health of Piglets by Shuaiju Guo, Huiling Chu, Bangwang Peng, Junlong Niu, Xiaopeng Yang, Yongpeng Guo, Zhixiang Wang, Wei Zhang

“…In conclusion, glyceryl lactate and its combination with lactic acid improved piglet growth performance by enhancing intestinal barrier function, antioxidant capacity, microbial community structure, and SCFA production.…”
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Cenobamate reduces epileptiform activity in the ex vivo F98 rat glioma model by Ferdinand Forberger, Fabiana Santana Kragelund, Katrin Porath, Rüdiger Köhling, Rüdiger Köhling, Timo Kirschstein, Timo Kirschstein, Falko Lange, Falko Lange

“…Therefore, for the first time, we evaluated the efficacy of cenobamate, a novel anticonvulsant shown to inhibit persistent sodium currents and modulate GABAA receptor function, in a preclinical model of glioma-associated epilepsy. …”
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N-methyl-D-aspartate Receptors and Depression: Linking Psychopharmacology, Pathology and Physiology in a Unifying Hypothesis for the Epigenetic Code of Neural Plasticity by Stefano Comai, Sara De Martin, Andrea Mattarei, Clotilde Guidetti, Marco Pappagallo, Franco Folli, Andrea Alimonti, Paolo L. Manfredi

“…This NMDAR Ca²⁺ quantal hypothesis for the epigenetic code of neural plasticity integrates recent psychopharmacology findings into established physiological and pathological mechanisms of brain function.…”
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