Role of PDE4 Family in Cardiomyocyte Physiology and Heart Failure by Ivan Sherstnev, Aleksandra Judina, Giovanni Battista Luciani, Alessandra Ghigo, Emilio Hirsch, Julia Gorelik

“…Although PDE4 plays a smaller role in overall cAMP hydrolysis in human hearts than in rodents, its compartmentalised function remains critical. Recent therapeutic advances have shifted from pan-PDE4 inhibitors to isoform-specific approaches to enhance efficacy while minimising systemic toxicity. …”
Get full text

Beyond Stress Granules: G3BP1 and G3BP2 Redundantly Suppress SARS-CoV-2 Infection by Duo Xu, Mahamaya Biswal, Quanqing Zhang, Christine Light, Yijie Wu, Chenjin Ye, Luis Martínez-Sobrido, Jikui Song, Rong Hai

“…Our data collectively supports the notion that G3BP1 and G3BP2 play a critical role in modulating the host–virus interface during SARS-CoV-2 infection, and that their multifaceted function in cellular defense extends beyond the stress granule pathway.…”
Get full text

Synergistic inhibition of TNBC by USP33 and TAP63 through autophagy and ferroptosis activation by Feilin Qu, Wei Jian, Yixiang Huang, Xiqian Zhou, Xuehui Wang, JunJie Li, Gang Wang, Mainly

“…Mechanistically, USP33 stabilized TAP63 through K48-linked deubiquitination, triggering autophagy and ferroptosis by disrupting mitochondrial function and redox balance. Co-overexpression of USP33 and TAP63 synergistically suppressed tumor growth in vitro and in vivo. …”
Get full text

Hemoadhican-based self-leveling Janus patch for comprehensive prevention of postoperative adhesions by Rui Fang, Ning Yu, Simeng Chen, Xi Xu, Jianfa Zhang

“…This patch consists of three distinct functional layers: an anti-adhesion layer, a reinforcement layer, and a wet tissue adhesion layer. …”
Get full text

Establishing a physiologically based pharmacokinetic framework for aldehyde oxidase and dual aldehyde oxidase‐CYP substrates by Nihan Izat, Jayaprakasam Bolleddula, Pasquale Carione, Leticia Huertas Valentin, Robert S. Jones, Priyanka Kulkarni, Darren Moss, Vincent C. Peterkin, Dan‐Dan Tian, Andrea Treyer, Karthik Venkatakrishnan, Michael A. Zientek, Jill Barber, J. Brian Houston, Aleksandra Galetin, Daniel Scotcher

“…PBPK models were developed for capmatinib, idelalisib, lenvatinib, zaleplon, ziprasidone, and zoniporide, incorporating in vitro functional data from human liver subcellular fractions and human hepatocytes. …”
Get full text

A lightweight triple-modal fusion network for progressive mild cognitive impairment prediction in Alzheimer's disease by Xiangyu Shen, Xiangyang Hu, Renfeng Zhang, Yunzhan Fu, Jiamin Xu, Degang Lyu, Hongbiao Xie, Hongbiao Xie, Deen Shi, Changsheng Shi, Lisi Li, Yuantong Gao

“…Although multimodal neuroimaging and clinical data provide complementary information, existing fusion models often face challenges such as high computational complexity and limited interpretability.MethodsTo address these limitations, we introduce TriLightNet, an innovative lightweight triple-modal fusion network designed to integrate structural MRI, functional PET, and clinical tabular data for predicting MCI-to-AD conversion. …”
Get full text

Knockdown of p53 Enhances LncRNA A2M‐AS1 Inhibition of Pancreatic Cancer Progression via Regulating MAPK Pathway by Yu Cen, Yihui Luo, Yi Nan, Wenxi Kuang, Xianglian Zhang, Jiexia Lu, Chunxiao Xie, Mingzhi Xie, Enran Chen, Haixing Jiang, Shanyu Qin

“…The PANC‐1 and BxPC‐3 cell lines were used for functional assays, including cell proliferation, apoptosis, migration, and invasion assays. …”
Get full text

Study of bioactive 3D-printed scaffolds incorporating zinc-based MOF for bone defect repair and anti-inflammatory applications by Yu Han, Xiufeng Jia, Yinwei Yang, Pei Guo, Chao Li, Yunze Zhang, Li Yin, Bo Jia, Haitao Wang

“…The development of bioactive scaffolds capable of orchestrating osteogenesis while modulating inflammatory responses remains a critical challenge in bone tissue engineering. …”
Get full text

A Comprehensive Study Employing Computational Analysis and Mendelian Randomization Has Revealed the Impact of Key Genes on Liver Cancer by Size Li, Wenying Qi, Junzheng Wu, Chunhua Luo, Shihao Zheng, Xu Cao, Wei Wang, Qiyao Liu, Hongbo Du, Xiaoke Li, Xiaobin Zao, Yongan Ye

“…<b>Methods</b>: We integrated data from the public databases with MR analysis to identify differentially expressed genes (DEGs) associated with Hepatocellular Carcinoma (HCC). We conducted functional enrichment analyses to determine the biological processes and signaling cascades associated with the identified DEGs. …”
Get full text

Autophagy inhibitor 3-methyladenine mitigates the severity of colitis in aged mice by inhibiting autophagy by Ailing Liu, Hongying Wang, Hong Lv, Hong Yang, Yue Li, Jiaming Qian

“…Background: The elderly ulcerative colitis (UC) patients pose unique challenges due to their comorbidities, diminished functional capacity, and heightened risk of treatment-related complications. …”
Get full text

Genome-Wide Characterization of <i>9-Cis-Epoxycarotenoid Dioxygenase</i> Genes in Luffa Identifies <i>LcNCED2</i> as Being Associated with ABA Levels During Seed Germination by Pingping Fang, Xifeng Li, Haoxin Mu, Jing Wei, Ting Zhang, Xueyan Wang, Qinwei Guo, Qunfeng Lou

“…Our findings provide a comprehensive genomic characterization of the <i>NCED</i> family in Luffa cylindrica and <i>Luffa acutangula</i> and reveal the functional role of <i>LcNCED2</i> in regulating ABA levels, which may play a critical role in seed germination.…”
Get full text

Single‐cell RNA sequencing of peripheral blood mononuclear cells from bronchopulmonary dysplasia by Yufeng Liu, Chun Yan, Yushan Li, Ruoxing Zhou, Xiaoyu Lin, Qiong Meng, Sitao Li, Limei Zhong, Yanfang Tan, Wangkai Liu

“…T and B cell subsets exhibited phenotypic and functional changes, with B cells serving as crucial interaction hubs in cell communication networks. …”
Get full text

The impact of elevated CO2 on methanogen abundance and methane emissions in terrestrial ecosystems: A meta-analysis by Yiwen Ding, Mingyu Wang, Xiaojuan Du, Xue He, Tianle Xu, Xinyu Liu, Fuqiang Song

“…The results show that eCO2 promotes both the abundance of the functional methanogenic gene mcrA and CH4 emissions. …”
Get full text

Exploring extracellular vesicles as novel therapeutic agents for intervertebral disc degeneration: delivery, applications, and mechanisms by Yuxin Jin, Ouqiang Wu, Zhihua Chen, Linjie Chen, Kai Zhang, Qizhu Chen, Haijun Tian, Xinzhou Wang, Morgan Jones, Kenny Yat Hong Kwan, Yan Michael Li, Pooyan Makvandi, Xiangyang Wang, Xiang Hai, Jun Zhang, Aimin Wu

“…We provides a comprehensive review of the significant role of extracellular vesicle cargo in mediating repair mechanisms. It discusses the functional enhancement advantages exhibited by extracellular vesicles under current bioengineering modifications and drug loading. …”
Get full text

Epigenetic control of tissue resident memory T cells by Zhiyi Lan, Zhiyi Lan, Zhiyi Lan, Zeyu Chen, Zeyu Chen, Nan Yang, Nan Yang, Tong Liu, Tong Liu, Siqi Li, Siqi Li, Yuling Shi, Yuling Shi, Jun Gu, Jun Gu

“…Tissue-resident memory T cells (TRM) represent a heterogeneous population of T cells that exhibit both effector and memory functionalities. They express specific gene signatures that enable them to occupy tissues without recirculating, thus providing a first response against reencountered pathogens or antigens. …”
Get full text

PZT optical memristors by Chenlei Li, Hongyan Yu, Tao Shu, Yueyang Zhang, Chengfeng Wen, Hengzhen Cao, Jin Xie, Hanwen Li, Zixu Xu, Gong Zhang, Zejie Yu, Huan Li, Liu Liu, Yaocheng Shi, Feng Qiu, Daoxin Dai

“…Here, we reveal the first lead zirconate titanate (PZT) optical memristor, working with a paradigm of functional duality: non-volatile setting and ultrafast volatile modulation via the Pockels effect. …”
Get full text

Phosphoglycerate dehydrogenase stabilizes protein kinase C delta type mRNA to promote hepatocellular carcinoma progression by Bin Cheng, Pai Peng, Shi Chen, Rui Liu, Xiaosong Li, Ke Wang, Jing Ma, Kai Wang, Ni Tang, Ailong Huang

“…However, the non-catalytic post-transcriptional regulatory functions of metabolic enzymes in hepatocellular carcinoma (HCC) remain largely unexplored. …”
Get full text

miR-4537 curtails ferroptosis by targeting MIOX in renal cell carcinoma by Hui Li, Mengyu Fu, Lingli Wang, Yanpeng Dai, Zongxing Lv, Shilin Geng

“…Further investigations into MIOX regulation identified four miRNAs via TargetScan predictions, with miR-4537 significantly upregulated in ccRCC cell lines. Functional assays involving miR-4537 mimics and inhibitors, combined with ferroptosis inducers and inhibitors, elucidated its impact on ccRCC cell growth and ferroptosis modulation. …”
Get full text

Predictive biomarkers for cardiometabolic risk in postmenopausal women: insights into visfatin, adropin, and adiponectin by Anna Maria Cybulska, Daria Schneider-Matyka, Ireneusz Walaszek, Mariusz Panczyk, Dorota Ćwiek, Anna Lubkowska, Elżbieta Grochans, Kamila Rachubińska, Katarzyna Malewicz, Mariusz Chabowski, Mariusz Chabowski

Get full text

Mediterranean fever gene variants may prevent the development of lupus nephritis in Japanese patients with systemic lupus erythematosus by Yushiro Endo, Tomohiro Koga, Lamiaa Mohamed, Yoshika Tsuji, Masataka Umeda, Hiroko Hayashi, Tatsuya Kishino, Atsushi Kawakami

Get full text