Energy metabolism in cardiovascular diseases: unlocking the hidden powerhouse of cardiac pathophysiology by Li Chen, Mingtai Chen, Xinrui Yang, Yuanli Hu, Caiwei Qiu, Youyou Fu, Xiaoyu Lan, Gang Luo, Qiuyu Liu, Mengnan Liu

“…., mitochondrial oxidative phosphorylation (OXPHOS), regulation of glucose and lipid metabolism) and their dysregulation in disease states, while evaluating intervention strategies targeting metabolic pathways, such as mitochondrial function enhancement and substrate utilization modulation. …”
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A Novel Reduced Component High Boost Multilevel Inverter by Pratik Kar, Rachita Ruchismita Sarangi, Durgesh Prasad Bagarty, Prakash Kumar Ray, Asit Mohanty, Manzoore Elahi M. Soudagar, Yasser Fouad, Sagar Shelare

“…A comprehensive comparison between the proposal and other capacitor based multilevel inverter topologies is carried out based on number of components, voltage stress, cost function and other performance parameters. The main novelty lies in the reduction in number of components, multiple extension variants basic topology, addressing capacitor voltage imbalance and high inrush current during charging. …”
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FFTL-Net: a network for the classification of skin diseases based on feature fusion and transfer learning by Xiaowei Song, Yurong Mei, Zhilei Zhao, Hao Chang, Lina Han, Hui Wang, Xinyi Zhang, Guoqiang Wang

“…Finally, the Softmax-loss function of category equilibrium and the domain adaptive strategy based on the maximum mean difference are established. …”
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Gut microbiota in health and disease: advances and future prospects by Yusheng Zhang, Hong Wang, Yiwei Sang, Mei Liu, Qing Wang, Hongjun Yang, Xianyu Li

“…Abstract The gut microbiota plays a critical role in maintaining human health, influencing a wide range of physiological processes, including immune regulation, metabolism, and neurological function. Recent studies have shown that imbalances in gut microbiota composition can contribute to the onset and progression of various diseases, such as metabolic disorders (e.g., obesity and diabetes) and neurodegenerative conditions (e.g., Alzheimer's and Parkinson's). …”
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p53-dependent chromatin relaxation is required for DNA double-strand break repair by Chen Hongyu, Shan Jin, Qi Wenjing, Chen Lili, Zeng Xianlu

“…These results underscore the pivotal function of p53 <?A3B2 tlsb=-.015w?…”
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Genome-wide identification and characterization of Dof gene family in Salvia miltiorrhiza by Xinyu Wang, Qichao Wang, Siyu Hao, Jianjun Zhu, Guoyin Kai, Wei Zhou

“…The present studies offers important data about the underlying function of SmDof12 and SmDof29 involved in the biosynthesis of phenolic acid or tanshinone, and provides valuable insights into further research of the SmDof gene families in S. miltiorrhiza.…”
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Doxorubicin-mediated testicular toxicity is associated with dysregulated mTOR/Beclin-1 pathways, oxidative stress, inflammation and apoptosis in Wistar rats: preventive role of lut... by Jennifer Efe Jaiyeoba-Ojigho, Jerome Ndudi Asiwe, Joseph Chimezie, Blessing Oluwakemi Abe, Oghenemarho Monalisa Ataikiru, Taniyohwo Mamerhi Enaohwo, Alexander Obidike Naiho, Lilian Ebele Chris-Ozoko, Godstime Jesukobiruo Ibada, Sylvester Ifeakachukwu Okuepusu, Favour Isioma Ikukaiwe, Winnie Taiye Ogwu

“…Abstract Background Lutein offers undoubted hope for preventing doxorubicin uncharacteristic reproductive function which remains a worldwide health concern in cancer chemotherapy. …”
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Protein allosteric site identification using machine learning and per amino acid residue reported internal protein nanoenvironment descriptors by Folorunsho Bright Omage, José Augusto Salim, Ivan Mazoni, Inácio Henrique Yano, Luiz Borro, Jorge Enrique Hernández Gonzalez, Fabio Rogerio de Moraes, Poliana Fernanda Giachetto, Ljubica Tasic, Raghuvir Krishnaswamy Arni, Goran Neshich

“…Allosteric regulation plays a crucial role in modulating protein functions and represents a promising strategy in drug development, offering enhanced specificity and reduced toxicity compared to traditional active site inhibition. …”
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A genome-wide base-editing screen uncovers a pivotal role of paxillin δ ubiquitination in influenza virus infection by Jiamei Guo, Zhuo Zhou, Ruining Li, Zhifang Xing, Lei Zhang, Shiyi Zhao, Wensheng Wei, Jianwei Wang, Tao Deng

“…Here, we leverage a genome-wide CRISPR base-editing screen to identify functional lysine residues in host factors required for influenza A virus (IAV) replication. …”
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Triglyceride metabolism controls inflammation and microglial phenotypes associated with APOE4 by Roxan A. Stephenson, Jordy Sepulveda, Kory R. Johnson, Adrian Lita, Jaanam Gopalakrishnan, Dominic J. Acri, Alexandra Beilina, Linling Cheng, Linda G. Yang, Jessica T. Root, Michael E. Ward, Christian Combs, William C. Skarnes, Mark R. Cookson, Han-Yu Shih, Mioara Larion, G. William Rebeck, Priyanka S. Narayan

“…Summary: Changes to cellular lipids accompany shifts in microglial cell state, but the functional significance of these metabolic changes remains poorly understood. …”
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Immune Checkpoints in B Cells: Unlocking New Potentials in Cancer Treatment by Xiaoye Shi, Xiangshu Cheng, Aimin Jiang, Wenjie Shi, Lingxuan Zhu, Weiming Mou, Antonino Glaviano, Zaoqu Liu, Quan Cheng, Anqi Lin, Linhui Wang, Peng Luo

“…Aberrant B‐cell IC signals not only impair the function of B cells themselves, but also modulate the tumor‐killing effects of other immune cells, ultimately fostering an immunosuppressive TME and facilitating tumor immune escape. …”
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Platelets subvert antitumor efficacy of T cell-recruiting bispecific antibodies by Melanie Märklin, Gundram Jung, Jonas S Heitmann, Helmut R Salih, Martina Svenja Lutz, Boris Klimovich, Stefanie Maurer, Latifa Zekri, Clemens Hinterleitner

“…Together, our findings demonstrate that platelets undermine the efficacy of T cell-recruiting bsAb and identify modulation of platelet function as a means to reinforce the effectiveness of bsAb treatment.…”
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K+-H+ coupling strategy for immune regulation and bone defect repair by Lintao Hu, Ke Yang, Yiyu Chen, Haoli Wang, Zezhou Fu, Lejian Jiang, Jiachen Xu, Hongsen Tian, Yiwei Zhu, Zhanqiu Dai, Yijun Li, Xianhua Chen, Xianfeng Lin, Pengfei Chen, Chenhui Gu, Shunwu Fan

“…Ion homeostasis is crucial for maintaining cell function. Potassium ion (K+) is one of the most important cations in the human body, and it plays key role in maintaining biological activities and cellular functions, including the intricate balance of ion homeostasis that underpins both physiological and pathological processes. …”
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Circadian regulation of endoplasmic reticulum calcium response in cultured mouse astrocytes by Ji Eun Ryu, Kyu-Won Shim, Hyun Woong Roh, Minsung Park, Jae-Hyung Lee, Eun Young Kim

“…Astrocytes, the most abundant glial cells, play crucial roles in CNS functions, but the impact of the circadian clock on astrocyte functions remains largely unexplored. …”
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A proximity-induced chimera platform for targeted protein arginine methylation by Yanlin Jian, Tianyang Zhou, Chendong Guo, Yibo Gao, Chen Yao, Zixi Wang, Xuehan Jiang, Ke Wang, Jian Ma, Yang Gao, Yizeng Fan, Jing Liu, Bohan Ma, Lei Li

“…Therefore, MeTAG represents a feasible approach to modulate protein methylation and thereby perturbs protein function in biological and therapeutic contexts.…”
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The Inhibition of Prolyl Endopeptidase (PREP) by KYP-2047 Treatment to Reduce Myocardial Ischemia/Reperfusion Injury by Laura Cucinotta, Nicoletta Palermo, Alessio Ardizzone, Anna Paola Capra, Michela Campolo, Emanuela Esposito, Giovanna Casili, Marika Lanza

“…Additionally, KYP-2047 was able to modulate p-38 and p-ERK expression, suggesting an improving role in recovering cardiac function. …”
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VCINet: Visual Cue-Inspired Feature Learning Network for SAR Building Segmentation by Mengyu Wang, Zhiyuan Yan, Wenhui Diao, Xudong Hu, Yingchao Feng, Linlin Xin, Junxi Li, Xian Sun

“…First, to improve intraclass variance and emphasize internal consistency, an elaborately designed pattern guidance module is introduced. We systematically study the stable spatial pattern of buildings and leverage the variogram function to model the characteristic to constrain deep network training. …”
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SSCD-YOLO: Semi-Supervised Cross-Domain YOLOv8 for Pedestrian Detection in Low-Light Conditions by Fangliang Cao, Kai Yan, Hongliang Chen, Zhen Wang, Yunliang Du, Zekang Zheng, Kefan Li, Baozhu Qi, Mingjia Wang

“…Additionally, a cross-domain distillation loss function is designed to improve the performance and efficiency of multi-scale object detection. …”
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Cross-Modality Consistency Network for Remote Sensing Text-Image Retrieval by Yuchen Sha, Yujian Feng, Miao He, Yichi Jin, Shuai You, Yimu Ji, Fei Wu, Shangdong Liu, Shaoshuai Che

“…In addition, we propose the cross-modality distinction loss function to learn semantic consistency between modalities by compacting intraclass samples and separating interclass samples. …”
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HMS-Net: A Hierarchical Multilabel Fine-Grained Ship Detection Network in Remote Sensing Images by Yunchao Yang, Zhengning Zhang, Pengming Feng, Yiming Yan, Guangjun He, Shaobo Liu, Pengyong Zhang, Haorao Gao

“…Furthermore, we design a hierarchical relationship constraint loss function to explicitly model interclass relationships among ships, optimizing feature distance measurements between different classes. …”
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