Supplementary zinc and vitamin D in management of symptomatic oral lichen planus: a three-arm randomized clinical trial by Alaa Aboushousha, Yasmine Kamal, Shereen Ali

“…Both zinc and vitamin D are essential micronutrients implicated in OLP pathogenesis, with zinc influencing epithelial growth, wound healing, and oxidative stress mitigation, while vitamin D modulates immune cell function, cytokine activity, and keratinocyte behavior. …”
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Sulforaphane from Brassica Oleracea Induces Apoptosis in Oral Squamous Carcinoma Cells via p53 Activation and Mitochondrial Membrane Potential Dysfunction by Pooja Narain Adtani, Sura Ali Ahmed Fuoad Al-Bayati, Walid Shaaban Elsayed

“…<b>Conclusions:</b> The data obtained indicate that SFN has significant potential to induce apoptosis in OECM-1 cells by disrupting mitochondrial function and modulating apoptotic pathways. The outcomes of our research indicate SFN’s potential as a viable treatment drug for OSCC.…”
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Huaier suppresses lung cancer by simultaneously and independently inhibiting the antioxidant pathway SLC7A11/GPX4 while enhancing ferritinophagy by Xingxing Shi, Kun Liu, Yuchang Tian, Xinyi Bi, Junkai Zhang, Fengyi Ma, Wensheng Wei, Tongbiao Zhao

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TNFα levels and macrophages expression reflect an inflammatory potential of trigeminal ganglia in a mouse model of familial hemiplegic migraine. by Alessia Franceschini, Sandra Vilotti, Michel D Ferrari, Arn M J M van den Maagdenberg, Andrea Nistri, Elsa Fabbretti

“…Latent changes in trigeminal ganglion structure and function resembling inflammatory conditions may predispose to acute attacks of migraine pain. …”
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Cardiac alterations induced by Trypanosoma cruzi extracellular vesicles and immune complexes. by Alberto Cornet-Gomez, Francisco O'Valle, José M Garrido, Fernando Rodríguez Serrano, Ana I Nieto, Antonio Osuna

“…Extracellular vesicles (EVs) have been studied for their role in parasite-host cell communication, in modulating the host's immune response and more recently as diagnostic tools.…”
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Inhibition of neuroinflammation by GIBH-130 (AD-16) reduces neurodegeneration, motor deficits, and proinflammatory cytokines in a hemiparkinsonian model by Maria E. Bianchetti, Ana Flavia F. Ferreira, Luiz R. G. Britto

“…Our results revealed an enhancement in the motor function of the AD-16-treated animals, as well as reduced nigrostriatal neurodegeneration. …”
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Navigating novel resources: A field test of the effects of small mammal personality on dispersal of Quercus seeds by Ivy Yen, Alessio Mortelliti

“…Put together, our results indicate that behavioral diversity may be important to consider for the maintenance of ecological function and provide a basis from where conservationists can work toward clarifying plant fitness in their novel ranges, species‐specific extinction probabilities, and future trends in forest regeneration.…”
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The Hybrid Histidine Kinase LadS Forms a Multicomponent Signal Transduction System with the GacS/GacA Two-Component System in Pseudomonas aeruginosa. by Gaël Chambonnier, Lorène Roux, David Redelberger, Firas Fadel, Alain Filloux, Melissa Sivaneson, Sophie de Bentzmann, Christophe Bordi

“…LadS hybrid HK phenotypically antagonizes the function of RetS by a mechanism that has never been investigated. …”
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A lightweight semantic segmentation method for concrete bridge surface diseases based on improved DeeplabV3+ by Zhiyuan Yu, Chunquan Dai, Xiaoming Zeng, Yunlong Lv, Haisheng Li

“…Finally, the focal loss function was used to solve the problem of sample imbalance. …”
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Design of Constant Speed Controller for Hydraulic Retarder Based on Robust Control by Pengxiang Song, Ao Meng, Yang Ding

“…Then, based on the concept of sliding mode control, the sliding mode controller with saturation function and the high-frequency robust controller are developed to modulate the filling rate of the hydraulic retarder in response to variations in vehicle speed. …”
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Cryptogenic organizing pneumonia complicated by pulmonary embolism following glucocorticoid therapy: a case report by Dong Liu, Luna Zhao, Xinxin Zhang, Ye Liu, Chao Wu

“…The temporal association between steroid tapering and PE suggests that glucocorticoids may modulate endothelial function and coagulation pathways, highlighting the need for mechanistic studies to inform thromboembolic surveillance in COP management.…”
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A Reconfigurable Multiport Converter for Integrated PV/EV/Battery Systems by Omair Khan, Branislav Hredzak, John E. Fletcher

“…., four of the eight primary side switches are either modulated or used as connectors. Similarly, the primary bridge can act to transfer power across the transformer or function as a synchronous switch. …”
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Fine-grained individual tree crown segmentation based on high-resolution images by Y. Wang, X. Dou, X. Liang

“…Its cover, distribution, structure are highly relevant to the function of water cycling, carbon storage, and climate modulating of forest. …”
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Repeatability and reproducibility of a double-pass optical quality analysis device. by Chen-Chen Xu, Ting Xue, Qin-Mei Wang, Yi-Ni Zhou, Jin-Hai Huang, A-Yong Yu

“…The repeatability and reproducibility of the modulation transfer function cut off frequency (MTF cutoff), the Strehl ratio, the OQAS values (OVs) at contrasts of 100%, 20% and 9%, and the objective scatter index (OSI) were analyzed.…”
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O-GlcNAcylation of FBP1 promotes pancreatic cancer progression by facilitating its Lys48-linked polyubiquitination in hypoxic environments by Yi Zhu, Xiaoman He, Xiaojing Ma, Yan Zhang, Wei Feng

“…O-linked N-acetylglucosamine transferase (OGT) interacts with FBP1 and induces its O-GlcNAcylation at serine 47 residue (FBP1-S47) to modulate its protein function in pancreatic cancer cells. …”
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Anatomical transcriptome of G protein-coupled receptors leads to the identification of a novel therapeutic candidate GPR52 for psychiatric disorders. by Hidetoshi Komatsu, Minoru Maruyama, Shuuhei Yao, Tokuyuki Shinohara, Kensuke Sakuma, Sachiko Imaichi, Tomoko Chikatsu, Kanako Kuniyeda, Foo Kok Siu, Lam Sock Peng, Katherine Zhuo, Lay Sock Mun, Tan Min Han, Yoshio Matsumoto, Tadatoshi Hashimoto, Nobuyuki Miyajima, Yasuaki Itoh, Kazuhiro Ogi, Yugo Habata, Masaaki Mori

“…Detailed histological investigation suggests that GPR52 may modulate dopaminergic and glutamatergic transmission in neuronal circuits responsible for cognitive function and emotion. …”
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From Saddle-Shaped to Dual-Peak Radiation: Synergistic Control of Laser Parameters for Collimation Leap and Quadratic Power Scaling in Nonlinear Thomson Scattering by Junyuan Xu, Junze Shi, Yi Zhang, Ying Cao, Youwei Tian

“…The above research has a pioneering guiding significance for the modulation of X-rays in optical laboratories.…”
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Application value of high flux hemodialysis in uremic elders by Chen Yan, Zhang Guang-lu

“…Objective To explore the application value of high flux hemodialysis（HFHD）in uremic elders.Methods From October 2018 to January 2020,a total of 102 uremic elders aged over 70 years were selected and randomized into two groups of study and control（n=51 each）.On the basis of routine intervention, study group received 12-week HFHD while control group had 12-week low flux hemodialysis（LFHD）.Clinical efficacy, blood urea nitrogen（BUN）,serum creatinine（Scr）,p-cresol sulfate（PCS）,indolyl sulfate（IS）and serum creatinine（Scr）of two groups were statistically analyzed.And β2-microglobulin（β2-mg）,parathyroid hormone（PTH）,neutrophil（NE）phagocytic function（phagocytic rate/index）,serum inflammatory factors such as C-reactive protein（CRP）,tumor necrosis factor-α（TNF-α）,interleukin-6（IL-6）and interleukin-8（IL-8）were measured.The parameters of calcium and phosphorus metabolism, such as serum calcium（CA）and phosphorus（P）,were followed up for 3 months.Results The overall effective rate of study group was higher than that of control group（94.12% vs 80.39%）（P<0.05）.At 6 and 12 weeks of treatment, serum BUN,Scr, PCs, IS, β2-MG,PTH,CRP and TNF-α declined and their levels were lower than controls.The levels of IL-6,IL-8 and P were lower in study group than those in control group（P<0.05）;At 6 and 12 weeks of treatment, NE phagocytosis rate/index of two groups were higher than pre-treatment and study group was higher than control group（P<0.05）;no significant inter-group difference existed in mortality at Month 1/2/3 post-treatment（P>0.05）.Conclusion HFHD technology can effectively improve the therapeutic efficacy for uremic elders.It is probably correlated to a more effective removal of toxins, a modulation of serum inflammatory factors, calcium and phosphorus metabolism and NE phagocytosis.…”
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Identification of the early and late responder genes during the generation of induced pluripotent stem cells from mouse fibroblasts. by Jihwan Park, Yoo-Wook Kwon, Seokjin Ham, Chang-Pyo Hong, Seonghye Seo, Moon Kyung Choe, So-I Shin, Choon-Soo Lee, Hyo-Soo Kim, Tae-Young Roh

“…A comparative investigation of the iPSCp generated by unwanted reprogramming showed that the two groups of genes on the pathway from somatic cells to iPSC might function as sequential reprogramming-competent early and late responders to the induction stimulus. …”
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Optical Quality and Related Factors in Ocular Hypertension: Preliminary Study by Yu-jing Wang, Yan-ning Yang, Lin-ying Huang, Bo Wang, Yu-can Han, Jiang-bo Yan

“…A total of 12 eyes with OHT and 20 control eyes underwent testing with Optical Quality Analysis System II (OQAS II) to evaluate the modulation transfer function cut off frequency (MTF cutoff), the Strehl 2D ratio (SR), objective scatter index (OSI), tear-film mean OSI (TFOSI), and the OQAS values (OV100%,OV20%, and OV9%). …”
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