Nematode serine protease inhibitor SPI-I8 negatively regulates host NF-κB signalling by hijacking MKRN1-mediated polyubiquitination of RACK1 by Fei Wu, Yanqiong Chen, Xueqiu Chen, Danni Tong, Jingru Zhou, Zhendong Du, Chaoqun Yao, Yi Yang, Aifang Du, Guangxu Ma

“…Although much is known about the nature of nematode effectors in immune modulation, little is known about the action mode of these molecules. …”
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Hsa-circVIM regulates breast cancer tumor progression and tamoxifen sensitivity by sponging miR-1294 in hormone receptor-positive breast cancer cells by Ying Chen, Zhenhua Zhang, Xue Luo, Meini Cen, Peng Dai, Xiaoyan Zhu

“…Bioinformatic analyses were conducted to make function and pathway enrichment analyses. Results hsa-circVIM expression was raised in breast cancer and predicted unsatisfactory overall survival outcomes. …”
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New Pharmacological Insight into Etanercept and Pregabalin in Allodynia and Nociception: Behavioral Studies in a Murine Neuropathic Pain Model by Loulwah Alothman, Emad Alhadlaq, Asma Alhussain, Alwaleed Alabdulkarim, Youssef Sari, Shakir D. AlSharari

“…Pregabalin, an anticonvulsant that modulates calcium channels, is effective but can impair mental and motor functions, especially in older patients. …”
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The Investigation of Caspase-3 and Tumor Necrosis Factor-Alpha Expression in Placentas of Patients with Preterm Premature Rupture of Membranes by Işılay Sezen Ermiş, Fırat Aşır, Süleyman Cemil Oğlak, Özge Kaplan, Gül Ebru Aydeniz, Engin Deveci

“…Tumor necrosis factor-α (TNF-α) released from activated macrophages has various functions such as modulation of cell growth and differentiation, immunoregulation, coagulation, and regulation of endothelial cell function. …”
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Host metabolic shift during systemic Salmonella infection revealed by comparative proteomics by Yuanyuan Wang, Chunmei Wu, Jiacong Gao, Xudong Du, Xiangyun Chen, Mei Zhang

“…Previous studies have suggested that SPI-2 function to modulate host vesicle trafficking and immune response to promote systemic infection. …”
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Partial Inhibition of Epithelial-to-Mesenchymal Transition (EMT) Phenotypes by Placenta-Derived DBMSCs in Human Breast Cancer Cell Lines, In Vitro by Yasser Basmaeil, Abdullah Al Subayyil, Haya Bin Kulayb, Altaf A. Kondkar, Maha Alrodayyan, Tanvir Khatlani

“…We also investigated how these cancer cells lines affect the functional competence of DBMSCs. By co-culturing DBMSCs with cancer cells, we analyzed changes in functions of both cell types, as well as alterations in their genomic and proteomic profile. …”
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Gardeniae Fructus oil alleviate depression-like behaviors via the microbiota-gut-brain axis in mice with chronic unpredictable mild stress by Man Han, Fei Zeng, Yi Liu, Wenxin Shi, Shijuan Shao, Chunchao Yan, Yunzhong Chen

“…OGF could effectively attenuate depression-like behaviors in mice with chronic unpredictable mild stress by modulating the microbiota-gut-brain axis. Mechanisms include improving gut dysbiosis, regulating short-chain fatty acids, protecting the intestinal barrier function, reducing hippocampal damage, and alleviating neuroinflammation by inhibiting the activation of the TLR4/NF-κB/NLRP3 pathway. …”
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Moringa oleifera as a multifunctional feed additive: synergistic nutritional and immunomodulatory mechanisms in livestock production by Raza Mohai Ud Din, Salwa Eman, Muhammad Hammad Zafar, Zhang Chong, Ahmed A. Saleh, Ahmed A. Saleh, Hosameldeen Mohamed Husien, Hosameldeen Mohamed Husien, Mengzhi Wang, Mengzhi Wang

“…These findings underscore M. oleifera is potential to enhance disease resistance and immune function in animals, advocating for its strategic incorporation into sustainable animal nutrition practices.…”
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Improved YOLOv8 Model for Multi-type Lung Nodule Detection by BAO Qiangqiang, TANG Siyuan, LI Qingqian, WANG Naiyu, YANG Min, GU Yu, ZHAO Jinliang, GAO Jingbo, WANG Jiaxin, QU Yuhan

“…Firstly, the RepViTCAA module is proposed to improve the C2f module of the main part to enhance the accuracy of tiny lung nodule detection and the lightweight design of the model. …”
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Omega-3 Fatty Acids and Neuroinflammation in Depression: Targeting Damage-Associated Molecular Patterns and Neural Biomarkers by Ikbal Andrian Malau, Jane Pei-Chen Chang, Yi-Wen Lin, Cheng-Chen Chang, Wei-Che Chiu, Kuan-Pin Su

“…Major Depressive Disorder (MDD) is a prevalent mental health condition with a complex pathophysiology involving neuroinflammation, neurodegeneration, and disruptions in neuronal and glial cell function. Microglia, the innate immune cells of the central nervous system, release inflammatory cytokines in response to pathological changes associated with MDD. …”
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Vorinostat impairs the cancer-driving potential of leukemia-secreted extracellular vesicles by Crescenzo Massaro, Giulia Sgueglia, Annamaria Muro, Damiana Pieragostino, Paola Lanuti, Maria Concetta Cufaro, Cristina Giorgio, Erika D’Agostino, Laura Della Torre, Serena Rubina Baglio, Marinella Pirozzi, Mariacarla De Simone, Lucia Altucci, Carmela Dell’Aversana

“…Methods Leukemia-secreted extracellular vesicles (EVs) were isolated by Differential UltraCentrifugation, and their miRNome and proteomic profiling cargo were analyzed following treatment with SAHA (Vorinostat) in Acute Myeloid Leukemia (AML) and Chronic Myeloid Leukemia (CML). The epigenetic modulation of leukemia-secreted EVs content on interesting key target molecules was validated, and their differential functional impact on cellular viability, cell cycle progression, apoptosis, and tumorigenicity was assessed. …”
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The role of CD47 in immune escape of colon cancer and its correlation with heterogeneity of tumor immune microenvironment by Qiu-Si Tian, ChunMei Zhang, Zhi-Jun Bao, ZhiGang Pei

“…Background Cluster of differentiation 47 (CD47), a transmembrane protein, plays a critical role in regulating cellular functions and maintaining immune homeostasis. Its expression has been shown to influence cancer prognosis. …”
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Imbalanced and Unchecked: The Role of Metal Dyshomeostasis in Driving COPD Progression by Ye Cui, Xinqian Du, Yunqi Li, Dan Wang, Zhe Lv, Huihui Yuan, Yan Chen, Jie Liu, Ying Sun, Wei Wang

“…We specifically focus on iron, copper, and zinc, given their well-characterized roles in orchestrating cytokine production, immune cell function, antioxidant depletion, and matrix remodeling. …”
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Impact of Electromagnetic Field on the Physicochemical Properties, Permeability, and Accumulation of Salicylic Acid by Karolina Zyburtowicz-Ćwiartka, Anna Nowak, Anna Muzykiewicz-Szymańska, Łukasz Kucharski, Maciej Konopacki, Rafał Rakoczy, Paula Ossowicz-Rupniewska

“…Transdermal drug delivery offers a non-invasive route for the systemic and localized administration of therapeutics; however, the skin’s barrier function limits its efficiency. This study investigates the application of various electromagnetic field (EMF) configurations to enhance the transdermal delivery of salicylic acid, a model compound with moderate lipophilicity and ionizability. …”
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The Role of Oxidative Stress in Skin Disorders Associated with Alcohol Dependency and Antioxidant Therapies by Joanna Wróblewska, Anna Długosz, Damian Czarnecki, Wioletta Tomaszewicz, Błażej Błaszak, Joanna Szulc, Weronika Wróblewska

“…Antioxidants may offer protective and regenerative effects by scavenging free radicals, modulating inflammatory responses, and enhancing skin barrier function. …”
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MTHFD1 Regulates Autophagy to Promote Growth and Metastasis in Colorectal Cancer via the PI3K‐AKT–mTOR Signaling Pathway by Zhihao Li, Haoxian Ke, Jiawei Cai, Shubiao Ye, Junfeng Huang, Chi Zhang, Ming Yuan, Ping Lan, Xianrui Wu

“…Our aim was to elucidate the function of MTHFD1 in colorectal cancer (CRC). Methods In vitro assessments of the proliferation, invasion, and migration abilities of CRC cells were conducted using Immunohistochemistry, Transwell invasion assays, Western blot (WB), and Cell counting Kit‐8 assays. …”
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Immunological synapse: structures, molecular mechanisms and therapeutic implications in disease by Zheng Chao, Qi Mei, Chunguang Yang, Jing Luo, Peikun Liu, Hao Peng, Xiangdong Guo, Zhinan Yin, Le Li, Zhihua Wang

“…Numerous recent studies have addressed key signaling mechanisms and reported novel targets related to IS, further broadening our understanding of its function and regulatory factors. However, a comprehensive review that highlights recent progress and consolidates past knowledge is still lacking. …”
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Impaired nutrient absorption, reduced bone mass and alterations in the gut microbiome contribute to postnatal growth retardation in a mouse model of MWS by Yangyang Ge, Lingya Liu, Lihua Wu, Xiaofan Liu, Yingao Hao, Shixu Wang, Yi Xiong, Zi Yang, Zhen Zhang, Qi Li, Bo Li, Jianxin Wu, Guangxu Ren, Qian Jiang

“…Abstract Mowat‒Wilson syndrome (MWS), a rare genetic disorder caused by heterozygous loss-of-function mutations in ZEB2, is characterised by significant growth retardation with unclear mechanisms. …”
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Lunar Rickshaw – A non-Motorized Vehicle Designed for Exploration and Rescue Missions on the Moon’s South Pole by Marius POP, Dan NETOIU, Tiberiu SALAORU, Dana LEPADATU, Calin COMAN, Mircea BOCIOAGA

“…We have designed a simple, lightweight vehicle concept—a Lunar Rickshaw (LR)—engineered to rapidly and safely transport an incapacitated astronaut from a remote location to the Lunar Module (LM). In addition to its primary function for emergency evacuation, the Lunar Rickshaw can also serve as a mobile platform for carrying essential tools during extravehicular activities (EVAs). …”
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Metabolic Reprogramming in Respiratory Viral Infections: A Focus on SARS-CoV-2, Influenza, and Respiratory Syncytial Virus by Jordi Camps, Simona Iftimie, Andrea Jiménez-Franco, Antoni Castro, Jorge Joven

“…The dysregulation of mitochondrial function and oxidative stress pathways also contributes to disease severity and long-term complications, such as persistent inflammation and immune exhaustion. …”
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