Radiotherapy and breast cancer: finally, an lncRNA perspective on radiosensitivity and radioresistance by Fatemeh Yazarlou, Ivan Martinez, Leonard Lipovich, Leonard Lipovich, Leonard Lipovich, Leonard Lipovich, Leonard Lipovich

“…Long non-coding RNAs (lncRNAs) are a poorly understood but abundant class of human genes that yield functional non-protein-coding RNA transcripts. Here, we canvass the field to seek evidence for the hypothesis that lncRNAs contribute to radioresistance in breast cancer. …”
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Macrophage Notch1 Participates in LPS-Induced Acute Lung Injury via Regulating CCR5 Expression in Mice by Ruiyu Zhang, Hui Du, Zhi Liu, Yuxi Lei, Huizhi Hu, Junwen Zheng, Pu Yang, Dongchi Zhao

“…Molecular profiling of CCR5 and inflammatory mediators was performed through real-time quantitative reverse transcription PCR (qRT-PCR) and immunofluorescence staining. Functional assessments of macrophage migration were carried out using scratch wound healing assays and transwell migration assays. …”
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Delivery of bone marrow mesenchymal stem cell-derived exosomes into fibroblasts attenuates intestinal fibrosis by weakening its transdifferentiation via the CCN2-TGF-β axis by Fangmei Ling, Wenkai Yang, Meng Yuan, Yidong Chen, Junrong Li, Jinhua Wu, Liangru Zhu

“…This study elucidates the regulatory mechanisms by which bone mesenchymal stem cell-derived exosomes (BMSC-Exo) modulate the myofibroblastic transdifferentiation of intestinal fibroblast. …”
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Halogenated 2,4-diphenyl indeno[1,2-B]pyridinol derivatives as potential inhibitors of the androgen receptor (PDB ID: 58TE): A study of QSAR modeling, molecular docking, and pharma... by Auwal Salisu Isa, Adamu Uzairu, Umar Mele Umar, Muhammad Tukur Ibrahim, David Ebuka Arthur, Samuel Ndaghiya Adawara

“…The comprehensive molecular understanding obtained, including the critical role of ligand functional groups in determining interaction types, pointing out the utility of the model in identifying potential therapeutic agents. …”
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Advances in the mechanism of small extracellular vesicles promoting the development of hepatocellular carcinoma through multi-network fusion by Xiaoying Yuan, Defa Huang, Liang Peng, Yilong Lin, Lijuan Wang, Jiawei Yan, Youming Qiu, Chenggui Song, Qi Wang

“…Currently, elucidating the molecular mechanisms of HCC pathogenesis and identifying effective therapeutic targets constitute major research priorities in this field.Small extracellular vesicles (sEVs) are phospholipid bilayer vesicles (30-150 nm in diameter) carrying functional proteomes and nucleic acids (e.g., miRNAs, lncRNAs) with substantial biological activity. …”
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Genomic and Fermentation Characterization of <i>Kluyveromyces marxianus</i> and <i>Saccharomyces cerevisiae</i> in Root Extract-Based Low-Alcohol Beverage by Eun-Ju Lee, Seung-Hyun Choi, Min-Ju Seo, A-Reum Lee, Chan-Song Jang, Woong-Kwon Kwak, Jung-Ki Kwak, Jae-Ho Lee, Won-Joo Yoon, Seok-Min Yoon

“…Fermentation is widely recognized for enhancing the sensory attributes and nutritional value in foods, with recent research focusing on non-alcoholic and root-based functional beverages. In this study, the genomic and fermentation characteristics of <i>Kluyveromyces marxianus</i> LRCC8279 (KM8279) and <i>Saccharomyces cerevisiae</i> LRCC8293 (SC8293) were analyzed, specifically for their application in root extract-based low-alcohol fermentations. …”
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Bioinformatics mining and experimental validation of prognostic biomarkers in colorectal cancer by Feng Huang, Salah A. Alshehade, Wei Guo Zhao, Zhuo Ya Li, Jung Yin Fong, Chin Tat Ng, Li Chen, Sasikala Chinnappan, Mohammed Abdullah Alshawsh, Karthikkumar Venkatachalam, Malarvili Selvaraja

“…WGCNA analysis highlighted the MEbrown module, which comprised 1,639 genes that exhibited strong correlations with CRC progression. …”
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B. ANIMALIS AND THE LECTIN OF B. SUBTILIS DIFFERENTLY REGULATE CYTOKINES PRODUCTION BY MACROPHAGES IN TUMOUR-BEARERS by N.I. Fedosova, N.L. Cheremshenko, S.V. Gogol, T.V. Symchych, I.M. Voyeykova, О.O. Lykhova, V.F. Chekhun

“…By producing a variety of soluble factors, including cytokines, macrophages (Mph) modulate the activity of other immune cells and have direct effects on cancer cells. …”
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Heat stress in chickens induces temporal changes in the cecal microbiome concomitant with host enteric serotonin responses by Joshua M. Lyte, Xinglin Jia, Valentina Caputi, Danyang Zhang, Karrie M. Daniels, Gregory J. Phillips, Mark Lyte

“…Heat stress is a potent modulator of the avian neuroendocrine system with concomitant impact on the gut microbiome. …”
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Contrasting Trends in Plant Diversity and Soil Carbon Mineralization Under Precipitation‐Driven Vegetation and Soil Carbon Dynamics in the Mongolian Plateau by Jia Mi, Fei Wang, Jing Shi, Qianju Wang, Haiyan Pang, Jianhao Yu, Dima Chen, Yongfei Bai

“…We measured plant diversity and biomass for both species and functional groups in 12 grassland sites. In the laboratory, we analyzed soil nutrients and microbial communities. …”
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Interplay between innate-like T-cells and microRNAs in cancer immunity by Mohammad Javad Yousefi, Yashmin Afshar, Amirmohammad Amoozadehsamakoosh, Alma Naseri, Fereshteh Soltani, Niloufar Yazdanpanah, Kiarash Saleki, Nima Rezaei

“…We will underscore the synergetic effects of the expression of miRNA in tumor and immune cells, influencing ILTC’s function and cancer progression. We emphasized the recent and innovative therapeutic approaches, novel delivery systems, and CAR-T cell-based strategy, and the therapeutic potential of modifying the expression of miRNA to regulate the miRNA expression to modulate ILTC activity and improve cancer treatment.…”
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Event-related theta synchronization over sensorimotor areas differs between younger and older adults and is related to bimanual motor control by Andreas Wulff-Abramsson, Ana Zvornik, Keenie Ayla Andersen, Yan Yang, Mikael Novén, Jesper Lundbye-Jensen, Leo Tomasevic, Anke Ninija Karabanov

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Human Placenta Hydrolysate Protects Against Acetaminophen-Induced Liver Injury in Mice by Inyoung Hwang, Chi-Gu Kang, So-Jung Lim, Hyun-Jin Kim, Ryun Kang, So-Hyun Jeon, Sang-Hoon Lee, Jae-Won Kim, Ju-Seop Kang

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Exercise and exerkines: Mechanisms and roles in anti-aging and disease prevention by Xuan Lu, Ying Chen, Yue Shi, Yi Shi, Xianbin Su, Peijie Chen, Die Wu, Hui Shi

“…Exercise has been shown to modulate mitochondrial function, immune responses, and inflammatory pathways, thereby attenuating aging through the regulation of exerkines secreted by diverse tissues and organs. …”
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Impact of tobacco and PM2.5 on lung cancer immunotherapy by Zheng Caihua, Huang Mei, Xian Guilan, Zhu Zhiguo, Zhou Qiuli, Zhu Gan, Zhu Zhuohao, Chen Zhi, Dai Jinxuan, Pang Xuexin, Li Bihui

“…However, prolonged exposure to these environmental factors may disrupt normal immune function. On the one hand, harmful components in tobacco directly damage immune cell viability and functionality, thus diminishing the immune system's ability to recognize and eliminate lung cancer cells. …”
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Low-Dose Oral Ginger Improves Daily Symptom Scores in Asthma by Charles W. Emala, Tarnjot K. Saroya, Yuqi Miao, Shuang Wang, Shengmin Sang, Emily A. DiMango

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Discovery of Carbonic Anhydrase 9 as a Novel CLEC2 Ligand in a Cellular Interactome Screen by Sebastian Hoffmann, Benedict-Tilman Berger, Liane Rosalie Lucas, Felix Schiele, John Edward Park

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Photo-induced hydrous organic aggregates for photoactivatable luminescence by Zeyang Ding, Rufan Mo, Zonghang Liu, Ying Peng, Yixuan Chen, Xiao Li, Fulong Ma, Guoqing Zhang, Zheng Zhao, Parvej Alam, Bo Wu, Zijie Qiu, Ben Zhong Tang

“…Abstract Harnessing light to regulate molecular aggregation behavior has become an essential approach to confer useful properties for functional materials at the aggregate level. Current examples of photo-induced aggregation predominantly occur in solution, but the solvent—ubiquitous as it is—is often overlooked as a potential participant in the aggregation process. …”
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Intelligent nanozymes: Biomimetic design, mechanisms and biomedical applications by Zhuoran Wang, Yaxin Hou, Guoheng Tang, Yucong Li, Yue Zhao, Yixin Yu, Guannan Wang, Xiyun Yan, Kelong Fan

“…However, their catalytic activities are typically lower than those of natural enzymes, and the lack of precise control over their functional modulation limits their therapeutic potential. …”
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FMRP cooperates with miRISC components to repress translation and regulate neurite morphogenesis in Drosophila by Navneeta Kaul, Sarala J. Pradhan, Nathan G. Boin, Madeleine M. Mason, Julian Rosales, Emily L. Starke, Emily C. Wilkinson, Erich G. Chapman, Scott A. Barbee

“…Specific target RNAs play critical roles in neurodevelopment, including the regulation of neurite morphogenesis, synaptic plasticity, and cognitive function. The different biological functions of FMRP are modulated by its cooperative interaction with distinct sets of neuronal RNA and protein-binding partners. …”
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