The ubiquitin code of RAS proteins: Decoding its role in cancer progression by Yedan Shi, Yong Shen, Xiuyuan Zhang, Ning Zhu, Yuwei Ding, Ying Yuan, Juan Wang

“…Recent studies have revealed that ubiquitination dynamically regulates the stability, membrane localization, and signaling transduction of RAS proteins, profoundly impacting their oncogenic functions. A series of ubiquitination sites, E3 ligases, deubiquitinases, and regulatory proteins are involved in RAS ubiquitination. …”
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Recent Advances in the Therapeutic Potential of Cannabinoids Against Gliomas: A Systematic Review (2022–2025) by Farideh A. Javid, Andrej Belancic, Man Ki Kwok, Yun Wah Lam

“…Cannabinoids have been shown to modulate immune responses in glioma, influencing T cell infiltration, myeloid suppressor cell recruitment, and tumor‐associated macrophage function. …”
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The endocannabinoidome–gut microbiome–brain axis as a novel therapeutic target for autism spectrum disorder by Antonella Campanale, Dario Siniscalco, Vincenzo Di Marzo

“…Research highlights the roles of the endocannabinoidome (eCBome) and gut microbiome (GM), both crucial for brain and gut function. This review summarizes research on therapeutic targets within the eCBome–GM–brain axis for ASD and related comorbidities. …”
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Transcriptional corepressor OsTPR1 regulates tillering and lateral root development in rice by Yi Hsuan Hou, Chia Ying Kuo, Tin Yau Edwin Lai, Ming Hong Xiao, Shin Lon Ho

“…This study explored the function of the rice TPR gene OsTPR1. Transgenic rice lines overexpressing OsTPR1 (OsTPR1-Ox) exhibited reduced lateral root density, whereas OsTPR1 RNA interference lines (OsTPR1-Ri) showed increased lateral root density. …”
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Mitochondrial Dysfunction: The Silent Catalyst of Kidney Disease Progression by Nikola Pavlović, Marinela Križanac, Marko Kumrić, Katarina Vukojević, Joško Božić

“…Additionally, dietary interventions and novel regulators such as adenogens are emerging as promising strategies to modulate mitochondrial function and attenuate kidney disease progression. …”
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A Spatial–Frequency Combined Transformer for Cloud Removal of Optical Remote Sensing Images by Fulian Zhao, Chenlong Ding, Xin Li, Runliang Xia, Caifeng Wu, Xin Lyu

“…The core of SFCRFormer is the spatial–frequency combined Transformer (SFCT) block, which implements cross-domain feature reinforcement through a dual-branch spatial attention (DBSA) module and frequency self-attention (FreSA) module to effectively capture global context information. …”
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Bidirectional substance P signaling between periodontal ligament fibroblasts and sensory neurons under mechanical stress by Judit Symmank, Lara Löffler, Ulrike Schulze-Späte, Collin Jacobs

“…Conversely, activated neurons elicited a robust pro-inflammatory response in PdLFs along with an increased osteoclastogenesis.DiscussionOur findings demonstrate that PdL fibroblasts could function as a novel non-neuronal source of SP modulating sensory neuron activation. …”
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Long Noncoding RNA MIR4435-2HG is Involved in Osteogenic Differentiation and Inflammation in Human Dental Pulp Stem Cells by Feijun Wu, Zhisheng Jiang

“…The aim of this study was to elucidate the function of long noncoding RNA MIR4435-2 host gene (MIR4435-2HG) in osteogenic differentiation and inflammatory response of dental pulp cells in vitro, offering insights into pulpitis mechanisms and potential treatment strategies. …”
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A novel histone acetylation-associated gene signature with prognostic value in Ewing sarcoma by Anshun Wu, Fayin Liu, Lei Zhou, Runyi Jiang, Shangjiang Yu, Zihuan Zhou, Qi Zhang, Qian Zhang, Dongjie Jiang, Shaohui He, Haifeng Wei

“…Abstract Histone acetylation is an important epigenetic modification, modulating the development of many tumors. However, the functions of most histone acetylation-related genes (HARGs) and their prognostic values in Ewing sarcoma (EWS) remain unclear. …”
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Antioxidant and Anti-Inflammatory Activities of Cutlassfish Head Peptone in RAW 264.7 Macrophages by Su-Jin Lee, Jeonghyeon Im, Svini Dileepa Marasinghe, Eunyoung Jo, Minthari Sakethanika Bandara, Youngdeuk Lee, Jaewon Lee, Gun-Hoo Park, Chulhong Oh

“…These findings suggest its potential not only as a therapeutic agent for conditions related to chronic inflammation, such as cardiovascular diseases and arthritis, but also as a functional ingredient in foods and nutraceuticals aimed at alleviating inflammation-related disorders.…”
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IGF2BP2 orchestrates global expression and alternative splicing profiles associated with glioblastoma development in U251 cells by Wenqing Liu, Yan Liu, Haoyuan Li, Shixiong Wang, Pengfei Chen, Zhongtao Liu, Xianhao Huo, Jihui Tian

“…Furthermore, IGF2BP2 selectively bound to 3′ and 5′ untranslated regions (UTRs) via GG[AU]C motifs, and IFIH1 was identified as a direct binding partner and upregulated gene upon IGF2BP2 overexpression. Functional enrichment analysis suggested that IGF2BP2 influences pathways related to RNA splicing and immune responses. …”
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Evaluation of Antifibrotic Mechanisms of 3′5-Dimaleamylbenzoic Acid on Idiopathic Pulmonary Fibrosis: A Network Pharmacology and Molecular Docking Analysis by Karina González-García, Jovito Cesar Santos-Álvarez, Juan Manuel Velázquez-Enríquez, Cecilia Zertuche-Martínez, Edilburga Reyes-Jiménez, Rafael Baltiérrez-Hoyos, Verónica Rocío Vásquez-Garzón

“…Results: A total of 57 common targets were identified between 3′5-DMBA and IPF; caspase 8, 9, 3, and 7; myeloid leukemia-induced cell differentiation protein Mcl-1; and poly [ADP-ribose] polymerase 1 are primary targets regulating PPI networks. Functional analysis revealed that the common targets are involved in the pathological features of tissue fibrosis and primarily in the apoptotic process. …”
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TIGAR coordinates senescence-associated secretory phenotype via lysosome repositioning and α-tubulin deacetylation by Hae Yun Nam, Seung-Ho Park, Geun-Hee Lee, Eun-Young Kim, SangEun Lee, Hyo Won Chang, Eun-Ju Chang, Kyung-Chul Choi, Seong Who Kim

“…Considering the functional value of the cell-secretome in aging-related diseases, these findings suggest the feasibility of TIGAR for the regulation of secretory phenotypes.…”
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State-of-the-Art on the Impact of Bimodal Acoustic Stimulation on Speech Perception in Noise in Adults: A Systematic Review by Antonio Casarella, Anna Notaro, Carla Laria, Nicola Serra, Elisabetta Genovese, Rita Malesci, Gennaro Auletta, Anna Rita Fetoni

“…CIs stimulate the auditory nerve by bypassing damaged hair cells, while HAs amplify sounds by requiring a functional hearing residual. The aim of this systematic review is to investigate the advantages and disadvantages of BS such as speech perception in noise. …”
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Aurora kinase B inhibitor AZD1152: repurposing for treatment of lupus nephritis driven by the results of clinical trialsResearch in context by Yue Zhao, Zuguo Zheng, Xuexiao Jin, Shaoshan Liang, Changming Zhang, Mingchao Zhang, Yue Lang, Ping Li, Zhihong Liu

“…Transcriptome sequencing and functional assays were performed to elucidate its mechanisms of action. …”
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Exploring fatty acids from royal jelly as a source of histone deacetylase inhibitors: from the hive to applications in human well-being and health by Fernanda Aparecida dos Santos France, Debora Kazumi Maeda, Ana Beatriz Rodrigues, Mai Ono, Franciele Lopes Nogueira Marchetti, Marcos Martins Marchetti, Allana Cristina Faustino Martins, Roberto da Silva Gomes, Cláudia Aparecida Rainho

“…Biochemical assays and gene expression analyses (Reverse Transcriptase – quantitative Polymerase Chain Reaction) were performed to evaluate the functional effects of the major RJ fatty acids, 10-HDA and 10-HDAA (10-hydroxy-decanoic acid), in two human cancer cell lines (HCT116 and MDA-MB-231). …”
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Targeting Sodium Transport Reveals CHP1 Downregulation as a Novel Molecular Feature of Malignant Progression in Clear Cell Renal Cell Carcinoma: Insights from Integrated Multi-Omic... by Yun Wu, Ri-Ting Zhu, Jia-Ru Chen, Xiao-Min Liu, Guo-Liang Huang, Jin-Cheng Zeng, Hong-Bing Yu, Xin Liu, Cui-Fang Han

“…Survival analysis showed that high CHP1 expression correlated with improved prognosis. Functional analyses, including pseudotime trajectory, Mfuzz clustering, and cell–cell communication modeling, indicated that CHP1⁺ epithelial cells engage in immune interaction via PPIA–BSG signaling. …”
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Gallic acid prevents obesity in mice on a high-fat diet via the gut microbiota-adipose tissue axis by Shiyan Jian, Xiaoying Jian, Lan Ye, Kang Yang, Limeng Zhang, Yixuan Xie, Jinping Deng, Yulong Yin, Baichuan Deng

“…Here, we found that high-fat diet (HFD) promoted lipid deposition and gut microbiota dysbiosis in mice, whereas GA slowed down lipid deposition and restored gut microbiota dysbiosis and its functional profile, as evidenced by the reduction of the obesity-causing bacterium Desulfovibrio and the enrichment of the beneficial bacterium Lachnospiraceae_NK4A136_group, Clostridiales_unclassified, Oscillospira and Adlercreutzia. …”
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Layilin regulates Treg motility and suppressive capacity in skin by Victoire Gouirand, Sean Clancy, Courtney Macon, Jose Valle, Mariela Pauli, Hong-An Truong, Jarish Cohen, Maxime Kinet, Margaret M Lowe, Samuel J Lord, Kristen Skruber, Hobart Harris, Esther Kim, Isaac Neuhaus, Karin Reif, Ali A Zarrin, R Dyche Mullins, Michael D Rosenblum

“…Mechanistically, layilin enhanced in vitro human Treg adhesion via modulation of lymphocyte function-associated antigen-1, resulting in distinct cytoskeletal alterations consistent with enhanced focal adhesion and lamellipodia formation. …”
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Implantation of Neuronal Stem Cells Enhances Object Recognition without Increasing Neurogenesis after Lateral Fluid Percussion Injury in Mice by Laura B. Ngwenya, Sarmistha Mazumder, Zachary R. Porter, Amy Minnema, Duane J. Oswald, H. Francis Farhadi

“…Cell transplantation has been linked to enhanced cognitive function after experimental traumatic brain injury, yet the mechanism of recovery is poorly understood. …”
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