When animal viruses meet N6-methyladenosine (m6A) modifications: for better or worse? by Wenjing Wang, Yufei Jin, Ziyun Xie, Mei He, Jing Li, Zihan Wang, Saiya Ma, Wuchao Zhang, Jie Tong

“…Finally, the review explores how m6A modification affects the following three aspects of the replication of animal RNA viruses: the regulation of viral genomic RNA function, the alteration of the m6A landscape in cells after viral infection, and the modulation of antiviral immunity through m6A modification. …”
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Characterization of the effects of hyaluronan oligosaccharides on human gut microbiota using a simulated batch fermentation system by Xinwei Gao, Hongkang Zhu, Litao Hu, Jieyu Sun, Wenjie Zuo, Ping Liu, Yang Wang, Guocheng Du, Zhen Kang

“…Furthermore, analysis of microbial function predicted the downregulation of pathological events in nine human diseases, particularly infectious ones (parasitic and bacterial). …”
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Mono-(2-ethylhexyl) phthalate induces trophoblast hypoxia and mitochondrial dysfunction through HIF-1α-miR-210-3p axis in HTR-8/SVneo cell line by Sunitha Meruvu, Zehuan Ding, Mahua Choudhury

“…The exposure to the ubiquitous phthalate metabolite mono-(2-ethylhexyl) phthalate (MEHP) is connected to dysregulated trophoblast function and placenta health; however, the underlying mechanisms preluding this scenario remain to be elucidated. …”
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Intervention strategies for Parkinson’s disease: the role of exercise and mitochondria by Ganggang Xu, Chunlian Ma, Chunlian Ma, Yi Yang, Yi Yang

“…Many studies demonstrate that aerobic, resistance, and mind-body exercises demonstrably improve gait stability, postural control, and cognitive function in PD patients. However, standardized exercise prescriptions for PD prevention and treatment remain underutilized in clinical practice. …”
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Les Liaisons dangereuses: the paradoxical outcomes of the cytotoxic activity of tumor macrophages by O. V. Kovaleva, M. A. Rashidova, V. V. Sinyov, O. S. Malashenko, A. N. Gratchev

“…Moreover, tumor cells resulting from interaction with cytotoxic macrophages possess other properties that provide growth advantages.This review is dedicated to describing a new pro-tumor function of M1 macrophages, traditionally considered anti-tumor.…”
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Induction of Fetal Hemoglobin In Vivo Mediated by a Synthetic γ-Globin Zinc Finger Activator by Flávia C. Costa, Halyna Fedosyuk, Renee Neades, Johana Bravo de Los Rios, Carlos F. Barbas, Kenneth R. Peterson

“…Our results demonstrate that ATFs function in an animal model to increase gene expression. …”
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3D reconstruction of fruit trees and fruit semantic segmentation based on NeRF and improved RandLA-Net by Dacheng YANG, Jun GUO, Jing YANG, Yali ZHANG, Yubin LAN

“…A bilateral enhancement module was added after the encoder layer, and a loss function more suitable for the fruit point cloud segmentation task was adopted. …”
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Spinal neuron-glial crosstalk and ion channel dysregulation in diabetic neuropathic pain by Jie Wu, Jie Wu, Haijun Hu, Haijun Hu, Xi Li, Xi Li

“…In light of the rising incidence of diabetes and the current scarcity of effective DNP treatments, a thorough investigation into the interactions between neurons and glial cells, especially the mechanisms of ion channel function in DNP, is imperative for identifying potential drug targets, developing novel therapeutic strategies, and thereby enhancing the prospects for DNP management.…”
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The potential of efferocytosis for the treatment of bronchial asthma: A review of current trends, mechanisms and prospects by Baohe Liu, Tingting Zu, Yaqi Lu, Chaopin Xing, Meng Gao, Fuling Wu, Mengqi Jiang

“…Barriers are formed through epithelial-mesenchymal transition, which impairs the regenerative capacity of the damaged epithelium and its barrier function, leading to an imbalance in epithelial-mesenchymal homeostasis. …”
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Phytochemicals Targeting Inflammatory Pathways in Alcohol-Induced Liver Disease: A Mechanistic Review by Swati Tirunal Achary, Prerna Gupta, Apoorva Rajput, Wanphidabet Sohkhia, Srinivasa Reddy Bonam, Bidya Dhar Sahu

“…No effective medication promotes liver function, shields the liver from harm, or aids in hepatic cell regeneration. …”
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Oocyte and dietary supplements: a mini review by Hao Chen, Shuoqi Wang, Meiying Song, Dongxia Yang, Hongmei Li

“…Rising rates of infertility have stimulated interest in dietary supplements to improve oocyte quality through mitochondrial function, antioxidant activity, and epigenetically regulated metabolic pathways. …”
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Improved YOLOv7-Tiny for the Detection of Common Rice Leaf Diseases in Smart Agriculture by Fuxu Guo, Jing Li, Xingcheng Liu, Sinuo Chen, Hongze Zhang, Yingli Cao, Songhong Wei

“…The MobileNetV3 lightweight network is introduced to replace the backbone network of YOLOv7-tiny, which reduces the size of the model parameters and improves the extraction capability of features of different sizes; the RCS-OSA is used to replace the original ELAN-1 module, which improves the extraction capability of interlayer features; the TSCODE detector head is designed to enhance the extraction capability of the model for small targets; and the MPDIoU loss function is used to improve the model’s convergence speed and effect. …”
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Assembly of MSCs into a spheroid configuration increases poly(I:C)-mediated TLR3 activation and the immunomodulatory potential of MSCs for alleviating murine colitis by Chao-Ting Ho, Ying-Chi Kao, Yueh-Ming Shyu, I-Ching Wang, Qiao-Xuan Liu, Shao-Wen Liu, Shih-Chen Huang, Han Chiu, Li-Wen Hsu, Tzu-Sheng Hsu, Wan-Chen Hsieh, Chieh-Cheng Huang

“…However, the therapeutic efficacy of these cells remains suboptimal, primarily due to the harsh peritoneal microenvironment, which compromises MSC viability and functional capacity after transplantation. Methods To address these limitations, this study aimed to improve MSC engraftment and functionality by assembling MSCs into three-dimensional (3D) spheroids and priming them with the Toll-like receptor 3 (TLR3) agonist polyinosinic-polycytidylic acid (poly(I:C)). …”
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Lithic industries, modern tools, and language: An evolutionary perspective through fMRI by Chloé Bryche, Mathieu Lesourd, Arthur Seye, Alexandre Bluet, Natalie Uomini, Yves Rossetti, Emanuelle Reynaud, Giovanni Federico, François Osiurak

“…Participants performed a tool evaluation task, in which they assessed the functionality of both tool types across three levels of complexity designed to reflect embedded constraints. …”
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Integrating gut microbiome and neuroplasticity genomics in alcohol use disorder therapy by Ilias Koutromanos, Evangelia Legaki, Nikolas Dovrolis, Efthimios Vassilopoulos, Arthur Stem, Vasilis Vasiliou, Elias Tzavellas, Maria Gazouli

“…Patients were classified as responders or non-responders, and microbial composition, functional pathways, and host-microbiota interactions were analyzed using multi-omic correlation frameworks. …”
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Genome-wide CRISPR/Cas9 screen reveals factors that influence the susceptibility of tumor cells to NK cell-mediated killing by Eric Vivier, Benjamin Rossi, Laurent Gauthier, Emilie Narni-Mancinelli, Justine Galluso, Sophie Guia, Aurore Fenis, Camille Baudesson De Chanville, Hakim Medjouel, Bertrand Escaliere, Angelika Modelska, Margaux Vienne, Noella Lopes, Amelie Pouchin, Sandrine Roulland

“…This includes the diverse array of tumor ligands recognized by NK cells and the mechanisms that NK cells employ to eliminate tumor cells.Methods In this study, we employed a genome-wide CRISPR/Cas9 screening approach in conjunction with functional cytotoxicity assays to delineate the pathways modulating the susceptibility of colon adenocarcinoma HCT-116 cells to NK cell-mediated cytotoxicity.Results Analysis of guide RNA distribution in HCT-116 cells that survived co-incubation with NK cells identified ICAM-1 as a pivotal player in the NKp44-mediated immune synapse, with NKp44 serving as an activating receptor crucial for the elimination of HCT-116 tumor cells by NK cells. …”
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Promoting Resilience in Youth through Mindfulness mEditation (PRYME): Study protocol for a randomized controlled trial investigating the effects of mindfulness training as add-on t... by Maud Schepers, Paul Lagerweij, Dirk Geurts, Florian Krause, Hanneke den Ouden, Roshan Cools, Anne Speckens, Guusje Collin

“…Secondary outcomes include measures of self-compassion, rumination, experiential avoidance, and well-being. In addition, (functional) magnetic resonance imaging and computerized cognitive tasks are conducted at baseline and at end of treatment. …”
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Comparative evaluation of immunomodulatory cytokines for oncolytic therapy based on a high-efficient platform for oHSV1 reconstruction by Yingzheng Gao, Yufang Zou, Changjing Wu, Juan Tao, Zuqing Nie, Jinyuan Yan, Pengfei Wang, Xinwei Huang

“…Flow cytometry confirmed functional differences in immune activation: OV-IL15Fu expanding cytotoxic lymphocytes (CD8⁺ T/NK cells), OV-IFNG preferentially promote Th1 polarization and innate immune activation, and OV-GMCSF failed to activate T cells despite myeloid infiltration. …”
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Organ of Corti macrophages: a distinct group of cochlear macrophages with potential roles in supporting cell degeneration and survival by Mengxiao Ye, Celia Zhang, Dalian Ding, Guang-Di Chen, Henry J. Adler, Rania Sharaf, Bo Hua Hu

“…These macrophages exhibit an activated state and display a distinct functional profile compared to macrophages outside the organ of Corti. …”
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Metabolic characterization of selected probiotic consortia during gluten and wheat bread simulated digestion by Mirco Vacca, Giuseppe Celano, Olga Nikoloudaki, Bodo Speckmann, Francesco Maria Calabrese, Marco Gobbetti, Maria de Angelis

“…The inspection of the free amino acid profiles allowed for distinguishing the two MCs, whereas the detection of a heterogeneous panel of volatile organic compounds supported the presence/activity of microbial enzymes without statistically significant differences between MCs. As functional contribution, digested extracts with MCs also proved to reduce the inflammatory cytokine concentrations in cell lines exposed to lipopolysaccharide trigger. …”
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