Exploring the anti-inflammatory mechanism of geniposide in rheumatoid arthritis via network pharmacology and experimental validation by Meng Huang, Jing Jiang, Yue-Jia li, Meng-Ying Jiang, Min Yang, Hui Deng, Yong-Gang Wu, Li-Juan Wu, Xiao Leng, Jian-Lin Chen, Wen-Kui Sun

“…Abstract Rheumatoid arthritis (RA) is a chronic autoimmune disease that affects millions worldwide, characterized by joint pain, swelling, and functional impairment. Current treatments like Non-steroidal anti-inflammatory drugs (NSAIDs), corticosteroids, and biologics, have limitations including side effects and resistance problems, which create a need for new therapeutic strategies. …”
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37LRP induces invasion in hypoxic lung adenocarcinoma cancer cells A549 through the JNK/ERK/c-Jun signaling cascade by Yongan Zhou, Yafang Wang, Zhengwei Zhao, Yanxia Wang, Ning Zhang, Helong Zhang, Lili Liu

“…Electrophoresis mobility shift assay and chromatin immunoprecipitation demonstrated a functional activator protein 1 binding site within 37-kDa laminin receptor precursor gene regulatory sequence located at −271 relative to the transcriptional initiation point. …”
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CSEPC: a deep learning framework for classifying small-sample multimodal medical image data in Alzheimer’s disease by Jingyuan Liu, Xiaojie Yu, Hidenao Fukuyama, Toshiya Murai, Jinglong Wu, Qi Li, Zhilin Zhang

“…The architecture first extracts balanced multiscale features from structural MRI (sMRI) data and functional MRI (fMRI) data using a cross-scale pyramid module. …”
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Isocitrate Dehydrogenase-Wildtype Glioma Adapts Toward Mutant Phenotypes and Enhanced Therapy Sensitivity Under D-2-Hydroxyglutarate Exposure by Geraldine Rocha, Clara Francés-Gómez, Javier Megías, Lisandra Muñoz-Hidalgo, Pilar Casanova, Jose F. Haro-Estevez, Vicent Teruel-Martí, Daniel Monleón, Teresa San-Miguel

“…<b>Methods:</b> Experiments were conducted using <i>IDH</i>-wildtype (<i>IDH</i>-wt) and <i>IDH</i>-mutant (<i>IDH</i>-mut) glioma cell lines under controlled oxygen conditions. Functional assays included cell viability, cell cycle analysis, apoptosis profiling, migration, and surface marker expression via flow cytometry. …”
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Atmosphere regulation: unraveling effective strategies for creating high-performance iron ore/biochar composite nanomaterials in ball milling processes by Hui Zhang, Zi Cheng, Kai Hu, Boxiong Shen, Honghong Lyu, Jingchun Tang

“…Specifically, the composites ball-milled under nitrogen atmosphere exhibited smaller particle sizes, larger specific surface area (ascending from 27.0 to 187.6 m2 g−1), and richer distribution of surface functional groups and Fe(II) species. All these characteristics significantly enhanced their redox activities. …”
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Effects of water and fertilizer management on soil bacterial communities, enzyme activities, and nutrient availability in greenhouse tomatoes. by Xiaona Lyu, Hasnuri Mat Hassan, Yaling Zan, Jiongrui Tan

“…Microbial communities under I2 (PCo1 = 11.13%) showed greater homogeneity while preserving treatment-specific patterns, suggesting slight deficit irrigation balances stability and functional differentiation. The C1 treatment also elicited the most pronounced enhancement in soil enzyme activities, particularly phosphatase (PHO, 9.51 mg g ⁻ ¹) and catalase (CAT, 2.29 mL g ⁻ ¹). …”
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Bibliometric and visualization analysis of hydrogel research in spinal cord injury: comparative study of Chinese and English literature by Wenju Bai, Xiaoyuan Huang, Jian Liu, Kamiran Halike, Jinyong Li, Xv Zhang, Tengwu Chang, Jichao Wang

“…., Chuanxiongzine and stem cell transplantation), while WoSCC demonstrates notable advantages in establishing therapeutic loops encompassing drug delivery systems, functional recovery evaluation, and neuroimmune modulation strategies.ConclusionBy integrating WoSCC and CNKI data, this study comprehensively elucidates geographical disparities in research priorities between China and the global scientific community regarding hydrogel-mediated SCI repair, thereby proposing an evidence-based framework for international collaborative innovation. …”
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Electrical Properties of Cu-Based Coordination Complexes: Insights from In Situ Impedance Spectroscopy by Jana Pisk, Marko Dunatov, Martina Stojić, Nenad Judaš, Ivica Đilović, Marta Razum, Luka Pavić

“…This study underscores the pivotal role of ligand modifications in modulating the functional properties of coordination complexes, offering valuable insights for the advancement of materials chemistry.…”
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Physical–Mathematical Modeling and Simulations for a Feasible Oscillating Water Column Plant by Fabio Caldarola, Manuela Carini, Alessandro Costarella, Gioia De Raffele, Mario Maiolo

“…Lastly, the study also discusses the additional structural and functional benefits of inclined walls over traditional parallelepiped-shaped chambers, both from a structural and construction point of view, and for the possible use for coastal defense.…”
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<i>Artemisia absinthium</i> L. Extract Targeting the JAK2/STAT3 Pathway to Ameliorate Atherosclerosis by Jiayi Yang, Tian Huang, Lijie Xia, Jinyao Li

“…It holds potential value for development as a functional food or drug for the prevention and treatment of atherosclerosis.…”
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Quantitative Analysis of Ginger Maturity and Pulsed Electric Field Thresholds: Effects on Microstructure and Juice’s Nutritional Profile by Zhong Han, Pan He, Yu-Huan Geng, Muhammad Faisal Manzoor, Xin-An Zeng, Suqlain Hassan, Muhammad Talha Afraz

“…Collectively, these results reveal a maturity-dependent mechanism of electro-permeabilization in plant tissues, offering new insights into optimizing non-thermal processing for functional food production.…”
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Expression characteristics of metabotropic glutamate receptor 4 in cochlear hair cells during early postnatal stages in mice by CHEN Zhiji, LIU Xuelai, ZHOU Xiaoqing

“…Conclusion‍　‍Postnatal upregulation of mGluR4 at IHC synaptic regions correlates with functional maturation. These findings suggest mGluR4 may modulate vesicular exocytosis regulation and exert pharmacological inhibition on glutamate release, potentially influencing synaptic plasticity during auditory pathway refinement. …”
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Unraveling the molecular mechanisms of paclitaxel in high-grade serous ovarian cancer through network pharmacology by Yihao Pei, Ziqi Yang, Ben Li, Xiping Chen, Yiming Mao, Yun Ding

“…Their protein expression patterns in HGSOC tissues were validated using the Human Protein Atlas (HPA) database. Functional enrichment analysis was conducted using Gene Ontology and the Kyoto Encyclopedia of Genes and Genomes. …”
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Soil and climate factors affect the nutrient resorption characteristics of desert shrub roots in Xinjiang, China by Yan Luo, Yan Luo, Yan Luo, Wenya Wei, Yaxuan Wang, Tianai Xue, Kaijuan Du

“…Our study was designed to compare nutrient resorption efficiency patterns among shrub species and assess how the these patterns respond to variations in climatic conditions and edaphic properties.ResultsThe results indicated that nitrogen resorption efficiency (NRE), phosphorus resorption efficiency (PRE), and potassium resorption efficiency (KRE) for all plants were 29.14 ± 0.98%, 37.58 ± 0.92%, and 42.20 ± 0.93%, respectively. Among functional groups, angiosperms exhibited higher PRE (36.31 ± 1.00%) and KRE (41.85 ± 0.98%) than gymnosperms. …”
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Structural characterization of a purified polysaccharide from Chrysanthemum vestitum and its effects on acute lung injury in mice by Shujuan Xue, Ruixue Li, Jishu Wang, Xiaojun Li, Yuchen Guo, Yisen Qiao, Bao Zhang, Lili Wang, Suiqing Chen

“…These findings indicate that CVP_C has potential for use as a natural anti-inflammatory agent and functional food ingredient for the promotion of respiratory and gastrointestinal health. …”
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Zebrafish as a model system for studying reproductive diseases by Wenwen Zha, Weitao Hu, Chenkai Ge, Jianjun Chen, Jianjun Chen, Zigang Cao

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Study on the molecular mechanism of UBA52 and BARD1 regulating hepatocellular carcinoma through the PI3 K/AKT signaling pathway by Chenrui Yang, Yanzhong Zhang, Yajuan Liu, Xiaoyong Wu, Fangyuan Sun

“…Methods This study integrated HCC datasets (GSE135631, GSE184733, GSE202853) from the gene expression omnibus (GEO) database to screen for differentially expressed genes (DEGs), perform functional enrichment analysis, weighted gene co-expression network analysis (WGCNA), construct protein–protein interaction (PPI) networks, and conduct survival analysis. …”
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Defect and solvent engineering of optoelectronic response in 2D materials: A DFT study on graphene, silicon carbide, and boron nitride for solar cell sensitizers by Mohammed A. Al-Seady, Lina Abd Oun AL-Jamal, Eman Ahmed, Mousumi Upadhyay Kahaly

“…In the present investigation, the geometrical, electronic, photovoltaic parameters, and optical properties of graphene (G), silicon carbide (SiC), and boron nitride (BN) nanostructures were studied using density functional theory (DFT) and time-dependent DFT (TD-DFT) methods. …”
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Sciatic nerve injury treated by acupuncture: a bibliometric study and visualization analysis by Yan Wang, Yan Wang, Fei Pei, Yahui Wang, Lijie Lv, Tianyi Li, Shujin Wang, Huan Qin

“…Based on the keyword emergence, it is predicted that future studies will continue to focus on acupuncture treatment, functional recovery after SNI, and spinal cord injury, which may become the research hotspots in this field. …”
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Characterization of Mucosal Immune-Related lncRNAs and mRNAs in a Mouse Model of Allergic Conjunctivitis by Zhang H, Zhang H, Leng Q, Zheng YJ

“…Differential gene expression was identified using DESeq2, and functional enrichment was analyzed using GO, KEGG, and GSEA. …”
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