Preparation of bio-carbon by polymerization of bio-tar: a critical review on mechanisms, processes, and applications by Yuxuan Sun, Jixiu Jia, Lili Huo, Xinyi Zhang, Lixin Zhao, Ziyun Liu, Yanan Zhao, Zonglu Yao

“…Notably, oxygenated compounds containing carbonyl groups and furan rings serve as critical precursors in bio-tar polymerization, where their unsaturated oxygen-containing functional groups facilitate bond cleavage and recombination. …”
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Decoding the immune landscape in Ewing sarcoma pathogenesis: The role of tumor infiltrating immune cells and immune milieu by Rajiv Ranjan Kumar, Nikita Agarwal, Akshi Shree, Jaya Kanta Gorain, Ekta Rahul, Shuvadeep Ganguly, Sameer Bakhshi, Uttam Sharma

“…These elements impair anti-tumor immune responses by modulating the function of tumor-infiltrating immune cells, such as regulatory T cells (Tregs), CD8+ T cells, and natural killer cells. …”
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Acyl CoA-binding protein in brown adipose tissue acts as a negative regulator of adaptive thermogenesis by Albert Blasco-Roset, Tania Quesada-López, Alberto Mestres-Arenas, Joan Villarroya, Francisco J. Godoy-Nieto, Rubén Cereijo, Celia Rupérez, Ditte Neess, Nils J. Færgeman, Marta Giralt, Anna Planavila, Francesc Villarroya

“…While much is known regarding the biological signals that trigger BAT thermogenesis, relatively little is known about the repressors that may impair BAT function in physiological and pathological settings. …”
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Polyamines at the crossroad between cell metabolism and epigenetic regulation in acute leukemias by Francesca Pirini, Anna Ferrari, Mouna Jandoubi, Irene Azzali, Davide Angeli, Rossana Mondrone, Chiara Bracci, Francesca Ruggieri, Giovanni Martinelli, Giorgia Simonetti

“…Recently, there is an increasing interest in understanding polyamine functions in acute leukemias, due to the linkage between leukemic gene drivers, polyamine metabolism alterations and epigenetic defects. …”
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Identification of USP39 as a prognostic and predictive biomarker for determining the response to immunotherapy in pancreatic cancer by Jiahui Yuan, Beibei Xu, Yongcheng Su, Pingping Zhang, Xianbin Zhang, Peng Gong

“…This study specifically focused on exploring the clinical relevance and molecular functions of USP39 in pancreatic adenocarcinoma (PAAD), with particularly emphasis on its role in shaping the TIME and modulating responses to immunotherapy. …”
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BET Protein Inhibition Relieves MDSC-Mediated Immune Suppression in Chronic Lymphocytic Leukemia by Erin M. Drengler, Audrey L. Smith, Sydney A. Skupa, Elizabeth Schmitz, Eslam Mohamed, Dalia El-Gamal

“…Previously, we investigated how the novel BET inhibitor OPN-51107 (OPN5) prevents CLL disease expansion, modulates T-cell immune function, and alters gene expression related to MDSCs. …”
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Brain Derived Neurotrophic Factor and cognitive markers in subjects with Alzheimer’s disease by Naybí Prendes Rivero, Levis Verde Corvo, Belkis López González, Iris Dany Carmenate Rodríguez, Nibaldo B Mesa Hernández, María A Robinson Agramonte

“…The factor levels were correlated with the episodic memory, the executive functions, and the global cognitive function in Alzheimer’s disease patients. …”
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Potential protective regulatory effects on radiation−induced esophageal injury in TUT4−/− mice by Huiwen Ren, Wei Li, Zhigang Fan, Jianlin Wang, Zhiqiang Sun, Renhua Huang, Judong Luo, Bo Gao

“…IntroductionTerminal uridyl transferase 4 (TUT4), a nucleotide transferase that modifies miRNA sequences, plays a critical role in regulating miRNA target interactions and function. However, its involvement in radiation-induced esophageal injury remains poorly understood.MethodsTo investigate this, we performed computational analysis of RNA-seq data from irradiated esophageal tissues of wild-type and TUT4-knockout (TUT4–/–) mice, identifying 53 differentially expressed mRNAs (DEmRNAs), of which 30 were upregulated and 23 downregulated.ResultsGene Ontology and Kyoto Encyclopedia of Genes and Genomes enrichment analyses revealed that these DEmRNAs were significantly associated with biological processes including lipid metabolism, fatty acid metabolism, proteolysis, and broader metabolic functions. …”
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pH- and redox-sensitive selenium-incorporated mesoporous silica nanoparticles for osteosarcoma-targeted treatment by L. He, Z. Javid Anbardan, P. Habibovic, S. van Rijt

“…The MS surface was further functionalized with hyaluronic acid (HA) using disulfide bonds (to create SeMSDox-SS-HA), to function as a gatekeeper and to enable pH- and redox-responsive release. …”
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Loss of <i>Myostatin</i> Shapes the Transcriptomic and Epigenetic Landscapes Across Multiple Muscle Types in Cattle by Chao Hai, Xuefei Liu, Chunling Bai, Guanghua Su, Lei Yang, Guangpeng Li

“…Further, 102 differentially expressed genes (DEGs) were commonly identified across all three muscle types; their KEGG enrichment included immune-related and cellular interaction pathways (e.g., antigen processing and presentation, and cell adhesion molecules), many of which intersect with axon guidance functions. Core regulators such as <i>SEMA3A</i>, <i>PLXNA1</i>, and <i>NTN1</i> were epigenetically modulated in MT gluteus and heart. …”
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Mannan-Binding Lectin Regulates Inflammatory Cytokine Production, Proliferation, and Cytotoxicity of Human Peripheral Natural Killer Cells by Jia Zhou, Mengyao Hu, Jie Li, Yan Liu, Jialiang Luo, Liyun Zhang, Xiao Lu, Daming Zuo, Zhengliang Chen

“…Natural killer (NK) cells represent the founding members of innate lymphoid cells (ILC) and play critical roles in inflammation and the immune response. NK cell effector functions are regulated and fine-tuned by various immune modulators. …”
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Snhg12 targets miR-199a-5p to regulate osteogenic differentiation of TDSCs via the Fzd4/Wnt/β-catenin pathway by Xinyue Li, Binbin Xu, Zhongjie Wang, Mengyi Li, Hao Wu, Bao Chen

“…Through lncRNA sequencing in this study, we observed an up-regulation of small nucleolar RNA host gene 12 (Snhg12) in HO tissues. The precise function of Snhg12 in the process of tendon stem cells (TDSCs) osteogenic differentiation remains uncertain. …”
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An atomically controlled insulator-to-metal transition in iridate/manganite heterostructures by Enyang Men, Deyang Li, Haiyang Zhang, Jingxin Chen, Zhihan Qiao, Long Wei, Zhaosheng Wang, Chuanying Xi, Dongsheng Song, Yuhan Li, Hyoungjeen Jeen, Kai Chen, Hong Zhu, Lin Hao

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Pharmacological or genetic inhibition of LTCC promotes cardiomyocyte proliferation through inhibition of calcineurin activity by Lynn A. C. Devilée, Abou bakr M. Salama, Jessica M. Miller, Janice D. Reid, Qinghui Ou, Nourhan M. Baraka, Kamal Abou Farraj, Madiha Jamal, Yibing Nong, Todd K. Rosengart, Douglas Andres, Jonathan Satin, Tamer M. A. Mohamed, James E. Hudson, Riham R. E. Abouleisa

“…Mechanistically, LTCC inhibition by RRAD or nifedipine induced CM cell cycle by modulating calcineurin activity. Moreover, ectopic expression of RRAD/CDK4/CCND in combination induced CM proliferation in vitro and in vivo, improved cardiac function and reduced scar size post-myocardial infarction.…”
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The role of fibroblast-neutrophil crosstalk in the pathogenesis of inflammatory diseases: a multi-tissue perspective by Chen Cai, Lanxi Guan, Chenhao Wang, Runjie Hu, Lingling Ou, Qianzhou Jiang

“…This review synthesizes evidence from skin, lung, gut, cardiovascular, joint, sinus, and oral diseases, revealing conserved molecular pathways where fibroblasts secrete chemokines (CXCL1/8/12) to recruit neutrophils, which, in turn, release neutrophil extracellular traps (NETs), elastase, and cytokines to modulate fibroblast function. Additionally, we identify critical tissue-specific differences, including the predominance of IL-36 signaling in COPD, IL-17-carrying NETs in systemic lupus erythematosus (SLE) and pulmonary fibrosis, and specialized fibroblast subpopulations, such as IDO1+ cells in CRSwNP and TNFRSF21+ cells in periodontitis. …”
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Annexin-A1 deficiency uncovers female-specific pathways in blood pressure control and cardiovascular remodeling in mice by Jaideep Singh, Kristy L. Jackson, Haoyun Fang, Feng Shii Tang, Cindy Gueguen, Alex M. Parker, HsinErh Chen, Cameron J. Nowell, Helen Kiriazis, Ekaterina Salimova, Owen L. Woodman, Rebecca H. Ritchie, Geoffrey A. Head, David W. Greening, Cheng Xue Qin

“…Here, we demonstrate that deficiency of ANXA1 exacerbates angiotensin II-induced adverse aortic and cardiac structural remodeling, mitochondrial proteome dysregulation, and impaired mitochondrial function in preclinical hypertensive models, exacerbated in females. …”
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Gingipain regulates isoform switches of PD-L1 in macrophages infected with Porphyromonas gingivalis by Yilin Zheng, Ziyi Wang, Yao Weng, Heriati Sitosari, Yuhan He, Xiu Zhang, Noriko Shiotsu, Yoko Fukuhara, Mika Ikegame, Hirohiko Okamura

“…P. gingivalis infection increased the PD-L1 transcripts expression and selectively upregulated a specific coding isoform that more effectively binds to PD-1 on T cells, thereby inhibiting immune function. Biological experiments also detected AS switch of PD-L1 in P. gingivalis-infected or gingipain-treated macrophages. …”
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Phasic attractors for flexible and adaptive working memory in spiking recurrent neural networks by Willian S Girão, Thomas F Tiotto, Jelmer P Borst, Niels A Taatgen, Elisabetta Chicca

“…Acting as a temporary storage and manipulation mechanism, working memory enables individuals to actively hold and manipulate relevant information essential for ongoing tasks. This cognitive function is pivotal for various complex processes, including problem-solving, language comprehension, and decision-making. …”
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Negative regulation of lymphangiogenesis by Tenascin-C delays the resolution of inflammation by Daisuke Katoh, Yoshiyuki Senga, Kento Mizutani, Kazuaki Maruyama, Daishi Yamakawa, Tadashi Yamamuro, Michiaki Hiroe, Keiichi Yamanaka, Akihiro Sudo, Naoyuki Katayama, Toshimichi Yoshida, Kyoko Imanaka-Yoshida

“…Genetic deletion of Tnc promotes lymphangiogenesis and improves lymphatic drainage function, thereby accelerating the resolution of inflammation. …”
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RUNX2 enhances bladder cancer progression by promoting glutamine metabolism by Zhigang Huang, Bin Liu, Xiaoju Li, Chenghua Jin, Quansen Hu, Zhiwei Zhao, Yimin Sun, Qian Wang

“…Overall, this research affirms the crucial function of RUNX2 as a key transcription factor to promoting glutamine and cancer development through modulation of SLC7A6. …”
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