Circ_HUWE1: a novel regulator of lipid accumulation, inflammation, and gut microbiota in atherosclerosis by Zulong Sheng, Yi Fan, Zhenjun Ji, Yanru He, Rui Zhang, Yuyu Yao, Genshan Ma

“…Mechanistically, circ_HUWE1 functioned as a competing endogenous RNA (ceRNA) by sponging miR-143-3p, thereby upregulating IGFBP5 expression. …”
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Maternal consumption of yoghurt activating the aryl hydrocarbon receptor increases group 3 innate lymphoid cells in murine offspring by Grégory Pimentel, Thomas Roder, Cornelia Bär, Sandro Christensen, Zahra Sattari, Cristina Kalbermatter, Ueli von Ah, Christelle A. M. Robert, Pierre Mateo, Rémy Bruggmann, Stephanie C. Ganal-Vonarburg, Guy Vergères

“…They bind to the aryl hydrocarbon receptor (AhR), thereby modulating development of intestinal group 3 innate lymphoid cells (ILC3) and subsequent interleukin-22 production. …”
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A genome-wide screen for FTY720-sensitive mutants reveals genes required for ROS homeostasis by Kanako Hagihara, Kanako Kinoshita, Kouki Ishida, Shihomi Hojo, Yoshinori Kameoka, Ryosuke Satoh, Teruaki Takasaki, Reiko Sugiura

“…Fingolimod hydrochloride (FTY720), a sphingosine-1-phosphate (S1P) analogue, is an approved immune modulator for the treatment of multiple sclerosis (MS). …”
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LUCAT1-Mediated Competing Endogenous RNA (ceRNA) Network in Triple-Negative Breast Cancer by Deepak Verma, Sumit Siddharth, Ashutosh S. Yende, Qitong Wu, Dipali Sharma

“…Recent emergence of competing endogenous RNA (ceRNA) networks has highlighted how long noncoding RNAs (lncRNAs), microRNAs (miRs), and mRNA orchestrate a complex interplay meticulously modulating mRNA functionality. Focusing on TNBC, this study aimed to construct a ceRNA network using differentially expressed lncRNAs, miRs, and mRNAs. …”
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Comprehensive bioinformatics analysis of EXOSC family genes in head and neck squamous cell carcinoma by Xuezhong Zhang, Mengmeng Zhao, Tingting Chu, Jiasha Wei, Qingmei Jia

“…Gene co-expression and enrichment analyses were used to elucidate potential molecular functions, and a protein–protein interaction (PPI) network was constructed via GeneMANIA. …”
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Enhancer profiling uncovers Jmjd1c as an essential suppressor in neuropathic pain by targeting Socs3 by Le Zhang, Yan Xie, Shun Wang, Moxuan Gong, Zheping Chen, Chuanxin Wang, Peilong Li

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A Cross-Tissue Transcriptome-Wide Association Study Reveals Novel Susceptibility Genes for Diabetic Kidney Disease in the FinnGen Cohort by Menghan Liu, Zehua Li, Yao Lu, Pingping Sun, Ying Chen, Li Yang

“…Five complementary analytical frameworks—sparse canonical correlation analysis (sCCA), functional summary-based imputation (FUSION), fine-mapping of causal gene sets (FOCUS), summary-data-based Mendelian randomization (SMR), and multi-marker analysis of genomic annotation (MAGMA)—were integrated to nominate candidate genes. …”
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Unraveling the pathogenesis of bone marrow hematopoietic injury and the therapeutic potential of natural products by Jing Long, Hengzhou Lai, Yuqing Huang, Fengming You, Yifang Jiang, Qixuan Kuang

“…Bone marrow hematopoietic injury encompasses a range of pathological conditions that disrupt the normal function of the hematopoietic system, primarily through the impaired production and differentiation of bone marrow hematopoietic cells. …”
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Multi-scale attention-enhanced deep learning approach for detecting seven trunk pests and diseases in Shanghai’s urban plane trees by Tianyang Song, Guohua Hu, Tianci Yu, Xing Meng, Yanting Zhang, Ruiqing Yang, Benyao Wang, Xia Li

“…Key improvements include integrating the Selective Kernel Attention (SKA) mechanism for multi-scale feature enhancement, augmenting the Spatial Pyramid Pooling Fast (SPPF) module with average pooling to preserve subtle details, and employing the WIoUv3 loss function to improve localization accuracy. …”
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SIGIRR: An Orphan Receptor Mediating Anti-inflammatory Actions by Siqi Cheng, Lingyue Cui, Jingyi Chen, Qianwei Xiu, Rujia Si, Xiaoguang Yang, Ying Shi

“…Due to its unique structure and function, SIGIRR is commonly referred to as an ‘orphan receptor’, with IL-37 being the only confirmed ligand molecule for SIGIRR to date. …”
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Enhancing Tendon Regeneration: Investigating the Impact of Topography on the Secretome of Adipose‐Derived Stem Cells by Qiuzi Long, Chuanquan Liu, Haotian Zheng, Mingyue Wang, Hanmei Liu, Yue Liu, Zhicheng Cao, Yuzhi Sun, Qingyun Mo, Ludvig J. Backman, Jialin Zhu, Lizhi Hu, Jinlong Huang, Wei Zhang, Jialin Chen

“…This modulation activates the MAPK, GPCR and Integrin signaling pathways which may account for the enhanced effect on tendon regeneration. …”
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Custom affinity probes reveal DNA-damage-induced, ssDNA-independent chromatin SUMOylation in budding yeast by Vera Tröster, Ronald P. Wong, Arne Börgel, Baris Cakilkaya, Christian Renz, Martin M. Möckel, Karolin Eifler-Olivi, Joana Marinho, Thomas Reinberg, Sven Furler, Jonas V. Schaefer, Andreas Plückthun, Eva Wolf, Helle D. Ulrich

“…In vivo application pinpoints Smt3’s essential function to the nucleus and demonstrates DARPin-mediated sensitization toward various stress conditions. …”
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TTLL4 mediates the PI3K/AKT/MDM2 pathway to promote hepatocellular carcinoma progression and predict patient prognosis by Zeping He, Desheng Chen, Lei Li, Shanbao Li, Fangbin Song, Jinfeng Cai, Xueyan Guo, Yaohao Luo, Xinshuai Wang, Zeping Chen, Junming Xu

“…The effects of TTLL4 on cell proliferation, migration, and apoptosis were studied using functional assays and flow cytometry. In vivo, tumor growth and metastasis were evaluated through subcutaneous implantation and tail vein injection. …”
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Submonolayered Ru-modified Pd mesoporous nanosheets as multifunctional electrocatalyst for hydrogen evolution and alcohol oxidation reactions by Xinran Jiao, Chaoqun Ma, Biao Huang, Dengke Zhao, Fukai Feng, Sumei Han, Nailiang Yang, Qipeng Lu, Yiyao Ge, Qian Xu

“…The structural modulation of metal-based heterostructure plays a vital role in achieving enhanced performances for highly efficient electrocatalysis. …”
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Tumor Organoids Grown in Mixed-Composition Hydrogels Recapitulate the Plasticity of Pancreatic Cancers by Ioritz Sorzabal-Bellido, Xabier Morales, Iván Cortés-Domínguez, Maider Esparza, Lucía Grande, Pedro Castillo, Silvia Larumbe, María Monteserín, Shruthi Narayanan, Mariano Ponz-Sarvise, Silve Vicent, Carlos Ortiz-de-Solórzano

“…Tumor-derived organoids are valuable tools for drug screening; however, their clinical relevance relies on how accurately they recapitulate the phenotypic and functional characteristics of the original tumors. In this study, we present a quantitative analysis of how hydrogel composition influences the phenotype, tissue remodeling, metabolism, and drug resistance of PDAC organoids. …”
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A Molecularly Defined Medullary Network for Control of Respiratory Homeostasis by Tianjiao Deng, Xinyi Jing, Liuqi Shao, Yakun Wang, Congrui Fu, Hongxiao Yu, Xiaoyi Wang, Xue Zhao, Fanrao Kong, Yake Ji, Xiaochen Tian, Wei He, Shangyu Bi, Luo Shi, Hanqiao Wang, Fang Yuan, Sheng Wang

“…Abstract The dynamic interaction between central respiratory chemoreceptors and the respiratory central pattern generator constitutes a critical homeostatic axis for stabilizing breathing rhythm and pattern, yet its circuit‐level organization remains poorly characterized. Here, the functional connectivity between two key medullary hubs: the nucleus tractus solitarius (NTS) and the preBötzinger complex (preBötC) are systematically investigated. …”
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Genomic Characterization of Four Novel Probiotic Strains with Enzymatic Activity and Their Effects on Carp (<i>Cyprinus carpio</i>) by Evgeniya Valeryevna Prazdnova, Maria Sergeevna Mazanko, Victoria Nikolaevna Shevchenko, Radomir Viktorovich Skripnichenko, Maksim Pavlovich Kulikov, Lilia Sergeevna Golovko, Vadim Alexeevich Grigoriev, Tatiana Alexandrovna Maltseva, Daria Borisovna Kulikova, Dmitry Vladimirovich Rudoy

“…Whole-genome sequencing was performed and functional annotation identified probiotic-related genes. …”
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GLI2-HRD1 axis facilitates 5-FU resistance in gastric cancer cells by regulating ubiquitination degradation of UCK2 by Chaorong Xue, Xuanzi Zhang, Wanling Yu, Hanbin Lin, Junrong Zhang, Jiawen Liu, Zongqi Weng, Manduo Ouyang, Xinjian Lin

“…In 5-FU-resistant GC cells, the transcription factor GLI2 and the E3 ubiquitin ligase HRD1 were both upregulated, while UCK2 expression was significantly reduced. Functional assays demonstrated that lowering UCK2 or increasing HRD1 expression enhanced GC cell proliferation and 5-FU resistance, with HRD1 mediating 5-FU resistance through the ubiquitination and degradation of UCK2. …”
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Shigella effector IpaH1.4 subverts host E3 ligase RNF213 to evade antibacterial immunity by Xindi Zhou, Huijing Zhang, Yaru Wang, Danni Wang, Zhiqiao Lin, Yuchao Zhang, Yubin Tang, Jianping Liu, Yu-Feng Yao, Yixiao Zhang, Lifeng Pan

“…Finally, our cell based functional assays demonstrate that the targeting of host RNF213 by IpaH1.4 promotes S. flexneri proliferation within infected cells. …”
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Neuropeptide Ecdysis‐Triggering Hormone and Its Receptor Mediate the Fecundity Improvement of ‘Candidatus Liberibacter Asiaticus’‐Infected Diaphorina citri Females and CLas Prolife... by Xiaoge Nian, Bo Wang, Paul Holford, George Andrew Charles Beattie, Shijian Tan, Weiwei Yuan, Yijing Cen, Yurong He, Songdou Zhang

“…Collectively, the orchestrated functional interplay involving 20E, ETH, and JH increases energy metabolism and promotes the fecundity of CLas+ D. citri and CLas proliferation. …”
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