MS CETSA deep functional proteomics uncovers DNA repair programs leading to gemcitabine resistance by Ying Yu Liang, Khalidah Khalid, Hai Van Le, Hui Min Vivian Teo, Mindaugas Raitelaitis, Marc-Antoine Gerault, Jane Jia Hui Lee, Jiawen Lyu, Allison Chan, Anand Devaprasath Jeyasekharan, Wai Leong Tam, Pär Nordlund, Nayana Prabhu

“…Here we use a deep functional proteomics implementation of the Cellular Thermal Shift Assay to reveal a range of induced biochemical responses to gemcitabine in resistant and sensitive diffuse large B cell lymphoma cell lines. …”
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Advances in non-invasive brain stimulation: enhancing sports performance function and insights into exercise science by Shuo Qi, Jinglun Yu, Li Li, Chen Dong, Zhe Ji, Lei Cao, Zhen Wei, Zhiqiang Liang

“…By elucidating the mechanisms of action and potential benefits, this study aims to arm researchers with the tools necessary to modulate targeted brain regions, thereby deepening our understanding of the intricate interplay between brain function and human behavior.…”
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ProS1-MerTK signaling in CD4 T cells: implications for TIL expansion and functionality by Annina Kurzay, Sara Fresnillo Saló, Anne Rahbech, Tina Seremet, Cecilie Oelvang Madsen, Christopher Aled Chamberlain, Emilie Bülow Jensen, Viet Thy Luu, Özcan Met, Marlies J W Peeters, Per thor Straten

“…These findings establish ProS1-MerTK as a key pathway for modulating CD4 T cell functionality and highlight its therapeutic potential to enhance TIL-based ACT outcomes.…”
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Dopamine Treatment and Cognitive Functioning in Individuals with Parkinson’s Disease: The “Cognitive Flexibility” Hypothesis Seems to Work by Alberto Costa, Antonella Peppe, Ilenia Mazzù, Mariachiara Longarzo, Carlo Caltagirone, Giovanni A. Carlesimo

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March5-mediated Trim28 degradation preserves islet β-cell function in mice by Yangshan Chen, Wei Pang, Guixing Ma, Yongcong Yan, Zhiyu Xiao, Yong Chen, Zhen Ding, Litong Chen, Xiaoting Hou, Huiling Cao

“…However, the regulatory pathways underlying β-cell function remain incompletely understood. Here, we identify that March5 and Trim28 as key modulators of β-cell function. …”
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Proton-Sensing G Protein-Coupled Receptors and Their Potential Role in Exercise Regulation of Arterial Function by Fengzhi Yu, Dandan Jia, Ru Wang

“…Recent studies have shown that the activation or inhibition of these receptors modulates a number of arterial functions, including angiogenesis, arterial relaxation, and arterial inflammation. …”
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Mechanical properties and energy absorption of CoCrNi functionally graded TPMS cellular structures by Zhaoyi Wang, Junxian Zhou, Yunzhuo Lu, Dongming Li, Deyu Yue, Xu Zhang, Bingzhi Chen

“…Functionally gradient triply periodic minimal surface (TPMS) structures are found widespread applications in fields such as aerospace and defense engineering, owing to flexible modulation of lightweight and energy-absorbing properties. …”
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In Vitro Prevention of Salmonella Lipopolysaccharide-Induced Damages in Epithelial Barrier Function by Various Lactobacillus Strains by Chun-Yan Yeung, Jen-Shiu Chiang Chiau, Wai-Tao Chan, Chun-Bin Jiang, Mei-Lien Cheng, Hsuan-Liang Liu, Hung-Chang Lee

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Neural Mechanisms and Alterations of Sweet Sensing: Insights from Functional Magnetic Resonance Imaging Studies by Tobias Long, Colette C. Milbourn, Alison Smith, Kyaw Linn Su Khin, Amanda J. Page, Iskandar Idris, Qian Yang, Richard L. Young, Sally Eldeghaidy

“…Both internal and external factors tightly regulate their signalling pathways, and dysfunction within these systems may contribute to the development of metabolic disorders such as obesity and type 2 diabetes (T2D). Functional magnetic resonance imaging (fMRI) has provided valuable insights into the neural mechanisms underlying sweet sensing by mapping brain responses to both lingual/oral and gastrointestinal sweet stimuli. …”
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MicroRNAs in Liver Fibrosis: Unraveling Intercellular Crosstalk and the Regulatory Functions of MicroRNA-223 by Chinnatam Phetkong, Chaiyaboot Ariyachet

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ARF6-dependent regulation of P2Y receptor traffic and function in human platelets. by Venkateswarlu Kanamarlapudi, Sian E Owens, Keya Saha, Robert J Pope, Stuart J Mundell

“…These data describe a novel function of ARF6 in the internalization of P2Y purinoceptors and demonstrate the integral importance of this small GTPase upon platelet ADP receptor function.…”
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Integrated multi-omics analysis reveals the functional signature of microbes and metabolomics in pre-diabetes individuals by Yanmin Liu, Qinwei Qiu, Yang Chen, Yusheng Deng, Wei Huang, Chen Sun, Xiaoxiao Shang, Xinyan Chen, Chengrui Wang, Lijuan Han, Shiyan Chen, Jiamin Yuan, Fuping Xu, Zhimin Yang, Xiaodong Fang, Li Huang

“…Using an integrated analysis of human microbiota and metabolomics data, we seek to identify the functional signature associated with PD and gain insights into potential mechanisms driving its progression to type 2 diabetes. …”
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Tail Anchored protein insertion mediated by CAML and TRC40 links to neuromuscular function in mice. by Ying Zhang, Lihong He, Justin Gundelach, Anjie Ge, Helena Edlund, Stefan Norlin, Richard J Bram

“…Thus, it is valuable to identify additional genes that can impact motor neuron survival and function. In this report, we describe mice that express globally reduced levels of calcium-modulating cyclophilin ligand (CAML) protein. …”
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Transfer of preclinical study data on the influence of cimicifuga racemosaon functional changes in the hippocampus during menopause by Petra Stute, Hans-Heinrich Henneicke-von Zepelin, Petra Nicken

“…Focus was laid on changes in the hippocampal function, that is disturbed by hormonal fluctuations, but can also be brought back into balance by iCR.…”
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Multi-functional mechanisms of immune evasion by the streptococcal complement inhibitor C5a peptidase. by Nicola N Lynskey, Mark Reglinski, Damien Calay, Matthew K Siggins, Justin C Mason, Marina Botto, Shiranee Sriskandan

“…Taken together, these data show that ScpA is a multi-functional virulence factor with both complement-dependent and independent roles in streptococcal pathogenesis.…”
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Rat retinal function attenuation with IOP elevation is impacted by both blood pressure and intracranial pressure by Sera N. Ganearachchi, Anna K. van Koeverden, Christine T. O. Nguyen, Zheng He, Vickie H. Y. Wong, Bang V. Bui, Da Zhao

“…The ocular perfusion pressure (BP–IOP) relationship largely accounts for the effect of IOP and BP modulation on retinal function but could not account for differences in ganglion cell function between ICP levels.…”
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Depth-dependent contributions of various vascular zones to cerebral autoregulation and functional hyperemia: An in-silico analysis. by Hadi Esfandi, Mahshad Javidan, Rozalyn M Anderson, Ramin Pashaie

“…Autoregulation and neurovascular coupling are key mechanisms that modulate myogenic tone (MT) in vessels to regulate cerebral blood flow (CBF) during resting state and periods of increased neural activity, respectively. …”
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The Role of Social Functioning Between Vitality and Mental Distress in Hypertension: A Partial Mediation Model by Sara Guidotti, Francesca Giordano, Carlo Pruneti

“…Moreover, positive associations were found between mental distress and vitality and between vitality and physical and social functioning along with heart rate. Notably, it was determined that vitality negatively predicted mental distress directly and indirectly by mediating social functioning. (4) Conclusions: Despite these promising findings, this study’s cross-sectional nature does not allow for the definition of the causal relationship between the investigated variables. …”
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Heat Stress Impairs Endometrial Function During Implantation by Regulating Autophagy in Hainan Black Goat by Xiaoping Li, Yanyu Sun, Yi Min, Xinyu Wang, Diqi Yang, Hui Peng

“…However, the effects of HS on endometrial function during the peri-implantation period in Hainan black goats remain unclear. …”
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Effects of Aqueous Extracts from Wheat Bran Layers on the Functional Properties of Wheat Starch and Gluten by Bingbing Wu, Chunlei Yu, Zhongwei Chen, Bin Xu

“…This study aims to investigate the influence of aqueous extracts from different WB layers (aleurone layer, AL; non-aleurone layer, NAL) and their components on the functional properties of wheat starch and gluten. The results indicate that the AL-rich fraction yielded a higher extract content (30.6%) compared to the NAL-rich fraction (15.1%), attributable to the higher cellular content in the AL. …”
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