Aggregation potency and proinflammatory effects of SARS-CoV-2 proteins by Monica Costa, Da-Wei Wang, Kai-Dong Zhao, Lin Yuan, Anita Krisko, Jia-Yi Li, Tiago Outeiro, Wen Li

“…We found that the ER stress was induced and that the autophagy-lysosome pathway was inhibited upon viral protein expression. Boosting autophagy function attenuated protein aggregation, suggesting that modulation of autophagy might be a valid strategy for inhibiting cytotoxic effects of SARS-CoV- 2 proteins. …”
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Nuclear receptors in metabolism and diseases: Mechanistic and therapeutic insights by Chen-Ying Zhu, Pei-Han Yu, Qi Sun, De-Fei Hong, Chang Yang, Hua Naranmandura

“…Nuclear receptors (NRs) are ligand-activated transcription factors that function as metabolic sensors, integrating endogenous and xenobiotic signals to regulate gene networks controlling metabolism, immunity, and cellular homeostasis. …”
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Neuromorphic Wireless Split Computing With Multi-Level Spikes by Dengyu Wu, Jiechen Chen, Bipin Rajendran, H. Vincent Poor, Osvaldo Simeone

“…Simulation and experimental results using software-defined radios reveal performance improvements achieved by multi-level SNN models and provide insights into the optimal payload size as a function of the connection quality between the transmitter and receiver.…”
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RSA-PT: A Point Transformer-Based Semantic Segmentation Network for Uninterrupted Operation in a Distribution Network Scene by Deyu Nie, Linong Wang, Shaocheng Wu, Zhenyang Chen, Yongwen Li, Bin Song

“…To this end, the authors embedded the improved RSA (residual spatial attention) module and modified the loss function of network, proposing a deep learning network called RSA-PT for the semantic segmentation of a distribution network scene point cloud. …”
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Blue and far-red light modify the adaptation of Lemna minor L. to cadmium stress based on glutathione, phytochelatin, chemical element and free amino acid levels by Anamaria Iulia Török, Oana Cadar, Balázs Kalapos, Magda Pál, Gabriella Szalai, Zsuzsa Mednyánszky, Krisztián Gierczik, András Székely, Livia Simon-Sarkadi, Gábor Kocsy

“…Fr light and Cd in turn resulted in the greatest cysteine and glutathione levels, which may contribute to the proper function of the redox-sensitive proteins. In summary, the greatest Cd-extraction capacity of L. minor can be reached in W light. …”
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Metabolic Reprogramming in Toll-like Receptor-Mediated Platelet Activation by Lih T. Cheah, Jawad S. Khalil, Mary McKay, Mohammad Ali, Cedric Duval, Amanda J. Unsworth, Khalid M. Naseem

“…Targeting platelet metabolism plasticity may offer a novel strategy to inhibit platelet function in TLR-initiated diseases.…”
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Pharmacodynamics of huaier aqueous extract against papillary thyroid carcinoma in vivo and in vitro by Fa-Zhan Xu MS, Lu-Lu Zheng MS, Jia-Bo Qin MS, Yi-Xuan Li MS, Ke-Hao Chen MS, Ling-Hui Dai MS, Qiao-Ling Zhu MS, Jian-Feng Sang MD

“…In this study, we explored the function of huaier in PTC. We treated a PTC cell line (TPC-1) with varying concentration gradients of huaier and we observed that huaier effectively inhibited the proliferation of TPC-1 cells with an IC50 of 2.538 mg/ml. …”
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Gene Expression Profiling in Behcet’s Disease Indicates an Autoimmune Component in the Pathogenesis of the Disease and Opens New Avenues for Targeted Therapy by Antonio Puccetti, Piera Filomena Fiore, Andrea Pelosi, Elisa Tinazzi, Giuseppe Patuzzo, Giuseppe Argentino, Francesca Moretta, Claudio Lunardi, Marzia Dolcino

“…Among differentially expressed genes the top enriched gene function was immune response, characterized by upregulation of Th17-related genes and type I interferon- (IFN-) inducible genes. …”
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Edge-Enhanced GCIFFNet: A Multiclass Semantic Segmentation Network Based on Edge Enhancement and Multiscale Attention Mechanism by Long Chen, Zhiyuan Qu, Yao Zhang, Jingyang Liu, Ruwen Wang, Dezheng Zhang

“…Moreover, we enhance the network's ability to extract edge information during training by sharing parameters between the backbone and employing a specialized loss function. The network proposed in this article utilizes both channel attention and spatial attention at different stages, effectively utilizing edge information. …”
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Effect of Mechanical Force Stress on the Inflammatory Response in Human Periodontal Ligament Cells by Thira Rojasawasthien, Supreda Suphanantachat Srithanyarat, Wajathip Bulanawichit, Thanaphum Osathanon

“…Moreover, hPDLSCs, together with contiguous hPDL cells, respond to various mechanical forces by regulating the immune function of several immune cells. This complex relationship between the mechanical force stress, inflammation, and the cellular response in hPDLSCs warrants further research to develop therapeutic strategies for periodontal and related diseases.…”
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Retinal Inflammation and Reactive Müller Cells: Neurotrophins’ Release and Neuroprotective Strategies by Bijorn Omar Balzamino, Andrea Cacciamani, Lucia Dinice, Michela Cecere, Francesca Romana Pesci, Guido Ripandelli, Alessandra Micera

“…Retinal diseases require prompt attention to restore function or reduce progressive impairments. Genetics, epigenetics, life-styling/quality and external environmental factors may contribute to developing retinal diseases. …”
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Targeting the Electron Transport System for Enhanced Longevity by Marko Radovic, Lucas P. Gartzke, Simon E. Wink, Joris A. van der Kleij, Frouwkje A. Politiek, Guido Krenning

“…Compounds such as Elamipretide, Sonlicromanol, SUL-138, and others modulate metabolism and mitochondrial function while exhibiting similarities to metformin and rapamycin, highlighting their potential in promoting longevity. …”
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Membrane-dependent dynamics and dual translocation mechanisms of ABCB4: Insights from molecular dynamics simulations by Veronica Crespi, Ágota Tóth, Angelika Janaszkiewicz, Thomas Falguières, Florent Di Meo

“…This study provides new insights into the relationship between membrane environment and ABCB4 function, contributing to our understanding of its role in bile physiology and susceptibility to genetic and xenobiotic influences.…”
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Transcranial direct current stimulation combined with physical exercise in rotator cuff tendinopathy: a protocol for a blinded randomised controlled trial by César Augusto Medeiros Silva, Clécio Gabriel de Souza, Vinicius Batista Lima, Hannely Beatriz Menezes Cosme, Romário Nóbrega Santos Fonseca, Fuad Ahmad Hazime, Rodrigo Scattone da Silva, Rodrigo Pegado de Abreu Freitas

“…Secondary outcomes will include physical function, range of motion, global perception of change and treatment adherence.Ethics and dissemination This protocol was approved by the Ethics Committee Health Sciences College of Trairi, Federal University of Rio Grande do Norte (number: 6.821.408). …”
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Engineered exosomes restore miR-508-5p expression in uterine corpus endometrial carcinoma and reduce tumor progression and metastasis by targeting DLL3 by Yue-Ying Li, Yue-Ying Li, Hui Liu, Jia-Lu Feng, Wen-Yan Tian, Wen-Yan Tian, Juan Du, Li-Ping Zhang

“…This study investigates the roles of DLL3 and miR-508-5p in EC progression and explores a therapeutic approach using engineered exosomes to modulate their expression.MethodsTCGA data were analyzed, in vitro and in vivo experiments were performed to assess DLL3 and miR-508-5p function, and bioinformatics was used to confirm their interaction. …”
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The impact of obesity on female infertility - summary of current knowledge by Izabela Jastrzębska, Oliwia Sysło, Weronika Goliat, Konrad Haraziński, Nikola Rubik, Maksym Gmur, Michał Gajewski, Barbara Sławińska, Zuzanna Błecha, Nicole Tacka

“…Brief Description of the State of Knowledge: Adipose tissue influences gonadal function by secretion of adipokines, such as leptin, adiponectin, ghrelin and resistin. [1] Adipokines are important modulators of glucose metabolism, because they may primarily contribute to adverse fat distribution, altered appetite and satiety, impaired insulin sensitivity or insulin secretion, and to inflammation [2]. …”
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Hashimoto’s Thyroiditis and Female Fertility: Endocrine, Immune, and Microbiota Perspectives in Assisted Reproduction—A Narrative Review by Emilia Cristina Popa, Laura Maghiar, Teodor Andrei Maghiar, Ilarie Brihan, Laura Monica Georgescu, Bianca Anamaria Toderaș, Liliana Sachelarie, Anca Huniadi

“…Recent studies suggest that gut microbiota may modulate immune function and affect fertility outcomes among women with autoimmune thyroid conditions. …”
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Identification of Low‐Value Defects in Infrared Images of Porcelain Insulators Based on STCE‐YOLO Algorithm by Shaotong Pei, Weiqi Wang, Chenlong Hu, Keyu Li, Haichao Sun, Mianxiao Wu, Bo Lan

“…Finally, the SIoU loss function is employed to further enhance performance in complex scenes containing small targets. …”
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Administration of Panobinostat Is Associated with Increased IL-17A mRNA in the Intestinal Epithelium of HIV-1 Patients by Ane Bjerg Christensen, Anders Dige, Johan Vad-Nielsen, Christel R. Brinkmann, Mia Bendix, Lars Østergaard, Martin Tolstrup, Ole S. Søgaard, Thomas A. Rasmussen, Jens Randel Nyengaard, Jørgen Agnholt, Paul W. Denton

“…These results suggest that panobinostat therapy may influence the restoration of mucosal barrier function in these patients.…”
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Exploring the anticancer mechanism of cardiac glycosides using proteome integral solubility alteration approach by Wenjie Qin, Yinhua Deng, Huan Ren, Yanling Liu, Ling Liu, Wenhui Liu, Yuxi Zhao, Chen Li, Zhiling Yang

“…This study aims to explore their multifaceted mechanisms in cancer cell biology using proteome integral solubility alteration (PISA), focusing on the interaction with key proteins implicated in cellular metabolism and mitochondrial function. Methods We conducted lysate‐based and intact‐cell PISA assays on cancer cells treated with CGs (Digoxin, Digitoxin, Ouabain) to analyze protein solubility changes. …”
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