Functional Dyspepsia: Subtypes, Risk Factors, and Overlap with Irritable Bowel Syndrome in a Population of African Patients by Sylvester Chuks Nwokediuko, Uchenna Ijoma, Olive Obienu

“…Patients with upper gastrointestinal symptoms who presented for endoscopy were administered a questionnaire containing the functional dyspepsia and irritable bowel syndrome modules of the Rome III diagnostic criteria. …”
Get full text

In Vitro Co-culture of Bacterial and Mammalian Cells to Investigate Effects of Potential Probiotics on Intestinal Barrier Function by Ajitpal Purba, Rachel Anderson, Dulantha Ulluwishewa

“…Human intestinal barrier function is crucial for health. Beneficial microbes, such as commensal gut bacteria and probiotics, are known to contribute to the regulation of this barrier function. …”
Get full text

Spatial and functional profiles distinguish target sets of Parkinson’s disease and antipsychotic drugs with different clinical effects by Kalyani B. Karunakaran, Sanjeev Jain, Darius Widera, Graeme S. Cottrell

“…In summary, our study identified specific spatial and functional features that distinguish the target sets of PD and antipsychotic drugs with different clinical effects.…”
Get full text

Effects of Increasing the Nitrogen–Phosphorus Ratio on the Structure and Function of the Soil Microbial Community in the Yellow River Delta by Jinzhao Ma, Zehao Zhang, Jingkuan Sun, Tian Li, Zhanyong Fu, Rui Hu, Yao Zhang

“…The response of the BS and the RS bacterial community to the N:P ratio differed, as influenced by soil organic carbon (SOC) content in terms of diversity, community composition, mutualistic networks, and functional composition. This study demonstrates that the effect of the N:P ratio on soil bacterial community is different for plant roots and emphasizes the role of plant roots in shaping soil bacterial community during environmental change.…”
Get full text

From fragmented to functional: Improving rehabilitation data in Georgia's health information systems for better decision-making by Nino Kotrikadze, Akaki Zoidze, George Gotsadze

“…The UHCP facilities employ the functional assessment tool but no standardized reporting persist. …”
Get full text

Systematic identification of post-transcriptional regulatory modules by Matvei Khoroshkin, Andrey Buyan, Martin Dodel, Albertas Navickas, Johnny Yu, Fathima Trejo, Anthony Doty, Rithvik Baratam, Shaopu Zhou, Sean B. Lee, Tanvi Joshi, Kristle Garcia, Benedict Choi, Sohit Miglani, Vishvak Subramanyam, Hailey Modi, Christopher Carpenter, Daniel Markett, M. Ryan Corces, Faraz K. Mardakheh, Ivan V. Kulakovskiy, Hani Goodarzi

“…This study provides a detailed map of RBP interactions and deconvolves them into distinct regulatory modules with annotated functions and target regulons. …”
Get full text

Metagenomic and physicochemical profiling reveal microbial functions in pit mud for Jiang-Nong Jianxiang Baijiu fermentation by Lianbin Cao, Hongmei Sun, Ziyi Xu, Xiaoxiao Xu, Guangchuan Shi, Jianqiang Zhang, Changli Liang, Tongbiao Li, Chaoying Liu, Mingcheng Wang, Shilin Tian, Enzhong Li

Get full text

Enhanced inhibitory effects of GABA on renal and hepatic function, molecular profiles, and histological changes in male albino mice by Mohammed Abdullah Ajeel, Israa A. Al-Robaiee

“…The histological changes were detected using hematoxylin and eosin histopathological examination. Liver and kidney function test were utilized to detect any functional changes. …”
Get full text

An influence of a modulating signal starting phase on the modulation detection by A. P. SĘK, E. B. SKRODZKA

“…This paper is concerned with an influence of a modulator starting phase on psychometric functions of amplitude modulation (AM) and frequency modulation (FM) detection, for low modulation rates, i.e. fmod = 2 and 5 Hz. …”
Get full text

YOLOGX: an improved forest fire detection algorithm based on YOLOv8 by Caixiong Li, Yue Du, Xing Zhang, Peng Wu

Subjects: Get full text

A comparative study of visual outcome of two extended depth of focus intraocular lenses after cataract surgery by Alaa Badawy, Mohamed Hosny, Mohamed Anis, Sarah Azzam, Yehia Salah

Subjects: Get full text

PK2/PKR1 Signaling Regulates Bladder Function and Sensation in Rats with Cyclophosphamide-Induced Cystitis by Biao Chen, Huiping Zhang, Lili Liu, Jiaojiao Wang, Zhangqun Ye

“…Combining a nonselective antagonist of prokineticin receptors (PKRA), we further evaluated the regulatory role of PK2 in modulating bladder function and visceral pain sensation via conscious cystometry and pain behavioral scoring. …”
Get full text

Biological Functions and Clinical Implications of CFLAR: From Cell Death Mechanisms to Therapeutic Targeting in Immune Regulation by Zhang H, Li X, Lin L

“…This review provides an in-depth exploration of CFLAR’s structural and functional properties, focusing on its involvement in apoptosis, autophagy, and immune modulation. …”
Get full text

Regulation and Function of the cGAS-STING Pathway: Mechanisms, Post-Translational Modifications, and Therapeutic Potential in Immunotherapy by Chen Y, Yue S, Yu L, Cao J, Liu Y, Deng A, Lu Y, Yang J, Li H, Du J, Xia J, Li Y, Xia Y

“…These modifications are interconnected and collectively influence pathway functionality. We summarize the functions of cGAS-STING and its PTMs in immune and non-immune cells across various diseases, and explore potential clinical applications.Keywords: cGAS, STING, immunity, immunotherapy, post-transcriptional regulation…”
Get full text

Immune and Angiogenic Profiling of Mesenchymal Stem Cell Functions in a Subcutaneous Microenvironment for Allogeneic Islet Transplantation by Jocelyn Nikita Campa‐Carranza, Simone Capuani, Ashley L. Joubert, Nathanael Hernandez, Tommaso Bo, Octavio I. Sauceda‐Villanueva, Marzia Conte, Letizia Franco, Marco Farina, Gabrielle E. Rome, Yitian Xu, Junjun Zheng, Lissenya B. Argueta, Jean A. Niles, Fotis Nikolos, Corrine Ying Xuan Chua, Shu‐Hsia Chen, Joan E. Nichols, Norma S. Kenyon, Alessandro Grattoni

“…Importantly, this work discovers sex‐specific differences in both processes, which influence islet engraftment and long‐term function.…”
Get full text

Intermittent fasting reduces alpha-synuclein pathology and functional decline in a mouse model of Parkinson’s disease by Éva M. Szegő, Lennart Höfs, Anna Antoniou, Elisabeth Dinter, Nadine Bernhardt, Anja Schneider, Donato A. Di Monte, Björn H. Falkenburger

“…IF, initiated four weeks post-induction of aSyn pathology, improved motor function and reduced dopaminergic neuron and axon terminal degeneration. …”
Get full text

Effects of sensory room intervention on autonomic function in healthy adults: A pilot randomized controlled trial. by Hikari Otsuka, Keisuke Irie, Tomohiro Kogata, Azumi Onitsuka, Hiroyuki Inadomi

“…As a result, 1) SRI significantly increased RSA compared with SA. 2) It also reduced the variability of RSA in response to specific sensory stimuli compared with SA. 3) However, no significant differences existed in negative mood or attentional function between the groups. The results suggest that sensory rooms might contribute to the sensory modulation, including that of the autonomic nervous system. …”
Get full text

CD73 promotes the immunoregulatory functions of hepatic Tregs through enzymatic and nonenzymatic pathways in MASLD development by Hua Jin, Xinjie Zhong, Chunpan Zhang, Yongle Wu, Jie Sun, Xiyu Wang, Zeyu Wang, Jingjing Zhu, Yuan Jiang, Xiaonan Du, Zihan Zhang, Dong Zhang, Guangyong Sun

“…Regulatory T cells (Tregs) highly express CD73 and play a critical role in modulating the immune response. However, the roles and mechanisms by which CD73 modulates Tregs in MASLD are still unknown. …”
Get full text

Aspartate Metabolism‐Driven Gut Microbiota Dynamics and RIP‐Dependent Mitochondrial Function Counteract Oxidative Stress by Shunshun Jin, Jian Wu, Chenyu Wang, Yiwen He, Yulong Tang, Le Huang, Hui Zhou, Di Liu, Ziping Wu, Yanzhong Feng, Heshu Chen, Xinmiao He, Guan Yang, Can Peng, Jiazhang Qiu, Tiejun Li, Yulong Yin, Liuqin He

“…These results demonstrate that Asp signaling alleviates oxidative stress by dynamically modulating the gut microbiota and RIP‐dependent mitochondrial function, providing a potential therapeutic strategy for oxidative stress disease treatment.…”
Get full text

Transcription of GABAA receptor subunits in circulating monocytes and association to emotional brain function in premenstrual dysphoric disorder by Louise Stiernman, Erika Comasco, Maja Johansson, Marie Bixo

“…We related mRNA subunit expression to serum levels of neurosteroids and to functional activation of the amygdala, a key brain region involved in emotion generation, measured using functional magnetic resonance imaging (fMRI). …”
Get full text