Huntington’s disease cellular phenotypes are rescued non-cell autonomously by healthy cells in mosaic telencephalic organoids by Maura Galimberti, Maria R. Nucera, Vittoria D. Bocchi, Paola Conforti, Elena Vezzoli, Matteo Cereda, Camilla Maffezzini, Raffaele Iennaco, Andrea Scolz, Andrea Falqui, Chiara Cordiglieri, Martina Cremona, Ira Espuny-Camacho, Andrea Faedo, Dan P. Felsenfeld, Thomas F. Vogt, Valeria Ranzani, Chiara Zuccato, Dario Besusso, Elena Cattaneo

“…Abstract Huntington’s disease (HD) causes selective degeneration of striatal and cortical neurons, resulting in cell mosaicism of coexisting still functional and dysfunctional cells. The impact of non-cell autonomous mechanisms between these cellular states is poorly understood. …”
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Stacking selected polarization switching and phase transition in vdW ferroelectric α-In2Se3 junction devices by Yuyang Wu, Tianjiao Zhang, Deping Guo, Bicheng Li, Ke Pei, Wenbin You, Yiqian Du, Wanchen Xing, Yuxiang Lai, Wei Ji, Yuda Zhao, Renchao Che

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Unveiling the Important Role of Gut Microbiota and Diet in Multiple Sclerosis by Amina Džidić Krivić, Emir Begagić, Semir Hadžić, Amir Bećirović, Emir Bećirović, Harisa Hibić, Lejla Tandir Lihić, Samra Kadić Vukas, Hakija Bečulić, Tarik Kasapović, Mirza Pojskić

“…Namely, gut microbiota has a vital role in regulating immune function by influencing immune cell development, cytokine production, and intestinal barrier integrity. …”
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Acupuncture treatment of Satoyoshi syndrome: a case report of a rare disease by Yu Gong, Xudong Zhang, Xiaomin Hao, Jipeng Liu, Bingnan Yue, Chuan Liu, Tianqi Xia, Yi Yang, Longteng Tu, WeiJie Qiu, Yu Liu, Qingguo Liu

“…It is believed to exert its effects by modulating the neuroendocrine-immune network, enhancing immune cell function, and restoring homeostatic pathways. …”
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Regulation of Notch signaling by multiple Ankyrin repeat containing protein Mask by Bappi Sarkar, Jyoti Singh, Dipti Verma, Mousumi Mutsuddi, Ashim Mukherjee

“…Abstract Background Notch pathway is an evolutionarily conserved, highly pleiotropic signaling system that governs diverse developmental processes. Its diverse functions are attributed to the intricate regulatory mechanisms that finely tune the pathway. …”
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5-methylcytosine regulated CCNL2 promotes tumorigenesis and cisplatin resistance of ovarian cancer with therapeutic implications by Kai Zhang, Guiyun Cheng, Wenwen Jiang, Beihua Kong, Shu Yao, Xihan Liu

“…Mutation of the key residue of YBX1 required for m5C function led to decreased CCNL2 expression. Further investigation of the YBX1 regulatory network identified a direct interaction between YBX1 and MATR3, which cooperatively modulated downstream targets. …”
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Resveratrol Alleviates Skeletal Muscle Insulin Resistance by Downregulating Long Noncoding RNA by Zhihong Liu, Zhimei Zhang, Guangyao Song, Xing Wang, Hanying Xing, Chao Wang

“…Additionally, NONMMUT044897.2 was proven to function as a ceRNA of microRNA- (miR-) 7051-5p. Suppressor of Cytokine Signaling 1 (SOCS1) was confirmed as a target of miR-7051-5p. …”
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Quality of life in patients with non-small cell lung cancer by Šarac Sanja, Milić Rade, Vasiljević Mira, Šarac Momir

“…Monitoring of changes in the QoL among patients with locally advanced and metastatic NSCLC showed that chemotherapy did not decrease the global health status but led to significant changes in the social and financial functioning of patients. Some symptoms associated with the disease reduced in the intensity but some new occurred as a result of chemotherapy. …”
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Polyamine-Mediated Growth Regulation in Microalgae: Integrating Redox Balance and Amino Acids Pathway into Metabolic Engineering by Leandro Luis Lavandosque, Flavia Vischi Winck

“…Polyamines (putrescine, spermidine, and spermine) biology in microalgae, particularly <i>Chlamydomonas reinhardtii</i>, is reviewed, exploring their critical function in modulating cell cycle progression, enzymatic activity, and stress responses through nucleic acid stabilization, protein synthesis regulation, and post-translational modifications. …”
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Hypocretin: a promising target for the regulation of homeostasis by Yutong Wang, Yutong Wang, Su Fu, Jian Mao, Kun Cui, Hong Jiang, Hong Jiang

“…Yet, human data remain inconsistent, in part due to methodological variability and the limited availability of cerebrospinal fluid sampling to accurately assess central hypocretin function. Therapeutically, the hypocretin system is a promising target across several domains. …”
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Regulation of the Inflammatory Response, Proliferation, Migration, and Epithelial-Mesenchymal Transition of Human Lens Epithelial Cells by the lncRNA-MALAT1/miR-26a-5p/TET1 Signali... by Yaru Hu, Xue Han, Yue Chen, Jinbiao Cai, Juan Li, Yuchen Fan, Jianfeng Wang, Shanglun Xie

“…Objective. To investigate the function of MALAT1 in the inflammatory response, proliferation, migration, and epithelial-mesenchymal transition (EMT) of inflammatory and injured human lens epithelial cells (HLECs) and to reveal the underlying molecular signals. …”
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A long non-coding RNA lncRNA18313 regulates resistance against cadmium stress in wheat by Sujing Zhao, Hongxia Bai, Ziyi Fan, Mo Zhu, Zongbo Qiu, Zongbo Qiu

“…However, the exact biological functions and potential regulatory mechanism, especially in wheat’s response to cadmium (Cd) stress, are still poorly understood. …”
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Hydrogen sulfide (H2S) coordinates redox balance, carbon metabolism, and mitochondrial bioenergetics to suppress SARS-CoV-2 infection. by Ragini Agrawal, Virender Kumar Pal, Suhas K S, Gopika Jayan Menon, Inder Raj Singh, Nitish Malhotra, Naren C S, Kailash Ganesh, Raju S Rajmani, Aswin Sai Narain Seshasayee, Nagasuma Chandra, Manjunath B Joshi, Amit Singh

“…Notably, non-invasive measurement of respiratory functions using unrestrained whole-body plethysmography (uWBP) of SARS-CoV-2-infected mice showed improved pulmonary function variables, including pulmonary obstruction (Penh), end-expiratory pause (EEP), and relaxation time (RT) upon GYY4137 treatment. …”
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FABP7 in Hepatic Macrophages Promotes Fibroblast Activation and CD4+ T-Cell Migration by Regulating M2 Polarization During Liver Fibrosis by Hirofumi Miyazaki, Tunyanat Wannakul, Shuhan Yang, Dandan Yang, Ayano Karasawa, Ai Shishido, Ruizhu Cao, Yui Yamamoto, Yoshiteru Kagawa, Shuhei Kobayashi, Masaki Ogata, Motoko Maekawa, Yuji Owada

“…Therefore, regulation of hepatic macrophage function by FABP7 is a potential therapeutic target for liver fibrosis.…”
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Sphingolipid Metabolism and Signalling Pathways in Heart Failure: From Molecular Mechanism to Therapeutic Potential by Zhao M, Bian R, Xu X, Zhang J, Zhang L, Zheng Y

“…Conversely, sphingosine-1-phosphate (S1P) and ceramide-1-phosphate (C1P) regulate vascular function and influence cardiac remodeling. Additionally, enzymes such as diacylglycerol acyltransferase 1 (DGAT1) and sphingosine-1-phosphate lyase 1 (SGPL1) modulate cardiac lipid metabolism. …”
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Raw and boiled ginger (Zingiber officinale Roscoe) inclusive diet improves fertility parameters in high cholesterol diet-induced obese rats by Akomolafe Seun Funmilola, Atoyebi David Ayodeji

“…Conclusion This study found that both raw and boiled ginger-supplemented diets improved sexual function in obese rats by modulating metabolic hormones, sperm parameters, steroidogenic enzymes, and reproductive hormones, with the boiled ginger treatment outperforming the raw ginger treatment. …”
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The Role of Prion Protein in Reelin/Dab1 Signaling: Implications for Neurodegeneration by Irene Giulia Rolle, Anna Burato, Merve Begüm Bacınoğlu, Fabio Moda, Giuseppe Legname

“…PrP^C has also been implicated in several physiological functions. The protein is abundant in the nervous system, and it is critical for cell signaling in cellular communication, where it acts as a scaffold for various signaling molecules. …”
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PiRNA hsa_pir_018849 promotes the proliferation and invasion of osteosarcoma cells by regulating the stability of CCN5 mRNA by Jiale Huang, Saishuai Yang, Peng Liu, He Jiang, Zhiming Cui, Jiajia Chen

“…Conclusion PiRNA hsa_piR_018849 regulates the function of osteosarcoma cells by targeting and inhibiting the expression of CCN5.…”
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Nursing practice in relation to older people’s fundamentals of care in nursing homes: An exploratory design by O.M. Nordaunet, E.R. Gjevjon, H. Aagaard, C. Olsson, G. Borglin

“…We have highlighted the intricate nature of nursing practice, its relationship with clinical decision-making processes, and the functional and performance levels of nursing activities. …”
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Extracellular vesicles of Limosilactobacillus fermentum SLAM216 ameliorate skin symptoms of atopic dermatitis by regulating gut microbiome on serotonin metabolism by Hyejin Choi, Min-Jin Kwak, Youbin Choi, An Na Kang, Daye Mun, Ju Young Eor, Mi Ri Park, Sangnam Oh, Younghoon Kim

“…Importantly, in an atopic dermatitis-like cell model induced by TNFα/IFNγ, LF216EV significantly modulated the expression of immune regulatory genes (TSLP, TNFα, IL-6, IL-1β, and MDC), indicating its potential functionality in atopic dermatitis. …”
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