Influence of subaxial cervical spine surgery on the sagittal alignment of the cervical and global spine. A prospective observational study by M. Bolcha, J. Lodin, D. Cihlář, M. Sameš, P. Vachata

“…Pain relief and functional improvement are comparable in kyphotic and non-kyphotic patients, irrespective of relordotization magnitude. …”
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Closed-Loop Spinal Cord Stimulation in Chronic Pain Management: Mechanisms, Clinical Evidence, and Emerging Perspectives by Nicholas Mangano, Andrew Torpey, Catherine Devitt, George A. Wen, Christopher Doh, Abhishek Gupta

“…<b>Results</b>: Clinical trials, including the Avalon and Evoke studies, have demonstrated that closed-loop spinal cord stimulation provides superior pain relief, functional improvement, and reduced opioid dependence compared to traditional open-loop systems. …”
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Multiomic Analysis Provided Insights into the Responses of Carbon Sources by Wood-Rotting Fungi <i>Daldinia carpinicola</i> by Peng Yang, Xingchi Ma, Yu Zhang, Yanan Sun, Hao Yu, Jiandong Han, Meng Ma, Luzhang Wan, Fansheng Cheng

“…<i>Daldinia carpinicola</i> is a newly identified species of wood-rotting fungi, with substantial aspects of its biology and ecological function yet to be clarified. A Nanopore third-generation sequencer was employed for de novo genome assembly to examine the genetic characteristics. …”
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Leveraging 'golden-hour' WUE for developing superior vegetable varieties with optimal water-saving and growth traits by Rujia Jiang, Ting Sun, Zheng Shi, Menachem Moshelion, Pei Xu

“…However, while reducing stomatal conductance can boost water use efficiency (WUE), it results in a decline in photosynthetic assimilation capacity, because stomata function as a shared conduit for both CO2 intake and water evaporation. …”
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Enhancing immune response in broiler chicks against newcastle disease virus using lemongrass and geranium oils: A comprehensive study on biochemical and antioxidant effects by Saif W. Bahgat, Mohamed A. Lebda, Nabil M. Taha, Mohamed S. Elfeky, Mustafa Shukry, Mohamed Soliman, Aml E. Hashem

“…Biochemically, LO and GO improved liver and kidney function markers, including reduced serum ALT, AST, creatinine, and MDA, alongside a two-fold increase in spleen antioxidant Nuclear factor erythroid 2–related factor 2 (Nrf2) levels. …”
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Apigenin as a multifaceted antifibrotic agent: Therapeutic potential across organ systems by Xiaoyong Hu, Djandan Tadum Arthur Vithran, Zhaoying Yang, Ting Zou, Yuanyuan Dou, Hongjian Li

“…In pulmonary fibrosis, apigenin attenuates oxidative stress, suppresses fibroblast activation, and reduces collagen accumulation, improving lung function. It also demonstrates protective effects in pancreatic and renal fibrosis by reducing oxidative damage and inflammation. …”
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Gestational hypercholanemia suppresses pregnancy‐associated adipose mass increase and stimulates a pro‐inflammatory environment in mice by Vanya Nikolova, Alice L. Mitchell, Elena Bellafante, Eugene Jansen, Georgia Papacleovoulou, Per‐Olof Bergh, Hanns‐Ulrich Marshall, Catherine Williamson

“…We investigated how cholic acid (CA) supplementation in murine pregnancy impacts adipose tissue function. Mice were fed normal or 0.5% CA‐supplemented chow from identification of copulatory plug until gestational day 14 or 15 (n = 10–11/group) and were matched experimentally with nonpregnant mice (n = 7/group). …”
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The genomic architecture of circulating cytokine levels points to drug targets for immune-related diseases by Marek J. Konieczny, Murad Omarov, Lanyue Zhang, Rainer Malik, Tom G. Richardson, Sebastian-Edgar Baumeister, Jürgen Bernhagen, Martin Dichgans, Marios K. Georgakis

“…Integration with transcriptomic data point to key regulatory mechanisms, such as the buffering function of the Atypical Chemokine Receptor 1 (ACKR1) acting as scavenger for multiple chemokines and the role of tumor necrosis factor receptor-associated factor 1 (TRAFD1) in modulating the cytokine storm triggered by TNF signaling. …”
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Simulation and Experimental Study of Ventilated Active Cooling for the Logging Tool Electronics Section by YANG Gengjia, DENG Chao, PENG Jiale, TIAN Zhibin, WEI Zanqing, LUO Xiaobing

“…The simulation results show that the maximum cooling rate of the circuit board is 3.6 °C/min, and the heat storage module completes the liquid-solid phase change and restores the heat storage function after cooling for 3.5 h. …”
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PAR2 deficiency impairs antitumor immunity and attenuates anti-PD1 efficacy in colorectal cancer by Zilin Liu, Xuehui Jiang, Ziliang Ke, Weihong Wang, Jianqiang Tang, Yun Dai

“…However, the role of PAR2 in modulating the tumor microenvironment remains unclear. …”
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Acupuncture ameliorates inflammation by regulating gut microbiota in acute ischemic stroke by Haoyue Yan, Yini Hua, Jinxia Ni, Xiaona Wu, Jingni Xu, Ziniu Zhang, Juwei Dong, Zhihao Xiong, Lei Yang, Hongwei Yuan

“…Results: Acupuncture improved the degree of impaired neurological function in MCAO rats and regulated the type and abundance of intestinal bacteria, increased SCFAs of MCAO rats, decreased HDAC1 and HDAC2, modulated the Th17/Treg imbalance, reduced the level of inflammatory factors in the peripheral blood and altered the pathology of the intestine and brain. …”
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Enhancing mPFC to BLA information transmission through chemical genetics to improve exploratory behavior in chronic stress rats by Jiangzihui Guo, Qingying Cao, Huicong Jie, Yuqing Li, Wenwen Bai, Tiaotiao Liu, Xuyuan Zheng

“…The pathogenesis of depression is fundamentally linked to the dysregulation of neural circuit structure and function. Notably, the medial prefrontal cortex (mPFC) and basolateral amygdala (BLA) are critical brain regions in the regulation of depression-related behaviors. …”
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Mild Traumatic Brain Injury Impairs Coupling of CA1 Neuronal Activity to Theta Oscillations by Brian Noble, Ryota Homma, John I. Broussard, Dustin Robinson, Anthony N. Moore, Jing Zhao, Pramod K. Dash

“…Both clinical and experimental studies have indicated that hippocampal function is often impaired in persons with mTBI. However, the neural mechanisms underlying these impairments are not well understood. …”
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FREQ‐NESS Reveals the Dynamic Reconfiguration of Frequency‐Resolved Brain Networks During Auditory Stimulation by Mattia Rosso, Gemma Fernández‐Rubio, Peter Erik Keller, Elvira Brattico, Peter Vuust, Morten L Kringelbach, Leonardo Bonetti

“…In conclusion, FREQ‐NESS effectively maps the brain's spatiotemporal dynamics, providing a comprehensive view of brain function by revealing a landscape of simultaneous, frequency‐resolved networks and their interaction.…”
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Prognostic Value of TBC1D1 and Its Relationship With the Tumor Microenvironment in Pancreatic Cancer: A Study Based on Single‐Cell Sequencing by Linfeng Yang, Duan Yan, Jun Yu, Dawei Deng, Lin Ma, Ruixin Yu, Song Wei, Jiahui Yu, Chuan Lan, Pengsheng Yi

“…However, its specific function in pancreatic cancer (PC) remains poorly understood. …”
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Three-Dimensional Spatio-Temporal Slim Weighted Generative Adversarial Imputation Network: Spatio-Temporal Silm Weighted Generative Adversarial Imputation Net to Repair Missing Oce... by Yiwan Yue, Juan Li, Yu Zhang, Meiqi Ji, Jingyao Zhang, Rui Ma

“…Additionally, a spatio-temporal continuity loss function is designed to ensure the physical rationality of the data. …”
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Avenanthramide-C as Alzheimer’s Disease-Modifying Therapy: Early and Sustained Intervention Prevents Disease Progression in Mouse Models by Alen Benhur Pravin Nathan, Areeba Aziz, Semyeong Choi, Seunghee Lee, Seyoung Jeon, Hyung-Seok Kim, Jonghyun Cho, Jihoon Jo

“…Our findings suggest that early and sustained Avn-C treatment preserves cognitive function, modulates multiple pathological pathways, and may slow or prevent AD progression by targeting early neurodegenerative processes before irreversible damage occurs.…”
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Development and characterization of AD-214, an anti-CXCR4 i-body-Fc fusion for the treatment of idiopathic pulmonary fibrosis by Jason P. Lynch, Louise Organ, Khamis Tomusange, Lukasz Kowalczyk, Dallas J. Hartman, Angus Tester, Chris Hosking, Michael Foley

“…To address these limitations, we developed AD-214, an anti-CXCR4-Fc-fusion protein composed of an anti-CXCR4 i-body (AD-114) tethered at its C terminus to constant domains 2 and 3 of the Fc region of a mutated human IgG1 lacking effector function. AD-214 binds with high affinity and specificity to CXCR4, modulates intracellular signaling, and inhibits key fibrotic pathways. …”
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Age and weekly physical activity are correlated with ballistic VR decision making and reaction time shooting performance at rest by Alex Buga, Xavier El-Shazly, Christopher D. Crabtree, Justen T. Stoner, Lucas Arce, Drew D. Decker, Bradley T. Robinson, Madison L. Kackley, Teryn N. Sapper, John Paul V. Anders, William J. Kraemer, Jeff S. Volek

“…The first test measured decision-making as a function of shooting a series of correct shapes (squares/triangles/circles) and colors (green/red/blue), twice, in under 2 s. …”
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Characterizing the impact of CPSF30 gene disruption on TuMV infection in Arabidopsis thaliana by Yanping Wei, Quan Yuan, Dalal Sulaiman Alshaya, Abdul Waheed, Kotb A. Attia, Sajid Fiaz, Muhammad Shahid Iqbal

“…Furthermore, comprehensive mRNA-Seq and miRNA-Seq analysis of Col-0 and cpsf30 mutants revealed global transcriptional reprogramming, highlighting CPSF30’s role in selectively modulating gene expression during TuMV infection. In conclusion, this research underscores CPSF30’s critical role in the TuMV lifecycle and sets the stage for further exploration of its function in plant viral regulation.…”
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