The interplay between antimicrobial resistance, heavy metal pollution, and the role of microplastics by Igori Balta, Joanne Lemon, Anna Gadaj, Iuliana Cretescu, Ducu Stef, Ioan Pet, Lavinia Stef, David McCleery, Alastair Douglas, Nicolae Corcionivoschi, Nicolae Corcionivoschi

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DESAIN DAN PERANCANGAN INSTRUMEN MONITORING KEKERUHAN AIR DENGAN SISTEM REAL TIME CLOCK (RTC) by Refpo Rahman, Fades Br. Gultom

“…ABSTRAK   Instrumen monitoring tingkat kekeruhan air dapat dirancang dengan Arduino Uno. Modul turbidity sensor dan modul RTC DS3231 digunakan untuk mengukur tingkat kekeruhan air secara real time yang hasil pengukuran tersimpan otomatis di dalam SD card. …”
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Multiple intramolecular triggers converge to preferential G protein coupling in the CB2R by Adrian Morales-Pastor, Tamara Miljuš, Miguel Dieguez-Eceolaza, Tomasz Maciej Stępniewski, Vicente Ledesma-Martin, Franziska M. Heydenreich, Tilman Flock, Bianca Plouffe, Christian Le Gouill, Jean Duchaine, David A. Sykes, Colin Nicholson, Eline J. Koers, Wolfgang Guba, Arne C. Rufer, Uwe Grether, Michel Bouvier, Dmitry B. Veprintsev, Jana Selent

“…Our insights highlight the complexity of GPCR signaling and provide a framework for the rational design of drug candidates tailored to evoke specific functional responses, ultimately enhancing the precision and efficacy of therapeutic interventions.…”
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Mapping the genetic landscape establishing a tumor immune microenvironment favorable for anti-PD-1 response by Daniel A. Skelly, John P. Graham, Mingshan Cheng, Mayuko Furuta, Andrew Walter, Thomas A. Stoklasek, Hongyuan Yang, Timothy M. Stearns, Olivier Poirion, Ji-Gang Zhang, Jessica D.S. Grassmann, Diane Luo, William F. Flynn, Elise T. Courtois, Chih-Hao Chang, David V. Serreze, Francesca Menghi, Laura G. Reinholdt, Edison T. Liu

“…Summary: Identifying host genetic factors modulating immune checkpoint inhibitor (ICI) efficacy is experimentally challenging. …”
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Engineering cardiolipin binding to an artificial membrane protein reveals determinants for lipid-mediated stabilization by Mia L Abramsson, Robin A Corey, Jan L Skerle, Louise J Persson, Olivia Anden, Abraham O Oluwole, Rebecca J Howard, Erik Lindahl, Carol V Robinson, Kvido Strisovsky, Erik G Marklund, David Drew, Phillip J Stansfeld, Michael Landreh

“…Integral membrane proteins carry out essential functions in the cell, and their activities are often modulated by specific protein-lipid interactions in the membrane. …”
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Development of a new N-terminomic method to study the pathodegradome of the Staphylococcus aureus V8 protease in human neutrophils by Emilee M. Mustor, Andrew M. Frey, Mary-Elizabeth Jobson, Dale Chaput, Lindsey Neil Shaw

“…In so doing, we captured ~350 V8 targets, revealing critical insight into how this virulence factor can modulate neutrophil functionality on various levels relevant to S. aureus disease progression. …”
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Reactive Oxygen Species in Asthma: Regulators of Macrophage Polarization and Therapeutic Implications: A Narrative Review by Liu Y, Zhang M, Wang T, Zhang J

“…ARG1 rich M2 cells convert L-arginine into proline, fostering collagen deposition; Ym1/2, Fizz1 and CD206 correlate with airway remodeling and declining lung function. Emerging antioxidant and macrophage-polarization strategies that selectively modulate ROS show promise in rebalancing M1/M2 responses and attenuating airway hyper-responsiveness. …”
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Entity class-restricted twin attention-based aggregation for geographic knowledge graph inference by Jinlan Kong, Xiaohui He, Haichuan Fang, Roujia Ji, Peng Yang, Shuang Li, Haofei Li, Haonan Sun, Mengjia Qiao, Panle Li, Xijie Cheng, Qinglei Zhou, Jiandong Shang

“…Abstract Geographic knowledge graphs (GeoKGs) describe and simulate geographic phenomena by storing geographic entities with their semantic relations, providing a foundation for many real-world tasks such as urban function identification. However, GeoKGs are often incomplete due to manual construction, leading to inaccurate and/or suboptimal decision-making. …”
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Local-Descriptors-Based Rectification Network for Few-Shot Remote Sensing Scene Classification by Anyong Qin, Bin Luo, Qiang Li, Cuiming Zou, Yu Zhao, Tiecheng Song, Chenqiang Gao

“…Furthermore, we employ an LD-based contrastive loss function to guarantee that the rectified LD semantics are consistent with the corresponding scene image. …”
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A Label Correction Learning Framework for Gully Erosion Extraction Using High-Resolution Remote Sensing Images and Noisy Labels by Chunhui Zhao, Yi Shen, Nan Su, Yiming Yan, Shou Feng, Wei Xiang, Yong Liu, Tianhao Zhao

“…To achieve this, we introduce three key components in the framework, including an adaptive correction loss function, a multitree refinement module, and a noise correction module. …”
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Drought-tolerant fungal microbes, Aspergillus oryzae and Aspergillus fumigatus, elevate physiohormonal and antioxidant responses of maize under drought stress by Kiran Niaz, Mamoona Rauf, Muhammad Arif, Muhammad Hamayun, Humaira Gul, Abeer Hashem, Elsayed Fathi Abd_Allah, Qiang-Sheng Wu

“…In addition, the enhanced adventitious root development at the root/stem interface, and elongated main root development optimum stomatal activity of SAB- and CBW-inoculated maize plants were observed under drought stress. SAB and CBW modulated the expression of the ZmBSK1, ZmAPX, and ZmCAT1 genes in the maize shoot and root tissues under drought stress vs. control, signifying an essential regulatory function for SAB/CBW-induced drought stress tolerance via phytohormonal signaling pathway leading to the antioxidant upregulation.DiscussionThese findings imply that the exogenous administration of the SAB/CBW consortium might be a rather efficient strategy that contributes to optimizing the physio-hormonal attributes and antioxidant potential to alleviate the drought stress in maize.…”
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Diagnostic ultrasound enhances, then reduces, exogenously induced brain activity of mice by Henry Tan, Devon J. Griggs, Devon J. Griggs, Lucas Chen, Kahte Adele Culevski, Kathryn Floerchinger, Alissa Phutirat, Gabe Koh, Nels Schimek, Pierre D. Mourad, Pierre D. Mourad

“…Given the near ubiquity of diagnostic ultrasound systems, further progress along this line of research could one day lead to the widespread use of diagnostic ultrasound to intentionally modulate human brain function during exogenous stimulation.…”
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Characterization and Comparison of Lipids in Yak Colostrum, Buffalo Colostrum, and Cow Colostrum Based on UHPLC-QTOF-MS Lipidomics by Ruohan Li, Yuzhuo Wang, Changhui Li, Jiaxiang Huang, Qingkun Zeng, Ling Li, Pan Yang, Pengjie Wang, Min Chu, Jie Luo, Fazheng Ren, Hao Zhang

“…Its lipids serve as a key energy source and facilitate cellular functions. While yak colostrum (YC) and buffalo colostrum (BC) exhibit high nutritional value, their lipid compositions remain unclear. …”
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Exosomes in cartilage microenvironment regulation and cartilage repair by Han Longfei, Hou Wenyuan, Fang Weihua, Peng Peng, Lu Sun, Lin Kun, He Mincong, He Mincong, Yang Fan, Yang Fan, He Wei, He Wei, Wei Qiushi, Wei Qiushi, Wei Qiushi

“…Its pathology is defined by the progressive degradation of articular cartilage, formation of bone spurs, and synovial inflammation, resulting in pain, joint function limitations, and substantial societal and familial burdens. …”
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Prostate cancer and metabolic syndrome: exploring shared signature genes through integrative analysis of bioinformatics and clinical data by Maomao Guo, Sudong Liang, Zhenghui Guan, Jingcheng Mao, Zhibin Xu, Wenchao Zhao, Hao Bian, Jianfeng Zhu, Jiangping Wang, Xin Jin, Yuan Xia

“…Comprehensively bioinformatics analyses, including functional enrichment, LASSO, and random forest algorithms, coupled with receiver operating characteristic (ROC) and precision recall curve (PRC) analyses were conducted. …”
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SPL-108 mitigates metastasis and chemoresistance in tubo-ovarian carcinoma by Olivia D. Lara, Elke Van Oudenhove, Luiza Pereira, Selim Misirlioglu, Douglas A. Levine, Kari E. Hacker

“…In vitro experiments (cell viability assay, Western blot analysis, Calcein AM fluorescence assay, and migration assay) were carried out to determine the functional effects of SPL-108 in TOCs. Findings: Ovarian cancer cell lines OVCAR5 and OVCAR8 expressed higher protein levels of CD44 as demonstrated through Western Blot analysis. …”
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Effects of meglumine antimoniate and allopurinol treatment on the fecal microbiome profile in dogs with leishmaniosis by Joan Martí-Carreras, Marina Carrasco, Marc Noguera-Julian, Olga Francino, Rodolfo Oliveira Leal, Lluís Ferrer, Gaetano Oliva, Jenifer Molina, Xavier Roura

“…Further studies with larger cohorts are recommended to confirm these findings and explore the functional roles of the gut microbiota in modulating immune responses in Leishmania-infected dogs.…”
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Investigating the temperature-dependent selectivity of CO2 reduction on Ru-cluster catalysts supported by MXene by Yueying Liu, Xiang Li, Yi Li, Rong Wei, Hongwei Tan, Xichen Li, Guangju Chen

“…Specifically, CO2 exhibits distinct adsorption modes on planar and tetrahedral Ru4 clusters, leading to divergent CO2 reduction pathways. Density functional theory (DFT) calculations suggest that the tetrahedral Ru4 cluster demonstrates higher selectivity for the reduction of CO2 to carbon monoxide (CO) compared to the planar configuration. …”
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Genome-wide identification and stress-responsive expression profiling of the TCP gene family in Cenchrus fungigraminus under drought and cold stress by Shijie Ke, Xin He, Mengmeng Zhang, Lin Luo, Yuxin Chen, Yixue Cui, Yelin Huang

“…Conclusions In total, 40 CfuTCP genes were identified in C. fungigraminus. Functional predictions suggested the roles of CfuTCPs in modulating multiple C. fungigraminus physiological processes and metabolic pathways. …”
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Multi-omics analyses reveal altered gut microbial thiamine production in obesity by Yu Xia, Yu Xia, Longya Lu, Lulu Wang, Yanyan Qiu, Xingyin Liu, Weihong Ge, Weihong Ge, Weihong Ge

“…Our findings provide a rationale for developing treatments that utilize thiamine to prevent obesity by modulating gut microbiota.…”
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