Long noncoding RNAs in familial hypercholesterolemia: biomarkers, therapeutics, and AI in precision medicine by Hussam Daghistani, Gehan A. Hegazy, Manal Alkhalofah, Afaf Alsobeihy, Sara Nasser, Hoda Gad, Taghreed Shamrani, Mohammed Mufrrih, Dareen Alyousfi

“…Emerging RNA-based therapeutics, including antisense oligonucleotides, small interfering RNAs (siRNAs), and CRISPR-based gene-editing tools, hold promise for modulating lncRNA function to restore lipid homeostasis. …”
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Theaflavin-3,3'-digallate alleviates glucolipotoxicity-induced insulin secretion dysfunction in pancreatic β-TC-6 cells and zebrafish via anti-ferroptotic mechanisms by activating... by Kaixi Wang, Huanqing Zhu, Jiaxin Kang, Shuna Chen, Puming He, Youying Tu, Bo Li

“…Together, this work revealed the critical role of SERCA2 in ferroptosis regulation, and demonstrated TF3 targeted SERCA2 to inhibit ER stress and ferroptosis, thereby protecting β-cell secretory function from glucolipotoxicity.…”
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The Role of Vitamins in Pediatric Urinary Tract Infection: Mechanisms and Integrative Strategies by Joanna Wróblewska, Hanna Złocińska, Marcin Wróblewski, Jarosław Nuszkiewicz, Alina Woźniak

“…Vitamin D strengthens innate immunity by promoting antimicrobial peptide production, such as cathelicidins, and improves epithelial barrier function, while vitamin E mitigates oxidative stress, reducing renal inflammation and tissue damage. …”
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Targeted temperature management alleviates post-resuscitation myocardial dysfunction by inhibiting ferroptosis by Yingying Zhang, Weiwei Du, Ting Kong, Tianfeng Hua, Honghao Ma, Yan Hu, Sinong Pan, Bingrui Ling, Min Yang, Cheng Cheng

“…We found that TTM at 33 °C significantly improved post-resuscitation hemodynamics and myocardial function, reducing both myocardial and mitochondrial damage in the rat model of CA/CPR. …”
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Distribution, Phytochemical Insights, and Cytotoxic Potential of the <i>Sesbania</i> Genus: A Comprehensive Review of <i>Sesbania grandiflora</i>, <i>Sesbania sesban</i>, and <i>Se... by Fatma Alzahraa Mokhtar, Mariam Ahmed, Aishah Saeed Al Dhanhani, Serag Eldin I. Elbehairi, Mohammad Y. Alfaifi, Ali A. Shati, Amal M. Fakhry

“…Notably, sesbanimides derived from <i>S. grandiflora</i> seeds have demonstrated potent cytotoxic effects by disrupting mitochondrial function. While <i>S. sesban</i> and <i>S. cannabina</i> have been less extensively studied, early findings highlight their potential through the inhibition of key cancer pathways and the identification of bioactive compounds such as galactomannan derivatives and 2-arylbenzofurans. …”
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Activated clay and cocoa nib shells-integrated polyvinyl alcohol membranes for fouling mitigation in water treatment by Elikplim Nyabi, Roland Tsoeke Agbetsi, Gideon Addai, Francis Opoku, Mandela Toku, Ray Bright Voegborlo, Eric Selorm Agorku

“…The synergy between AC’s surface charge modulation and CNS’s microstructural enhancement creates a dual-function mechanism of Donnan exclusion and size-sieving, which significantly boosts separation efficiency and antifouling performance. …”
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<i>Vibrio cholerae</i> Gut Colonization of Zebrafish Larvae Induces a Dampened Sensorimotor Response by Isabella Cubillejo, Kevin R. Theis, Jonathan Panzer, Xixia Luo, Shreya Banerjee, Ryan Thummel, Jeffrey H. Withey

“…<b>Conclusion:</b> This suggests that early <i>V. cholerae</i> colonization of the larval gut microbiome has a dampening effect on sensorimotor function, supporting the idea of a link between the gut microbiome and behavior.…”
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Disease‐causing mutations in the XIAP BIR2 domain impair NOD2‐dependent immune signalling by Rune Busk Damgaard, Berthe Katrine Fiil, Carsten Speckmann, Monica Yabal, Udo zur Stadt, Simon Bekker‐Jensen, Philipp J. Jost, Stephan Ehl, Niels Mailand, Mads Gyrd‐Hansen

“…We show that the RIPK2 binding site in XIAP overlaps with the BIR2 IBM‐binding pocket and find that a bivalent Smac mimetic compound (SMC) potently antagonises XIAP function downstream of NOD2 to limit signalling. These findings suggest that impaired immune signalling in response to NOD1/2 stimulation is a general defect in XLP2 and demonstrate that the XIAP BIR2‐RIPK2 interaction may be targeted pharmacologically to modulate inflammatory signalling.…”
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LncRNA HOTAIR promotes aerobic glycolysis by recruiting Lin28 to induce inflammation and apoptosis in acute lung injury by Junjie Xie, Zhicong Zheng, Bin Wang, Jianfang Zhang, Junqi Jiang, Fengde Wu, Xiangming Zhong, Jianfeng Chen

“…The research findings presented in this article offer significant insights into the function of HOTAIR in ALI and suggest a potential therapeutic target for the treatment of this condition.…”
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Human ANP32A/B are SUMOylated and utilized by avian influenza virus NS2 protein to overcome species-specific restriction by Liuke Sun, Xing Guo, Mengmeng Yu, Xue-Feng Wang, Huiling Ren, Xiaojun Wang

“…The SIM-SUMO-mediated interactions between NS2 and huANP32A/B function to promote AIV polymerase activity by positively regulating AIV vRNP-huANP32A/B interactions and AIV vRNP assembly. …”
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Extracellular Vesicles From Prostate Cancer‐Corrupted Osteoclasts Drive a Chain Reaction of Inflammatory Osteolysis and Tumour Progression at the Bone Metastatic Site by Takaaki Tamura, Tomofumi Yamamoto, Akiko Kogure, Yusuke Yoshioka, Yusuke Yamamoto, Shinichi Sakamoto, Tomohiko Ichikawa, Takahiro Ochiya

“…Extracellular vesicles (EVs) play key roles in intercellular communication and actively function in the bone microenvironment. We report that PCa cells corrupt osteoclasts (OCs) via their secretomes, inducing a pathological phenotype. …”
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The interplay between homeostatic synaptic scaling and homeostatic structural plasticity maintains the robust firing rate of neural networks by Han Lu, Sandra Diaz-Pier, Maximilian Lenz, Andreas Vlachos

“…Homeostatic synaptic scaling further modulated recurrent connectivity, network activity, and structural plasticity outcomes. …”
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The potential role of biomarkers CD28 and PF4 in the pathogenesis of idiopathic pulmonary fibrosis and their impact on the prognosis: an immune microenvironment analysis by Li Yan, Jiang-Han Li, Ai-Li Zhang, He Li, Bo Pang, De-Yang Meng, Qian Fu, Li-Juan Du, Yan Su

“…Patients with IPF were stratified into high- and low-risk cohorts. Finally, functional enrichment analysis, immune infiltration analysis, regulatory network construction, and reverse transcription quantitative PCR (RT-qPCR) were conducted separately to validate the findings. …”
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Overexpression of the inwardly rectifying potassium channel Kir4.1 or Kir4.1 Tyr9Asp in Müller cells exerts neuroprotective effects in an experimental glaucoma model by Fang Li, Zhen Li, Shuying Li, Hong Zhou, Yunhui Guo, Yongchen Wang, Bo Lei, Yanying Miao, Zhongfeng Wang

“…Collectively, these results suggest that the tyrosine residue at position nine in Kir4.1 may serve as a functional modulation site in the retina in an experimental model of glaucoma. …”
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Exploration of the multiomics-based mechanisms of Gancao Nourishing-Yin decoction in regulating mitochondrial metabolic genes CYB5R3 and PICK1 to influence glioma progression by Yufeng Chen, Anjing Zhang, Li Lei, Kangping Xiao, Wenchao Mao

“…Colocalisation analysis, validation using the TCGA database, survival analysis, and functional annotations of mitochondrial energy pathways were performed to explore the mechanisms of action. …”
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Expression of Fc-Gamma Receptors of Neutrophils in Preterm Infants of Different Gestational Age by Vladimir E. Mukhin, Daria A. Praulova, Lyudmila L. Pankratyeva, Olga I. Mileva, Alexander G. Rumyantsev, Nikolay N. Volodin

“…Neutrophil culture of preterm infants in the presence of granulocyte colony stimulating factor (G-CSF) results in a 2.4–5-fold increase in CD16, CD32 expression and enhancement of oxygen burst.Conclusion: Preterm infants are characterized by deregulated expression of Fc-gamma receptors and functional impairment of neutrophils. G-CSF modulates the expression of CD16 and CD32 on the surface of neutrophils and enhances the oxygen burst in them.…”
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Yinzhihuang Oral Liquid Alleviates Intrahepatic Cholestasis of Pregnancy: Integrated Bioinformatics and Experimental Mechanistic Insight by Ting Liu, Xinrun Zhuang, Wei Gu, Wei Liu, Jin Zhang, Weijian Zeng, Jue Li, Yang Pan

“…ICP-related targets were gathered from multiple databases, and hub genes were selected through bioinformatics and previously identified differentially expressed proteins. Functional annotation and pathway enrichment analyses were conducted, with validation in TCA-induced cells treated with various YZH concentrations (0.1%–5.0%) compared to controls. …”
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Neuroinflammatory Signaling and Immune Cell Infiltration Differ in Brains of Rats Exposed to Space Radiation and Social Isolation by Austin M. Adkins, Zachary N. M. Luyo, Alea F. Boden, Riley S. Heerbrandt, Richard A. Britten, Laurie L. Wellman, Larry D. Sanford

“…The synergistic effects of combined SI and SR on immune system functionality and the brain remain unknown. Determining how single and combined inflight stressors modulate the immune system is crucial for fully understanding pathways impacting astronaut health and performance. …”
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Ovarian toxicity of endocrine-disrupting chemicals: current state of the problem by L. N. Kolomytseva, E. D. Nebora, A. D. Dzhamalutinov, D. I. Sufiyarov, D. R. Muginova, I. I. Mullagulova, A. S. Tushigov, Z. D. Bazarova, T. A. Nosinkova, L. A. Khuseynova, K. A. Derevyanko, M. P. Abaeva, Zh. Zh. Magomedova, S. M. Borlakova

“…Furthermore, we also discuss epigenetic inheritance mechanisms through which EDC may exert long-term effects on reproductive function across generations. Special attention is paid to therapeutic strategies aimed at mitigating EDC-induced damage, including the use of antioxidants, signaling pathway modulators, and epigenetic regulators. …”
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The APOE Gene Cluster in Normal Aging by Jolanta Florczak-Wyspiańska, Mikołaj Hurła, Damian Pikor, Joanna Poszwa, Izabela Korczowska-Łącka, Oliwia Szymanowicz, Agnieszka Pluto-Prądzyńska, Ulyana Goutor, Małgorzata Wiszniewska, Wojciech Kozubski, Jolanta Dorszewska

“…Additionally, the APOE gene cluster, which includes adjacent regulatory and interactive genes, was examined for its potential to modulate APOE expression and function, thereby influencing the aging process. …”
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