Deletion of Metabotropic Glutamate Receptors 2 and 3 (mGlu2 & mGlu3) in Mice Disrupts Sleep and Wheel-Running Activity, and Increases the Sensitivity of the Circadian System to... by David Pritchett, Aarti Jagannath, Laurence A Brown, Shu K E Tam, Sibah Hasan, Silvia Gatti, Paul J Harrison, David M Bannerman, Russell G Foster, Stuart N Peirson

“…These receptors are relevant to the pathophysiology and potential treatment of schizophrenia, and have also been implicated in sleep and circadian function. In the present study, we characterised the sleep and circadian rhythms of Grm2/3 double knockout (Grm2/3-/-) mice, to provide further evidence for the involvement of group II metabotropic glutamate receptors in the regulation of sleep and circadian rhythms. …”
Get full text

Performance of fiber-based QAM/FSO systems in turbulence with anisotropic tilt angle and random angular jitter by Chao Zhai, Zhenyuan Xue

“…To better align with realistic turbulence and practical application, we developed the expressions for probability density function (PDF) of fiber-coupling efficiency and BER of fiber-based quadrature amplitude modulation (QAM) FSO communication systems in the weak anisotropic non-Kolmogorov (ANK) horizontal link with anisotropic tilt angle and random angular jitter, for the first time. …”
Get full text

Improved Multi-Size, Multi-Target and 3D Position Detection Network for Flowering Chinese Cabbage Based on YOLOv8 by Yuanqing Shui, Kai Yuan, Mengcheng Wu, Zuoxi Zhao

“…Wise-IoU in combination with Inner-IoU is adopted as a new loss function to optimize the network for different quality samples and different size bounding boxes. …”
Get full text

Inwardly rectifying potassium channels: Critical insights for insect species and Apis mellifera by Fabien Sourisseau, Craig A. Doupnik, Pierre Charnet, Mohamed Chahine

“…Electrophysiological studies have confirmed that Drosophila Kir channels function in a way analogous to their mammalian counterparts, indicating that their roles in cellular and developmental signaling have been evolutionarily conserved. …”
Get full text

Altered human cytomegalovirus-encoded miRNAs in host circulation: novel disease biomarkers and potential aetiological agents by Cheng Wang, Jun-Jun Wang, Chunni Zhang

“…Importantly, some circulating miRNAs that were encapsulated in extracellular microvesicles (MVs) have been identified as critical mediators of intercellular communication, and function as novel cell-cell crosstalk gene-regulators. …”
Get full text

Enzyme-Based Anti-Inflammatory Therapeutics for Inflammatory Diseases by Kannan Badri Narayanan

“…These enzymes function by scavenging reactive oxygen species (ROS), inhibiting cytokine transcription, degrading circulating cytokines, and blocking cytokine release by targeting exocytosis-related receptors. …”
Get full text

Multivariate MOF nanozyme utilizes glucose-activated self-cascade strategy for enhanced antibacterial efficacy and accelerated diabetic wounds healing by Yuxin Huang, Dixi Chen, T. M. Wong, Baolin Li, Yongxin Shi

“…The impaired immune function observed in diabetic patients significantly increases their susceptibility of diabetic wounds to bacterial infections. …”
Get full text

Molecular Pathogenesis of Avian Splenic Injury Under Thermal Challenge: Integrated Mitigation Strategies for Poultry Heat Stress by Qing Liu, Lizhen Ma, Lili Liu, Ding Guan, Zhen Zhu, Xiangjun Hu

“…At the physiological level, the impact of HS is characterized by disrupted metabolic homeostasis through interrupting neuroendocrine function. This, in turn, results in a significant suppression of humoral immune response. …”
Get full text

Kaempferol enhances ER-mitochondria coupling and protects motor neurons from mitochondrial dysfunction and ER stress in C9ORF72-ALS by Federica Pilotto, Paulien Hermine Smeele, Olivier Scheidegger, Rim Diab, Martina Schobesberger, Julieth Andrea Sierra-Delgado, Smita Saxena

“…Treatment of symptomatic C9ORF72 mice with kaempferol, normalized mitochondrial calcium uptake, restored mitochondria function, and diminished ER stress. Importantly, in vivo, chronic kaempferol administration ameliorated pathological motor dysfunction and inhibited motor neuron degeneration, highlighting the translational potential of kaempferol. …”
Get full text

FADS1, a lipid metabolism-related diagnostic biomarker in KIRC by Tianmin Yang, Kai Sun, Fan Peng, Yuhu Hao, Qingjie Bai, Hanpu Yu, Qinghua Xia

“…In addition, in vitro experiments were conducted to confirm the biological function of FADS1. Results The findings indicated that FADS1 is highly expressed in KIRC and contributes to tumor development. …”
Get full text

Characterizing the magnetic noise power spectrum of dark spins in diamond by Ethan Q Williams, Chandrasekhar Ramanathan

“…We develop techniques utilizing harmonics of the CPMG filter function to improve characterization of high-frequency signals, which we demonstrate on the ^13 C nuclear Larmor frequency. …”
Get full text

Basal ganglia components have distinct computational roles in decision-making dynamics under conflict and uncertainty. by Nadja R Ging-Jehli, James F Cavanagh, Minkyu Ahn, David J Segar, Wael F Asaad, Michael J Frank

“…Moreover, theta dynamics in BG structures modulated the onset and shape of this collapse but differentially across task conditions. …”
Get full text

Effect of the total flavonoids of Dracocephalum moldavica L. on metabolic associated fatty liver disease in rats by Xiaoyu Sun, Na Ge, Qingqing Liang, Qian Wang, Hui Yu, Min Jin

“…Furthermore, the total flavonoids of D. moldavica have been demonstrated to enhance the intestinal mucosal barrier function, reduce LPS translocation, and inhibit the activation of hepatic TLR4/MyD88/NF-κB pathway. …”
Get full text

Response of Watermelon to Drought Stress and Its Drought-Resistance Evaluation by Kaili Ren, Taoxia Tang, Weiping Kong, Yongquan Su, Yuping Wang, Hong Cheng, Yonggang Yang, Xiaoqin Zhao

“…Drought stress indices, phenotypic plasticity indices, and membership function values were calculated, followed by a correlation analysis, principal component analysis, and cluster analysis, to comprehensively evaluate the drought resistance of 13 watermelon genotypes. …”
Get full text

Probiotic Potential and Modulatory Effects of Mixed Culture of Lactic Acid Bacteria on Mice Infected With Escherichia coli O157:H7 by Adaeze Ngozi Ibejekwe, Michael Macvren Dashen, Anayochukwu Chibuike Ngene, Otumala John Egbere

“…Hematological and liver function tests showed no significant differences between treated and control groups, except for elevated hematocrit in T3 and reduced total bilirubin in treated groups (p<0.05). …”
Get full text

Clinical relevance of nutraceuticals in hypertension management: mechanisms, efficacy, and integration into therapeutic protocols by Samuel Oluwadare Olalekan, Patrick Godwin Okwute, Ifabunmi Oduyemi Osonuga, Bukunola Oluyemisi Adegbesan, Esther Nkechi Ezima, Idowu Matthew Adeyemi

“…Another is vasodilation mediated by endothelial function, which enhances vascular relaxation and lowers systemic vascular resistance by restoring nitric oxide bioavailability and reducing inflammation. …”
Get full text

Glycolytic Dysfunction in Granulosa Cells and Its Contribution to Metabolic Dysfunction in Polycystic Ovary Syndrome by Cao Z, Zhou Q, An J, Guo X, Jia X, Qiu Y

“…Epigenetic changes and non-coding RNAs further modulate glycolytic enzyme expression, destabilizing metabolic homeostasis within ovarian follicles. …”
Get full text

YOLO-TARC: YOLOv10 with Token Attention and Residual Convolution for Small Void Detection in Root Canal X-Ray Images by Yin Pan, Zhenpeng Zhang, Xueyang Zhang, Zhi Zeng, Yibin Tian

“…Additionally, to optimize the training process, a bounding box loss function is adopted to achieve faster and more accurate bounding box predictions. …”
Get full text

Myricetin alleviates learning and memory deficits in trimethyltin Alzheimer’s phenotype via attenuating hippocampal endoplasmic reticulum stress and regulating inflammation and oxi... by Zahra Asgari, Saeid Iranzadeh, Mehrdad Roghani

“…Learning and memory-related function was assessed using passive avoidance, novel object recognition, and Y-maze tests. …”
Get full text

Surface defect detection model of laser cutting polycrystalline cubic boron nitride tool based on asymptotic fusion strategy by Anfu Zhu, Jiaxiao Xie, Heng Guo, Jie Wang, Zilong Guo, Lei Xu, SiXin Zhu, Zhanping Yang, Bin Wang

“…In the backbone network, the C3SE module is constructed by modeling the correlation between feature channels to improve the model’s focus on key features in order to enhance the feature extraction and processing capability of the backbone network; In the neck network, adaptive spatial fusion operation and direct interaction of non-adjacent layers are utilized for multi-scale information fusion, and the asymptotic feature pyramid network for object detection (AFPN) is used instead of the FPN structure to improve the detection performance; In the head network, a soft suppression mechanism is introduced to reduce the overlapping frame score using a decay function, thus improving the detection accuracy. …”
Get full text