Neural signature of chronic migraine mice model and related photophobia in the primary visual cortex by Kai-Bo Zhang, Cheng Peng, Zhen Liu, Sheng-Lin Zhao, Chen-Lu Zhu, Shou-Yi Wu, Tian-Xiao Wang, Zhi-Lei Li, Jing-Gui Gao, Yun-Hao Xu, Tian-Hua Fan, Hong Xie, Ji-Song Guan, Yong-Gang Wang

“…Cortical circuit activity patterns and behavioral correlates were assessed through combined chemogenetic manipulation and pharmacological interventions, with a particular focus on primary visual cortex functional modulation. Results Following chronic migraine induction, spontaneous hyperactivation emerged in cortical activity patterns within the primary visual cortex. …”
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NAG-1/GDF15 as a tumor suppressor in colorectal cancer: inhibition of β-catenin and NF-κB pathways via interaction with EpCAM by Jaehak Lee, Ilju Kim, Junsun Ryu, Thomas Eling, Seung Joon Baek

“…While the biological function of pro-NAG-1/GDF15 remains unclear, our study reveals its crucial role in suppressing oncogenic signaling. …”
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Mobile malware detection method using improved GhostNetV2 with image enhancement technique by Yao Du, CaiXia Gao, Xi Chen, MengTian Cui, LiLi Xu, AoJi Ning

“…Second, we make three improvements to GhostNetV2 to more effectively identify malicious code, including introducing channel shuffling in the Ghost module, replacing the squeeze and excitation mechanism with a more efficient channel attention mechanism, and optimizing the activation function. …”
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Emergency Control Strategy for High Proportion Renewable Power System Considering the Frequency Aggregation Response of Multi-Type Power Generations by Chang Ye, Kezheng Jiang, Dan Liu, Chunyu Zhang, Di Zhang, Ziwen Liu

“…On this basis, a system frequency emergency control model considering the adjustment characteristics of multi-type power generations is established. The objective function of the model is to minimize the frequency modulation cost after disturbance accident, while the constraint conditions include the output power of multi-type power generations and the transient index of frequency stability. …”
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Protocol for a co-design study for the development of a chronotherapeutic mobile health behaviour change intervention targeting light exposure among older adults [version 2; peer r... by Julia Woerle, Manuel Spitschan, Denz Del Villar, Resshaya Roobini Murukesu, Zahrah Alwi Alkaff

“…Through its wide-ranging effects on human physiology and behaviour, daily light exposure is an important environmental modulator of healthy ageing. Integrating mobile health (mHealth) technology with behaviour change strategies offers a promising approach to optimise light exposure and positively impact sleep, rest-wake cycles, cognitive function, and mood at scale. …”
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Cathelicidin: Insights into Its Impact on Metabolic Syndrome and Chronic Inflammation by Alina Delia Popa, Andreea Gherasim, Lavinia Caba, Otilia Niță, Mariana Graur, Laura Mihalache, Lidia Iuliana Arhire

“…The activation of Toll-like receptors (TLRs) by cathelicidin stimulates the secretion of pro-inflammatory cytokines, contributing to the disruption of insulin function in adipose cells. Cathelicidin also influences lipid metabolism, with recent research showing a negative relationship between LL-37 levels and HDL cholesterol. …”
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Huangqi fuling decoction inhibits the invasion and metastasis of gastric cancer via the TNF signaling pathway by Yanhai Luo, Jianqiao Ruan, Junfei Zhang, Simin Zhang, Minghui Zhang, Yuan Tian, Wenyi Wang, Jiali Wang, Cunyan Ma, Jing Wang

“…Abstract Gastric cancer (GC) is a prevalent digestive tract malignancy, and Huangqi Fuling decoction (HF) has shown potential in enhancing immune function and exhibiting anti-GC activity. However, its mechanisms remain unclear. …”
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Time-Controlled SPAD Receivers in Optical Wireless Communication System by Junzhi Liu, Wei Jiang, Shiva Kumar, M. Jamal Deen

“…To validate the feasibility of these two modes, we designed a free-running SPAD front-end circuit with post-layout transient simulation results and some measurements to show its function and performance. This SPAD circuit is improved by a novel mixed passive-active quench and reset front-end circuit that achieves a very short dead time. …”
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Ursolic acid induces apoptosis and disrupts host-parasite interactions in Theileria annulata-infected cells by Sakshi Singh, Madhusmita Subudhi, Vengatachala Moorthy A, Akash Suresh, Paresh Sharma

“…Mechanistic investigations revealed that UA triggers DNA damage, elevates reactive oxygen species (ROS) levels, disrupts mitochondrial function, and induces sub-G1 phase arrest, culminating in apoptosis primarily via the intrinsic pathway. …”
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Thyroid hormone signaling in ocular development and diseases by Pengbo Zhang, Yan Nie, Nan-Ji Lu, Qianfeng Jiao, Xiaofang Wang, Xibo Zhang, Longqian Liu

“…Additionally, the well-documented association between abnormal thyroid function and proptosis further emphasizes the critical role of TH signaling in orbital tissue homeostasis. …”
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Fermented Herbal Formulas KIOM-MA128 Ameliorate IL-6-Induced Intestinal Barrier Dysfunction in Colon Cancer Cell Line by Kwang Il Park, Dong Gun Kim, Bo Hyoung Lee, Jin Yeul Ma

“…Increased IL-6 expression has been reported in IBD patients, which may be associated with intestinal barrier function through discontinuous tight junction (TJ). …”
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Role of isoflavones in multiple sclerosis by V. Anushya vardhini, S. Sowmiya, S. Abdul Sameer, R. Sakthi, R. Divya, A. Monisha

“…This process involved the use of specific search terms and Boolean operators, including “isoflavones” AND “multiple sclerosis,” “phytoestrogens” AND “neuroprotection,” and “soy isoflavones” AND “autoimmune diseases,” to locate relevant articles. The function of isoflavones in multiple sclerosis is examined in this review, with particular attention paid to their mechanisms of action, which include immune response modulation, antioxidant effects, and possible influence on neurodegenerative processes. …”
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Field Obstacle Detection and Location Method Based on Binocular Vision by Yuanyuan Zhang, Kunpeng Tian, Jicheng Huang, Zhenlong Wang, Bin Zhang, Qing Xie

“…Therefore, accurate recognition of obstacles in the field environment is an essential function. To ensure the safety and enhance the operational efficiency of autonomous farming equipment, this study proposes an improved YOLOv8-based field obstacle detection model, leveraging depth information obtained from binocular cameras for precise obstacle localization. …”
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The Paradox of Clean Eating: Neuroactive Dysbiosis and Pesticide Residues in Fruit- and Vegetable-Based Diets by Ramona Alina Tomuța, Andrada Florina Moldovan, Loredana Matiș, Lavinia Maris, Timea Claudia Ghitea, Florin Banica

“…The study underscores the need for a comprehensive evaluation of food safety and microbiome function as interconnected determinants of neurological health.…”
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Multiscale guided attention network for optic disc segmentation of retinal images by A Z M Ehtesham Chowdhury, Andrew Mehnert, Graham Mann, William H. Morgan, Ferdous Sohel

“…A custom loss function is proposed to retain the optic disc's geometrical shape (i.e., elliptical) constraint and to alleviate the blood vessels' influence in the overlapping region between the OD and vessels. …”
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Ticks’ tricks: immunomodulatory effects of ixodid tick saliva at the cutaneous tick-host interface by Lisa Kleissl, Lisa Kleissl, Sophie Weninger, Florian Winkler, Margarida Ruivo, Michiel Wijnveld, Johanna Strobl, Johanna Strobl

“…Recent studies have focused on the effect of tick saliva on cells at the cutaneous tick-host interface and have suggested a strong immunomodulatory function. Within seconds after a tick bite, saliva containing various bioactive molecules is secreted into the host’s skin, leading to vasodilation, inhibition of coagulation and anti-inflammatory actions. …”
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Hyperspectral Reconstruction Method Based on Global Gradient Information and Local Low-Rank Priors by Chipeng Cao, Jie Li, Pan Wang, Weiqiang Jin, Runrun Zou, Chun Qi

“…First, to improve the prior model’s efficiency in utilizing information of different frequencies, we design a gradient sampling strategy and training framework based on decision trees, leveraging changes in the loss function gradient information to enhance the model’s predictive capability for data of varying frequencies. …”
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Dual Role of HNF4α in Colorectal Adenocarcinoma During Carcinogenesis and Metastasis by Ju Seok Kim, Kyung-Hee Kim, Jun Young Heo, Min Kyung Choi, Min-Kyung Yeo

“…This study was to investigate the significance of HNF4α in CRAC and mechanisms governing its function. The expression patterns and clinical relevance of HNF4α were evaluated in relation to nuclear factor kappa B (NF-κb), Yes-associated protein (YAP), and epithelial–mesenchymal transition markers. …”
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Lnc-DC promotes estrogen independent growth and tamoxifen resistance in breast cancer by Wan-Xin Peng, Pratirodh Koirala, Huaixiang Zhou, Jiahong Jiang, Ziqiang Zhang, Liu Yang, Yin-Yuan Mo

“…Abstract Selective estrogen receptor modulators (SERMs) such as tamoxifen have proven to be effective in the treatment of estrogen receptor (ER) positive breast cancer. …”
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STAR-YOLO: A High-Accuracy and Ultra-Lightweight Method for Brain Tumor Detection by Liyan Sun, Linxuan Zheng, Zhiguo Xiao, Yi Xin, Linqing Jiang

“…The model refines the backbone network and enhances the C2f module within the neck network. It also integrates SimAM, a parameter-free attention mechanism, and utilizes ShapeIoU as the localization loss function. …”
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