Biological function of RNA-binding proteins in myocardial infarction: a potential emerging therapeutic limelight by Chenyang Jin, Yutong Ye, Longzhe Gao, Zikan Zhong, Changzuan Zhou, Xiaoyu Wu, Xudong Li, Genqing Zhou, Songwen Chen, Yong Wei, Lidong Cai, Shaowen Liu, Juan Xu

“…RBPs, as key regulators coordinating cell differentiation and tissue homeostasis, exhibit specific functions in gene transcription, RNA modification and processing, and post-transcriptional gene expression. …”
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Kiperin Postbiotic Supplement-Enhanced Bacterial Supernatants Promote Fibroblast Function: Implications for Regenerative Medicine by Lutfiye Karcioglu Batur, Cuneyd Yavas, Yağmur Ekenoğlu Merdan, Ashabil Aygan

“…This study aimed to evaluate the effects of a postbiotic supplement (PS)—composed of inactivated strains of <i>Escherichia coli</i>, <i>Lacticaseibacillus rhamnosus</i>, and <i>Lactiplantibacillus plantarum</i>—on fibroblast function, particularly in the context of bacterial secretomes from common pathogenic strains. …”
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Compositional and functional gut microbiota alterations in mild cognitive impairment: links to Alzheimer’s disease pathology by Kang-Chen Fan, Chen-Ching Lin, Yen-Ling Chiu, Seong-Ho Koh, Yi-Chien Liu, Yi-Fang Chuang

“…Notably, species within the same genera, such as Bacteroides and Ruminococcus, showed opposing effects, while Akkermansia muciniphila correlated with reduced amyloid burden, suggesting a protective role. Functional profiling revealed microbial pathways contributing to energy metabolism and neuroinflammation, mediating the relationship between gut microbes and brain health. …”
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Individuals co-exposed to sand fly saliva and filarial parasites exhibit altered monocyte function. by Moussa Sangare, Yaya Ibrahim Coulibaly, Naureen Huda, Silvia Vidal, Sameha Tariq, Michel Emmanuel Coulibaly, Siaka Yamoussa Coulibaly, Lamine Soumaoro, Ilo Dicko, Bourama Traore, Ibrahim Moussa Sissoko, Sekou Fantamady Traore, Ousmane Faye, Thomas B Nutman, Jesus G Valenzuela, Fabiano Oliveira, Seydou Doumbia, Shaden Kamhawi, Roshanak Tolouei Semnani

“…<h4>Conclusions/significance</h4>Together, our data suggest that SG or recombinant salivary proteins from Pd alter human monocyte function by upregulating selective inflammatory cytokines.…”
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Neuronal guidance signaling in neurodegenerative diseases: Key regulators that function at neuron-glia and neuroimmune interfaces by Junichi Yuasa-Kawada, Mariko Kinoshita-Kawada, Masaki Hiramoto, Satoru Yamagishi, Takayasu Mishima, Shin’ichiro Yasunaga, Yoshio Tsuboi, Nobutaka Hattori, Jane Y. Wu

“…Particular focus is placed on how neuronal guidance mechanisms control neuron-glia and neuroimmune interactions and modulate microglial function under physiological and pathological conditions. …”
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Performance of the UNICEF/UN Washington Group tool for identifying functional difficulty in rural Zimbabwean children. by Thomas Frederick Dunne, Jaya Chandna, Florence Majo, Naume Tavengwa, Batsirai Mutasa, Bernard Chasekwa, Robert Ntozini, Andrew J Prendergast, Jean H Humphrey, Melissa J Gladstone

“…We evaluated functional difficulty prevalence in HIV-exposed and HIV-unexposed children using the Washington Group Child Functioning Module (WGCFM), comparing absolute difference using chi-squared or Fisher's exact tests. …”
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Metaproteomics reveals diet-induced changes in gut microbiome function according to Crohn’s disease location by Stefano Levi Mortera, Valeria Marzano, Federica Rapisarda, Chiara Marangelo, Ilaria Pirona, Pamela Vernocchi, Marta Di Michele, Federica Del Chierico, Maria A. Quintero, Irina Fernandez, Hajar Hazime, Rose M. Killian, Norma Solis, Mailenys Ortega, Oriana M. Damas, Siobhan Proksell, David H. Kerman, Amar R. Deshpande, Luis Garces, Franco Scaldaferri, Antonio Gasbarrini, Maria T. Abreu, Lorenza Putignani

“…However, the impact of diet modulation on GM function in CD patients is understudied. …”
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Meta-analysis of the effects of multi-component exercise on cognitive function in older adults with cognitive impairment by Hualei Liu, Zhiyuan Sun, Zhiyuan Sun, Haiqing Zeng, Jincheng Han, Mengqi Hu, Dewei Mao, Dewei Mao, Xuewen Tian, Ran Li

“…In conclusion, multi-component exercise can delay the decline in cognitive function in the elderly, and the intervention effects are modulated by various variables. …”
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Transcriptional analysis of murine biliary atresia identifies macrophage heterogeneity and subset-specific macrophage functions by Kyle D. Gromer, Shang-Yang Chen, Gaurav Gadhvi, Liang Feng, Colin Shearn, Swati Antala, Swati Antala, Joshua B. Wechsler, Carla M. Cuda, Cara L. Mack, Ronald J. Sokol, William J. Janssen, Richard M. Green, Harris Perlman, Deborah R. Winter, Sarah A. Taylor, Sarah A. Taylor

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Effect of Wendan decoction granules on preventing endolymphatic hydrops and protecting vestibular function in Guinea pigs by Jingjing Xia, Tiancheng Xie, Jinli Liu, Weikang Cheng, Longyan Liao, Ming Chen, Haibing Hua, Xiaobing Hou

“…The effects of Wendan decoction granules on neurological function, cochlear hydrops, the ultrastructure of the cochlear Corti organ area, inflammatory response, and the expression of AQP2 and P38MAPK in guinea pigs were examined using behavioral experiments, hematoxylin and eosin staining, scanning electron microscopy, ELISA, qRT-PCR, and immunohistochemistry staining. …”
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Impact of Radiotherapy on Endocrine Function and Gut Microbiota in Cervical Cancer Patients Undergoing Ovarian Transposition by Xie S, Liu M, Li W

“…Outcomes measured included ovarian and endocrine function, quality of life, adverse reactions, and gut microbiota composition. …”
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Non-immune targeting of CXCR3 compromises mitochondrial function and suppresses tumor growth in glioblastoma by Travis Yui Hei Chan, Bo Chen, Wanjun Tang, Henry Hei Chan, Yogesh K. H. Wong, Ethan C. L. Wong, Junbo Liao, Anson Cho-Kiu Ng, Jenny Sum Yee Wong, Gilberto Ka-Kit Leung, Karrie M. Kiang

“…Notably, activation of phosphorylated-STAT3 rescued cell viability in CXCR3-depleted cells, suggesting that CXCR3 may modulate mitochondrial function through a STAT3-dependent mechanism, consistent with the known functional role of STAT3 in maintaining mitochondrial redox balance. …”
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The Function of Myostatin in Ameliorating Bone Metabolism Abnormalities in Individuals with Type 2 Diabetes Mellitus by Exercise by Chenghao Zhong, Xinyu Zeng, Xiaoyan Yi, Yuxin Yang, Jianbo Hu, Rongbin Yin, Xianghe Chen

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Genomic and functional characterization of a Butyricicoccus porcorum strain isolated from human gut microbiota by Ni Zhao, Peiling Geng, Alejandro Gaher Perez, Anakha Chandramana Maya, Brijesh Yadav, Yuxuan Du, Yong Ge

“…Our findings uncover the crucial roles of B. porcorum in supporting intestinal homeostasis and provide a novel functional modulator to potentially optimize microbial strategies for improving intestinal health.IMPORTANCEReduced abundance of the Butyricicoccus genus has been associated with human intestinal disorders, including inflammatory bowel diseases. …”
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Integration and functionality of human iPSC-derived microglia in a chimeric mouse retinal model by Chun Tang, Qi-Qi Zhou, Xiu-Feng Huang, Ya-Yi Ju, Bi-Lin Rao, Zhi-Cong Liu, Yi-An Jia, Zhan-Pei Bai, Qing-Yang Lin, Lin Liu, Jia Qu, Jun Zhang, Mei-Ling Gao

“…Our approach achieved over 86% integration of human microglia, which maintained key functions including proliferation, immune responsiveness, and synaptic pruning over a 14-day culture period. scRNA-seq of xMG revealed a shift in microglial signatures compared to monoculture iMG, indicating a transition to a more in vivo-like phenotype. …”
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Serum extracellular matrix biomarkers in rheumatoid arthritis, psoriatic arthritis and psoriasis and their association with hand function by Helena Port, Birte Coppers, Sonja Tragl, Eva Manger, Lisa M. Niemiec, Sara Bayat, David Simon, Filippo Fagni, Giulia Corte, Anne-Christine Bay-Jensen, Koray Tascilar, Axel J. Hueber, Katja G. Schmidt, Verena Schönau, Michael Sticherling, Simon Heinrich, Sigrid Leyendecker, Daniela Bohr, Georg Schett, Arnd Kleyer, Signe Holm Nielsen, Anna-Maria Liphardt

“…Especially PsA and PsO had higher levels of inflammatory biomarkers compared to RA and controls, likely due to modulation by treatment. Predominantly in PsO, ECM formation biomarkers were associated with hand function impairments.…”
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Preserving cognitive function in patients with Alzheimer's disease: The Alzheimer's disease neuroprotection research initiative (ADNRI) by Jie Liu, Heleen vanBeusekom, Xian‐Le Bu, Gong Chen, Paulo Henrique Rosado de Castro, Xiaochun Chen, Xiaowei Chen, Andrew N. Clarkson, Tracy D. Farr, Yuhong Fu, Jianping Jia, Jukka Jolkkonen, Woojin Scott Kim, Paula Korhonen, Shen Li, Yajie Liang, Guang‐Hui Liu, Guiyou Liu, Yu‐Hui Liu, Tarja Malm, Xiaobo Mao, Joaquim Miguel Oliveira, Mike M. Modo, Pedro Ramos‐Cabrer, Karsten Ruscher, Weihong Song, Jun Wang, Xuanyue Wang, Yun Wang, Haitao Wu, Lize Xiong, Yi Yang, Keqiang Ye, Jin‐Tai Yu, Xin‐Fu Zhou, Marietta Zille, Colin L. Masters, Piotr Walczak, Johannes Boltze, Xunming Ji, Yan‐Jiang Wang

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Detection and discrimination of modulation type at low modulation rates by A. P. SĘK

“…For a sinusoidal carrier at a frequency of 1 kHz, amplitude (AM) or frequency (FM) modulated by a sinusoidal modulator at a rate of fmod = 2, 5 or 10 Hz, psychometric functions for the detection and the discrimination of modulation type were measured as a function of an appropriate modulation index (i.e. m or β). …”
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Role of Inflammation and Motility Disorders in the Development, Course and Consequences of Functional Gastrointestinal and Biliary Tract Diseases (Literature Review and Expert Pane... by V. T. Ivashkin, D. S. Bordin, T. L. Lapina, M. A. Livzan, A. V. Okhlobystin, E. A. Poluektova, A. S. Trukhmanov, Yu. P. Uspenskiy, Yu. O. Shulpekova

“…Aim: to present the results of the Expert Panel with a discussion of modern concepts of the pathogenesis of functional gastrointestinal diseases and the possibilities of multitarget therapy with trimebutine.   …”
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Comprehensive bioinformatic analysis reveals prognostic significance and functional insights of candidate gene expression in colorectal cancer by Tao-Wei Ke, Sheng-Chi Chang, Chung-Min Yeh, Shu-Hui Lin, Kun-Tu Yeh

“…We initially identified differentially expressed genes (DEGs) and applied weighted gene co-expression network analysis (WGCNA) to the GSE41258 dataset to reveal key gene modules associated with CRC. Enrichment analyses were conducted to gain insights into the underlying biology of CRC, particularly focusing on pathways linked to the identified gene modules. …”
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