Gut microbiota-derived SCFAs and MetS-related nephropathy by Xiaofang Tian, Li Sun, Shengjie Guo, Liying Yuan, Tang Zhang, Chengqian Huang, Tingting He, Qianfeng Jiang, Yizhou Zeng

“…Particularly, considerable research has suggested that gut microbiota-derived short-chain fatty acids (SCFAs) have an intimate relationship with MetS-related nephropathy. The functions of SCFAs are involved in modulating energy metabolism, regulating immune and inflammatory responses, and inhibiting oxidative stress and mitochondrial damage, which are mainly through the activation of transmembrane G protein-coupled receptors (GPRs) and the inhibition of Histone deacetylase activity (HDAC). …”
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Oxidative Nanopatterning of Titanium Surface Influences mRNA and MicroRNA Expression in Human Alveolar Bone Osteoblastic Cells by Maidy Rehder Wimmers Ferreira, Roger Rodrigo Fernandes, Amanda Freire Assis, Janaína A. Dernowsek, Geraldo A. Passos, Fabio Variola, Karina Fittipaldi Bombonato-Prado

“…Among the treated surfaces, we observed an increase of alkaline phosphatase activity as a function of the surface texture, with higher activity shown by cells adhering onto nanotextured surfaces. …”
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Proximity‐dependent biotinylation reveals an interaction between ubiquitin‐specific peptidase 46 and centrosome‐related proteins by Kazuma Yoshioka, Reiko Nakagawa, Chi Lieu Kim Nguyen, Hayate Suzuki, Kiyohiro Ishigaki, Seiya Mizuno, Tsukasa Okiyoneda, Shizufumi Ebihara, Kazuya Murata

“…Protein ubiquitination extensively modulates protein functions and controls various biological processes, such as protein degradation, signal transduction, transcription, and DNA repair. …”
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Preventive Effects of Chitosan Coacervate Whey Protein on Body Composition and Immunometabolic Aspect in Obese Mice by Gabriel Inácio de Morais Honorato de Souza, Aline Boveto Santamarina, Aline Alves de Santana, Fábio Santos Lira, Rachel de Laquila, Mayara Franzoi Moreno, Eliane Beraldi Ribeiro, Claudia Maria da Penha Oller do Nascimento, Bruno Rodrigues, Elisa Esposito, Lila Missae Oyama

“…Functional foods containing bioactive compounds of whey may play an important role in prevention and treatment of obesity. …”
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PI3K/AKT signaling mediates stress-inducible amyloid formation through c-Myc by Emma Lacroix, Evgenia A. Momchilova, Sahil Chandhok, Mythili Padavu, Richard Zapf, Timothy E. Audas

“…Summary: In response to environmental stress, eukaryotic cells reversibly form functional amyloid aggregates called amyloid bodies (A-bodies). …”
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Proline-2′-deoxymugineic acid, a phytosiderophore analog, drives beneficial rhizobacterial community formation to promote peanut micronutrition by Tianqi WANG, Nanqi WANG, Kunguang WANG, Qiaofang LU, Zhechao DOU, Zhiguang CHI, Dongming CUI, Motofumi SUZUKI, Yuanmei ZUO

“…PDMA application led to the development of a tight, stable microbial network, as indicated by higher topological parameters and a greater variety of keystone genera. Functional prediction revealed that PDMA fosters microbial communication in the rhizosphere. …”
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Glycosaminoglycan sugar side chains on perineuronal nets in the fastigial nucleus regulate motor skills by Man Han, Peng Fu, Chuan-lin Zhang, Jing-wen Duan, Tong Wu, Yan Zeng

“…Summary: Perineuronal nets (PNNs), composed primarily of chondroitin sulfate proteoglycans with core proteins and glycosaminoglycan (GAG) side chains, are specialized extracellular matrices that modulate synaptic transmission. However, the specific function of PNNs in the cerebellum, particularly in the fastigial nucleus (FN), and their influence on motor skill regulation remains unclear. …”
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Comparative analysis of centrally mediated and inflammatory pain experiences amongst patients diagnosed with rheumatoid arthritis: A multimethods study by Zoe Rutter‐Locher, Tom Esterine, Ruth Williams, Leonie S. Taams, Kirsty Bannister, Bruce W. Kirkham, Heidi Lempp

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Comparative analysis of Microtus fortis and murine hosts reveals a correlation between BRD4 and hepatic inflammation during Schistosoma japonicum infection by Ming Yuan, Mingrou Wu, Yunyi Hu, Siyu Zhao, Jehangir Khan, Zhanhong Yuan, Yun Huang, Tianqiong He, Zhijun Zhou, Jia Shen, Zhongdao Wu

“…BRD4-associated gene expression patterns were analyzed through correlation-based classification, followed by protein–protein interaction network construction and functional enrichment analyses. In addition, BRD4 was pharmacologically inhibited in vivo using JQ1, and hepatic inflammation and worm load were evaluated at 14 days post-infection. …”
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Pericytes in castration-resistant prostate cancer associated with disease progression and immunotherapy response: insights from single-cell analysis by Yifeng Qiu, Yuhan Wang, Jiahe Liu, Kai Sun, Shigeo Horie, Zhitong Bing, Qi Hou

“…Subsequently, we thoroughly delineated the phenotypic and functional characteristics of the CRPC-pericytes subpopulation. …”
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A synergistic blend of dietary organic acids, monoglycerides and phytobiotics enhance growth performance, intestinal mucosal height, and anti-viral immune gene expression in juveni... by Charlene Goh, Susan Gibson-Kueh, David Bal, I.-Tung Chen, Waldo Nuez-Ortín, Jose A. Domingos, Xueyan Shen

“…Recent findings suggest that functional diets provide a broader advantage over the pathogen-specific protection of vaccines by improving growth performance, gut health, and immunity in teleosts. …”
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Comprehensive characterization of lncRNA N6-methyladenosine modification dynamics throughout bovine skeletal muscle development by Cui Mao, Wei You, Yuta Yang, Haijian Cheng, Xin Hu, Xianyong Lan, Enliang Song

“…Conclusions These findings highlight the regulatory and functional significance of dynamic lncRNA methylation in skeletal muscle development.…”
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Fatty acid metabolism shapes immune responses in chronic lymphocytic leukemia by Yang Zhang, Jun Ma, Peipei Li, Kang Lu, Yang Han, Xinting Hu, Xiaosheng Fang, Xin Wang, Ya Zhang

“…Single-cell RNA sequencing was used to analyze the expression of key FAM genes in CLL immune cell subsets and investigate cellular communication. Functional assays, including cell viability, drug sensitivity, and oxygen consumption assays, were performed to assess the impact of fatty acid oxidation (FAO) inhibition on CLL cells. …”
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Targeting APE1/Ref-1 to alleviate formalin-induced pain and spinal neuro-inflammation in rats: a promising therapeutic approach by Eman Elgendy, Amira Zaky, Mayssaa Wahby, Marc Landry, Marc Landry, Ahmad Bassiouny

“…We inhibited the redox function of APE1 using E3330 and assessed its effects on pain behavior. …”
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Green tea polyphenol epigallocatechin-3-gallate mediates an antioxidant response via Nrf2 pathway in heat-stressed poultry: A review by Ibrar Muhammad Khan, Haji Gul, Samiullah Khan, Nourhan Nassar, Anam Khalid, Ayman A. Swelum, Zaigui Wang

“…These responses aim to dissipate heat but often result in energy imbalances, oxidative stress, and impaired immune function. Green tea polyphenols (GTPs) mitigate heat stress in poultry birds by modulating oxidative stress pathways, primarily by scavenging reactive oxygen species (ROS) and enhancing antioxidant defense mechanisms. …”
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New discoveries in therapeutic targets and drug development pathways for type 2 diabetes mellitus under the guidance of precision medicine by Xinyi Tian, Liuqing Wang, Lu Zhang, Xiao Chen, Wenjun Wang, Kaiqi Zhang, Xiaolei Ge, Zhengrong Luo, Xu Zhai, Huaqiang Shao

“…Furthermore, regulating inhibiting serine phosphorylation, reducing proinsulin synthesis, adjusting central nervous system function, modulating transcription factors MondoA and ChREBP, adjusting Omega-3 fatty acid levels, and regulating the mammalian target of rapamycin (mTOR) signaling pathway are also considered promising therapeutic targets. …”
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Metaproteomics in the One Health framework for unraveling microbial effectors in microbiomes by Robert Heyer, Maximilian Wolf, Dirk Benndorf, Sergio Uzzau, Jana Seifert, Lucia Grenga, Martin Pabst, Heike Schmitt, Bart Mesuere, Tim Van Den Bossche, Sven-Bastiaan Haange, Nico Jehmlich, Mariagrazia Di Luca, Manuel Ferrer, Sergio Serrano-Villar, Jean Armengaud, Helge B. Bode, Patrick Hellwig, Catherine Robbe Masselot, Renaud Léonard, Paul Wilmes

“…Here, we highlight the potential of metaproteomics in elucidating microbial effectors and their impact on microbiomes and discuss their potential for modulating microbiomes to foster desired functions. …”
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Integrated microbiome and metabolome analysis reveals a novel interplay between gut microbiota and metabolites in differentiated thyroid carcinoma by Xue Jiang, Qian Liu, Dongkun Xu, Hua Pang, Yuhong Shi

“…Furthermore, Spearman’s rank correlations were utilized to explore the potential functional relationships between the 10 distinctive microbial species and the top 10 differential metabolites. …”
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The Potential Anti-Cancer Effects of Polish Ethanolic Extract of Propolis and Quercetin on Glioma Cells Under Hypoxic Conditions by Małgorzata Kłósek, Anna Kurek-Górecka, Radosław Balwierz, Grażyna Pietsz, Zenon P. Czuba

“…Tissue hypoxia is commonly observed in head cancers and contributes to both molecular and functional changes in tumour cells. It is known to stimulate erythropoiesis, angiogenesis, and metabolic alterations within tumour cells. …”
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Black tea rich in polygonatum sibiricum polysaccharides inhibits osteoporosis in ovariectomized mice through immune regulation and gut microbiota suppression by Shiyu Gao, Yikang Yu, Jialu shu, Biqian Yang, Baiqiao Zhang, Jinhao Xu, Zhenwei Wang

“…CBT has been shown to functional behavioral assessments and bone microstructure, thereby effectively retarding the progression of osteoporosis. …”
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